ES8303411A1 - Un procedimiento para la preparacion de derivados de tiofilina o teobromina. - Google Patents
Un procedimiento para la preparacion de derivados de tiofilina o teobromina.Info
- Publication number
- ES8303411A1 ES8303411A1 ES505184A ES505184A ES8303411A1 ES 8303411 A1 ES8303411 A1 ES 8303411A1 ES 505184 A ES505184 A ES 505184A ES 505184 A ES505184 A ES 505184A ES 8303411 A1 ES8303411 A1 ES 8303411A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- image
- stands
- lower alkyl
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE TEOFILINA O TEOBROMINA, DE FORMULA (I), EN LA QUE W Y W'' SON DISTINTOS Y REPRESENTAN METILO O UNO DE VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), CON UN COMPUESTO DE FORMULA (III), EN LAS QUE G Y G'' SON DIFERENTES Y REPRESENTAN METILO O (CH )<NA, SIENDO A HALOGENO O P-TOLUEN-SULFONILOXI Y N UN NUMERO DE 2 A 10; X ES CARBONO O NITROGENO; R ES HIDROGENO O ALQUILO INFERIOR Y Z PUEDE SER UNO DE VARIOS RADICALES. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE EN PRESENCIA DE UN CAPTADOR DE ACIDO A TEMPERATURA ENTRE LA AMBIENTE Y LA DE EBULLICION DEL DISOLVENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACCION VASODILATADORA, DE INCREMENTO DE FLUJO SANGUINEO, ANTIISTAMINICA, ANALGESICA, ANTIASMATICA E HIPOTENSORA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55121712A JPS5746983A (en) | 1980-09-04 | 1980-09-04 | Theophylline derivative and its preparation |
JP12171380A JPS5746984A (en) | 1980-09-04 | 1980-09-04 | Theobromine derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
ES505184A0 ES505184A0 (es) | 1983-02-01 |
ES8303411A1 true ES8303411A1 (es) | 1983-02-01 |
Family
ID=26459005
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES505184A Expired ES8303411A1 (es) | 1980-09-04 | 1981-09-03 | Un procedimiento para la preparacion de derivados de tiofilina o teobromina. |
Country Status (10)
Country | Link |
---|---|
US (2) | US4426383A (es) |
CA (1) | CA1172632A (es) |
CH (1) | CH651042A5 (es) |
DE (1) | DE3134929A1 (es) |
ES (1) | ES8303411A1 (es) |
FR (1) | FR2489331A1 (es) |
GB (1) | GB2083470B (es) |
IT (1) | IT1138196B (es) |
NL (1) | NL8104073A (es) |
SE (2) | SE456910B (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4426383A (en) * | 1980-09-04 | 1984-01-17 | Eisai Co., Ltd. | Theophylline and theobromine derivatives |
ES506046A0 (es) * | 1981-10-06 | 1983-02-01 | Invest Tecnica Aplicada | Procedimiento de obtencion de nuevas xantinas con actividad farmacologica |
FR2531085A1 (fr) * | 1982-07-28 | 1984-02-03 | Adir | Nouveaux derives de la xanthine, leur procede de preparation et les compositions pharmaceutiques les renfermant |
IT1203656B (it) * | 1983-06-10 | 1989-02-15 | Medosan Ind Biochimi | Attivita' antiaggregante piastrinica,antiinfiammatoria e broncolitica di esteri aroilpirrol e pirrilfenil acetici delle 7 (w-ossialchil) teofilline |
US4548939A (en) * | 1984-10-01 | 1985-10-22 | Janssen Pharmaceutica N. V. | 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones |
NL8700245A (nl) * | 1986-02-14 | 1987-09-01 | Sandoz Ag | Purinederivaten, werkwijzen voor hun bereiding en geneesmiddelen die deze derivaten bevatten. |
US4710572A (en) * | 1986-07-30 | 1987-12-01 | American Home Products Corporation | Histamine H1 antagonists |
US4716165A (en) * | 1986-09-24 | 1987-12-29 | American Home Products Corporation | Histamine H1 antagonists |
US4716166A (en) * | 1986-10-21 | 1987-12-29 | American Home Products Corporation | Histamine H1 antagonists |
JP2552494B2 (ja) * | 1987-04-08 | 1996-11-13 | ヘキストジャパン株式会社 | イミダゾチアジアジン誘導体及びその製造法 |
FR2618151B1 (fr) * | 1987-07-16 | 1991-01-11 | Synthelabo | Derives de piperidine, leur preparation et leur application en therapeutique |
US4876257A (en) * | 1988-03-03 | 1989-10-24 | Ortho Pharmaceutical Corporation | 6-Substituted purinyl piperazine derivatives useful as cardiotonic and antiarrhythmic agents |
US5164390A (en) * | 1988-03-03 | 1992-11-17 | Ortho Pharmaceutical Corporation | 6-substituted purinyl piperazine derivatives |
US5021574A (en) * | 1988-03-03 | 1991-06-04 | Ortho Pharmaceutical Corporation | 6-substituted purinyl piperazine derivatives |
US5332733A (en) * | 1990-11-24 | 1994-07-26 | Kali-Chemie Pharma Gmbh | Heterocyclically substituted piperazinoakylbenzoxazine and piperazinoalkylbenzothiazine compounds, processes for preparing them, and medicaments containing them |
US5681954A (en) * | 1993-05-14 | 1997-10-28 | Daiichi Pharmaceutical Co., Ltd. | Piperazine derivatives |
US6407116B1 (en) | 1997-09-16 | 2002-06-18 | Takeda Chemical Industries, Inc. | Nitrogenous fused-ring compounds, process for the preparation of the same, and drugs |
WO1999031101A1 (en) * | 1997-12-17 | 1999-06-24 | University Of South Florida | Adenosine receptor antagonists with improved bioactivity |
US6979687B1 (en) * | 2002-09-27 | 2005-12-27 | Ing-Jun Chen | Theophylline-based soluble guanylyl cyclase activators KMUP-1 analogues enhanced cyclic GMP and K+ channel activities on rabbit corpus cavernosum smooth muscle and intercavernous pressure activities |
US20050209243A1 (en) * | 2002-09-27 | 2005-09-22 | Ing-Jun Chen | Theophylline-based soluble guanylyl cyclase activators KMUP-1 analogues enhanced cyclic GMP and K+ channel activities on rabbit corpus cavernosum smooth muscle and intercavernous pressure activities |
CA2529750A1 (en) * | 2003-06-20 | 2005-02-24 | Arena Pharmaceuticals, Inc. | N-phenyl-piperazine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases |
US20090285899A1 (en) * | 2003-07-31 | 2009-11-19 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a methylxanthine derivative for treatment of asthma or chronic obstructive pulmonary disease |
US20050026848A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a methylxanthine derivative for treatment of asthma or chronic obstructive pulmonary disease |
WO2006064780A1 (ja) * | 2004-12-14 | 2006-06-22 | Shionogi & Co., Ltd. | 便秘治療剤 |
WO2008121019A1 (ru) * | 2007-03-29 | 2008-10-09 | Obschestvo S Ogranishennoi Otvetstvennostu 'farmving' | Средство противогистаминного антиаллергического действия и способ его получения |
US8163761B2 (en) * | 2007-06-22 | 2012-04-24 | Hydra Biosciences, Inc. | Methods and compositions for treating disorders |
WO2009140517A1 (en) | 2008-05-14 | 2009-11-19 | Hydra Biosciences, Inc. | Compounds and compositions for treating chemical warfare agent-induced injuries |
TWI368511B (en) * | 2009-04-30 | 2012-07-21 | Univ Kaohsiung Medical | Synthesis and pharmacokinetic activities of pulmodil and pulmodil-1, two chlorophenylpiperazine salt derivatives |
TWI368513B (en) * | 2009-04-30 | 2012-07-21 | Univ Kaohsiung Medical | Synthesis of pulmodil and pulmodil-1, two chlorophenylpiperazine salt derivatives, and rhokinase-dependent inhibition activity on pulmonary artery endothelium dysfunction, medial wall thickness and vascular obstruction thereof |
US8470805B2 (en) * | 2009-04-30 | 2013-06-25 | Kaohsiung Medical University | Processes for preparing piperazinium salts of KMUP and use thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR882044A (fr) * | 1940-05-03 | 1943-05-14 | Bosch Gmbh Robert | Procédé de fabrication de graisses lubrifiantes |
GB1133989A (en) * | 1964-12-08 | 1968-11-20 | Chugai Pharmaceutical Co Ltd | Theophylline derivatives, their salts and process for preparing the same |
DE1620576A1 (de) | 1966-11-25 | 1970-02-26 | Troponwerke Dinklage & Co | Verfahren zur Herstellung von Theophyllin- und Theobrominverbindungen |
CA975367A (en) * | 1972-03-20 | 1975-09-30 | John D. Mccoll | Preparation of 7-propyl substituted theophyllines |
JPS55118488A (en) * | 1979-03-05 | 1980-09-11 | Eisai Co Ltd | Theobromine derivative and its preparation |
DE2922159A1 (de) | 1979-05-31 | 1980-12-04 | Boehringer Mannheim Gmbh | Neue xanthin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US4426383A (en) * | 1980-09-04 | 1984-01-17 | Eisai Co., Ltd. | Theophylline and theobromine derivatives |
US4400381A (en) * | 1981-07-31 | 1983-08-23 | Laroche-Navarron, S.A. | Piperazine derivatives of theophylline |
-
1981
- 1981-08-31 US US06/298,227 patent/US4426383A/en not_active Expired - Fee Related
- 1981-09-02 NL NL8104073A patent/NL8104073A/nl not_active Application Discontinuation
- 1981-09-03 CA CA000385142A patent/CA1172632A/en not_active Expired
- 1981-09-03 GB GB8126653A patent/GB2083470B/en not_active Expired
- 1981-09-03 ES ES505184A patent/ES8303411A1/es not_active Expired
- 1981-09-03 CH CH5675/81A patent/CH651042A5/fr not_active IP Right Cessation
- 1981-09-03 DE DE19813134929 patent/DE3134929A1/de not_active Ceased
- 1981-09-03 SE SE8105240A patent/SE456910B/sv not_active IP Right Cessation
- 1981-09-04 IT IT23790/81A patent/IT1138196B/it active
- 1981-09-04 FR FR8116855A patent/FR2489331A1/fr active Granted
-
1983
- 1983-04-11 US US06/484,044 patent/US4564617A/en not_active Expired - Fee Related
-
1987
- 1987-11-20 SE SE8704599A patent/SE457083B/sv not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE3134929A1 (de) | 1982-06-09 |
SE457083B (sv) | 1988-11-28 |
SE8105240L (sv) | 1982-03-05 |
FR2489331B1 (es) | 1984-11-30 |
US4426383A (en) | 1984-01-17 |
IT8123790A0 (it) | 1981-09-04 |
US4564617A (en) | 1986-01-14 |
SE8704599D0 (sv) | 1987-11-20 |
NL8104073A (nl) | 1982-04-01 |
CH651042A5 (fr) | 1985-08-30 |
IT1138196B (it) | 1986-09-17 |
GB2083470A (en) | 1982-03-24 |
GB2083470B (en) | 1984-09-12 |
CA1172632A (en) | 1984-08-14 |
FR2489331A1 (fr) | 1982-03-05 |
ES505184A0 (es) | 1983-02-01 |
SE8704599L (sv) | 1987-11-20 |
SE456910B (sv) | 1988-11-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed |
Effective date: 19960401 |