AT369743B - Verfahren zur herstellung von neuen penemverbindungen - Google Patents

Verfahren zur herstellung von neuen penemverbindungen

Info

Publication number
AT369743B
AT369743B AT0793479A AT793479A AT369743B AT 369743 B AT369743 B AT 369743B AT 0793479 A AT0793479 A AT 0793479A AT 793479 A AT793479 A AT 793479A AT 369743 B AT369743 B AT 369743B
Authority
AT
Austria
Prior art keywords
connections
producing new
penem
new penem
producing
Prior art date
Application number
AT0793479A
Other languages
German (de)
English (en)
Other versions
ATA793479A (de
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ATA793479A publication Critical patent/ATA793479A/de
Application granted granted Critical
Publication of AT369743B publication Critical patent/AT369743B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT0793479A 1978-12-18 1979-12-17 Verfahren zur herstellung von neuen penemverbindungen AT369743B (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96866378A 1978-12-18 1978-12-18
FR7930749A FR2471382A1 (fr) 1978-12-18 1979-12-14 Nouveaux derives antibacteriens de 7-oxo-4-thia-1-azabicyclo (3.2.0) hept-2-ene, leur procede de production et composition les contenant
FR797930748A FR2476089B1 (fr) 1978-12-18 1979-12-14 Nouveaux derives substitues de 7-oxo-4-thia-1-azabicyclo(3.2.0) hept-2-ene, procede et composes intermediaires pour leur production, composition pharmaceutique les contenant et leur application a la lutte contre des infections bacteriennes

Publications (2)

Publication Number Publication Date
ATA793479A ATA793479A (de) 1982-06-15
AT369743B true AT369743B (de) 1983-01-25

Family

ID=27250972

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0793479A AT369743B (de) 1978-12-18 1979-12-17 Verfahren zur herstellung von neuen penemverbindungen

Country Status (8)

