FR2403340A1 - Derives imidazoliques utiles comme medicaments - Google Patents

Derives imidazoliques utiles comme medicaments

Info

Publication number
FR2403340A1
FR2403340A1 FR7826420A FR7826420A FR2403340A1 FR 2403340 A1 FR2403340 A1 FR 2403340A1 FR 7826420 A FR7826420 A FR 7826420A FR 7826420 A FR7826420 A FR 7826420A FR 2403340 A1 FR2403340 A1 FR 2403340A1
Authority
FR
France
Prior art keywords
medicinal products
derivatives useful
imidazolic
imidazolic derivatives
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7826420A
Other languages
English (en)
French (fr)
Other versions
FR2403340B1 (OSRAM
Inventor
Anna Krasso
Ernst-Peter Krebs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2403340A1 publication Critical patent/FR2403340A1/fr
Application granted granted Critical
Publication of FR2403340B1 publication Critical patent/FR2403340B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR7826420A 1977-09-19 1978-09-14 Derives imidazoliques utiles comme medicaments Granted FR2403340A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU78140 1977-09-19
CH814978 1978-07-28

Publications (2)

Publication Number Publication Date
FR2403340A1 true FR2403340A1 (fr) 1979-04-13
FR2403340B1 FR2403340B1 (OSRAM) 1981-02-13

Family

ID=25702876

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7826420A Granted FR2403340A1 (fr) 1977-09-19 1978-09-14 Derives imidazoliques utiles comme medicaments

Country Status (36)

Country Link
US (2) US4182766A (OSRAM)
EP (1) EP0001279B1 (OSRAM)
JP (1) JPS5459274A (OSRAM)
AR (1) AR224350A1 (OSRAM)
AT (1) AT368152B (OSRAM)
AU (1) AU519711B2 (OSRAM)
BG (1) BG28708A3 (OSRAM)
BR (1) BR7806148A (OSRAM)
CA (1) CA1106849A (OSRAM)
DD (1) DD138210A5 (OSRAM)
DE (2) DE2840591A1 (OSRAM)
DK (1) DK406578A (OSRAM)
EG (1) EG13530A (OSRAM)
ES (1) ES473451A1 (OSRAM)
FI (1) FI64365C (OSRAM)
FR (1) FR2403340A1 (OSRAM)
GB (1) GB2004281B (OSRAM)
GR (1) GR73069B (OSRAM)
HU (1) HU176111B (OSRAM)
IE (1) IE47363B1 (OSRAM)
IL (1) IL55557A (OSRAM)
IN (1) IN148930B (OSRAM)
IT (1) IT1098858B (OSRAM)
MC (1) MC1213A1 (OSRAM)
MT (1) MTP835B (OSRAM)
NL (1) NL7809529A (OSRAM)
NO (1) NO149962C (OSRAM)
NZ (1) NZ188405A (OSRAM)
OA (1) OA06054A (OSRAM)
PH (1) PH16342A (OSRAM)
PL (1) PL114494B1 (OSRAM)
PT (1) PT68573A (OSRAM)
RO (1) RO75258A (OSRAM)
SE (1) SE7809792L (OSRAM)
SU (1) SU793390A3 (OSRAM)
YU (1) YU216778A (OSRAM)

Families Citing this family (58)

