FR2466503B1 - Procede de culture de cellules animales sous forme de cultures en suspension et monocouches dans des recipients de fermentation - Google Patents

Procede de culture de cellules animales sous forme de cultures en suspension et monocouches dans des recipients de fermentation

Info

Publication number
FR2466503B1
FR2466503B1 FR8021190A FR8021190A FR2466503B1 FR 2466503 B1 FR2466503 B1 FR 2466503B1 FR 8021190 A FR8021190 A FR 8021190A FR 8021190 A FR8021190 A FR 8021190A FR 2466503 B1 FR2466503 B1 FR 2466503B1
Authority
FR
France
Prior art keywords
cultivation
suspension
animal cells
fermentation containers
layer cultures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8021190A
Other languages
English (en)
Other versions
FR2466503A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intermedicat GmbH
Original Assignee
Intermedicat GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intermedicat GmbH filed Critical Intermedicat GmbH
Publication of FR2466503A1 publication Critical patent/FR2466503A1/fr
Application granted granted Critical
Publication of FR2466503B1 publication Critical patent/FR2466503B1/fr
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04Filters; Permeable or porous membranes or plates, e.g. dialysis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/24Gas permeable parts

Landscapes

  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FR8021190A 1979-10-05 1980-10-03 Procede de culture de cellules animales sous forme de cultures en suspension et monocouches dans des recipients de fermentation Expired FR2466503B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2940446A DE2940446C2 (de) 1979-10-05 1979-10-05 Züchtung von tierischen Zellen in Suspensions- und Monolayerkulturen in Fermentationsgefäßen

Publications (2)

Publication Number Publication Date
FR2466503A1 FR2466503A1 (fr) 1981-04-10
FR2466503B1 true FR2466503B1 (fr) 1985-08-09

Family

ID=6082819

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8021190A Expired FR2466503B1 (fr) 1979-10-05 1980-10-03 Procede de culture de cellules animales sous forme de cultures en suspension et monocouches dans des recipients de fermentation

Country Status (5)

Country Link
US (1) US4649114A (fr)
JP (1) JPS6023834B2 (fr)
DE (1) DE2940446C2 (fr)
FR (1) FR2466503B1 (fr)
GB (1) GB2059436B (fr)

