FR2411179B1 - - Google Patents

Info

Publication number
FR2411179B1
FR2411179B1 FR7900172A FR7900172A FR2411179B1 FR 2411179 B1 FR2411179 B1 FR 2411179B1 FR 7900172 A FR7900172 A FR 7900172A FR 7900172 A FR7900172 A FR 7900172A FR 2411179 B1 FR2411179 B1 FR 2411179B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7900172A
Other versions
FR2411179A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of FR2411179A1 publication Critical patent/FR2411179A1/fr
Application granted granted Critical
Publication of FR2411179B1 publication Critical patent/FR2411179B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
FR7900172A 1977-05-09 1979-01-04 Nouveaux derives de l'acide 2-(4-thio-2-oxoazetidine-1-yl)-3-methyl-crotonique et procedes pour leur preparation Granted FR2411179A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU77306A LU77306A1 (fr) 1977-05-09 1977-05-09

Publications (2)

Publication Number Publication Date
FR2411179A1 FR2411179A1 (fr) 1979-07-06
FR2411179B1 true FR2411179B1 (fr) 1982-04-23

Family

ID=19728568

Family Applications (8)

Application Number Title Priority Date Filing Date
FR7813535A Granted FR2405949A1 (fr) 1977-05-09 1978-05-08 Composes thia-aza a noyau b-lactame utiles notamment comme medicaments
FR7900169A Granted FR2405950A1 (fr) 1977-05-09 1979-01-04 Nouveaux 1 oxydes de l'acide penicillanique utiles dans la synthese de medicaments
FR7900173A Granted FR2422637A1 (fr) 1977-05-09 1979-01-04 Nouveaux derives de l'acide 2(4-thio-2-oxo-azetidin-1-yl)-3-methylene-butyrique et procede de preparation
FR7900167A Granted FR2405955A1 (fr) 1977-05-09 1979-01-04 Nouveaux ylides utiles dans la synthese de medicaments
FR7900170A Granted FR2405945A1 (fr) 1977-05-09 1979-01-04 Nouveaux derives de l'acide 4 dithio 3-methylenebutyrique et procede pour leur preparation
FR7900168A Granted FR2405934A1 (fr) 1977-05-09 1979-01-04 Nouvelles 4-thio-2-oxo azetidines utiles dans la synthese de medicaments
FR7900172A Granted FR2411179A1 (fr) 1977-05-09 1979-01-04 Nouveaux derives de l'acide 2-(4-thio-2-oxoazetidine-1-yl)-3-methyl-crotonique et procedes pour leur preparation
FR7900171A Granted FR2405946A1 (fr) 1977-05-09 1979-01-04 Nouveaux derives de l'acide 3-methyl-crotonique et procede pour leur preparation

Family Applications Before (6)

Application Number Title Priority Date Filing Date
FR7813535A Granted FR2405949A1 (fr) 1977-05-09 1978-05-08 Composes thia-aza a noyau b-lactame utiles notamment comme medicaments
FR7900169A Granted FR2405950A1 (fr) 1977-05-09 1979-01-04 Nouveaux 1 oxydes de l'acide penicillanique utiles dans la synthese de medicaments
FR7900173A Granted FR2422637A1 (fr) 1977-05-09 1979-01-04 Nouveaux derives de l'acide 2(4-thio-2-oxo-azetidin-1-yl)-3-methylene-butyrique et procede de preparation
FR7900167A Granted FR2405955A1 (fr) 1977-05-09 1979-01-04 Nouveaux ylides utiles dans la synthese de medicaments
FR7900170A Granted FR2405945A1 (fr) 1977-05-09 1979-01-04 Nouveaux derives de l'acide 4 dithio 3-methylenebutyrique et procede pour leur preparation
FR7900168A Granted FR2405934A1 (fr) 1977-05-09 1979-01-04 Nouvelles 4-thio-2-oxo azetidines utiles dans la synthese de medicaments

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7900171A Granted FR2405946A1 (fr) 1977-05-09 1979-01-04 Nouveaux derives de l'acide 3-methyl-crotonique et procede pour leur preparation

Country Status (13)