Country Link
JP (2) JPS5625110A (fr)
AT (1) AT369743B (fr)
BE (2) BE880663A (fr)
DE (2) DE2950913A1 (fr)
FR (2) FR2471382A1 (fr)
GB (4) GB2042514B (fr)
LU (2) LU81998A1 (fr)
NL (2) NL7909055A (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT368506B (de) * 1979-02-24 1982-10-25 Erba Farmitalia Verfahren zur herstellung von neuen penemcarbonsaeuren und deren salzen
DE3121510A1 (de) * 1980-07-04 1982-06-16 Farmitalia Carlo Erba S.p.A., 20159 Milano 6-alkyl-2-subst.-peneme und verfahren zu ihrer herstellung
JPS57176982A (en) * 1981-04-24 1982-10-30 Shionogi & Co Ltd Dioxolanylazetidinone compound, its preparation and use
ES8305366A1 (es) * 1981-07-08 1983-04-01 Hoechst Uk Ltd "procedimiento para la preparacion de derivados de penem".
JPS588084A (ja) * 1981-07-08 1983-01-18 Takeda Chem Ind Ltd （６ｒ）−置換−（５ｒ）−ペネム−３−カルボン酸誘導体およびその製造法
DE3274982D1 (en) * 1981-07-08 1987-02-12 Hoechst Uk Ltd Antibacterial penem derivatives
EP0180252B1 (fr) * 1981-07-15 1989-04-26 Sumitomo Pharmaceuticals Company, Limited Procédé de préparation de dérivés d'azétidinone
EP0082113A1 (fr) * 1981-12-04 1983-06-22 Ciba-Geigy Ag Dérivés 2-aminobutyl de 2-pénème, procédé de préparation et compositions pharmaceutiques qui les contiennent
HU185493B (en) * 1981-12-30 1985-02-28 Richter Gedeon Vegyeszet Process for producing new azabicyclo-bracket-3.2.0-bracket closedheptene derivatives
HU185491B (en) * 1981-12-30 1985-02-28 Richter Gedeon Vegyeszet Process for producing new azabicyclo-bracket-3.2.0-bracket closedheptane derivatives
NO831160L (no) * 1982-04-08 1983-10-10 Erba Farmitalia Fremstilling av substituerte penem-derivater
US4552696A (en) * 1982-04-09 1985-11-12 Bristol-Myers Company Carbapenem antibiotics
EP0099059B1 (fr) * 1982-07-08 1988-06-22 Hoechst Uk Limited Dérivés de pénème antibactériens
JPS5946289A (ja) * 1982-09-08 1984-03-15 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物及びその製造法
EP0109362A1 (fr) * 1982-11-16 1984-05-23 Ciba-Geigy Ag Composés hétérocycliques, procédé pour leur préparation, compositions pharmaceutiques les contenant et leur application
PH21930A (en) * 1982-11-16 1988-04-08 Ciba Geigy Ag 6-hydroxy-lower alkylpenem compounds,pharmaceutical composition containing same and method of use thereof
EP0109044B1 (fr) * 1982-11-16 1986-10-15 Schering Corporation Pénèmes, compositions pharmaceutiques les contenant, procédé pour leur préparation
DE3372968D1 (en) * 1982-11-16 1987-09-17 Ciba Geigy Ag Heterocyclyl-thio compounds, process for their preparation, pharmaceutical compositions containing them and their use
DE3382761T2 (de) * 1982-11-29 1995-03-09 Schering Corp Verfahren zur Herstellung von Penem-Verbindungen.
US4610823A (en) * 1983-01-25 1986-09-09 Merck & Co., Inc. Process for preparing substituted 2-thioxopenams and 2-substituted thiopenems
US4675317A (en) * 1983-01-25 1987-06-23 Merck & Co., Inc. 2-unsaturated alkylthio-pen-2-em-3-carboxylic acids
JPS59152387A (ja) * 1983-02-10 1984-08-31 Shionogi & Co Ltd 新規ペネム化合物
EP0125207A1 (fr) * 1983-05-06 1984-11-14 Ciba-Geigy Ag Dérivés de 2-tetrazolylpropyl-2-pénème, procédé pour leur préparation, compositions pharmaceutiques les contenant et leur application
EP0125208A1 (fr) * 1983-05-06 1984-11-14 Ciba-Geigy Ag Dérivés d'amino-alcoyl-inférieur-pénème, procédé pour leur préparation, compositions pharmaceutiques les contenant et leur application
CA1283906C (fr) * 1983-05-09 1991-05-07 Makoto Sunagawa COMPOSE DE .beta.-LACTAM ET PROCEDE DE PRODUCTION
US4656165A (en) * 1983-09-02 1987-04-07 Ciba-Geigy Corporation Aminomethyl penem compounds
DK613984A (da) * 1983-12-30 1985-07-01 Ciba Geigy Ag 2-heterocyclyl-6-hydroxylavalkyl-2-penem-forbindelser samt deres fremstilling og anvendelse
GB8416565D0 (en) * 1984-06-29 1984-08-01 Hoechst Uk Ltd Antibacterial derivatives
GB8416651D0 (en) * 1984-06-29 1984-08-01 Erba Farmitalia Penem derivatives
GB2164334B (en) * 1984-09-10 1988-08-03 Hoechst Uk Ltd Antibacterial 7-oxo-4-thia-1-azabicyclo 3,2,0 hept-2-ene derivativess
JPH075463B2 (ja) * 1985-03-09 1995-01-25 サントリー株式会社 抗菌剤
JP2520229B2 (ja) * 1985-03-09 1996-07-31 サントリー株式会社 ２−アゼチジノン誘導体の製造法
GB8509180D0 (en) * 1985-04-10 1985-05-15 Erba Farmitalia Penem derivatives
GB8509181D0 (en) * 1985-04-10 1985-05-15 Erba Farmitalia Penem derivatives
GB2179350B (en) * 1985-08-16 1989-11-15 Hoechst Uk Ltd 7-oxo-4-thia-1-azabicyclo3.2.0hept-2-ene derivatives
GB8520631D0 (en) * 1985-08-16 1985-09-25 Hoechst Uk Ltd Derivatives
GB2187448B (en) * 1986-03-06 1990-10-24 Erba Farmitalia Penem derivatives
US4826832A (en) * 1986-05-06 1989-05-02 Ciba-Geigy Corporation Penen compounds
GB2195627A (en) * 1986-08-12 1988-04-13 Hoechst Uk Ltd Penem derivatives
EP0256990A1 (fr) * 1986-08-20 1988-02-24 Ciba-Geigy Ag Composés à groupe pyridinio
EP0275002A1 (fr) * 1987-01-09 1988-07-20 Hoechst Aktiengesellschaft Procédé de préparation de dérivés de 7-oxo-4-thia-1-aza-bicyclo[3.2.0]-hept-2-ène
ES2058328T3 (es) * 1987-02-11 1994-11-01 Ciba Geigy Ag Acidos beta-lactama carboxilicos biciclicos.
GB8713515D0 (en) * 1987-06-10 1987-07-15 Erba Farmitalia Methoxymethyl compounds
EP0297042A1 (fr) * 1987-06-23 1988-12-28 Ciba-Geigy Ag Dérivés de pénème substitués
GB9110507D0 (en) * 1991-05-15 1991-07-03 Smithkline Beecham Plc Chemical compounds
ES2206557T3 (es) * 1995-02-17 2004-05-16 Daiichi Suntory Pharma Co., Ltd. Derivados que penem y agente antimicrobiano que los contiene.
WO1999036098A1 (fr) 1998-01-13 1999-07-22 Suntory Limited Composition antibacterienne contenant des antibiotiques et destinee a l'administration topique