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SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4321372A (en) * 1980-06-16 1982-03-23 Pfizer Inc. Antiulcer thiazol-2-ylcarbamoyl-carboxylic acids, esters and amides
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CH644116A5 (de) 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
US4368201A (en) * 1981-07-20 1983-01-11 Usv Pharmaceutical Corporation Tetrahydronaphthoxazoles
IL66340A (en) * 1981-08-13 1986-08-31 Haessle Ab Pharmaceutical compositions comprising pyridylmethyl-thiobenzimidazole derivatives,certain such novel derivatives and their preparation
HU193408B (en) * 1983-05-03 1987-10-28 Byk Gulden Lomberg Chem Fqb Process for production of new tree-cycle compounds
ZW4585A1 (en) * 1984-04-19 1985-11-20 Hoffmann La Roche Imidazole derivatives
DE3585252D1 (de) * 1984-07-06 1992-03-05 Fisons Plc Benzimidazole, und verfahren zu deren herstellung, deren formulierung und verwendung als magensaeuresekretionshemmende verbindungen.
GB2161160B (en) * 1984-07-06 1989-05-24 Fisons Plc Heterocyclic sulphinyl compounds
SE8404065D0 (sv) * 1984-08-10 1984-08-10 Haessle Ab Novel biologically active compounds
DE3501497A1 (de) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
US5869513A (en) * 1985-05-24 1999-02-09 G. D. Searle & Co. 2- (1H-benzimidazol-2-ylsulfinyl)methyl!benzenamines
AU5768886A (en) 1985-05-24 1986-11-27 G.D. Searle & Co. 2-((1-h-benzimidazol-2-ylsulfinyl)methyl)benzenamines
DK337086A (da) * 1985-08-12 1987-02-13 Hoffmann La Roche Benzimidazolderivater
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
SE8600658D0 (sv) * 1986-02-14 1986-02-14 Haessle Ab Novel composition of matter
US4687775A (en) * 1986-07-17 1987-08-18 G. D. Searle & Co. 2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles
US4772619A (en) * 1986-07-17 1988-09-20 G. D. Searle & Co. [(1H-benzimidazol-2-ylsulfinyl)methyl]-2-pyridinamines
US4721718A (en) * 1986-08-18 1988-01-26 G. D. Searle & Co. 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers
SE8604566D0 (sv) * 1986-10-27 1986-10-27 Haessle Ab Novel compunds
SE8604998D0 (sv) 1986-11-21 1986-11-21 Haessle Ab Novel pharmacological compounds
NZ222495A (en) 1986-11-21 1991-04-26 Haessle Ab Benzimidazole derivatives and pharmaceutical compositions
FI91754C (fi) * 1986-12-02 1994-08-10 Tanabe Seiyaku Co Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi
DE3701277A1 (de) * 1987-01-17 1988-07-28 Boehringer Mannheim Gmbh Neue tricyclische benzimidazole, verfahren zu ihrer herstellung und verwendung als arzneimittel
US4931557A (en) * 1988-10-17 1990-06-05 Eli Lilly And Company Method of resolving cis 3-amino-4-(2-furyl)vinyl)-1-methoxycarbonylmethyl-azetidin-2-one and di-p-toluoyl-tartaric acid salts thereof
IE64199B1 (en) * 1988-12-22 1995-07-12 Haessle Ab Compound with gastric acid inhibitory effect and process for its preparation
SE8804629D0 (sv) 1988-12-22 1988-12-22 Ab Haessle New therapeutically active compounds
SE8804628D0 (sv) 1988-12-22 1988-12-22 Ab Haessle New compounds
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
US5274099A (en) * 1989-12-20 1993-12-28 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
US5049674A (en) 1989-12-20 1991-09-17 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
SE9002206D0 (sv) 1990-06-20 1990-06-20 Haessle Ab New compounds
KR950702416A (ko) * 1992-07-08 1995-07-29 제임스 클리프튼 보올딩 돼지에서 위궤양을 완화시키기 위한 벤즈이미다졸(Benzimidazoles for alloviating stomach ulcers in swine)
WO1995029897A1 (en) 1994-04-29 1995-11-09 G.D. Searle & Co. METHOD OF USING (H+/K+) ATPase INHIBITORS AS ANTIVIRAL AGENTS
EP0854718B1 (en) * 1995-09-21 2004-03-10 Pharma Pass II LLC Novel composition containing an acid-labile benzimidazole and process for its preparation
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) * 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
KR100463031B1 (ko) * 1997-05-26 2005-04-06 동아제약주식회사 5-메톡시-2-[3,5-디메틸-4-메톡시피리딜메틸)설피닐]-1h-벤즈이미다졸의신규제조방법
US6174548B1 (en) 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6096340A (en) * 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6733778B1 (en) 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
EP1469839A2 (en) * 2002-01-25 2004-10-27 Santarus, Inc. Transmucosal delivery of proton pump inhibitors
EP1603537A4 (en) * 2003-02-20 2009-11-04 Santarus Inc NOVEL FORMULATION, ANTICIPATED COMPLEX IMMEDIATE RELEASE FOR A FAST AND CONTINUOUS SUPPRESSION OF MAGIC ACID
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
EP1648416A4 (en) * 2003-07-18 2012-03-28 Santarus Inc PHARMACEUTICAL FORMULATIONS FOR INHIBITING THE ACIDIC ACIDIFICATION AND MANUFACTURING AND USE METHOD
WO2005007117A2 (en) * 2003-07-18 2005-01-27 Santarus, Inc. Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US20060024362A1 (en) * 2004-07-29 2006-02-02 Pawan Seth Composition comprising a benzimidazole and process for its manufacture
GB2444593B (en) 2006-10-05 2010-06-09 Santarus Inc Novel formulations for immediate release of proton pump inhibitors and methods of using these formulations
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
CA2667682A1 (en) 2006-10-27 2008-05-15 The Curators Of The University Of Missouri Compositions comprising acid labile proton pump inhibiting agents, at least one other pharmaceutically active agent and methods of using same
JP2025532389A (ja) 2022-10-04 2025-09-29 ザビリュク，アルセニー 大動脈弁の石灰化の抑制

