FR2476089B1 - Nouveaux derives substitues de 7-oxo-4-thia-1-azabicyclo(3.2.0) hept-2-ene, procede et composes intermediaires pour leur production, composition pharmaceutique les contenant et leur application a la lutte contre des infections bacteriennes - Google Patents

Nouveaux derives substitues de 7-oxo-4-thia-1-azabicyclo(3.2.0) hept-2-ene, procede et composes intermediaires pour leur production, composition pharmaceutique les contenant et leur application a la lutte contre des infections bacteriennes

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Publication number
FR2476089B1
FR2476089B1 FR797930748A FR7930748A FR2476089B1 FR 2476089 B1 FR2476089 B1 FR 2476089B1 FR 797930748 A FR797930748 A FR 797930748A FR 7930748 A FR7930748 A FR 7930748A FR 2476089 B1 FR2476089 B1 FR 2476089B1
Authority
FR
France
Prior art keywords
thia
azabicyclo
hept
ene
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR797930748A
Other languages
English (en)
Other versions
FR2476089A1 (fr
Inventor
Marcel Menard
Alain Martel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US06/077,888 priority Critical patent/US4272437A/en
Priority to US06/077,886 priority patent/US4282150A/en
Priority to JP15931579A priority patent/JPS5625110A/ja
Priority to GB7943044A priority patent/GB2042515B/en
Priority to JP16088979A priority patent/JPS5625111A/ja
Priority to GB7943042A priority patent/GB2042514B/en
Priority to FR797930748A priority patent/FR2476089B1/fr
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Priority to NL7909056A priority patent/NL7909056A/xx
Priority to NL7909055A priority patent/NL7909055A/xx
Priority to FR7930749A priority patent/FR2471382A1/fr
Priority to LU81999A priority patent/LU81999A1/fr
Priority to BE0/198602A priority patent/BE880664A/fr
Priority to LU81998A priority patent/LU81998A1/fr
Priority to CA000342049A priority patent/CA1136617A/fr
Priority to BE0/198601A priority patent/BE880663A/fr
Priority to AT0793479A priority patent/AT369743B/de
Priority to DE19792950913 priority patent/DE2950913A1/de
Priority to DE19792950898 priority patent/DE2950898A1/de
Publication of FR2476089A1 publication Critical patent/FR2476089A1/fr
Priority to GB08207198A priority patent/GB2106113B/en
Priority to GB08215252A priority patent/GB2109379B/en
Application granted granted Critical
Publication of FR2476089B1 publication Critical patent/FR2476089B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR797930748A 1978-12-18 1979-12-14 Nouveaux derives substitues de 7-oxo-4-thia-1-azabicyclo(3.2.0) hept-2-ene, procede et composes intermediaires pour leur production, composition pharmaceutique les contenant et leur application a la lutte contre des infections bacteriennes Expired FR2476089B1 (fr)

Priority Applications (20)

Application Number Priority Date Filing Date Title
US06/077,888 US4272437A (en) 1978-12-18 1979-09-21 Antibacterial agents, and 4-thio azetidinone intermediates
US06/077,886 US4282150A (en) 1978-12-18 1979-09-21 2,6-Disubstituted penem compounds
JP15931579A JPS5625110A (en) 1978-12-18 1979-12-10 Antibacterial
GB7943044A GB2042515B (en) 1978-12-18 1979-12-13 Antibacterial agents
JP16088979A JPS5625111A (en) 1978-12-18 1979-12-13 Antibacterial
GB7943042A GB2042514B (en) 1978-12-18 1979-12-13 Antibacterial agents
NL7909056A NL7909056A (nl) 1978-12-18 1979-12-14 Gesubstitueerde penemverbindingen met antibacterieee activiteit.
NL7909055A NL7909055A (nl) 1978-12-18 1979-12-14 Verbindingen met antibacterieele werking; farmaceutische preparaten, werkwijze voor het bestrijden van bacterieele infecties; tussenprodukten; werkwijze voor de bereiding van verbindingen met antibacterieele werking.
FR7930749A FR2471382A1 (fr) 1978-12-18 1979-12-14 Nouveaux derives antibacteriens de 7-oxo-4-thia-1-azabicyclo (3.2.0) hept-2-ene, leur procede de production et composition les contenant
FR797930748A FR2476089B1 (fr) 1978-12-18 1979-12-14 Nouveaux derives substitues de 7-oxo-4-thia-1-azabicyclo(3.2.0) hept-2-ene, procede et composes intermediaires pour leur production, composition pharmaceutique les contenant et leur application a la lutte contre des infections bacteriennes
LU81999A LU81999A1 (fr) 1978-12-18 1979-12-17 Nouveaux agents antibacteriens
LU81998A LU81998A1 (fr) 1978-12-18 1979-12-17 Agents antibacteriens
CA000342049A CA1136617A (fr) 1978-12-18 1979-12-17 Composes penem substitues en positions 2 et 6
BE0/198601A BE880663A (fr) 1978-12-18 1979-12-17 Agents antibacteriens
AT0793479A AT369743B (de) 1978-12-18 1979-12-17 Verfahren zur herstellung von neuen penemverbindungen
BE0/198602A BE880664A (fr) 1978-12-18 1979-12-17 Nouveaux agents antibacteriens
DE19792950913 DE2950913A1 (de) 1978-12-18 1979-12-18 Neue substituierte penemverbindungen, verfahren zu deren herstellung und arzneimittel
DE19792950898 DE2950898A1 (de) 1978-12-18 1979-12-18 Neue penemverbindungen, verfahren zu deren herstellung und arzneimittel
GB08207198A GB2106113B (en) 1978-12-18 1982-03-11 Azetidinones
GB08215252A GB2109379B (en) 1978-12-18 1982-05-25 Azetidinones

