FR2408612A1 - Nouveaux derives de 2-(syn)-hydroxyimino-acetamide de la cephalosporine - Google Patents

Nouveaux derives de 2-(syn)-hydroxyimino-acetamide de la cephalosporine

Info

Publication number
FR2408612A1
FR2408612A1 FR7719340A FR7719340A FR2408612A1 FR 2408612 A1 FR2408612 A1 FR 2408612A1 FR 7719340 A FR7719340 A FR 7719340A FR 7719340 A FR7719340 A FR 7719340A FR 2408612 A1 FR2408612 A1 FR 2408612A1
Authority
FR
France
Prior art keywords
hydroxyimino
cephalosporin
syn
new
acetamide derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7719340A
Other languages
English (en)
Other versions
FR2408612B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of FR2408612A1 publication Critical patent/FR2408612A1/fr
Application granted granted Critical
Publication of FR2408612B1 publication Critical patent/FR2408612B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA PRESENTE INVENTION DECRIT DES DERIVES 2-(SYN)-HYDROXYIMINO-ACETAMIDE DE LA CEPHALOSPORINE DE FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE Y EST H, OH, UN GROUPE ACYLOXY, CARBAMOYLOXY, AMMONIUM QUATERNAIRE, OU UN GROUPE THIO HETEROCYCLIQUE AZOTE SUBSTITUE SUR LE NOYAU OU BIEN DES SELS OU DES ESTERS DE CES DERIVES PHARMACEUTIQUEMENT ACCEPTABLES. UTILISATION DE CES PRODUITS COMME AGENTS ANTIBACTERIENS.
FR7719340A 1976-09-08 1977-06-23 Nouveaux derives de 2-(syn)-hydroxyimino-acetamide de la cephalosporine Granted FR2408612A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP51108101A JPS6011713B2 (ja) 1976-09-08 1976-09-08 セフアロスポリン誘導体およびその製造法

Publications (2)

Publication Number Publication Date
FR2408612A1 true FR2408612A1 (fr) 1979-06-08
FR2408612B1 FR2408612B1 (fr) 1982-10-15

Family

ID=14475887

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7719340A Granted FR2408612A1 (fr) 1976-09-08 1977-06-23 Nouveaux derives de 2-(syn)-hydroxyimino-acetamide de la cephalosporine

Country Status (22)

Country Link
US (1) US4264595A (fr)
JP (1) JPS6011713B2 (fr)
AT (1) AT352277B (fr)
AU (1) AU508551B2 (fr)
BE (1) BE856045A (fr)
CA (1) CA1316171C (fr)
CH (4) CH629813A5 (fr)
DE (3) DE2760448C2 (fr)
DK (2) DK159783C (fr)
ES (2) ES460124A1 (fr)
FI (1) FI67384C (fr)
FR (1) FR2408612A1 (fr)
GB (1) GB1587941A (fr)
GR (1) GR63635B (fr)
HU (1) HU182053B (fr)
MX (1) MX5198E (fr)
NL (1) NL189354C (fr)
NO (1) NO772170L (fr)
PH (2) PH15144A (fr)
PT (1) PT66735B (fr)
SE (1) SE464581B (fr)
ZA (1) ZA773775B (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0036510A2 (fr) * 1980-03-06 1981-09-30 Fujisawa Pharmaceutical Co., Ltd. Isomère syn de dérivés de céphalosporine et procédés pour leur préparation
EP0048504A2 (fr) * 1978-09-12 1982-03-31 Fujisawa Pharmaceutical Co., Ltd. Intermédiaires de céphalosporine, procédé pour leur préparation et pour la préparation de dérivés de céphalosporine
EP0049499A2 (fr) * 1980-10-06 1982-04-14 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Dérivés de céphalosporine, leur préparation, compositions pharmaceutiques les contenant et intermédiaires pour leur préparation
FR2508458A1 (fr) * 1981-06-29 1982-12-31 Sandoz Sa Nouveaux derives de l'acide cephalosporanique, leur preparation et leur application comme medicaments
EP0081971A2 (fr) * 1981-12-08 1983-06-22 Tanabe Seiyaku Co., Ltd. Dérivé de céphalosporine et procédé pour sa préparation

