FR2488606A1 - Derives indoliques, leur preparation et leurs applications en tant que medicaments - Google Patents

Derives indoliques, leur preparation et leurs applications en tant que medicaments Download PDF

Info

Publication number
FR2488606A1
FR2488606A1 FR8115515A FR8115515A FR2488606A1 FR 2488606 A1 FR2488606 A1 FR 2488606A1 FR 8115515 A FR8115515 A FR 8115515A FR 8115515 A FR8115515 A FR 8115515A FR 2488606 A1 FR2488606 A1 FR 2488606A1
Authority
FR
France
Prior art keywords
group
compound
general formula
hydrogen atom
indol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8115515A
Other languages
English (en)
French (fr)
Other versions
FR2488606B1 (enrdf_load_stackoverflow
Inventor
Ian Harold Coates
Keith Mills
Colin Frederick Webb
Michael Dennis Dowle
David Edmund Bays
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of FR2488606A1 publication Critical patent/FR2488606A1/fr
Application granted granted Critical
Publication of FR2488606B1 publication Critical patent/FR2488606B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
FR8115515A 1980-08-12 1981-08-11 Derives indoliques, leur preparation et leurs applications en tant que medicaments Granted FR2488606A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8026288 1980-08-12
GB8026287 1980-08-12

Publications (2)

Publication Number Publication Date
FR2488606A1 true FR2488606A1 (fr) 1982-02-19
FR2488606B1 FR2488606B1 (enrdf_load_stackoverflow) 1984-10-26

Family

ID=26276534

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8115515A Granted FR2488606A1 (fr) 1980-08-12 1981-08-11 Derives indoliques, leur preparation et leurs applications en tant que medicaments

Country Status (12)

Country Link
AU (1) AU550010B2 (enrdf_load_stackoverflow)
CH (1) CH652394A5 (enrdf_load_stackoverflow)
DE (1) DE3131752A1 (enrdf_load_stackoverflow)
DK (1) DK157995C (enrdf_load_stackoverflow)
ES (2) ES504694A0 (enrdf_load_stackoverflow)
FR (1) FR2488606A1 (enrdf_load_stackoverflow)
GB (1) GB2083463B (enrdf_load_stackoverflow)
IE (1) IE51493B1 (enrdf_load_stackoverflow)
IT (1) IT1171450B (enrdf_load_stackoverflow)
NL (1) NL8103764A (enrdf_load_stackoverflow)
NZ (1) NZ197998A (enrdf_load_stackoverflow)
SE (1) SE454777B (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5037845A (en) * 1984-08-01 1991-08-06 Glaxo Group Limited Indole derivative

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1170387B (it) * 1982-06-07 1987-06-03 Glaxo Group Ltd Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono
PT78358B (en) * 1983-04-07 1986-05-30 Smith Kline French Lab Chemical process
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8332435D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8607824D0 (en) * 1986-03-27 1986-04-30 Glaxo Group Ltd Chemical compounds
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
GB9104136D0 (en) * 1991-02-27 1991-04-17 Merck Sharp & Dohme Therapeutic agents
UA34452C2 (uk) * 1992-04-10 2001-03-15 Пфайзер Інк. Похідні ациламіноіндолу, що проявляють серотонінову 5-нт1 агоністичну активність та похідні аміноіндолу як проміжні сполуки
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
ES2070772B1 (es) * 1993-08-09 1996-02-16 Pfizer Derivados de acilaminoindol
WO1996017842A1 (en) * 1994-12-06 1996-06-13 Merck Sharp & Dohme Limited Azetidine, pyrrolidine and piperidine derivatives as 5ht1 receptor agonists
FR2731224B1 (fr) * 1995-03-02 1997-05-30 Pf Medicament Nouveaux derives bi-tryptaminiques sulfonamides, leur procede de preparation et leur utilisation a titre de medicaments
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2870162A (en) * 1954-04-28 1959-01-20 Upjohn Co Production of certain tryptamines and compounds produced in the process
FR1203195A (fr) * 1958-07-25 1960-01-15 Chimiotherapie Lab Franc Procédé de préparation d'un nouveau dérivé de la tryptamine
FR2211249A1 (en) * 1972-12-21 1974-07-19 Merck & Co Inc Cyclopropyl-substd. indomethacine analogues - anti-inflammatory, anti-pyretics, anti-arthritic and dermatologically active
FR2438651A1 (fr) * 1978-10-12 1980-05-09 Glaxo Group Ltd Nouveaux derives d'indole utiles comme medicaments, procedes pour leur preparation et compositions pharmaceutiques les contenant

