FR2477546A1 - Composes carbapenemes et leurs procedes de preparation - Google Patents
Composes carbapenemes et leurs procedes de preparation Download PDFInfo
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- FR2477546A1 FR2477546A1 FR8104632A FR8104632A FR2477546A1 FR 2477546 A1 FR2477546 A1 FR 2477546A1 FR 8104632 A FR8104632 A FR 8104632A FR 8104632 A FR8104632 A FR 8104632A FR 2477546 A1 FR2477546 A1 FR 2477546A1
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- 150000003952 β-lactams Chemical class 0.000 description 2
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- GVPFVAHMJGGAJG-UHFFFAOYSA-L cobalt dichloride Chemical compound [Cl-].[Cl-].[Co+2] GVPFVAHMJGGAJG-UHFFFAOYSA-L 0.000 description 1
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- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
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- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
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- 229910052749 magnesium Inorganic materials 0.000 description 1
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- 230000007935 neutral effect Effects 0.000 description 1
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- MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 1
- 229910003445 palladium oxide Inorganic materials 0.000 description 1
- JQPTYAILLJKUCY-UHFFFAOYSA-N palladium(ii) oxide Chemical compound [O-2].[Pd+2] JQPTYAILLJKUCY-UHFFFAOYSA-N 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
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- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
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- 238000003756 stirring Methods 0.000 description 1
- -1 sulfonyloxy Chemical group 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
- C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3070180A JPS56127381A (en) | 1980-03-10 | 1980-03-10 | Beta-lactam compound and its preparation |
| JP3070280A JPS56127382A (en) | 1980-03-10 | 1980-03-10 | Beta-lactam compound and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2477546A1 true FR2477546A1 (fr) | 1981-09-11 |
| FR2477546B1 FR2477546B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1983-07-29 |
Family
ID=26369103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8104632A Granted FR2477546A1 (fr) | 1980-03-10 | 1981-03-09 | Composes carbapenemes et leurs procedes de preparation |
Country Status (6)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4468350A (en) * | 1980-10-24 | 1984-08-28 | Kowa Co., Ltd. | KA-6643-Series antibiotics, process for producing same and medical composition containing same |
| EP0074599A1 (en) * | 1981-09-09 | 1983-03-23 | Takeda Chemical Industries, Ltd. | 5,6-cis-Carbapenem derivatives, their production and use |
| US4640915A (en) * | 1982-03-29 | 1987-02-03 | Fujisawa Pharmaceutical Co., Ltd. | 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives |
| US4698339A (en) * | 1983-09-28 | 1987-10-06 | Takeda Chemical Industries, Ltd. | Carbapenems, their production and use |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0001628A1 (en) * | 1977-10-19 | 1979-05-02 | Merck & Co. Inc. | 3-Substituted-6-substituted-7-oxo-1-azabicyclo (3.2.0)-hept-2-ene-2-carboxylic acid, its preparation and pharmaceutical compositions containing it |
| EP0008497A1 (en) * | 1978-07-26 | 1980-03-05 | Beecham Group Plc | Beta-lactam-containing compounds, their preparation and pharmaceutical compositions containing them |
| FR2454441A1 (fr) * | 1979-04-16 | 1980-11-14 | Kowa Co | Nouvel antibiotique et son procede de preparation a partir de souches appartenant au genre streptomyces |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4189473A (en) * | 1974-03-28 | 1980-02-19 | Beecham Group Limited | Antibiotic MM 13902 |
| GB1483142A (en) * | 1975-03-15 | 1977-08-17 | Beecham Group Ltd | Streptomycetal antibiotic |
| NL7704040A (nl) * | 1976-04-28 | 1977-11-01 | Merck & Co Inc | Werkwijze voor het bereiden van nieuwe anti- biotica. |
| US4210661A (en) * | 1977-01-27 | 1980-07-01 | Beecham Group Limited | Synthetic β-lactam compounds, a process for their preparation and compositions containing them |
| US4162323A (en) * | 1977-04-18 | 1979-07-24 | Merck & Co., Inc. | Antibiotic N-acetyl-dehydro-thienamycin |
| DE2862419D1 (en) * | 1977-11-12 | 1984-07-26 | Beecham Group Plc | Derivatives of 7-oxo-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylic acid, their preparation, pharmaceutical compositions containing them and intermediates |
| US4341706A (en) * | 1980-10-10 | 1982-07-27 | Merck & Co., Inc. | Process for the preparation of carbapenem antibiotics |
| US4341705A (en) * | 1980-10-10 | 1982-07-27 | Merck & Co., Inc. | Thienamycin derivatives |
-
1981
- 1981-02-20 US US06/236,310 patent/US4409147A/en not_active Expired - Fee Related
- 1981-03-06 CH CH153581A patent/CH645111A5/de not_active IP Right Cessation
- 1981-03-07 DE DE19813108666 patent/DE3108666A1/de not_active Withdrawn
- 1981-03-09 FR FR8104632A patent/FR2477546A1/fr active Granted
- 1981-03-09 GB GB8107351A patent/GB2071099B/en not_active Expired
- 1981-03-09 CA CA000372546A patent/CA1163270A/en not_active Expired
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0001628A1 (en) * | 1977-10-19 | 1979-05-02 | Merck & Co. Inc. | 3-Substituted-6-substituted-7-oxo-1-azabicyclo (3.2.0)-hept-2-ene-2-carboxylic acid, its preparation and pharmaceutical compositions containing it |
| EP0008497A1 (en) * | 1978-07-26 | 1980-03-05 | Beecham Group Plc | Beta-lactam-containing compounds, their preparation and pharmaceutical compositions containing them |
| FR2454441A1 (fr) * | 1979-04-16 | 1980-11-14 | Kowa Co | Nouvel antibiotique et son procede de preparation a partir de souches appartenant au genre streptomyces |
Also Published As
| Publication number | Publication date |
|---|---|
| CA1163270A (en) | 1984-03-06 |
| FR2477546B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1983-07-29 |
| US4409147A (en) | 1983-10-11 |
| GB2071099B (en) | 1983-11-16 |
| CH645111A5 (de) | 1984-09-14 |
| DE3108666A1 (de) | 1981-12-24 |
| GB2071099A (en) | 1981-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |