FR2408623A1 - Composes steroidiques oxygenes en 19 - Google Patents

Composes steroidiques oxygenes en 19

Info

Publication number
FR2408623A1
FR2408623A1 FR7833066A FR7833066A FR2408623A1 FR 2408623 A1 FR2408623 A1 FR 2408623A1 FR 7833066 A FR7833066 A FR 7833066A FR 7833066 A FR7833066 A FR 7833066A FR 2408623 A1 FR2408623 A1 FR 2408623A1
Authority
FR
France
Prior art keywords
group
carboxyl
atxyl
carboxyl group
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7833066A
Other languages
English (en)
Other versions
FR2408623B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of FR2408623A1 publication Critical patent/FR2408623A1/fr
Application granted granted Critical
Publication of FR2408623B1 publication Critical patent/FR2408623B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C07J33/007—Cyclic thioketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

LA PRESENTE INVENTION CONCERNE DES COMPOSES CHIMIQUES NOUVEAUX. IL S'AGIT DE COMPOSES STEROIDIQUES OXYGENES EN 19 DE LA SERIE DES PREGNANES DE FORMULE IA: (CF DESSIN DANS BOPI) OU R REPRESENTE UN ATOME D'HYDROGENE ET R UN GROUPE ALCANOYLE INFERIEUR-THIO ORIENTE EN A, OU R ET R REPRESENTENT ENSEMBLE UNE LIAISON CARBONE-CARBONE OU UN RADICAL METHYLENE ORIENTE EN A OU B, R UN GROUPE HYDROXYMETHYLE LIBRE OU ETHERIFIE PAR UN ALCOYLE INFERIEUR OU ESTERIFIE PAR UN ALCANOYLE INFERIEUR, UN GROUPE CARBOXYLE OU UN GROUPE ALCOXY INFERIEUR-CARBONYLE, ET R REPRESENTE UN ATOME D'HYDROGENE OU LE RADICAL ACYLE D'UN ACIDE CARBOXYLIQUE AC, AINSIQUE LES DERIVES 1,2-DEHYDRO DE CES CORPS ET LES SELS DE TOUS LES COMPOSES CORRESPONDANTS AYANT UN GROUPE CARBOXYLE LIBRE. CES COMPOSES SONT UTILES COMME MEDICAMENTS.
FR7833066A 1977-05-31 1978-11-23 Composes steroidiques oxygenes en 19 Granted FR2408623A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU77457A LU77457A1 (fr) 1977-05-31 1977-05-31

Publications (2)

Publication Number Publication Date
FR2408623A1 true FR2408623A1 (fr) 1979-06-08
FR2408623B1 FR2408623B1 (fr) 1982-03-05

Family

ID=19728591

Family Applications (3)

Application Number Title Priority Date Filing Date
FR7815730A Granted FR2405712A1 (fr) 1977-05-31 1978-05-26 Composes de la serie des pregnanes avec une fonction oxygene en position 19, procede de preparation et preparations pharmaceutiques qui contiennent ces composes
FR7833066A Granted FR2408623A1 (fr) 1977-05-31 1978-11-23 Composes steroidiques oxygenes en 19
FR7833067A Granted FR2405958A1 (fr) 1977-05-31 1978-11-23 Procede de preparation de composes steroidiques oxygenes en 19

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7815730A Granted FR2405712A1 (fr) 1977-05-31 1978-05-26 Composes de la serie des pregnanes avec une fonction oxygene en position 19, procede de preparation et preparations pharmaceutiques qui contiennent ces composes

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7833067A Granted FR2405958A1 (fr) 1977-05-31 1978-11-23 Procede de preparation de composes steroidiques oxygenes en 19

Country Status (27)