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2870162A (en) * 1954-04-28 1959-01-20 Upjohn Co Production of certain tryptamines and compounds produced in the process
FR1203195A (fr) * 1958-07-25 1960-01-15 Chimiotherapie Lab Franc Procédé de préparation d'un nouveau dérivé de la tryptamine
FR2211249A1 (en) * 1972-12-21 1974-07-19 Merck & Co Inc Cyclopropyl-substd. indomethacine analogues - anti-inflammatory, anti-pyretics, anti-arthritic and dermatologically active
FR2438651A1 (fr) * 1978-10-12 1980-05-09 Glaxo Group Ltd Nouveaux derives d'indole utiles comme medicaments, procedes pour leur preparation et compositions pharmaceutiques les contenant

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5037845A (en) * 1984-08-01 1991-08-06 Glaxo Group Limited Indole derivative

Also Published As

Publication number Publication date
DK357281A (da) 1982-02-13
CH652394A5 (fr) 1985-11-15
FR2488606B1 (enrdf_load_stackoverflow) 1984-10-26
ES8405371A1 (es) 1984-06-01
NZ197998A (en) 1985-08-16
IT1171450B (it) 1987-06-10
IT8149085A0 (it) 1981-08-11
ES8300699A1 (es) 1982-11-01
ES513934A0 (es) 1984-06-01
DK157995C (da) 1990-08-06
IE51493B1 (en) 1987-01-07
SE8104783L (sv) 1982-02-13
GB2083463B (en) 1984-05-10
GB2083463A (en) 1982-03-24
DK157995B (da) 1990-03-12
SE454777B (sv) 1988-05-30
NL8103764A (nl) 1982-03-01
AU7399581A (en) 1982-02-18
ES504694A0 (es) 1982-11-01
DE3131752C2 (enrdf_load_stackoverflow) 1992-04-23
AU550010B2 (en) 1986-02-27
DE3131752A1 (de) 1982-06-16
IE811832L (en) 1982-02-12

Similar Documents

Publication Publication Date Title
FR2488606A1 (fr) Derives indoliques, leur preparation et leurs applications en tant que medicaments
BE1000071A4 (fr) Derives d'indole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2530625A1 (fr) Derives d'indole, procedes pour leur preparation et compositions pharmaceutiques les contenant
CH651550A5 (fr) Derives de l'indole, leur preparation et compositions pharmaceutiques les contenant.
EP1115719B1 (fr) Derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
US4839377A (en) 5-substituted 3-aminoalkyl indoles
EP0593513B1 (en) Tryptamine analogues, their synthesis and their use as 5-ht1-like receptors or 5-ht2 receptor agonistes
CH663411A5 (fr) Derives d'indole utiles comme medicaments.
CH651551A5 (fr) Derives de l'indole, leur preparation et compositions pharmaceutiques les contenant.
FR2568571A1 (fr) Derive d'indole
EP0729455B1 (fr) Arylpiperazines derivees d'indole comme ligands pour les recepteurs 5 ht1-like 5 ht1b et 5 ht1d
FR2574077A1 (fr) Derives d'indoles, leur preparation et les compositions pharmaceutiques les contenant
FR2722190A1 (fr) Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant
FR2574793A1 (fr) Composes derives d'indole, compositions pharmaceutiques les contenant et procede pour leur preparation
BE1000072A4 (fr) Derives de l'indole utiles comme medicaments et procede et intermediaires pour leur preparation.
GB2082175A (en) Heterocyclic compounds
WO1999010344A1 (fr) Derives d'indole comme agonistes de 5-ht1b et 5-ht1d
WO1995001334A1 (fr) Composes indoliques derives d'arylamines comme ligands selectifs des recepteurs 5ht1d et 5ht¿1b?
EP0782568B1 (fr) Ethers aromatiques derives d'indoles comme "5ht1-like" ligands
FR2600061A1 (fr) Derives d'indole, composition pharmaceutique les contenant et procede pour leur preparation
WO1996026936A1 (fr) Nouveaux derives de piperazine amino-indole cycliques, leur procede de preparation et leur utilisation a titre de medicaments
FR2458552A1 (fr) Nouveaux alcaloides peptidiques de l'ergot de seigle, leur preparation et leur application comme medicaments
LU85915A1 (fr) Nouveaux derives d'indole utiles comme medicaments et intermediaires et procedes pour leur preparation

Legal Events

Date Code Title Description
ST Notification of lapse