Families Citing this family (164)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH651587A5 (de) * 1980-11-18 1985-09-30 Chemap Ag Verfahren und vorrichtung zur submersen zuechtung von zellkulturen.
US4537860A (en) * 1982-12-08 1985-08-27 Monsanto Company Static cell culture maintenance system
US5135853A (en) * 1983-07-22 1992-08-04 Rensselaer Polytechnic Institute Three compartment bioreactor and method of use
SE8306190L (sv) * 1983-11-10 1985-05-11 Ivar Wergeland Forfarande och anordning for forbettrad syrsettning av biologiska kulturer
US4764471A (en) * 1984-01-04 1988-08-16 Nabisco Brands, Inc. Continuous bioreactor and process
JPS60234580A (ja) * 1984-05-09 1985-11-21 Hitachi Ltd 動物細胞培養方法
AU596948B2 (en) * 1984-08-03 1990-05-24 Gesellschaft Fur Biotechnologische Forschung Mbh Process and apparatus for the bubble-free gassing of liquids, especially of culture media for propagating tissue cultures
US4978616A (en) * 1985-02-28 1990-12-18 Verax Corporation Fluidized cell cultivation process
WO1986005202A1 (fr) * 1985-02-28 1986-09-12 Verax Corporation Bioreacteur fluidise et procede de culture de cellules
DE3535183A1 (de) * 1985-10-02 1987-04-16 Biotechnolog Forschung Gmbh Vorrichtung und verfahren zur blasenfreien begasung von fluessigkeiten, insbesondere von kulturmedien zur vermehrung von gewebekulturen
JPS6312274A (ja) * 1986-07-03 1988-01-19 Takashi Mori バイオリアクタ
DE3633891A1 (de) * 1986-10-04 1988-04-07 Akzo Gmbh Verfahren und vorrichtung zum kultivieren von tierischen zellen
JPS63230079A (ja) * 1987-03-18 1988-09-26 Toyobo Co Ltd 動物細胞大量培養用通気装置
JPH0763354B2 (ja) * 1987-06-30 1995-07-12 リサーチ コーポレイション テクノロジーズ インコーポレイテッド 親水性隔膜と疎水性隔膜とで形成した区画室を備える細胞成長リアクタ
CA1309680C (fr) * 1987-07-24 1992-11-03 David Harano Culture de cellules d'insectes, a gazosiphon
DE3739650C1 (de) * 1987-11-23 1989-05-24 Immuno Ag Fermenter zum Zuechten von Zellkulturen
JPH01225475A (ja) * 1988-03-07 1989-09-08 Japan Gore Tex Inc 培養装置
US5081035A (en) * 1988-04-18 1992-01-14 The University Of Michigan Bioreactor system
GB2221917B (en) * 1988-05-16 1992-10-21 Nippon Steel Corp Organic polymer separation membrane having fluorene skeleton and oxygen enrichment device utilizing same
JPH03504329A (ja) * 1988-05-23 1991-09-26 マサチユセツツ・インスチチユート・オブ・テクノロジー 高酸素濃度における動物細胞の成長
US5026650A (en) * 1988-06-30 1991-06-25 The United States Of Amercia As Represented By The Administrator Of The National Aeronautics And Space Administration Horizontally rotated cell culture system with a coaxial tubular oxygenator
WO1990002171A1 (fr) * 1988-08-31 1990-03-08 Cellco Advanced Bioreactors, Inc. Reacteur de culture de cellules in vitro
US5075234A (en) * 1988-11-02 1991-12-24 Josefino Tunac Fermentor/bioreactor systems having high aeration capacity
US5002890A (en) * 1988-11-29 1991-03-26 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Spiral vane bioreactor
US4959322A (en) * 1989-03-07 1990-09-25 W. L. Gore & Associates, Inc. Culturing apparatus
US4897359A (en) * 1989-03-27 1990-01-30 Bio-Response, Inc. Apparatus for oxygenating culture medium
US4968331A (en) * 1989-05-15 1990-11-06 Nippon Steel Corporation Organic polymer separation membrane having fluorene skeleton and oxygen enrichment device utilizing same
US5510257A (en) * 1989-10-04 1996-04-23 Sirkar; Kamalesh K. Hollow fiber immobilization with chopped microporous hollow fibers
JPH078230B2 (ja) * 1990-03-20 1995-02-01 麒麟麦酒株式会社 細胞培養装置
US5352610A (en) * 1990-03-22 1994-10-04 Braeutigam Hans Juergen Tubular membrane assembly
US5039404A (en) * 1990-05-03 1991-08-13 Jmo Holding, Inc. Oxygen permeable membrane used in wastewater treatment
US5112760A (en) * 1990-06-05 1992-05-12 Centocor, Incorporated Mass transfer membrane for oxygenation of animal cell reactors
DE4025645A1 (de) * 1990-08-13 1992-02-20 Berkefeld Filter Anlagenbau Gm Membranmodul zum ein- oder austragen von gasen in fluessigkeiten ueber permeationsmembranen
KR0152100B1 (ko) * 1991-07-04 1998-10-01 시게루 미즈노 분화항원 표현형상 또는 기능상 분화, 성숙한 t세포를 제조하는 방법
