FR2405931A1 - Nouveaux derives de la phenylethanolamine utiles comme agents antihypertensifs et leur procede de preparation - Google Patents

Nouveaux derives de la phenylethanolamine utiles comme agents antihypertensifs et leur procede de preparation

Info

Publication number
FR2405931A1
FR2405931A1 FR7828743A FR7828743A FR2405931A1 FR 2405931 A1 FR2405931 A1 FR 2405931A1 FR 7828743 A FR7828743 A FR 7828743A FR 7828743 A FR7828743 A FR 7828743A FR 2405931 A1 FR2405931 A1 FR 2405931A1
Authority
FR
France
Prior art keywords
antihypertensify
agents
new
preparation process
derivatives useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7828743A
Other languages
English (en)
Other versions
FR2405931B1 (fr
Inventor
Kazuo Imai
Kunihiro Niigata
Takashi Fujikura
Shinichi Hashimoto
Toichi Takenaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP12203477A external-priority patent/JPS5473751A/ja
Priority claimed from JP12843677A external-priority patent/JPS5463048A/ja
Priority claimed from JP15535277A external-priority patent/JPS5495544A/ja
Priority claimed from JP7496478A external-priority patent/JPS552639A/ja
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of FR2405931A1 publication Critical patent/FR2405931A1/fr
Application granted granted Critical
Publication of FR2405931B1 publication Critical patent/FR2405931B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne de nouveaux dérivés de la phényléthanolamine. Le dérivé de la phényléthanolamine est représenté par la formule :
FR7828743A 1977-10-12 1978-10-09 Nouveaux derives de la phenylethanolamine utiles comme agents antihypertensifs et leur procede de preparation Granted FR2405931A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP12203477A JPS5473751A (en) 1977-10-12 1977-10-12 Phenyl ethanolamine derivatives and their preparation
JP12843677A JPS5463048A (en) 1977-10-26 1977-10-26 Novel phenyl ethanolamine derivatives and their preparation
JP15535277A JPS5495544A (en) 1977-12-23 1977-12-23 Phenylethanolamine derivative and its preparation
JP7496478A JPS552639A (en) 1978-06-21 1978-06-21 Phenylethanolamine derivative and its preparation

Publications (2)

Publication Number Publication Date
FR2405931A1 true FR2405931A1 (fr) 1979-05-11
FR2405931B1 FR2405931B1 (fr) 1982-11-19

Family

ID=27465764

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7828743A Granted FR2405931A1 (fr) 1977-10-12 1978-10-09 Nouveaux derives de la phenylethanolamine utiles comme agents antihypertensifs et leur procede de preparation

Country Status (16)

Country Link
US (1) US4217305A (fr)
AT (1) AT363457B (fr)
AU (1) AU526715B2 (fr)
CA (1) CA1147342A (fr)
CH (1) CH639948A5 (fr)
DE (1) DE2843016A1 (fr)
DK (1) DK168484B1 (fr)
ES (2) ES474149A1 (fr)
FR (1) FR2405931A1 (fr)
GB (1) GB2006772B (fr)
GR (1) GR65337B (fr)
IT (1) IT1160853B (fr)
NO (1) NO147148C (fr)
PT (1) PT68624A (fr)
SE (1) SE448232B (fr)
SU (2) SU982537A3 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2487827A1 (fr) * 1980-07-29 1982-02-05 Yamanouchi Pharma Co Ltd Nouveaux derives de la phenetylamine et procede pour leur production
EP0162404A2 (fr) * 1984-05-15 1985-11-27 Seitetsu Kagaku Co., Ltd. Procédé de préparation de 2-alcoyl-5-haloacétylbenzène-sulfonamides
FR2737494A1 (fr) * 1995-08-04 1997-02-07 Synthelabo Derives de benzenesulfonamide, leur preparation et leur application en therapeutique
WO2000058301A1 (fr) * 1999-03-30 2000-10-05 Sanofi-Synthelabo Derives de n-[2-(4-aminophenyl)ethyl]-2,3-dihydro-1,4-benzodioxine-2-methanamine, leur preparation et leur application en therapeutique

