FR2387232A1 - Derives de la substance antibiotique milbemycine et procedes de preparation - Google Patents

Derives de la substance antibiotique milbemycine et procedes de preparation

Info

Publication number
FR2387232A1
FR2387232A1 FR7810240A FR7810240A FR2387232A1 FR 2387232 A1 FR2387232 A1 FR 2387232A1 FR 7810240 A FR7810240 A FR 7810240A FR 7810240 A FR7810240 A FR 7810240A FR 2387232 A1 FR2387232 A1 FR 2387232A1
Authority
FR
France
Prior art keywords
milbemycin
derivatives
preparation
methods
antibiotic substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7810240A
Other languages
English (en)
Other versions
FR2387232B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of FR2387232A1 publication Critical patent/FR2387232A1/fr
Application granted granted Critical
Publication of FR2387232B1 publication Critical patent/FR2387232B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne la préparation des dérivés de la substance antibiotique milbémycine, appelée aussi B-41. La milbémycine est bromée, acétylée et hydrolysée pour donner son dérivé 13-hydroxy. Les nouveaux dérivés ont une activité antiparasitaire.
FR7810240A 1977-04-11 1978-04-06 Derives de la substance antibiotique milbemycine et procedes de preparation Granted FR2387232A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/786,172 US4093629A (en) 1977-04-11 1977-04-11 Derivatives of antibiotic substance milbemycin and processes therefor

Publications (2)

Publication Number Publication Date
FR2387232A1 true FR2387232A1 (fr) 1978-11-10
FR2387232B1 FR2387232B1 (fr) 1982-04-09

Family

ID=25137800

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7810240A Granted FR2387232A1 (fr) 1977-04-11 1978-04-06 Derives de la substance antibiotique milbemycine et procedes de preparation

Country Status (7)

Country Link
US (1) US4093629A (fr)
JP (1) JPS53130695A (fr)
AU (1) AU516707B2 (fr)
FR (1) FR2387232A1 (fr)
GB (1) GB1576185A (fr)
NZ (1) NZ186852A (fr)
ZA (1) ZA782023B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2463773A1 (fr) * 1979-08-23 1981-02-27 Sankyo Co Compose ayant des activites acaricides et anthelmintiques obtenu par culture d'un micro-organisme du genre streptomyces