JP3246664B2 (ja) * 1993-01-29 2002-01-15 ニュー ブルンズウイック サイエンティフィック カンパニー インコーポレイテッド 足場および懸濁細胞の培養方法並びにその装置
DE4412484A1 (de) * 1994-04-12 1995-10-19 Oepke Karl Wilhelm Dr Reaktor und Verfahren zur Anreicherung von Flüssigkeiten mit Gasen
DE19528871C2 (de) * 1994-08-24 1997-08-14 Forschungszentrum Juelich Gmbh Begasungs-Rohrmodul mit selektiv gasdurchlässiger Schlauchmembranen und damit versehene Reaktoren für Zellkulturtechnik sowie Wirbelschicht-Reaktoren für Zellkultivierung
US7560274B1 (en) * 1999-05-28 2009-07-14 Cellon S.A. Culture chamber
AU2001294922A1 (en) * 2000-10-02 2002-04-15 Thomas F. Cannon Automated bioculture and bioculture experiments system
US20020146817A1 (en) * 2000-10-02 2002-10-10 Cannon Thomas F. Automated bioculture and bioculture experiments system
EP1234553A1 (fr) * 2001-02-14 2002-08-28 Boris-Wolfgang Hochleitner Dispositif bioartificiel
US20080187949A1 (en) * 2001-10-26 2008-08-07 Millipore Corporation Multiplexed assays of cell migration
AU2002363076A1 (en) * 2001-10-26 2003-05-06 Virtual Arrays, Inc. Assay systems with adjustable fluid communication
US20040126773A1 (en) * 2002-05-23 2004-07-01 Beske Oren E. Assays with coded sensor particles to sense assay conditions
US20080207465A1 (en) * 2002-10-28 2008-08-28 Millipore Corporation Assay systems with adjustable fluid communication
AU2003287934A1 (en) * 2002-12-23 2004-07-14 Unisense Fertilitech Aps Device and method for non-invasive measurement of the individual metabolic rate of a substantially spherical metabolizing particle
WO2005068059A1 (fr) 2004-01-07 2005-07-28 Levtech, Inc. Sac melangeur a arroseur integre et receptacle pour detecteur
DE102004029709B4 (de) * 2004-06-21 2006-05-11 Sartorius Ag Vorrichtung und Verfahren zur Zell-Kultivierung in einem Kulturgefäß
US7745209B2 (en) 2005-07-26 2010-06-29 Corning Incorporated Multilayered cell culture apparatus
US7718405B2 (en) * 2005-09-19 2010-05-18 American Air Liquide, Inc. Use of pure oxygen in viscous fermentation processes
BE1016793A4 (fr) 2005-10-04 2007-06-05 Artelis Procede de culture de cellules et dispositif permettant sa mise en oeuvre.
JP5451073B2 (ja) * 2005-10-14 2014-03-26 ユニセンス・ファーティリテック・アクティーゼルスカブ 細胞集団における変化の決定
DE102005053334A1 (de) * 2005-11-07 2007-05-24 Bayer Technology Services Gmbh Module zur Membranbegasung
DE102006008687A1 (de) * 2006-02-24 2007-08-30 Bayer Technology Services Gmbh Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten
ATE477499T1 (de) * 2006-06-16 2010-08-15 Unisense Fertilitech As Embryonenqualitätsbeurteilung auf der grundlage von blastomerenteilung und bewegung
US7704178B2 (en) 2006-07-05 2010-04-27 United Technologies Corporation Oil baffle for gas turbine fan drive gear system
US8667688B2 (en) 2006-07-05 2014-03-11 United Technologies Corporation Method of assembly for gas turbine fan drive gear system
US9976437B2 (en) 2006-08-15 2018-05-22 United Technologies Corporation Epicyclic gear train
US8858388B2 (en) 2006-08-15 2014-10-14 United Technologies Corporation Gas turbine engine gear train
US8753243B2 (en) 2006-08-15 2014-06-17 United Technologies Corporation Ring gear mounting arrangement with oil scavenge scheme
US10107231B2 (en) 2006-08-15 2018-10-23 United Technologies Corporation Gas turbine engine with geared architecture
JP4817311B2 (ja) * 2006-08-17 2011-11-16 広島県 貧酸素化水質環境の改善処理方法及び改善処理装置
WO2008045072A1 (fr) 2006-10-12 2008-04-17 United Technologies Corporation Buse d'éjection à section variable intégrée à double cascade de fonctions et inverseur de poussée
AU2007332870A1 (en) 2006-12-07 2008-06-19 Wilson Wolf Manufacturing Corporation Highly efficient devices and methods for culturing cells
US20080273961A1 (en) 2007-03-05 2008-11-06 Rosenkrans William E Flutter sensing and control system for a gas turbine engine
DK2173853T3 (da) 2007-06-29 2011-07-04 Unisense Fertilitech As Indretning, system og fremgangsmåde til at overvåge og/eller dyrke mikroskopiske objekter
GB2450761B (en) * 2007-07-06 2010-08-04 Univ London Multi-functional chamber for housing a biological component