Country Link
US (1) US4309423A (fr)
JP (1) JPS53149964A (fr)
AT (1) AT365609B (fr)
AU (1) AU520330B2 (fr)
BE (1) BE867634A (fr)
CA (1) CA1114367A (fr)
DD (1) DD140146A5 (fr)
DE (1) DE2823239A1 (fr)
DK (1) DK240078A (fr)
ES (5) ES470282A1 (fr)
FI (1) FI781628A (fr)
FR (3) FR2405712A1 (fr)
GB (1) GB1603675A (fr)
GR (1) GR71594B (fr)
HU (1) HU181861B (fr)
IL (1) IL54805A (fr)
IT (1) IT7849581A0 (fr)
LU (1) LU77457A1 (fr)
NL (1) NL7805632A (fr)
NO (1) NO781884L (fr)
NZ (1) NZ187431A (fr)
PH (1) PH14606A (fr)
PL (1) PL207237A1 (fr)
PT (1) PT68095A (fr)
SE (1) SE7806244L (fr)
SU (1) SU786906A3 (fr)
ZA (1) ZA783125B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA18433A1 (fr) * 1978-05-26 1979-12-31 Ciba Geigy Ag Procede pour la synthese de la chaine laterale hydroxyacetyle de steroides du type pregnagne, nouveaux 21-hydroxy-20-oxo-17 alpha-pregnagnes et produits pharmaceutiques en renfermant
US4261985A (en) * 1978-11-22 1981-04-14 Ciba-Geigy Corporation Novel diuretics
US5002940A (en) * 1984-11-06 1991-03-26 Ciba-Geigy Corporation Solid drug formulations and stable suspensions
US4659704A (en) * 1985-05-21 1987-04-21 Ramot University Authority For Applied Research & Industrial Development Ltd. 19-hydroxyaldosterone and its preparation
FR2656309B1 (fr) * 1989-12-22 1992-05-07 Roussel Uclaf Nouveaux produits sterouides comportant en position 10, un radical ethyle substitue, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
FR2676740B1 (fr) * 1991-05-23 1993-11-05 Roussel Uclaf Nouveaux derives sterouides du pregna-4,9(11),17(20)-trie-3-one, leur preparation, leur application a la preparation de composes sterouides de type pregna-4,9(11),16-triene-3,20-dione et nouveaux intermediaires.
DE4433374A1 (de) * 1994-09-20 1996-03-21 Hoechst Ag 17-Desoxi-corticosteroid-21-/O/-Carbonsäure- ester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE60124289T2 (de) * 2000-09-18 2007-09-06 Applied Research Systems Ars Holding N.V. Verfahren zur herstellung von 21-hydroxy-6,19-oxidoprogesteron (21oh-6op)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2455272A1 (de) * 1973-11-29 1975-06-05 Steele Chem Co Ltd Steroidkomponenten und verfahren zu ihrer herstellung

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1146651B (de) * 1956-07-28 1963-04-04 Giuseppe Giusi Vorschub-Schaltgetriebe fuer Maschinen zum Ausschneiden von runden Scheiben aus Kunststoffplatten, insbesondere Knopfrondellen
US3039926A (en) * 1958-10-10 1962-06-19 Pfizer & Co C 19-hydroxy pregnenes
CH425774A (de) * 1961-07-14 1966-12-15 Ciba Geigy Verfahren zur Herstellung von 19-Nor-steroiden
GB1041534A (en) * 1963-04-24 1966-09-07 Merck & Co Inc 20-spiroxane compounds
US3493564A (en) * 1968-02-29 1970-02-03 American Home Prod 2,19-epoxy-delta**4,6-steroids and intermediates for their synthesis
BR6915132D0 (pt) * 1969-04-02 1973-02-08 Ciba Geigy Processo para a obtencao de delta 4 6-ou delta 5(10) 6-3-oxo-19-nor-esteroides
US3849404A (en) * 1973-03-09 1974-11-19 Searle & Co Purification of 6,7-dihydro-17-hydroxy-3-oxo-3'h-cyclopropa(6,7)-17alpha-pregna-4,6-diene-21-carboxylic acid gamma-lactones
JPS53116361A (en) * 1977-03-17 1978-10-11 Mitsubishi Chem Ind Ltd Preparation of 7 acylthioo44enee33oxosteroid