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4206205A (en) * 1977-10-03 1980-06-03 Merck & Co., Inc. Monosaccharide and aglycone derivatives of C-076
US4201861A (en) * 1977-10-03 1980-05-06 Merck & Co., Inc. Acyl derivatives of C-076 compounds
PH16612A (en) * 1977-12-19 1983-11-28 Merck & Co Inc 13-halo and 13-deoxy derivatives of c-076 compounds
US4203976A (en) * 1978-08-02 1980-05-20 Merck & Co., Inc. Sugar derivatives of C-076 compounds
US4200581A (en) * 1978-08-04 1980-04-29 Merck & Co., Inc. Alkyl derivatives of C-076 compounds
US4389397A (en) * 1980-08-04 1983-06-21 Merck & Co., Inc. Solubilization of ivermectin in water
US4285963A (en) * 1980-08-07 1981-08-25 Merck & Co., Inc. Novel derivatives of C-076 compounds
US4378353A (en) * 1981-02-17 1983-03-29 Merck & Co., Inc. Novel C-076 compounds
US4408059A (en) * 1981-12-04 1983-10-04 University Patents, Inc. Spiroketals useful as intermediates in the synthesis of milbemycin and avermectin macrolides
JPS59108785A (ja) * 1982-11-25 1984-06-23 Sankyo Co Ltd ミルベマイシン類の５−オキシム誘導体
US4469682A (en) * 1983-01-28 1984-09-04 Merck & Co., Inc. Avermectin and milbemycin phosphate esters, pharmaceutical compositions, and method of use
US4579864A (en) * 1984-06-11 1986-04-01 Merck & Co., Inc. Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives
EP0180539A1 (fr) * 1984-09-18 1986-05-07 Ciba-Geigy Ag 13-Halo- et 13-hydroxymilbémycine
AU574852B2 (en) * 1984-10-26 1988-07-14 Sankyo Company Limited 13 - acyloxy - 5 - ketomilbemycin derivatives and preparation of 13 - hydroxy - 5 - ketomilbemycin derivatives
GB2168345B (en) * 1984-12-14 1988-05-25 Ciba Geigy Ag Pesticidal 13b-substituted milbemycin derivatives
US4857509A (en) * 1985-01-22 1989-08-15 Ciba-Geigy Corporation 13β-alkylmilbemycin derivatives for controlling parasites of animals and plants
US4587247A (en) * 1985-02-25 1986-05-06 Merck & Co., Inc. Substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones, compositions and use
US4666937A (en) * 1985-03-04 1987-05-19 Merck & Co., Inc. Avermectin bioconversion products
JPS6289685A (ja) * 1985-05-31 1987-04-24 Sankyo Co Ltd １３−ハロゲンミルベマイシン誘導体
US4820758A (en) * 1985-07-22 1989-04-11 The Upjohn Company Novel [5.5]-spiroketals
US4812582A (en) * 1985-07-22 1989-03-14 The Upjohn Company Process for preparing aldol intermediates
US4686297A (en) * 1985-07-22 1987-08-11 The Upjohn Company Anthelmintic spiroketals useful for killing parasitic worms
US4814347A (en) * 1985-07-22 1989-03-21 The Upjohn Company Anthelmintic spiroketals and method of use
US4680419A (en) * 1985-07-22 1987-07-14 The Upjohn Company Spiroketals and process for preparing same
EP0246739B1 (fr) * 1986-03-25 1991-01-23 Sankyo Company Limited Composés macrolides, leur préparation et leur utilisation
JPH0819133B2 (ja) * 1986-03-25 1996-02-28 三共株式会社 １３−置換ミルベマイシン類の５−オキシム誘導体
ATE75745T1 (de) * 1986-07-02 1992-05-15 Ciba Geigy Ag Pestizide.
JP2587241B2 (ja) * 1986-07-24 1997-03-05 ビ−チヤム・グル−プ・ピ−エルシ− 新規化合物、その製法及びそれを含む医薬組成物
US4897416A (en) * 1987-02-18 1990-01-30 Ciba-Geigy Corporation Insecticides and parasiticides
EP0285561A3 (fr) * 1987-03-27 1989-10-25 Ciba-Geigy Ag Dérivés de la milbémycine à activité antiparasitaire et insecticide
EP0325462A3 (fr) * 1988-01-22 1989-11-02 Beecham Group Plc Dérivés de la milbémycine à activité anthelmintique
US5008250A (en) * 1988-05-25 1991-04-16 Merck & Co., Inc. Avermectins with a cleaved furan ring and an 8a hydroxy group
AU728221B2 (en) 1996-06-05 2001-01-04 Ashmont Holdings Limited Injectable compositions
US6495591B1 (en) 1997-10-02 2002-12-17 Essential Therapeutics, Inc. Fungal efflux pump inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2187778A1 (fr) * 1972-06-08 1974-01-18 Sankyo Co
FR2348970A1 (fr) * 1976-04-19 1977-11-18 Merck & Co Inc Nouveaux agents anthelmintiques et procedes pour leur preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950360A (en) * 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
US3984564A (en) * 1972-06-08 1976-10-05 Sankyo Company Limited Antibiotic substances B-41, their production and their use as insecticides and acaricides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2187778A1 (fr) * 1972-06-08 1974-01-18 Sankyo Co
FR2348970A1 (fr) * 1976-04-19 1977-11-18 Merck & Co Inc Nouveaux agents anthelmintiques et procedes pour leur preparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/76 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2463773A1 (fr) * 1979-08-23 1981-02-27 Sankyo Co Compose ayant des activites acaricides et anthelmintiques obtenu par culture d'un micro-organisme du genre streptomyces

Also Published As

Publication number Publication date
JPS53130695A (en) 1978-11-14
NZ186852A (en) 1984-09-28
FR2387232B1 (fr) 1982-04-09
ZA782023B (en) 1979-07-25
AU516707B2 (en) 1981-06-18
US4093629A (en) 1978-06-06
GB1576185A (en) 1980-10-01
AU3476178A (en) 1979-10-11

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