US11149650B2 (en) 2007-08-01 2021-10-19 Raytheon Technologies Corporation Turbine section of high bypass turbofan
US20150377123A1 (en) 2007-08-01 2015-12-31 United Technologies Corporation Turbine section of high bypass turbofan
US11346289B2 (en) 2007-08-01 2022-05-31 Raytheon Technologies Corporation Turbine section of high bypass turbofan
US11486311B2 (en) 2007-08-01 2022-11-01 Raytheon Technologies Corporation Turbine section of high bypass turbofan
US11242805B2 (en) 2007-08-01 2022-02-08 Raytheon Technologies Corporation Turbine section of high bypass turbofan
US9701415B2 (en) 2007-08-23 2017-07-11 United Technologies Corporation Gas turbine engine with axial movable fan variable area nozzle
US9957918B2 (en) 2007-08-28 2018-05-01 United Technologies Corporation Gas turbine engine front architecture
US20140157754A1 (en) 2007-09-21 2014-06-12 United Technologies Corporation Gas turbine engine compressor arrangement
US20140174056A1 (en) 2008-06-02 2014-06-26 United Technologies Corporation Gas turbine engine with low stage count low pressure turbine
BRPI0803630B1 (pt) * 2008-06-05 2018-11-06 Fundacao Univ Federal De Sao Carlos Ufscar biorreator de escoamento em vórtices de taylor para cultivo celular
JP2011526782A (ja) * 2008-07-05 2011-10-20 ウニセンス フェルティリテック アー/エス 1対1識別システム
US9885313B2 (en) 2009-03-17 2018-02-06 United Technologes Corporation Gas turbine engine bifurcation located fan variable area nozzle
WO2010122080A1 (fr) 2009-04-23 2010-10-28 Hemarina Bioréacteur utilisant des molécules transporteuses d'oxygène
US8778669B2 (en) 2009-07-22 2014-07-15 Corning Incorporated Multilayer tissue culture vessel
US9320269B2 (en) * 2009-09-25 2016-04-26 John Brassil Organ preservation system
US9995174B2 (en) 2010-10-12 2018-06-12 United Technologies Corporation Planetary gear system arrangement with auxiliary oil system
US10605167B2 (en) 2011-04-15 2020-03-31 United Technologies Corporation Gas turbine engine front center body architecture
US9410608B2 (en) 2011-06-08 2016-08-09 United Technologies Corporation Flexible support structure for a geared architecture gas turbine engine
US9631558B2 (en) 2012-01-03 2017-04-25 United Technologies Corporation Geared architecture for high speed and small volume fan drive turbine
US9239012B2 (en) 2011-06-08 2016-01-19 United Technologies Corporation Flexible support structure for a geared architecture gas turbine engine
US9506422B2 (en) 2011-07-05 2016-11-29 United Technologies Corporation Efficient, low pressure ratio propulsor for gas turbine engines
US9909505B2 (en) 2011-07-05 2018-03-06 United Technologies Corporation Efficient, low pressure ratio propulsor for gas turbine engines
US9938898B2 (en) 2011-07-29 2018-04-10 United Technologies Corporation Geared turbofan bearing arrangement
US9416677B2 (en) 2012-01-10 2016-08-16 United Technologies Corporation Gas turbine engine forward bearing compartment architecture
US20130186058A1 (en) 2012-01-24 2013-07-25 William G. Sheridan Geared turbomachine fan and compressor rotation
US9394852B2 (en) 2012-01-31 2016-07-19 United Technologies Corporation Variable area fan nozzle with wall thickness distribution
US20130192240A1 (en) 2012-01-31 2013-08-01 Peter M. Munsell Buffer system for a gas turbine engine
US10113434B2 (en) 2012-01-31 2018-10-30 United Technologies Corporation Turbine blade damper seal
US10400629B2 (en) 2012-01-31 2019-09-03 United Technologies Corporation Gas turbine engine shaft bearing configuration
US20150345426A1 (en) 2012-01-31 2015-12-03 United Technologies Corporation Geared turbofan gas turbine engine architecture
US8863491B2 (en) 2012-01-31 2014-10-21 United Technologies Corporation Gas turbine engine shaft bearing configuration
US20130192191A1 (en) 2012-01-31 2013-08-01 Frederick M. Schwarz Gas turbine engine with high speed low pressure turbine section and bearing support features
US20130192251A1 (en) 2012-01-31 2013-08-01 Peter M. Munsell Buffer system that communicates buffer supply air to one or more portions of a gas turbine engine
