ES8406492A1 - Un procedimiento para preparar derivados de cefalosporina. - Google Patents

Un procedimiento para preparar derivados de cefalosporina.

Info

Publication number
ES8406492A1
ES8406492A1 ES521955A ES521955A ES8406492A1 ES 8406492 A1 ES8406492 A1 ES 8406492A1 ES 521955 A ES521955 A ES 521955A ES 521955 A ES521955 A ES 521955A ES 8406492 A1 ES8406492 A1 ES 8406492A1
Authority
ES
Spain
Prior art keywords
cephalosporin derivatives
gram
bacteria
ethyl
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521955A
Other languages
English (en)
Other versions
ES521955A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ES521955A0 publication Critical patent/ES521955A0/es
Publication of ES8406492A1 publication Critical patent/ES8406492A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE CEFALOSPORINA.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) EN UN DISOLVENTE INERTE, COMO AMIDAS, NITRILOS, DICLOROMETANO, DIOXIDO DE AZUFRE Y OTROS, A TEMPERATURA ENTRE C20JC Y 20JC, PARA OBTENER UN COMPUESTO DE FORMULA (I), EN LA QUE R1 ES METILO O ETILO Y R2 ES UN GRUPO ALCOHILO DE CADENA LINEAL O RAMIFICADA DE C 5 A 7. AL REACCIONAR EL COMPUESTO DE FORMULA (I) CON UN ACIDO INORGANICO U ORGANICO, COMO ACIDO FOSFORICO, ACIDO CLORHIDRICO, ACIDO FUMARICO, ACIDO MANDELICO Y OTROSSE OBTIENEN LAS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES.SON UTILES CONTRA BACTERIAS GRAM-POSITIVAS POR PRESENTAR EXCELENTES ACTIVIDADES ANTIBACTERIANAS.
ES521955A 1982-04-30 1983-04-29 Un procedimiento para preparar derivados de cefalosporina. Expired ES8406492A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57073729A JPS58189186A (ja) 1982-04-30 1982-04-30 セフアロスポリン誘導体

Publications (2)

Publication Number Publication Date
ES521955A0 ES521955A0 (es) 1984-07-01
ES8406492A1 true ES8406492A1 (es) 1984-07-01

Family

ID=13526607

Family Applications (3)

Application Number Title Priority Date Filing Date
ES521955A Expired ES8406492A1 (es) 1982-04-30 1983-04-29 Un procedimiento para preparar derivados de cefalosporina.
ES528166A Expired ES8506318A1 (es) 1982-04-30 1983-12-19 Un procedimiento para preparar derivados de cefalosporina
ES528165A Granted ES528165A0 (es) 1982-04-30 1983-12-19 Un procedimiento para preparar derivados de cefalosporina

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES528166A Expired ES8506318A1 (es) 1982-04-30 1983-12-19 Un procedimiento para preparar derivados de cefalosporina
ES528165A Granted ES528165A0 (es) 1982-04-30 1983-12-19 Un procedimiento para preparar derivados de cefalosporina

Country Status (9)

Country Link
US (1) US4497809A (es)
EP (1) EP0093548B1 (es)
JP (1) JPS58189186A (es)
KR (1) KR840004757A (es)
CA (1) CA1215971A (es)
DE (1) DE3368638D1 (es)
ES (3) ES8406492A1 (es)
GR (1) GR78545B (es)
PT (1) PT76622B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5989691A (ja) * 1982-11-15 1984-05-23 Takeda Chem Ind Ltd セフアロスポリンエステル
CA1215354A (en) * 1983-06-02 1986-12-16 Akio Miyake Cephalosporin esters, their production and use
NZ208281A (en) * 1983-06-02 1986-11-12 Takeda Chemical Industries Ltd Cephalosporin ester derivatives and pharmaceutical compositions
JPS59225191A (ja) * 1983-06-02 1984-12-18 Takeda Chem Ind Ltd 経口用セフアロスポリン誘導体
JPS6038387A (ja) * 1983-08-10 1985-02-27 Takeda Chem Ind Ltd セフアロスポリンエステル
JPS60224693A (ja) * 1984-04-20 1985-11-09 Takeda Chem Ind Ltd セフアロスポリンエステル誘導体
GB9001405D0 (en) * 1990-01-22 1990-03-21 Leo Pharm Prod Ltd New intermediates,their production and use
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ176206A (en) * 1973-12-25 1978-03-06 Takeda Chemical Industries Ltd Cephalosporins
JPS603314B2 (ja) * 1976-08-31 1985-01-26 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
US4189479A (en) * 1977-12-22 1980-02-19 Takeda Chemical Industries, Ltd. Cephalosporin esters
JPS5777690A (en) * 1980-10-31 1982-05-15 Takeda Chem Ind Ltd Cephalosporin derivative

Also Published As

Publication number Publication date
ES8506731A1 (es) 1985-07-16
ES528166A0 (es) 1985-07-01
PT76622A (en) 1983-05-01
GR78545B (es) 1984-09-27
KR840004757A (ko) 1984-10-24
JPS58189186A (ja) 1983-11-04
ES521955A0 (es) 1984-07-01
EP0093548B1 (en) 1986-12-30
DE3368638D1 (en) 1987-02-05
ES8506318A1 (es) 1985-07-01
US4497809A (en) 1985-02-05
EP0093548A3 (en) 1984-10-10
ES528165A0 (es) 1985-07-16
PT76622B (en) 1986-01-17
CA1215971A (en) 1986-12-30
EP0093548A2 (en) 1983-11-09

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