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55124742A (en) * 1979-03-20 1980-09-26 Kyowa Hakko Kogyo Co Ltd Novel aminoalcohol derivative
US4206125A (en) * 1979-05-04 1980-06-03 Richardson-Merrell Inc. 5-[2-[(2,3-Dihydro-1,4-benzodioxan-2-ylmethyl)amino]-1-hydroxyethyl]-2-hydroxybenzoic acid derivatives
DD157796A5 (de) * 1979-12-04 1982-12-08 Ciba Geigy Ag Verfahren zur herstellung neuer derivate des 2-amino-aethanols
US4558156A (en) * 1980-02-08 1985-12-10 Yamanouchi Pharmaceutical Co., Ltd. Sulfamoyl-substituted phenethylamine derivatives
US5391825A (en) * 1980-02-08 1995-02-21 Yamanouchi Pharmaceutical Co., Ltd. Sulfamoyl substituted phenethylamine intermediates
JPS56110665A (en) * 1980-02-08 1981-09-01 Yamanouchi Pharmaceut Co Ltd Sulfamoyl-substituted phenetylamine derivative and its preparation
CA1219865A (fr) * 1982-05-14 1987-03-31 Leo Alig Derives de phenethanolamine d'aziridine
PT78388B (en) * 1983-04-12 1986-09-15 Smithkline Beckman Corp Dopamine-beta-hydroxylase inhibitors
JPS6051106A (ja) * 1983-08-31 1985-03-22 Yamanouchi Pharmaceut Co Ltd 塩酸アモスラロ−ル持続性製剤
US4678855A (en) * 1985-10-09 1987-07-07 Merck & Co., Inc. Substituted benzenesulfonamides
JPS62114952A (ja) * 1985-11-13 1987-05-26 Yamanouchi Pharmaceut Co Ltd 置換フエネチルアミン誘導体の製造法
NZ226934A (en) * 1987-11-13 1991-01-29 Glaxo Group Ltd Phenethanolamine derivatives and pharmaceutical compositions
BR9306399A (pt) * 1992-05-22 1998-09-15 Senju Pharma Co Composição farmacéutica para uso no tratamento de glaucoma
ES2208772T3 (es) * 1996-01-10 2004-06-16 Asahi Kasei Kabushiki Kaisha Nuevos compuestos triciclicos y compuestos farmaceuticos que contienen los mismos.
EP1075486A1 (fr) * 1998-05-06 2001-02-14 Duke University Methode de traitement des affections du bas appareil urinaire et de la vessie
US6835853B2 (en) 2001-10-31 2004-12-28 Synthon Bv Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith
CN1681495B (zh) 2002-08-19 2010-05-12 辉瑞产品公司 用于治疗过度增生性疾病的组合物
WO2004106299A2 (fr) 2003-05-30 2004-12-09 Ranbaxy Laboratories Limited Derives pyrroliques substitues
US7329780B2 (en) * 2003-12-09 2008-02-12 Cj Corporation Method of preparing optically pure phenethylamine derivatives
ATE439347T1 (de) * 2004-11-23 2009-08-15 Warner Lambert Co 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptansäure- derivate als hmg-co-a-reductase-inhibitoren zur behandlung von lipidemia
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
KR101329112B1 (ko) 2005-11-08 2013-11-14 랜박시 래보러터리스 리미티드 (3ｒ,5ｒ)-7-〔2-(4-플루오로페닐)-5-이소프로필-3-페닐-4-〔(4-히드록시 메틸 페닐 아미노)카르보닐〕-피롤-1-일〕-3,5-디히드록시 헵탄산 헤미 칼슘염의 제조 방법
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
EP2026766A1 (fr) 2006-05-17 2009-02-25 Synthon B.V. Composition en comprimé pour la libération prolongée de la tamsulosine
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
US8465770B2 (en) * 2008-12-24 2013-06-18 Synthon Bv Low dose controlled release tablet
CN102050766B (zh) * 2009-11-03 2013-08-07 安徽省新星药物开发有限责任公司 一种盐酸氨磺洛尔的合成方法
WO2014170786A1 (fr) 2013-04-17 2014-10-23 Pfizer Inc. Dérivés de n-pipéridin-3-ylbenzamide dans le traitement des maladies cardiovasculaires
WO2016055901A1 (fr) 2014-10-08 2016-04-14 Pfizer Inc. Composés d'amide substitué
CN113574055A (zh) 2019-01-18 2021-10-29 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2379515A1 (fr) * 1977-02-03 1978-09-01 Allen & Hanburys Ltd Nouveaux derives du type benzene-sulfamide et benzene-carboxamide, leur emploi et leur preparation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3701808A (en) * 1967-12-21 1972-10-31 Allen & Hanburys Ltd Phenylethanolamines
GB1266058A (fr) 1969-07-08 1972-03-08
GB1321701A (en) 1969-10-01 1973-06-27 Continental Pharma Amino-alcohols their salts and process for prepairing the same
US3711545A (en) * 1971-02-23 1973-01-16 Smith Kline French Lab Alpha-aminoalkyl-4-hydroxy-3-sulfamoylaminobenzyl alcohols
DE2115926C3 (de) * 1971-04-01 1978-05-03 C.H. Boehringer Sohn, 6507 Ingelheim 1 -(4-Hydroxy-3-dimethylaminosuIfamidophenyI)-2-aminoäthanderivate, Verfahren zu ihrer Herstellung und diese enthaltende Mittel
US4034112A (en) * 1973-06-22 1977-07-05 Imperial Chemical Industries Limited Ethanolamine derivatives having β-adrenergic blocking activity
US3860647A (en) * 1973-08-20 1975-01-14 Smithkline Corp {60 -Aminomethyl-4-hydroxy-3-sulfamyl-benzyl alcohols and 4-hydroxy-3-sulfamyl phenethylamines
GB1593651A (en) * 1977-02-03 1981-07-22 Allen & Hanburys Ltd Amides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2379515A1 (fr) * 1977-02-03 1978-09-01 Allen & Hanburys Ltd Nouveaux derives du type benzene-sulfamide et benzene-carboxamide, leur emploi et leur preparation