US10287914B2 (en) 2012-01-31 2019-05-14 United Technologies Corporation Gas turbine engine with high speed low pressure turbine section and bearing support features
US9169781B2 (en) 2012-01-31 2015-10-27 United Technologies Corporation Turbine engine gearbox
US20130192198A1 (en) 2012-01-31 2013-08-01 Lisa I. Brilliant Compressor flowpath
US8869508B2 (en) 2012-01-31 2014-10-28 United Technologies Corporation Gas turbine engine variable area fan nozzle control
US20150192070A1 (en) 2012-01-31 2015-07-09 United Technologies Corporation Geared turbofan gas turbine engine architecture
US10724431B2 (en) 2012-01-31 2020-07-28 Raytheon Technologies Corporation Buffer system that communicates buffer supply air to one or more portions of a gas turbine engine
US9835052B2 (en) 2012-01-31 2017-12-05 United Technologies Corporation Gas turbine engine with high speed low pressure turbine section and bearing support features
US8935913B2 (en) 2012-01-31 2015-01-20 United Technologies Corporation Geared turbofan gas turbine engine architecture
US10415468B2 (en) 2012-01-31 2019-09-17 United Technologies Corporation Gas turbine engine buffer system
US10107191B2 (en) 2012-02-29 2018-10-23 United Technologies Corporation Geared gas turbine engine with reduced fan noise
US8790075B2 (en) 2012-03-30 2014-07-29 United Technologies Corporation Gas turbine engine geared architecture axial retention arrangement
US10138809B2 (en) 2012-04-02 2018-11-27 United Technologies Corporation Geared turbofan engine with a high ratio of thrust to turbine volume
US10125693B2 (en) 2012-04-02 2018-11-13 United Technologies Corporation Geared turbofan engine with power density range
US20150308351A1 (en) 2012-05-31 2015-10-29 United Technologies Corporation Fundamental gear system architecture
US8572943B1 (en) 2012-05-31 2013-11-05 United Technologies Corporation Fundamental gear system architecture
EP3456943B1 (fr) 2012-09-28 2021-08-04 Raytheon Technologies Corporation Tube en t de mesure de debit en zones separees
BR112015007733B1 (pt) 2012-10-08 2022-05-03 United Technologies Corporation Motores de turbina a gás, e, método para distribuir peso entre um conjunto de propulsor e um conjunto de gerador de gás de um motor de turbina a gás
US11280271B2 (en) 2012-10-09 2022-03-22 Raytheon Technologies Corporation Operability geared turbofan engine including compressor section variable guide vanes
US9005550B2 (en) 2012-10-29 2015-04-14 Corning Incorporated Multi-layered cell culture vessel with manifold grips
US9920653B2 (en) 2012-12-20 2018-03-20 United Technologies Corporation Low pressure ratio fan engine having a dimensional relationship between inlet and fan size
US9932933B2 (en) 2012-12-20 2018-04-03 United Technologies Corporation Low pressure ratio fan engine having a dimensional relationship between inlet and fan size
US10436120B2 (en) 2013-02-06 2019-10-08 United Technologies Corporation Exhaust nozzle for an elongated gear turbofan with high bypass ratio
WO2014158439A1 (fr) 2013-03-12 2014-10-02 United Technologies Corporation Accouplement flexible pour turbine à engrenages
US11719161B2 (en) 2013-03-14 2023-08-08 Raytheon Technologies Corporation Low noise turbine for geared gas turbine engine
US10605172B2 (en) 2013-03-14 2020-03-31 United Technologies Corporation Low noise turbine for geared gas turbine engine
US10724479B2 (en) 2013-03-15 2020-07-28 United Technologies Corporation Thrust efficient turbofan engine
US9885282B2 (en) 2013-03-15 2018-02-06 United Technologies Corporation Turbofan engine bearing and gearbox arrangement
US10316758B2 (en) 2013-05-09 2019-06-11 United Technologies Corporation Turbofan engine front section
US10287917B2 (en) 2013-05-09 2019-05-14 United Technologies Corporation Turbofan engine front section
WO2015088619A2 (fr) 2013-10-16 2015-06-18 United Technologies Corporation Moteur à double flux à engrenages à efficacité modulaire ciblée
EP3063385A4 (fr) 2013-11-01 2017-07-12 United Technologies Corporation Agencement de réacteur à réducteur présentant un rapport de puissance divisé par noyau