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US4070477A (en) * 1975-12-08 1978-01-24 Ciba-Geigy Corporation 2-Penem compounds
LU77306A1 (fr) * 1977-05-09 1979-01-18
AU3796278A (en) * 1977-07-13 1980-01-17 Glaxo Group Ltd Penams and azetidinones
DE2732556A1 (de) * 1977-07-19 1979-02-01 Bayer Ag Verfahren zur herstellung von flammhemmenden polycarbonaten
JPS5466695A (en) * 1977-11-08 1979-05-29 Sankyo Co Ltd Azetidinone derivative and its preparation
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
JPS54117459A (en) * 1978-01-20 1979-09-12 Glaxo Group Ltd Novel lactam compound
EP0042026B1 (fr) * 1978-02-02 1986-01-08 Ciba-Geigy Ag Dérivés d'azétidin-2-one 3,4-disubstitués et procédé de préparation
IT1162268B (it) * 1978-02-16 1987-03-25 Glaxo Group Ltd Composti beta-lattamici procedimento per produrli composizioni che li contengono e intermedi per prepararli
EP0010358A1 (fr) * 1978-09-20 1980-04-30 Glaxo Group Limited Composés de bêta-lactame, procédés pour leur préparation, compositions les contenant, intermédiaires utilisables dans leur préparation et méthodes pour leur production
JPS5569591A (en) * 1978-11-17 1980-05-26 Sankyo Co Ltd Azetidinone derivative and its preparation
EP0013067A1 (fr) * 1978-12-22 1980-07-09 Beecham Group Plc Agents antibactériens à cycle bêta-lactame bicyclique, leur utilisation dans des compositions pharmaceutiques, procédés pour leur préparation et intermédiaires à utiliser dans de tels procédés
ZA80993B (en) * 1979-02-24 1981-02-25 Erba Farmitalia -lactam-containing antibacterial agents and -lactamase inhibitors and preparation thereof
AT368506B (de) * 1979-02-24 1982-10-25 Erba Farmitalia Verfahren zur herstellung von neuen penemcarbonsaeuren und deren salzen
US4269771A (en) * 1979-04-06 1981-05-26 Farmitalia Carlo Erba Total synthesis of 7-oxo-4-thia-1-azabicyclo-[3,2,0]-heptane-2-carboxyl derivatives useful as β-lactamase inhibitors and antibacterial agents
JPS55153789A (en) * 1979-04-11 1980-11-29 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
JPS55143993A (en) * 1979-04-27 1980-11-10 Sankyo Co Ltd Azetidinone derivative and its preparation

Also Published As

Publication number Publication date
GB2109379A (en) 1983-06-02
NL7909055A (nl) 1980-06-20
DE2950898A1 (de) 1980-07-03
FR2471382A1 (fr) 1981-06-19
GB2042515A (en) 1980-09-24
NL7909056A (nl) 1980-06-20
GB2106113A (en) 1983-04-07
FR2471382B1 (fr) 1983-07-29
ATA793479A (de) 1982-06-15
BE880663A (fr) 1980-06-17
JPS5625111A (en) 1981-03-10
GB2042514A (en) 1980-09-24
GB2042515B (en) 1983-07-27
JPS5625110A (en) 1981-03-10
BE880664A (fr) 1980-06-17
JPH0149718B2 (fr) 1989-10-25
DE2950913A1 (de) 1980-07-31
GB2109379B (en) 1983-09-21
LU81998A1 (fr) 1980-07-01
FR2476089A1 (fr) 1981-08-21
GB2106113B (en) 1983-08-03
GB2042514B (en) 1983-05-18
FR2476089B1 (fr) 1989-05-26
LU81999A1 (fr) 1980-07-21

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