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2487827A1 (fr) * 1980-07-29 1982-02-05 Yamanouchi Pharma Co Ltd Nouveaux derives de la phenetylamine et procede pour leur production
EP0162404A2 (fr) * 1984-05-15 1985-11-27 Seitetsu Kagaku Co., Ltd. Procédé de préparation de 2-alcoyl-5-haloacétylbenzène-sulfonamides
EP0162404A3 (en) * 1984-05-15 1986-04-30 Seitetsu Kagaku Co., Ltd. Process for preparing 2-alkyl-5-haloacetylbenzenesulfonamide
FR2737494A1 (fr) * 1995-08-04 1997-02-07 Synthelabo Derives de benzenesulfonamide, leur preparation et leur application en therapeutique
WO1997006136A1 (fr) * 1995-08-04 1997-02-20 Synthelabo Derives de benzenesulfonamide, leur preparation et leurs applications en therapeutique
WO2000058301A1 (fr) * 1999-03-30 2000-10-05 Sanofi-Synthelabo Derives de n-[2-(4-aminophenyl)ethyl]-2,3-dihydro-1,4-benzodioxine-2-methanamine, leur preparation et leur application en therapeutique
FR2791675A1 (fr) * 1999-03-30 2000-10-06 Synthelabo Derives de n-[2-(4-aminophenyl) ethyl] -2,3-dihydro-1,4- benzodioxinne-2-methanamine, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
SU932982A3 (ru) 1982-05-30
US4217305A (en) 1980-08-12
NO783442L (no) 1979-04-18
NO147148B (no) 1982-11-01
IT7869350A0 (it) 1978-10-11
NO147148C (no) 1983-02-09
ATA731778A (de) 1981-01-15
AU526715B2 (en) 1983-01-27
SE7810613L (sv) 1979-04-13
AU4064278A (en) 1980-04-17
FR2405931B1 (fr) 1982-11-19
CH639948A5 (de) 1983-12-15
AT363457B (de) 1981-08-10
ES474149A1 (es) 1979-10-16
IT1160853B (it) 1987-03-11
DK168484B1 (da) 1994-04-05
GB2006772A (en) 1979-05-10
DK452178A (da) 1979-04-13
DE2843016C2 (fr) 1988-10-13
SE448232B (sv) 1987-02-02
ES481549A1 (es) 1980-04-01
DE2843016A1 (de) 1979-04-26
GR65337B (en) 1980-08-18
SU982537A3 (ru) 1982-12-15
CA1147342A (fr) 1983-05-31
GB2006772B (en) 1982-02-03
PT68624A (en) 1978-11-01

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