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2455272A1 (de) * 1973-11-29 1975-06-05 Steele Chem Co Ltd Steroidkomponenten und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
PH14606A (en) 1981-10-02
ATA393178A (de) 1981-06-15
PL207237A1 (pl) 1979-06-04
IL54805A (en) 1982-11-30
AU3665078A (en) 1979-12-06
FR2405958B1 (fr) 1982-01-15
FR2405712B1 (fr) 1982-09-10
DD140146A5 (de) 1980-02-13
ZA783125B (en) 1979-06-27
CA1114367A (fr) 1981-12-15
DK240078A (da) 1978-12-01
AT365609B (de) 1982-02-10
GB1603675A (en) 1981-11-25
IT7849581A0 (it) 1978-05-29
AU520330B2 (en) 1982-01-28
FR2405958A1 (fr) 1979-05-11
NZ187431A (en) 1980-05-27
GR71594B (fr) 1983-06-17
ES478127A1 (es) 1979-05-16
SE7806244L (sv) 1978-12-01
NL7805632A (nl) 1978-12-04
FR2408623B1 (fr) 1982-03-05
BE867634A (fr) 1978-11-30
FR2405712A1 (fr) 1979-05-11
FI781628A (fi) 1978-12-01
LU77457A1 (fr) 1979-01-19
ES478125A1 (es) 1979-05-16
ES478128A1 (es) 1979-05-16
SU786906A3 (ru) 1980-12-07
PT68095A (de) 1978-06-01
HU181861B (en) 1983-11-28
ES478126A1 (es) 1979-05-16
ES470282A1 (es) 1979-09-16
IL54805A0 (en) 1978-07-31
NO781884L (no) 1978-12-01
JPS53149964A (en) 1978-12-27
DE2823239A1 (de) 1978-12-14
US4309423A (en) 1982-01-05

Similar Documents

Publication Publication Date Title
FR2420522A1 (fr) Derives de l'acide (m-benzoyl-phenoxy)-2 propionique et leurs applications comme medicaments
FR2504535B1 (fr) Disaccharides derives d'un acide uronique et d'une glucosamine et compositions pharmaceutiques les contenant pour le controle de la coagulation sanguine
FR2360587A1 (fr) Nouveaux derives d'amino-alcoyl-furannes utiles comme medicaments
FR2392971A1 (fr) Derives de l'acide prostanoique, leur preparation et medicament contenant ces substances
FR2408623A1 (fr) Composes steroidiques oxygenes en 19
AU639717B2 (en) 24-homo vitamin d derivatives, process for their production and pharmaceutical preparations obtained therefrom
ATE40110T1 (de) Polyether-carbonsaeure-derivate enthaltende reinigungsmittel, ihre herstellung und ihre verwendung.
FR2383907A1 (fr) Procede de preparation de derives de l'acide acetique et derives obtenus par ce procede
FR2450251A1 (fr) Derives de l'acide guanidinobenzoique, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2394546A1 (fr) Nouveaux derives de 1,2,3,4,6,7-hexahydro-11bah-benzo(a)-quinolizine, leur preparation et leur application en tant que medicaments
FR2453866A1 (fr) Derives peptidiques, procede pour leur preparation et leur application dans des preparations pharmaceutiques
BE905110A (fr) Poly-4-aminopyrrole-2-carboxamides et derives, procede pour leur preparation et leurs utilisations therapeutiques.
FR2452483A1 (fr) Derives d'alcenylphenylmaleimides, leurs dimeres lineaires et leur procede de preparation
FR2395272A1 (fr) Nouveaux medicaments derives de l'acide amidinopenicillanique
FR2355822A1 (fr) Derives d'esters de l'acide indolacetique. utiles comme anti-inflammatoires et analgesiques
FR2407941A1 (fr) Nouveaux derives de cholesterol
EP0124379B1 (fr) Dérivés d'hydroquinone et procédé pour leur production
FR2447375A1 (fr) Analogues de la prostaglandine e1 et compositions pharmaceutiques les contenant
FR2388789A1 (fr) Derives d'acide benzoique, leur procede de preparation et leur application therapeutique
FR2386545A1 (fr) L'acide 3-(2-aminoethylthio)-6-ethyl-7-oxo-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylique utile comme medicament
FR2411173A1 (fr) Anthranilates de n-hydroxyalkyl-carboxamides et leur application comme reticulants
FR2438649A1 (fr) Derives de 1-phenyl-1-propanol, leur preparation et leurs utilisations therapeutiques notamment comme antihypertenseurs, vasodilatateurs peripheriques et antithrombiques
FR2437405A1 (fr) Nouveaux alcoylbenzenes substitues basiques utiles comme medicaments
FR2416214A1 (fr) Derives d'acide naphtyl-1 acetique, leur procede de preparation et leur application therapeutique
FR2450260A1 (fr) Derives peptidiques, procede pour leur preparation et leur application dans des preparations pharmaceutiques

Legal Events

Date Code Title Description
ST Notification of lapse