US10502163B2 (en) 2013-11-01 2019-12-10 United Technologies Corporation Geared turbofan arrangement with core split power ratio
US8869504B1 (en) 2013-11-22 2014-10-28 United Technologies Corporation Geared turbofan engine gearbox arrangement
DE102014001615B3 (de) * 2014-02-10 2015-05-28 Yoen Ok Roth Vorrichtung für die Kultivierung von adhärenten Zellen
WO2015175056A2 (fr) 2014-02-19 2015-11-19 United Technologies Corporation Surface portante de moteur à turbine à gaz
EP3108118B1 (fr) 2014-02-19 2019-09-18 United Technologies Corporation Surface portante de moteur à turbine à gaz
WO2015175058A2 (fr) 2014-02-19 2015-11-19 United Technologies Corporation Surface portante de moteur à turbine à gaz
EP3108106B1 (fr) 2014-02-19 2022-05-04 Raytheon Technologies Corporation Pale de moteur à turbine à gaz
EP3108107B1 (fr) 2014-02-19 2023-10-11 Raytheon Technologies Corporation Moteur à double flux à engrenage avec aubes de compresseur basse pression
WO2015175051A2 (fr) 2014-02-19 2015-11-19 United Technologies Corporation Profil aérodynamique de moteur à turbine à gaz
EP3108104B1 (fr) 2014-02-19 2019-06-12 United Technologies Corporation Surface portante de moteur à turbine à gaz
US10605259B2 (en) 2014-02-19 2020-03-31 United Technologies Corporation Gas turbine engine airfoil
EP3108119B1 (fr) 2014-02-19 2023-10-04 RTX Corporation Moteur à double flux à engrenage avec aubes mobiles de compresseur basse pression
US10570915B2 (en) 2014-02-19 2020-02-25 United Technologies Corporation Gas turbine engine airfoil
WO2015175052A2 (fr) 2014-02-19 2015-11-19 United Technologies Corporation Profil aérodynamique de turbine à gaz
US10280843B2 (en) 2014-03-07 2019-05-07 United Technologies Corporation Geared turbofan with integral front support and carrier
US9879608B2 (en) 2014-03-17 2018-01-30 United Technologies Corporation Oil loss protection for a fan drive gear system
US9976490B2 (en) 2014-07-01 2018-05-22 United Technologies Corporation Geared gas turbine engine with oil deaerator
US10060289B2 (en) 2014-07-29 2018-08-28 United Technologies Corporation Geared gas turbine engine with oil deaerator and air removal
US9915225B2 (en) 2015-02-06 2018-03-13 United Technologies Corporation Propulsion system arrangement for turbofan gas turbine engine
US9470093B2 (en) 2015-03-18 2016-10-18 United Technologies Corporation Turbofan arrangement with blade channel variations
US10371168B2 (en) 2015-04-07 2019-08-06 United Technologies Corporation Modal noise reduction for gas turbine engine
US9874145B2 (en) 2015-04-27 2018-01-23 United Technologies Corporation Lubrication system for gas turbine engines
US10458270B2 (en) 2015-06-23 2019-10-29 United Technologies Corporation Roller bearings for high ratio geared turbofan engine
US10233773B2 (en) 2015-11-17 2019-03-19 United Technologies Corporation Monitoring system for non-ferrous metal particles
US10508562B2 (en) 2015-12-01 2019-12-17 United Technologies Corporation Geared turbofan with four star/planetary gear reduction
US10669948B2 (en) 2017-01-03 2020-06-02 Raytheon Technologies Corporation Geared turbofan with non-epicyclic gear reduction system
US10738646B2 (en) 2017-06-12 2020-08-11 Raytheon Technologies Corporation Geared turbine engine with gear driving low pressure compressor and fan at common speed, and failsafe overspeed protection and shear section
US10724445B2 (en) 2018-01-03 2020-07-28 Raytheon Technologies Corporation Method of assembly for fan drive gear system with rotating carrier
US11092020B2 (en) 2018-10-18 2021-08-17 Raytheon Technologies Corporation Rotor assembly for gas turbine engines
US11781506B2 (en) 2020-06-03 2023-10-10 Rtx Corporation Splitter and guide vane arrangement for gas turbine engines
US11814968B2 (en) 2021-07-19 2023-11-14 Rtx Corporation Gas turbine engine with idle thrust ratio
US11754000B2 (en) 2021-07-19 2023-09-12 Rtx Corporation High and low spool configuration for a gas turbine engine
US11719245B2 (en) 2021-07-19 2023-08-08 Raytheon Technologies Corporation Compressor arrangement for a gas turbine engine