Country Link
US (5) US4331676A (fr)
JP (1) JPS53137951A (fr)
AU (1) AU527917B2 (fr)
BE (1) BE866845A (fr)
CH (1) CH646173A5 (fr)
DE (1) DE2819655A1 (fr)
DK (1) DK200578A (fr)
ES (1) ES469568A1 (fr)
FR (8) FR2405949A1 (fr)
GB (4) GB1604751A (fr)
LU (1) LU77306A1 (fr)
NL (1) NL7804974A (fr)
SE (2) SE443980B (fr)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055573A (en) * 1976-11-19 1991-10-08 Merck & Co., Inc. Process for preparing 1-carba-2-penem-3-carboxylic acid
IN149747B (fr) * 1977-06-07 1982-04-03 Pfizer
US4234579A (en) * 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
JPS54117459A (en) * 1978-01-20 1979-09-12 Glaxo Group Ltd Novel lactam compound
EP0042026B1 (fr) * 1978-02-02 1986-01-08 Ciba-Geigy Ag Dérivés d'azétidin-2-one 3,4-disubstitués et procédé de préparation
IT1162268B (it) * 1978-02-16 1987-03-25 Glaxo Group Ltd Composti beta-lattamici procedimento per produrli composizioni che li contengono e intermedi per prepararli
EP0010358A1 (fr) * 1978-09-20 1980-04-30 Glaxo Group Limited Composés de bêta-lactame, procédés pour leur préparation, compositions les contenant, intermédiaires utilisables dans leur préparation et méthodes pour leur production
US4290948A (en) 1978-11-22 1981-09-22 Beecham Group Limited Process for their preparation of β-lactam antibacterial agents
AT365594B (de) * 1978-11-24 1982-01-25 Erba Farmitalia Verfahren zur herstellung von neuen 7-oxo-4-thia1-aza-bicyclo-(3,2,0)heptanderivaten
US4272437A (en) 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
US4282150A (en) 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
EP0013067A1 (fr) * 1978-12-22 1980-07-09 Beecham Group Plc Agents antibactériens à cycle bêta-lactame bicyclique, leur utilisation dans des compositions pharmaceutiques, procédés pour leur préparation et intermédiaires à utiliser dans de tels procédés
EP0061205B1 (fr) * 1979-01-10 1986-03-12 Schering Corporation Composés dérivés de 2-penème, procédé pour leur préparation et compositions pharmaceutiques les contenant
IL59081A0 (en) * 1979-01-10 1980-05-30 Schering Corp 2-penem compounds and a method for preparing them
AT368506B (de) * 1979-02-24 1982-10-25 Erba Farmitalia Verfahren zur herstellung von neuen penemcarbonsaeuren und deren salzen
US4420426A (en) 1979-03-05 1983-12-13 Pfizer Inc. 6-Alpha-halopenicillanic acid 1,1-dioxides
US4714761A (en) * 1979-03-05 1987-12-22 Pfizer Inc. 6,6-dihalopenicillanic acid 1,1-dioxides and process
US4269771A (en) * 1979-04-06 1981-05-26 Farmitalia Carlo Erba Total synthesis of 7-oxo-4-thia-1-azabicyclo-[3,2,0]-heptane-2-carboxyl derivatives useful as β-lactamase inhibitors and antibacterial agents
US4683226A (en) * 1979-08-01 1987-07-28 Schering Corporation 6-hydroxyalkyl-2-(substituted-thio)penem-3-carboxylic acids
US4406834A (en) 1979-09-21 1983-09-27 Bristol-Myers Company 2,6 Disubstituted penems and intermediates therefor
US4374065A (en) 1979-09-21 1983-02-15 Bristol-Myers Company Antibacterial agents of the β-lactam type
US4378314A (en) 1979-09-21 1983-03-29 Bristol Myers Company Antibacterial agents and metal containing azetidinone intermediates therefore
DE3069524D1 (en) * 1979-12-20 1984-11-29 Hoechst Uk Ltd Penem derivatives
US4482565A (en) * 1980-02-22 1984-11-13 Farmitalia Carlo Erba S.P.A. β-Lactam-containing antibacterial agents and β-lactamase inhibitors
JPS56142283A (en) * 1980-03-17 1981-11-06 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
JPS56142282A (en) * 1980-03-10 1981-11-06 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
EP0176064A1 (fr) * 1980-11-06 1986-04-02 Hoechst Uk Limited Intermédiaires pour la préparation de dérivés de 7-oxo-4-thia-1-aza-[3,2,0]heptane et de 7-oxo-4-thia-1-aza[3,2,0]hept-2-éne
ES8305366A1 (es) * 1981-07-08 1983-04-01 Hoechst Uk Ltd "procedimiento para la preparacion de derivados de penem".
DE3274982D1 (en) * 1981-07-08 1987-02-12 Hoechst Uk Ltd Antibacterial penem derivatives
JPS58116487A (ja) * 1981-12-28 1983-07-11 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物及びその製造法
JPS5835190A (ja) * 1981-08-25 1983-03-01 Sankyo Co Ltd ペネム−３−カルボン酸誘導体
JPS5946289A (ja) * 1982-09-08 1984-03-15 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物及びその製造法
US4595539A (en) * 1983-06-10 1986-06-17 Pfizer Inc. Preparation of penem derivatives and azetidinone intermediates
US4725678A (en) * 1983-06-10 1988-02-16 Pfizer Inc. Azetidinone intermediates for the preparation of penem derivatives
US5229381A (en) * 1983-12-01 1993-07-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US4680391A (en) * 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5229510A (en) * 1983-12-01 1993-07-20 Merck & Co., Inc. β-lactams useful in determining the amount of elastase in a clinical sample
JPS60243064A (ja) * 1984-05-17 1985-12-03 Taiho Yakuhin Kogyo Kk アゼチジノンジスルフイド誘導体
EP0379281A3 (fr) * 1989-01-19 1991-03-20 Cosmopolitan Textile Company Limited Méthode et appareil d'inspection d'une bande
US5104862A (en) * 1991-03-20 1992-04-14 Merck & Co., Inc. Bethalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
US5100880A (en) * 1991-03-20 1992-03-31 Merck & Co., Inc. Novel betalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
US5348953A (en) * 1991-06-25 1994-09-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
CA2147129A1 (fr) * 1992-10-27 1994-05-11 James B. Doherty Nouvelles azetidinones substituees utilisees comme agents anti-inflammatoires et anti-degeneratifs
US5591737A (en) * 1992-12-17 1997-01-07 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5747485A (en) * 1995-04-13 1998-05-05 Merck & Co., Inc. Substituted azetidiones as anti-inflammatory and antidegenerative agents
WO2004039776A2 (fr) * 2002-11-01 2004-05-13 Orchid Chemicals & Pharmaceuticals Ltd Procede de preparation de derives de l'azetidine
WO2009049086A1 (fr) 2007-10-09 2009-04-16 Larry Sutton Inhibiteurs de bêta-lactamase à large spectre
JP2015518854A (ja) * 2012-05-23 2015-07-06 セリックスビオ プライヴェート リミテッド 多発性硬化症の治療のための組成物および方法
EP3790843A1 (fr) * 2018-05-07 2021-03-17 Covestro Intellectual Property GmbH & Co. KG Support de stockage et procédé de séparation, de stockage et de transport de chlore à partir de gaz contenant du chlore
CN114720591B (zh) * 2022-03-22 2022-12-30 北京安胜瑞力科技有限公司 一种工业废水中dmac的定量分析方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE648188A (fr) 1963-05-29 1964-09-16
BE755940A (fr) * 1969-09-09 1971-03-09 Hoechst Ag Azetidinones-2 portant des substituants en position 4 et leur preparation
GB1368074A (en) * 1971-02-04 1974-09-25 Beecham Group Ltd Substituted beta-lactams and their preparation
DE2265798C2 (de) * 1971-06-24 1985-09-26 Fujisawa Pharmaceutical Co., Ltd., Osaka Verfahren zur Herstellung von Oxoazetidin-Derivaten
JPS4854056A (fr) * 1971-11-12 1973-07-30
US4070477A (en) * 1975-12-08 1978-01-24 Ciba-Geigy Corporation 2-Penem compounds
IN149747B (fr) * 1977-06-07 1982-04-03 Pfizer
GB2005246A (en) * 1977-07-13 1979-04-19 Glaxo Group Ltd beta -Lactam compounds and processes for their preparation
AU3796278A (en) * 1977-07-13 1980-01-17 Glaxo Group Ltd Penams and azetidinones
US4155912A (en) * 1977-12-14 1979-05-22 Bristol-Myers Company 2-Methylpenem-3-carboxylic acid antibiotics
US4169833A (en) * 1977-12-14 1979-10-02 Bristol-Myers Company Novel phosphorane intermediates for use in preparing penem antibiotics
US4192801A (en) * 1978-04-27 1980-03-11 Bristol-Myers Company Novel phosphorane intermediates for use in preparing penem antibiotics
US4182711A (en) * 1978-04-27 1980-01-08 Bristol-Myers Company Antibacterial agents of the β-lactam type
US4282150A (en) * 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
US4272437A (en) * 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates