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5760345B2 (fr) * 1974-12-19 1982-12-18 Takeda Chemical Industries Ltd
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
SE440655B (sv) 1976-01-23 1985-08-12 Roussel Uclaf Sett att framstella nya oximderivat av 7-amino-tiazolyl-acetamido-cefalosporansyra
US4963542A (en) * 1976-09-08 1990-10-16 Takeda Chemical Industries, Ltd. Cephalosporin derivatives
PH17188A (en) * 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
SE439312B (sv) * 1977-03-25 1985-06-10 Roussel Uclaf Sett att framstella nya oximderivat av 3-acetoximetyl-7-aminotiazolylacetamido cefalosporansyra
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
US5089490A (en) * 1977-04-02 1992-02-18 Hoechst Aktiengesellschaft Cephem derivatives
FR2410655A1 (fr) * 1977-12-05 1979-06-29 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2387235A1 (fr) * 1978-01-23 1978-11-10 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne
US4341775A (en) * 1978-09-11 1982-07-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4379922A (en) * 1978-09-12 1983-04-12 Fujisawa Pharmaceutical Co., Ltd. Cepham compounds
DE2945248A1 (de) * 1978-11-13 1980-05-22 Fujisawa Pharmaceutical Co Cephem-verbindungen, verfahren zu ihrer herstellung und sie enthaltende antibakterielle pharmazeutische mittel
CA1145744A (fr) * 1979-05-23 1983-05-03 Daniel Farge Thiovinyl-3 cephalosporines, leur preparation et les compositions qui les contiennent
FR2476087A1 (fr) * 1980-02-18 1981-08-21 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
IT1141286B (it) * 1980-04-17 1986-10-01 Dob Far Spa Esteri delle desacetossi cefalosporine loro sali e procedimenti per il loro ottenimento
JPS5759894A (en) * 1980-09-30 1982-04-10 Sankyo Co Ltd Cephalosporin for oral administration
US4431642A (en) * 1980-12-01 1984-02-14 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
EP0061234A3 (fr) * 1981-03-05 1983-11-16 Beecham Group Plc Dérivés de céphalosporine, leur préparation et des compositions pharmaceutiques les contenant
US4336253A (en) * 1981-03-11 1982-06-22 Eli Lilly And Company Cephalosporin antibiotics
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
US4396620A (en) * 1981-09-08 1983-08-02 Eli Lilly And Company Cephalosporin quinolinium betaines
US4406898A (en) * 1981-09-08 1983-09-27 Eli Lilly And Company Oxazole and oxadiazole cephalosporins
US4396619A (en) * 1981-09-08 1983-08-02 Eli Lilly And Company Cephalosporin betaines
GB8323034D0 (en) * 1983-08-26 1983-09-28 Fujisawo Pharmaceutical Co Ltd 7-substituted-3-vinyl-3-cephem compounds
US4761409A (en) * 1984-08-16 1988-08-02 Sumitomo Pharmaceuticals Company, Limited Cephem derivatives
ES8704943A1 (es) * 1984-12-27 1987-04-16 Banyu Pharma Co Ltd Un procedimiento para la fabricacion de derivados de cefalosporina.
GB8519606D0 (en) * 1985-08-05 1985-09-11 Fujisawa Pharmaceutical Co 3 7-d substituted-3-cephem compounds
NO862910L (no) * 1985-08-05 1987-02-06 Fujisawa Pharmaceutical Co Fremgangsmaate for fremstilling av 3,7-disubstituerte-3-cefemforbindelser.
US4814328A (en) * 1986-03-19 1989-03-21 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, and antibacterial agents
JPS6417892A (en) * 1987-07-14 1989-01-20 Totoku Electric Iron coated composite material and production thereof
JPH01230547A (ja) * 1988-01-14 1989-09-14 Takeda Chem Ind Ltd ３−オキソ酪酸第三ブチルの製造法及びその用途
DE3804841A1 (de) * 1988-02-17 1989-08-31 Hoechst Ag Cephalosporinderivate und verfahren zu ihrer herstellung
EP0333082A3 (fr) * 1988-03-15 1991-05-02 Takeda Chemical Industries, Ltd. Composés céphem, leur préparation et application
US5081116A (en) * 1989-04-12 1992-01-14 Yamanouchi Pharmaceutical Co., Ltd. Cephalosporin derivatives
DE3919259A1 (de) * 1989-06-13 1990-12-20 Hoechst Ag Kristalline cephem-saeureadditionssalze und verfahren zu ihrer herstellung
CA2054126A1 (fr) * 1990-10-26 1992-04-27 Michiyuki Sendai Production et utilisation de composes de type cephem
IL99898A (en) * 1990-11-09 1996-10-31 Eisai Co Ltd 7-Noble-3- Compounds Transformed Carbamoylloxy
YU48484B (sh) * 1991-05-24 1998-09-18 Hoechst Aktiengesellschaft Kristalne kiselinske adicione soli diastereomerno čistih 1-(2,2-dimetilpropioniloksi)-etilestara 3-cefem-4-karbonske kiseline
DE59209994D1 (de) * 1991-09-07 2004-04-29 Aventis Pharma Gmbh Diastereomer des 3-Cephem-4-carbonsäure-1-(-isopropoxycarbonyloxy)ethylesters und Verfahren zu dessen Herstellung
TW212181B (fr) * 1992-02-14 1993-09-01 Hoechst Ag
ES2117066T3 (es) * 1992-05-21 1998-08-01 Hoechst Ag Procedimiento para la disociacion de esteres profarmacos de cefalosporina para dar acido 7-amino-3-metoximetil-cef-3-em-4-carboxilico.
WO2009049086A1 (fr) 2007-10-09 2009-04-16 Larry Sutton Inhibiteurs de bêta-lactamase à large spectre
US8802387B2 (en) 2008-04-30 2014-08-12 Nanyang Technological University Methods and compounds for detecting beta-lactamase activity
US20100261700A1 (en) * 2009-04-09 2010-10-14 Larry Sutton Beta-lactamase inhibitors
JP6403289B2 (ja) 2013-03-12 2018-10-10 グラディウス ファーマシューティカルズ コーポレーションＧｌａｄｉｕｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏｒｐｏｒａｔｉｏｎ 誘導体化３−スチリル−セファロスポリン