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2522947A (en) * 1945-05-16 1950-09-19 Weyerhaeuser Timber Co Apparatus for growing aerobic organisms
US3821087A (en) * 1972-05-18 1974-06-28 Dedrick R Cell culture on semi-permeable tubular membranes
FR2197565B1 (fr) * 1972-08-30 1975-03-07 Rhone Poulenc Ind
US3948732A (en) * 1973-05-31 1976-04-06 Instrumentation Laboratory, Inc. Cell culture assembly
US3850748A (en) * 1973-06-28 1974-11-26 Lilly Co Eli Method of producing animal cells in suspension culture
CH593339A5 (fr) * 1973-07-02 1977-11-30 Monsanto Co
CS183856B1 (en) * 1975-09-19 1978-07-31 Jiri Sulc Device for preserving or transport microorganisms
US4087327A (en) * 1976-04-12 1978-05-02 Monsanto Company Mammalion cell culture process
AT345224B (de) * 1976-07-15 1978-09-11 Chemap Ag Verfahren und vorrichtung zum kultivieren von tierischen und humanen gewebezellen
JPS54122790A (en) * 1978-03-16 1979-09-22 Kanegafuchi Chem Ind Co Ltd Culturing method of microorganisms
US4242460A (en) * 1978-12-26 1980-12-30 Chick William L Cell culture device
JPS5642584A (en) * 1979-09-18 1981-04-20 Asahi Chem Ind Co Ltd Cell cultivation method
US4416993A (en) * 1981-06-11 1983-11-22 Mcleod & Miller (Engineers) Limited Apparatus with semi-permeable membrane, and method for cultivating micro-organisms
US4537860A (en) * 1982-12-08 1985-08-27 Monsanto Company Static cell culture maintenance system

Also Published As

Publication number Publication date
GB2059436A (en) 1981-04-23
JPS6023834B2 (ja) 1985-06-10
DE2940446C2 (de) 1982-07-08
JPS5661988A (en) 1981-05-27
GB2059436B (en) 1983-11-23
US4649114A (en) 1987-03-10
DE2940446A1 (de) 1981-04-09
FR2466503A1 (fr) 1981-04-10

Similar Documents

Publication Publication Date Title
FR2466503B1 (fr) Procede de culture de cellules animales sous forme de cultures en suspension et monocouches dans des recipients de fermentation
FR2540381B1 (fr) Procede pour stimuler la croissance des cellules; composition cosmetique, pharmaceutique et composition complementaire pour milieu de culture cellulaire appliquant ce procede
FR2640638B1 (fr) Bioreacteur et dispositif pour la culture de cellules animales
DE3888642D1 (de) Rollflasche zur Züchtung von Zellengewebekulturen.
FR2597497B1 (fr) Flacon de laboratoire destine a faire croitre des cultures de cellules et de tissus
FR2543158B1 (fr) Milieu de culture de cellules animales sans serum, sans hormones et sans facteurs de croissance et procedes de culture primaire et d'obtention de lignees cellulaires utilisant ce milieu
ATE225847T1 (de) Verfahren,zusammensetzungen und vorrichtungen zur erhaltung und zur züchtung menschlicher stammzellen und/oder hämatopoetischer zellen
IT1132101B (it) Procedimento per la produzione di etanolo in forte concentrazione impiegando microorganismi immobilizzati
GB2109406B (en) Process for culturing anaerobic bacteria and agents for preparing culture atmosphere
EP0201086A3 (en) Method of producing useful high-molecular-weight substances by culturing proliferous animal cells and culture system therefor
ES8402346A1 (es) Procedimiento para la obtencion de lineas de celulas animales y humanas cultivables permanentemente.
EP0380692A4 (en) Plant tissue culture process
AU551487B2 (en) Culturing human cells in algae extract
AT379170B (de) Bioreaktor zur anaeroben aufbereitung pflanzlicher und tierischer biomasse
BE905796A (fr) Adn de superoxyde dismutase de manganese humaine, son expression dans les bacteries et procede de recuperation de superoxyde dismutase de manganese humaine.
GB2054646B (en) Fermentor for cultures of micro-organisms
GB1547373A (en) Method of growing plant cells and/or photosynthetic bacteria
GB2054397B (en) Method and apparatus for stirring particles in suspension such as microcarriers for anchorage-dependent living cells in a liquid culture medium
AU581819B2 (en) Process for the immortalization of human and animal cells
FR2569419B1 (fr) Procede de preparation d'un milieu nutritif pour la culture de microorganismes et de cultures de cellules d'un macroorganisme
DE3871530D1 (de) Vorrichtung zum kultivieren von ruhenden zellen in einem bioreaktor.
DE2966082D1 (en) Process for growing human epidermal cells in tissue culture
ES439201A1 (es) Un procedimiento mejorado para preparar una vacuna por mediode un sistema de cultivo de celulas eucarioticas vivas.
EP0247881A3 (en) Process for culturing animal cells and appropriate media
EP0299067A4 (fr) Support pour milieu de culture de plantes.

Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse