FR2447925A1 - Solvats cristallins du 7-phenoxyacetamido-3-hydroxy-3-cephem-4-carboxylate de 4'-nitrobenzyle et de son sulfoxyde, et leur preparation - Google Patents

Solvats cristallins du 7-phenoxyacetamido-3-hydroxy-3-cephem-4-carboxylate de 4'-nitrobenzyle et de son sulfoxyde, et leur preparation

Info

Publication number
FR2447925A1
FR2447925A1 FR8001966A FR8001966A FR2447925A1 FR 2447925 A1 FR2447925 A1 FR 2447925A1 FR 8001966 A FR8001966 A FR 8001966A FR 8001966 A FR8001966 A FR 8001966A FR 2447925 A1 FR2447925 A1 FR 2447925A1
Authority
FR
France
Prior art keywords
phenoxyacetamido
cephem
carboxylate
hydroxy
nitrobenzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8001966A
Other languages
English (en)
French (fr)
Other versions
FR2447925B1 (US20080293856A1-20081127-C00150.png
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of FR2447925A1 publication Critical patent/FR2447925A1/fr
Application granted granted Critical
Publication of FR2447925B1 publication Critical patent/FR2447925B1/fr
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/247-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/32Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an araliphatic carboxylic acid, which is substituted on the aliphatic radical by hetero atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/247-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/30Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino-radical acylated by an araliphatic carboxylic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8001966A 1979-02-01 1980-01-30 Solvats cristallins du 7-phenoxyacetamido-3-hydroxy-3-cephem-4-carboxylate de 4'-nitrobenzyle et de son sulfoxyde, et leur preparation Granted FR2447925A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US846879A 1979-02-01 1979-02-01

Publications (2)

Publication Number Publication Date
FR2447925A1 true FR2447925A1 (fr) 1980-08-29
FR2447925B1 FR2447925B1 (US20080293856A1-20081127-C00150.png) 1984-02-03

Family

ID=21731772

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8001966A Granted FR2447925A1 (fr) 1979-02-01 1980-01-30 Solvats cristallins du 7-phenoxyacetamido-3-hydroxy-3-cephem-4-carboxylate de 4'-nitrobenzyle et de son sulfoxyde, et leur preparation

Country Status (32)

Country Link
EP (1) EP0014565B1 (US20080293856A1-20081127-C00150.png)
JP (1) JPS55104288A (US20080293856A1-20081127-C00150.png)
KR (1) KR830001890B1 (US20080293856A1-20081127-C00150.png)
AR (1) AR228342A1 (US20080293856A1-20081127-C00150.png)
AT (1) AT366052B (US20080293856A1-20081127-C00150.png)
AU (1) AU532573B2 (US20080293856A1-20081127-C00150.png)
BE (1) BE881423A (US20080293856A1-20081127-C00150.png)
BG (1) BG32857A3 (US20080293856A1-20081127-C00150.png)
CA (1) CA1142173A (US20080293856A1-20081127-C00150.png)
CH (1) CH647525A5 (US20080293856A1-20081127-C00150.png)
CS (1) CS214694B2 (US20080293856A1-20081127-C00150.png)
DD (1) DD148953A5 (US20080293856A1-20081127-C00150.png)
DE (1) DE3062095D1 (US20080293856A1-20081127-C00150.png)
DK (1) DK159157C (US20080293856A1-20081127-C00150.png)
ES (1) ES8103098A1 (US20080293856A1-20081127-C00150.png)
FI (1) FI68239C (US20080293856A1-20081127-C00150.png)
FR (1) FR2447925A1 (US20080293856A1-20081127-C00150.png)
GB (1) GB2041934B (US20080293856A1-20081127-C00150.png)
GR (1) GR72785B (US20080293856A1-20081127-C00150.png)
HU (2) HU181761B (US20080293856A1-20081127-C00150.png)
IE (1) IE49374B1 (US20080293856A1-20081127-C00150.png)
IL (1) IL59265A (US20080293856A1-20081127-C00150.png)
IT (1) IT1130239B (US20080293856A1-20081127-C00150.png)
LU (1) LU82118A1 (US20080293856A1-20081127-C00150.png)
NZ (1) NZ192750A (US20080293856A1-20081127-C00150.png)
PH (1) PH15152A (US20080293856A1-20081127-C00150.png)
PL (1) PL122609B1 (US20080293856A1-20081127-C00150.png)
PT (1) PT70742A (US20080293856A1-20081127-C00150.png)
RO (2) RO79181A (US20080293856A1-20081127-C00150.png)
SU (2) SU897109A3 (US20080293856A1-20081127-C00150.png)
YU (1) YU22480A (US20080293856A1-20081127-C00150.png)
ZA (1) ZA80523B (US20080293856A1-20081127-C00150.png)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3128949A1 (de) * 1981-07-22 1983-02-10 Basf Ag, 6700 Ludwigshafen Lichtempfindliche aufzeichnungsmaterialien zur herstellung von abriebs- und kratzfesten tiefdruckformen sowie verfahren zur herstellung von tiefdruckformen mittels dieser aufzeichnungsmaterialien
JPS6011491A (ja) * 1983-03-04 1985-01-21 Shionogi & Co Ltd セフアロチンナトリウムの結晶性凍結乾燥粉末の製造法
US4782144A (en) * 1987-09-14 1988-11-01 Eli Lilly And Company 1-carba(dethia)-3-hydroxy-3-cephem ester crystalline and crystalline solvate thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985747A (en) * 1974-05-24 1976-10-12 Bristol-Myers Company Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
US4044002A (en) * 1976-06-09 1977-08-23 Eli Lilly And Company Reduction process for cephalosporin sulfoxides