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4024134A (en) * 1971-01-29 1977-05-17 Glaxo Laboratories Limited Syn isomers of cephalosporins having α-hydroximino- or α-acyloxyiminoacylamido groups at position-7
US4033950A (en) * 1971-05-14 1977-07-05 Glaxo Laboratories Limited 3-Hydroxymethyl-7β-(2-alkoxy-or benzyloxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof
US4024137A (en) * 1971-05-14 1977-05-17 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(phenyl- or naphthylacetamido)] cephalosporins
US4093803A (en) * 1971-05-14 1978-06-06 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(thienyl-, furyl- or pyridylacetamido)] cephalosporins
US4092477A (en) * 1971-05-14 1978-05-30 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(phenyl- or naphthylacetamido)] cephalosporins
JPS5119765A (en) * 1974-08-09 1976-02-17 Takeda Chemical Industries Ltd Aminochiazoorujudotaino seizoho
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
FR2361893A2 (fr) * 1976-01-23 1978-03-17 Roussel Uclaf Nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
FR2346014A1 (fr) * 1976-01-23 1977-10-28 Roussel Uclaf Nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2383188A2 (fr) * 1976-01-23 1978-10-06 Roussel Uclaf Nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2361894A2 (fr) * 1976-01-23 1978-03-17 Roussel Uclaf Nouvelles oximes derivees de l'acide 7-aminothiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0048504A2 (fr) * 1978-09-12 1982-03-31 Fujisawa Pharmaceutical Co., Ltd. Intermédiaires de céphalosporine, procédé pour leur préparation et pour la préparation de dérivés de céphalosporine
EP0048504A3 (en) * 1978-09-12 1983-04-06 Fujisawa Pharmaceutical Co., Ltd. Intermediate compounds for preparing cephem compounds; processes for their preparation and processes for preparing cephem compounds
EP0036510A2 (fr) * 1980-03-06 1981-09-30 Fujisawa Pharmaceutical Co., Ltd. Isomère syn de dérivés de céphalosporine et procédés pour leur préparation
EP0036510A3 (en) * 1980-03-06 1981-12-02 Fujisawa Pharmaceutical Co., Ltd. Synisomer cephalosporin compounds, processes for their preparation; intermediates and their preparation
EP0049499A2 (fr) * 1980-10-06 1982-04-14 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Dérivés de céphalosporine, leur préparation, compositions pharmaceutiques les contenant et intermédiaires pour leur préparation
EP0049499A3 (en) * 1980-10-06 1983-09-07 F. Hoffmann-La Roche & Co. Aktiengesellschaft Cephalosporin derivatives, process for their preparation, pharmaceutical compositions containing them and intermediates for their preparation
FR2508458A1 (fr) * 1981-06-29 1982-12-31 Sandoz Sa Nouveaux derives de l'acide cephalosporanique, leur preparation et leur application comme medicaments
FR2511002A1 (fr) * 1981-06-29 1983-02-11 Sandoz Ag
EP0081971A2 (fr) * 1981-12-08 1983-06-22 Tanabe Seiyaku Co., Ltd. Dérivé de céphalosporine et procédé pour sa préparation
EP0081971A3 (fr) * 1981-12-08 1984-09-26 Tanabe Seiyaku Co., Ltd. Dérivé de céphalosporine et procédé pour sa préparation
US4576938A (en) * 1981-12-08 1986-03-18 Tanabe Seiyaku Co., Ltd. Cephalosporin compound and process for preparing the same

