FR2484281B1 - Procede de preparation de microspheres comportant un noyau solide et une matiere polymere - Google Patents

Procede de preparation de microspheres comportant un noyau solide et une matiere polymere

Info

Publication number
FR2484281B1
FR2484281B1 FR8111694A FR8111694A FR2484281B1 FR 2484281 B1 FR2484281 B1 FR 2484281B1 FR 8111694 A FR8111694 A FR 8111694A FR 8111694 A FR8111694 A FR 8111694A FR 2484281 B1 FR2484281 B1 FR 2484281B1
Authority
FR
France
Prior art keywords
microspheres
preparation
polymeric material
solid core
core
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8111694A
Other languages
English (en)
Other versions
FR2484281A1 (fr
Inventor
Jones Wing Fong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2484281A1 publication Critical patent/FR2484281A1/fr
Application granted granted Critical
Publication of FR2484281B1 publication Critical patent/FR2484281B1/fr
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • B01J13/125—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution by evaporation of the solvent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
FR8111694A 1980-06-13 1981-06-10 Procede de preparation de microspheres comportant un noyau solide et une matiere polymere Expired FR2484281B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/159,148 US4384975A (en) 1980-06-13 1980-06-13 Process for preparation of microspheres

Publications (2)

Publication Number Publication Date
FR2484281A1 FR2484281A1 (fr) 1981-12-18
FR2484281B1 true FR2484281B1 (fr) 1986-02-21

Family

ID=22571283

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8111694A Expired FR2484281B1 (fr) 1980-06-13 1981-06-10 Procede de preparation de microspheres comportant un noyau solide et une matiere polymere

Country Status (7)

Country Link
US (1) US4384975A (fr)
JP (1) JPS5727128A (fr)
CH (1) CH648217A5 (fr)
DE (1) DE3121983A1 (fr)
FR (1) FR2484281B1 (fr)
GB (1) GB2077693B (fr)
IT (1) IT1171290B (fr)

Families Citing this family (159)

* Cited by examiner, † Cited by third party
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DE3121983A1 (de) 1982-02-04
CH648217A5 (de) 1985-03-15
GB2077693A (en) 1981-12-23
IT8148654A0 (it) 1981-06-11
GB2077693B (en) 1983-11-30
JPS5727128A (en) 1982-02-13
US4384975A (en) 1983-05-24
IT1171290B (it) 1987-06-10
FR2484281A1 (fr) 1981-12-18

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