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96866378A 1978-12-18 1978-12-18
FR7930749A FR2471382A1 (fr) 1978-12-18 1979-12-14 Nouveaux derives antibacteriens de 7-oxo-4-thia-1-azabicyclo (3.2.0) hept-2-ene, leur procede de production et composition les contenant
FR797930748A FR2476089B1 (fr) 1978-12-18 1979-12-14 Nouveaux derives substitues de 7-oxo-4-thia-1-azabicyclo(3.2.0) hept-2-ene, procede et composes intermediaires pour leur production, composition pharmaceutique les contenant et leur application a la lutte contre des infections bacteriennes

Publications (2)

Publication Number Publication Date
FR2476089A1 FR2476089A1 (fr) 1981-08-21
FR2476089B1 true FR2476089B1 (fr) 1989-05-26

Family

ID=27250972

Family Applications (2)

Application Number Title Priority Date Filing Date
FR797930748A Expired FR2476089B1 (fr) 1978-12-18 1979-12-14 Nouveaux derives substitues de 7-oxo-4-thia-1-azabicyclo(3.2.0) hept-2-ene, procede et composes intermediaires pour leur production, composition pharmaceutique les contenant et leur application a la lutte contre des infections bacteriennes
FR7930749A Granted FR2471382A1 (fr) 1978-12-18 1979-12-14 Nouveaux derives antibacteriens de 7-oxo-4-thia-1-azabicyclo (3.2.0) hept-2-ene, leur procede de production et composition les contenant

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7930749A Granted FR2471382A1 (fr) 1978-12-18 1979-12-14 Nouveaux derives antibacteriens de 7-oxo-4-thia-1-azabicyclo (3.2.0) hept-2-ene, leur procede de production et composition les contenant

Country Status (8)