Also Published As

Publication number Publication date
DK161081C (da) 1991-11-11
DE2760271C2 (fr) 1988-08-18
CH629813A5 (de) 1982-05-14
HU182053B (en) 1983-12-28
DK161081B (da) 1991-05-27
DE2727753A1 (de) 1978-03-16
US4264595A (en) 1981-04-28
DK270377A (da) 1978-03-09
DK621189D0 (da) 1989-12-08
NL189354B (nl) 1992-10-16
FI67384C (fi) 1985-03-11
SE7707176L (sv) 1978-03-09
PT66735B (en) 1978-11-24
ZA773775B (en) 1978-05-30
DK621189A (da) 1989-12-08
GR63635B (en) 1979-11-27
DK159783B (da) 1990-12-03
NO772170L (no) 1978-03-09
AT352277B (de) 1979-09-10
MX5198E (es) 1983-04-25
CA1316171C (fr) 1993-04-13
CH634578A5 (de) 1983-02-15
GB1587941A (en) 1981-04-15
DE2760448C2 (fr) 1989-06-22
FI67384B (fi) 1984-11-30
PT66735A (en) 1977-07-01
ATA442477A (de) 1979-02-15
PH19543A (en) 1986-05-20
ES460124A1 (es) 1978-10-01
SE464581B (sv) 1991-05-13
CH630923A5 (de) 1982-07-15
NL189354C (nl) 1993-03-16
CH630386A5 (de) 1982-06-15
FR2408612B1 (fr) 1982-10-15
ES470782A1 (es) 1979-01-16
DE2727753C2 (fr) 1987-11-05
DK159783C (da) 1991-04-22
AU508551B2 (en) 1980-03-27
JPS5334794A (en) 1978-03-31
NL7707129A (nl) 1978-03-10
JPS6011713B2 (ja) 1985-03-27
FI771951A (fi) 1978-03-09
BE856045A (fr) 1977-12-23
PH15144A (en) 1982-08-24
AU2627177A (en) 1979-01-04

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