Also Published As

Publication number Publication date
KR830001890B1 (ko) 1983-09-17
EP0014565A1 (en) 1980-08-20
AT366052B (de) 1982-03-10
BG32857A3 (en) 1982-10-15
BE881423A (fr) 1980-07-30
FR2447925B1 (US20080293856A1-20081127-C00150.png) 1984-02-03
LU82118A1 (fr) 1980-04-23
DD148953A5 (de) 1981-06-17
RO83702B (ro) 1984-03-30
ZA80523B (en) 1981-09-30
RO79181A (ro) 1982-06-25
HU182095B (en) 1983-12-28
YU22480A (en) 1983-02-28
NZ192750A (en) 1982-05-25
SU938740A3 (ru) 1982-06-23
IL59265A (en) 1983-05-15
PH15152A (en) 1982-08-24
FI800300A (fi) 1980-08-02
SU897109A3 (ru) 1982-01-07
PT70742A (en) 1980-02-01
AR228342A1 (es) 1983-02-28
ES488229A0 (es) 1981-02-16
FI68239C (fi) 1985-08-12
IE800191L (en) 1980-08-01
GR72785B (US20080293856A1-20081127-C00150.png) 1983-12-05
CH647525A5 (fr) 1985-01-31
JPH0128035B2 (US20080293856A1-20081127-C00150.png) 1989-05-31
DK159157C (da) 1991-02-11
KR830001951A (ko) 1983-05-21
CA1142173A (en) 1983-03-01
EP0014565B1 (en) 1983-02-23
HU181761B (en) 1983-11-28
PL122609B1 (en) 1982-08-31
IT1130239B (it) 1986-06-11
GB2041934A (en) 1980-09-17
AU5502680A (en) 1980-08-07
GB2041934B (en) 1983-03-23
ATA49980A (de) 1981-07-15
PL221748A1 (US20080293856A1-20081127-C00150.png) 1980-12-15
FI68239B (fi) 1985-04-30
JPS55104288A (en) 1980-08-09
IL59265A0 (en) 1980-05-30
RO83702A (ro) 1984-03-15
AU532573B2 (en) 1983-10-06
DE3062095D1 (en) 1983-03-31
ES8103098A1 (es) 1981-02-16
DK159157B (da) 1990-09-10
IE49374B1 (en) 1985-09-18
IT8019607A0 (it) 1980-01-31
DK41180A (da) 1980-08-02
CS214694B2 (en) 1982-05-28

Similar Documents

Publication Publication Date Title
FI871041A (fi) Menetelmä terapeuttisesti käyttökelpoisten 3,5-disubstituoitujen pyrokatekolijohdannaisten valmistamiseksi
FR2385722A1 (fr) Nouveaux derives de cephalosporine, leur procede de preparation et leur application en therapeutique
FR2387938A1 (fr) Fluorures o-carbonyles a-carboxyles fluores et leur preparation
FR2387232A1 (fr) Derives de la substance antibiotique milbemycine et procedes de preparation
FR2430934A1 (fr) Nouveaux prostanoides et procede pour leur preparation
FR2401135A1 (fr) Nouveaux derives d'aminoalkyl-benzenes et procedes pour leur preparation
FR2375234A1 (fr) 1,2-dihydro-3h-pyrrolo(1,2-a)pyrrole-1-carboxylates et leur obtention
FR2447925A1 (fr) Solvats cristallins du 7-phenoxyacetamido-3-hydroxy-3-cephem-4-carboxylate de 4'-nitrobenzyle et de son sulfoxyde, et leur preparation
NO883833L (no) Fremgangsmaate for fremstilling av isoxazol-betacarbolinderivater.
FR2355020A1 (fr) Antibiotiques de b-lactames et leur procede de preparation
PT67839A (fr) Procede de preparation de nouveaux derives de la pyrido-(2,3-b)benzothiazepine-(1,5)substitues
FR2361881A2 (fr) Nouveaux sulfoxydes, leur procede de preparation et leur application
TNSN87138A1 (fr) Procede de preparation de nouveaux aminopropionamides
FR2367763A1 (fr) Nouvelles ( ( ( (phenyl substitue)-5 oxazolyl-2)methylene)
FR2389631A1 (US20080293856A1-20081127-C00150.png)
FR2445838A1 (fr) Nouveaux 1a,3b-dihydroxy-5-steroides
NO822229L (no) Fremgangsmaate ved fremstilling av 5,6,7,7a-tetrahydro-4h-thieno-(3,2-c)-pyridin-on-derivater
OA06526A (fr) Nouveaux dérivés halogénés de l'isopropylamino-pyrimidine et leur préparation.
FR2358449A1 (fr) Nouveaux derives de l'iso-indolinone utilisables comme pigments et leur preparation
FR2377406A1 (fr) Composes de tetrathiapentalene et de tetraselenapentalene
FR2403367A1 (fr) Nouveaux colorants anthraquinoniques et leur preparation
FR2378786A1 (fr) Nouveaux composes de cephalosporine et procedes pour leur preparation
FR2373563A1 (fr) 3 a-hydroxy-5b-cholest-24-ene, derives en 3 a de celui-ci et leur procede de preparation
FR2418800A1 (fr) Nouvelles cephalosporines et leur procede de preparation
FR2433010A1 (fr) Nouveaux derives du 1,4-bis-phenoxy-butane utilisables pour la lutte contre la vegetation indesirable et leur preparation