IT8123790A0 - Composto derivato della teofilina o della teobromina. - Google Patents

Composto derivato della teofilina o della teobromina.

Info

Publication number
IT8123790A0
IT8123790A0 IT8123790A IT2379081A IT8123790A0 IT 8123790 A0 IT8123790 A0 IT 8123790A0 IT 8123790 A IT8123790 A IT 8123790A IT 2379081 A IT2379081 A IT 2379081A IT 8123790 A0 IT8123790 A0 IT 8123790A0
Authority
IT
Italy
Prior art keywords
theophyline
theobromine
compound derived
derived
compound
Prior art date
Application number
IT8123790A
Other languages
English (en)
Other versions
IT1138196B (it
Inventor
Hachiro Sugimoto
Takaharu Nakamura
Sachiyuki Hamano
Toshiji Igarashi
Yoshiharu Daiku
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP12171380A external-priority patent/JPS5746984A/ja
Priority claimed from JP55121712A external-priority patent/JPS5746983A/ja
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of IT8123790A0 publication Critical patent/IT8123790A0/it
Application granted granted Critical
Publication of IT1138196B publication Critical patent/IT1138196B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
IT23790/81A 1980-09-04 1981-09-04 Composto derivato della teofillina o della teobromina IT1138196B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP12171380A JPS5746984A (en) 1980-09-04 1980-09-04 Theobromine derivative and its preparation
JP55121712A JPS5746983A (en) 1980-09-04 1980-09-04 Theophylline derivative and its preparation

Publications (2)

Publication Number Publication Date
IT8123790A0 true IT8123790A0 (it) 1981-09-04
IT1138196B IT1138196B (it) 1986-09-17

Family

ID=26459005

Family Applications (1)

Application Number Title Priority Date Filing Date
IT23790/81A IT1138196B (it) 1980-09-04 1981-09-04 Composto derivato della teofillina o della teobromina

Country Status (10)