Country Link
JP (2) JPS5625110A (fr)
AT (1) AT369743B (fr)
BE (2) BE880663A (fr)
DE (2) DE2950913A1 (fr)
FR (2) FR2476089B1 (fr)
GB (4) GB2042514B (fr)
LU (2) LU81999A1 (fr)
NL (2) NL7909056A (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
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IT1193922B (it) * 1979-02-24 1988-08-31 Erba Farmitalia Agenti antibatterici ed inibitori di beta -lattamasi e loro preparazione
DE3121510A1 (de) * 1980-07-04 1982-06-16 Farmitalia Carlo Erba S.p.A., 20159 Milano 6-alkyl-2-subst.-peneme und verfahren zu ihrer herstellung
JPS57176982A (en) * 1981-04-24 1982-10-30 Shionogi & Co Ltd Dioxolanylazetidinone compound, its preparation and use
JPS588084A (ja) * 1981-07-08 1983-01-18 Takeda Chem Ind Ltd （６ｒ）−置換−（５ｒ）−ペネム−３−カルボン酸誘導体およびその製造法
ES513672A0 (es) * 1981-07-08 1983-04-01 Hoechst Uk Ltd "procedimiento para la preparacion de derivados de penem".
EP0069378B1 (fr) * 1981-07-08 1987-01-07 Hoechst Uk Limited Dérivés de pénème antibactériens
EP0180252B1 (fr) * 1981-07-15 1989-04-26 Sumitomo Pharmaceuticals Company, Limited Procédé de préparation de dérivés d'azétidinone
EP0082113A1 (fr) * 1981-12-04 1983-06-22 Ciba-Geigy Ag Dérivés 2-aminobutyl de 2-pénème, procédé de préparation et compositions pharmaceutiques qui les contiennent
HU185493B (en) * 1981-12-30 1985-02-28 Richter Gedeon Vegyeszet Process for producing new azabicyclo-bracket-3.2.0-bracket closedheptene derivatives
HU185491B (en) * 1981-12-30 1985-02-28 Richter Gedeon Vegyeszet Process for producing new azabicyclo-bracket-3.2.0-bracket closedheptane derivatives
NO831160L (no) * 1982-04-08 1983-10-10 Erba Farmitalia Fremstilling av substituerte penem-derivater
US4552696A (en) * 1982-04-09 1985-11-12 Bristol-Myers Company Carbapenem antibiotics
US4738959A (en) * 1982-07-08 1988-04-19 Hoechst Uk Limited Antibacterial penem derivatives
JPS5946289A (ja) * 1982-09-08 1984-03-15 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物及びその製造法
DE3366926D1 (en) * 1982-11-16 1986-11-20 Schering Corp Penems, pharmaceutical compositions containing them, process for preparing them
EP0109362A1 (fr) * 1982-11-16 1984-05-23 Ciba-Geigy Ag Composés hétérocycliques, procédé pour leur préparation, compositions pharmaceutiques les contenant et leur application
PH21930A (en) * 1982-11-16 1988-04-08 Ciba Geigy Ag 6-hydroxy-lower alkylpenem compounds,pharmaceutical composition containing same and method of use thereof
EP0112283B1 (fr) * 1982-11-16 1987-08-12 Ciba-Geigy Ag Dérivés hétérocyclylthio, procédé pour leur préparation, compositions pharmaceutiques les contenant et leur application
EP0110280B1 (fr) * 1982-11-29 1994-10-12 Schering Corporation Procédé de préparation de dérivés de pénème
US4610823A (en) * 1983-01-25 1986-09-09 Merck & Co., Inc. Process for preparing substituted 2-thioxopenams and 2-substituted thiopenems
US4675317A (en) * 1983-01-25 1987-06-23 Merck & Co., Inc. 2-unsaturated alkylthio-pen-2-em-3-carboxylic acids
JPS59152387A (ja) * 1983-02-10 1984-08-31 Shionogi & Co Ltd 新規ペネム化合物
EP0125207A1 (fr) * 1983-05-06 1984-11-14 Ciba-Geigy Ag Dérivés de 2-tetrazolylpropyl-2-pénème, procédé pour leur préparation, compositions pharmaceutiques les contenant et leur application
EP0125208A1 (fr) * 1983-05-06 1984-11-14 Ciba-Geigy Ag Dérivés d'amino-alcoyl-inférieur-pénème, procédé pour leur préparation, compositions pharmaceutiques les contenant et leur application
CA1283906C (fr) * 1983-05-09 1991-05-07 Makoto Sunagawa COMPOSE DE .beta.-LACTAM ET PROCEDE DE PRODUCTION
US4656165A (en) * 1983-09-02 1987-04-07 Ciba-Geigy Corporation Aminomethyl penem compounds
DK613984A (da) * 1983-12-30 1985-07-01 Ciba Geigy Ag 2-heterocyclyl-6-hydroxylavalkyl-2-penem-forbindelser samt deres fremstilling og anvendelse
GB8416651D0 (en) * 1984-06-29 1984-08-01 Erba Farmitalia Penem derivatives
GB8416565D0 (en) * 1984-06-29 1984-08-01 Hoechst Uk Ltd Antibacterial derivatives
GB2164334B (en) * 1984-09-10 1988-08-03 Hoechst Uk Ltd Antibacterial 7-oxo-4-thia-1-azabicyclo 3,2,0 hept-2-ene derivativess
JP2520229B2 (ja) * 1985-03-09 1996-07-31 サントリー株式会社 ２−アゼチジノン誘導体の製造法
JPH075463B2 (ja) * 1985-03-09 1995-01-25 サントリー株式会社 抗菌剤
GB8509180D0 (en) * 1985-04-10 1985-05-15 Erba Farmitalia Penem derivatives
GB8509181D0 (en) * 1985-04-10 1985-05-15 Erba Farmitalia Penem derivatives
GB2179350B (en) * 1985-08-16 1989-11-15 Hoechst Uk Ltd 7-oxo-4-thia-1-azabicyclo3.2.0hept-2-ene derivatives
GB8520631D0 (en) * 1985-08-16 1985-09-25 Hoechst Uk Ltd Derivatives
GB2187448B (en) * 1986-03-06 1990-10-24 Erba Farmitalia Penem derivatives
US4826832A (en) * 1986-05-06 1989-05-02 Ciba-Geigy Corporation Penen compounds
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Also Published As

Publication number Publication date
ATA793479A (de) 1982-06-15
GB2042514A (en) 1980-09-24
LU81998A1 (fr) 1980-07-01
GB2106113B (en) 1983-08-03
GB2106113A (en) 1983-04-07
FR2471382A1 (fr) 1981-06-19
DE2950898A1 (de) 1980-07-03
FR2476089A1 (fr) 1981-08-21
BE880664A (fr) 1980-06-17
GB2042515B (en) 1983-07-27
BE880663A (fr) 1980-06-17
AT369743B (de) 1983-01-25
GB2109379A (en) 1983-06-02
FR2471382B1 (fr) 1983-07-29
GB2109379B (en) 1983-09-21
JPH0149718B2 (fr) 1989-10-25
NL7909055A (nl) 1980-06-20
GB2042515A (en) 1980-09-24
DE2950913A1 (de) 1980-07-31
JPS5625110A (en) 1981-03-10
JPS5625111A (en) 1981-03-10
GB2042514B (en) 1983-05-18
NL7909056A (nl) 1980-06-20
LU81999A1 (fr) 1980-07-21

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