Also Published As

Publication number Publication date
GB1604751A (en) 1981-12-16
FR2422637B1 (fr) 1982-04-23
FR2405946B1 (fr) 1983-09-30
AU3588478A (en) 1979-11-15
FR2405950A1 (fr) 1979-05-11
FR2405950B1 (fr) 1981-07-31
SE8305299D0 (sv) 1983-09-29
SE443980B (sv) 1986-03-17
GB1604754A (en) 1981-12-16
FR2405949B1 (fr) 1980-10-24
NL7804974A (nl) 1978-11-13
US4515717A (en) 1985-05-07
FR2411179A1 (fr) 1979-07-06
FR2405945A1 (fr) 1979-05-11
CH646173A5 (de) 1984-11-15
US4524028A (en) 1985-06-18
FR2405946A1 (fr) 1979-05-11
FR2405945B1 (fr) 1982-04-09
FR2422637A1 (fr) 1979-11-09
US4331676A (en) 1982-05-25
BE866845A (fr) 1978-11-09
JPS53137951A (en) 1978-12-01
US4518533A (en) 1985-05-21
FR2405955B1 (fr) 1981-07-31
FR2405934A1 (fr) 1979-05-11
GB1604753A (en) 1981-12-16
SE8305299L (sv) 1983-09-29
DE2819655A1 (de) 1978-11-23
ES469568A1 (es) 1980-01-01
US4447360A (en) 1984-05-08
DK200578A (da) 1978-11-10
SE7805217L (sv) 1978-11-10
FR2405934B1 (fr) 1980-09-05
AU527917B2 (en) 1983-03-31
LU77306A1 (fr) 1979-01-18
FR2405955A1 (fr) 1979-05-11
GB1604752A (en) 1981-12-16
FR2405949A1 (fr) 1979-05-11

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Legal Events

Date Code Title Description
ST Notification of lapse