Country Link
US (2) US4426383A (it)
CA (1) CA1172632A (it)
CH (1) CH651042A5 (it)
DE (1) DE3134929A1 (it)
ES (1) ES505184A0 (it)
FR (1) FR2489331A1 (it)
GB (1) GB2083470B (it)
IT (1) IT1138196B (it)
NL (1) NL8104073A (it)
SE (2) SE456910B (it)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4426383A (en) * 1980-09-04 1984-01-17 Eisai Co., Ltd. Theophylline and theobromine derivatives
ES506046A0 (es) * 1981-10-06 1983-02-01 Invest Tecnica Aplicada Procedimiento de obtencion de nuevas xantinas con actividad farmacologica
FR2531085A1 (fr) * 1982-07-28 1984-02-03 Adir Nouveaux derives de la xanthine, leur procede de preparation et les compositions pharmaceutiques les renfermant
IT1203656B (it) * 1983-06-10 1989-02-15 Medosan Ind Biochimi Attivita' antiaggregante piastrinica,antiinfiammatoria e broncolitica di esteri aroilpirrol e pirrilfenil acetici delle 7 (w-ossialchil) teofilline
US4548939A (en) * 1984-10-01 1985-10-22 Janssen Pharmaceutica N. V. 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
HU198052B (en) * 1986-02-14 1989-07-28 Sandoz Ag Process for producing purine derivatives substituted by side chain containing piperazinyl ring and pharmaceutical compositions comprising such compounds
US4710572A (en) * 1986-07-30 1987-12-01 American Home Products Corporation Histamine H1 antagonists
US4716165A (en) * 1986-09-24 1987-12-29 American Home Products Corporation Histamine H1 antagonists
US4716166A (en) * 1986-10-21 1987-12-29 American Home Products Corporation Histamine H1 antagonists
JP2552494B2 (ja) * 1987-04-08 1996-11-13 ヘキストジャパン株式会社 イミダゾチアジアジン誘導体及びその製造法
FR2618151B1 (fr) * 1987-07-16 1991-01-11 Synthelabo Derives de piperidine, leur preparation et leur application en therapeutique
US5021574A (en) * 1988-03-03 1991-06-04 Ortho Pharmaceutical Corporation 6-substituted purinyl piperazine derivatives
US4876257A (en) * 1988-03-03 1989-10-24 Ortho Pharmaceutical Corporation 6-Substituted purinyl piperazine derivatives useful as cardiotonic and antiarrhythmic agents
US5164390A (en) * 1988-03-03 1992-11-17 Ortho Pharmaceutical Corporation 6-substituted purinyl piperazine derivatives
US5332733A (en) * 1990-11-24 1994-07-26 Kali-Chemie Pharma Gmbh Heterocyclically substituted piperazinoakylbenzoxazine and piperazinoalkylbenzothiazine compounds, processes for preparing them, and medicaments containing them
US5681954A (en) * 1993-05-14 1997-10-28 Daiichi Pharmaceutical Co., Ltd. Piperazine derivatives
WO1999014203A1 (fr) 1997-09-16 1999-03-25 Takeda Chemical Industries, Ltd. Composes azotes a cycles condenses, procede de preparation de ces composes et medicaments
WO1999031101A1 (en) * 1997-12-17 1999-06-24 University Of South Florida Adenosine receptor antagonists with improved bioactivity
US20050209243A1 (en) * 2002-09-27 2005-09-22 Ing-Jun Chen Theophylline-based soluble guanylyl cyclase activators KMUP-1 analogues enhanced cyclic GMP and K+ channel activities on rabbit corpus cavernosum smooth muscle and intercavernous pressure activities
US6979687B1 (en) * 2002-09-27 2005-12-27 Ing-Jun Chen Theophylline-based soluble guanylyl cyclase activators KMUP-1 analogues enhanced cyclic GMP and K+ channel activities on rabbit corpus cavernosum smooth muscle and intercavernous pressure activities
EA200600071A1 (ru) * 2003-06-20 2006-08-25 Арена Фармасьютикалз, Инк. Производные n-фенилпиперазина и способы профилактики или лечения заболеваний, связанных с 5ht-рецептором
US20050026848A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a methylxanthine derivative for treatment of asthma or chronic obstructive pulmonary disease
US20090285899A1 (en) * 2003-07-31 2009-11-19 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a methylxanthine derivative for treatment of asthma or chronic obstructive pulmonary disease
WO2006064780A1 (ja) * 2004-12-14 2006-06-22 Shionogi & Co., Ltd. 便秘治療剤
PT2159226T (pt) * 2007-03-29 2016-12-16 Joint-Stock Company Obninsk Chemical Pharmaceutical Company Agente anti-histamínico e antialérgico e um método para a produção do mesmo
WO2009002933A1 (en) * 2007-06-22 2008-12-31 Hydra Biosciences, Inc. Methods and compositions for treating disorders
WO2009140517A1 (en) 2008-05-14 2009-11-19 Hydra Biosciences, Inc. Compounds and compositions for treating chemical warfare agent-induced injuries
TWI368511B (en) * 2009-04-30 2012-07-21 Univ Kaohsiung Medical Synthesis and pharmacokinetic activities of pulmodil and pulmodil-1, two chlorophenylpiperazine salt derivatives
TWI368513B (en) * 2009-04-30 2012-07-21 Univ Kaohsiung Medical Synthesis of pulmodil and pulmodil-1, two chlorophenylpiperazine salt derivatives, and rhokinase-dependent inhibition activity on pulmonary artery endothelium dysfunction, medial wall thickness and vascular obstruction thereof
US8470805B2 (en) * 2009-04-30 2013-06-25 Kaohsiung Medical University Processes for preparing piperazinium salts of KMUP and use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR882044A (fr) * 1940-05-03 1943-05-14 Bosch Gmbh Robert Procédé de fabrication de graisses lubrifiantes
GB1133989A (en) * 1964-12-08 1968-11-20 Chugai Pharmaceutical Co Ltd Theophylline derivatives, their salts and process for preparing the same
DE1620576A1 (de) 1966-11-25 1970-02-26 Troponwerke Dinklage & Co Verfahren zur Herstellung von Theophyllin- und Theobrominverbindungen
CA975367A (en) * 1972-03-20 1975-09-30 John D. Mccoll Preparation of 7-propyl substituted theophyllines
JPS55118488A (en) * 1979-03-05 1980-09-11 Eisai Co Ltd Theobromine derivative and its preparation
DE2922159A1 (de) 1979-05-31 1980-12-04 Boehringer Mannheim Gmbh Neue xanthin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4426383A (en) * 1980-09-04 1984-01-17 Eisai Co., Ltd. Theophylline and theobromine derivatives
US4400381A (en) * 1981-07-31 1983-08-23 Laroche-Navarron, S.A. Piperazine derivatives of theophylline

Also Published As

Publication number Publication date
ES8303411A1 (es) 1983-02-01
FR2489331B1 (it) 1984-11-30
FR2489331A1 (fr) 1982-03-05
GB2083470B (en) 1984-09-12
GB2083470A (en) 1982-03-24
DE3134929A1 (de) 1982-06-09
IT1138196B (it) 1986-09-17
SE456910B (sv) 1988-11-14
US4564617A (en) 1986-01-14
CA1172632A (en) 1984-08-14
US4426383A (en) 1984-01-17
NL8104073A (nl) 1982-04-01
SE8704599L (sv) 1987-11-20
ES505184A0 (es) 1983-02-01
SE8704599D0 (sv) 1987-11-20
SE457083B (sv) 1988-11-28
CH651042A5 (fr) 1985-08-30
SE8105240L (sv) 1982-03-05

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