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2331340A1 (fr) * 1974-05-16 1977-06-10 Haessle Ab Nouveaux derives du benzimidazole, procede pour leur obtention et compositions pharmaceutiques les contenant

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US2985661A (en) * 1956-02-06 1961-05-23 American Cyanamid Co Preparation of 2(omicron-aminophenyl)-benzimidazole
GB1234058A (OSRAM) * 1968-10-21 1971-06-03
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2331340A1 (fr) * 1974-05-16 1977-06-10 Haessle Ab Nouveaux derives du benzimidazole, procede pour leur obtention et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
RO75258A (ro) 1980-11-30
FI782847A7 (fi) 1979-03-20
DK406578A (da) 1979-03-20
JPS5459274A (en) 1979-05-12
BR7806148A (pt) 1979-04-17
EP0001279A1 (de) 1979-04-04
NO149962C (no) 1984-07-25
ATA673378A (de) 1982-01-15
FI64365C (fi) 1983-11-10
OA06054A (fr) 1981-06-30
DE2861237D1 (en) 1981-12-10
SE7809792L (sv) 1979-03-20
IN148930B (OSRAM) 1981-07-25
ES473451A1 (es) 1979-05-01
FI64365B (fi) 1983-07-29
GB2004281A (en) 1979-03-28
PT68573A (fr) 1978-10-01
MTP835B (en) 1979-11-14
MC1213A1 (fr) 1979-05-18
AR224350A1 (es) 1981-11-30
US4182766A (en) 1980-01-08
NO783155L (no) 1979-03-20
DE2840591A1 (de) 1979-03-29
EP0001279B1 (de) 1981-09-30
EG13530A (en) 1981-12-31
HU176111B (en) 1980-12-28
FR2403340B1 (OSRAM) 1981-02-13
NZ188405A (en) 1981-03-16
AU519711B2 (en) 1981-12-17
IT1098858B (it) 1985-09-18
GB2004281B (en) 1982-03-10
PH16342A (en) 1983-09-05
AT368152B (de) 1982-09-27
NL7809529A (nl) 1979-03-21
NO149962B (no) 1984-04-16
US4248880A (en) 1981-02-03
GR73069B (OSRAM) 1984-01-30
CA1106849A (en) 1981-08-11
IE47363B1 (en) 1984-03-07
BG28708A3 (bg) 1980-06-16
AU3981778A (en) 1980-03-20
PL209693A1 (pl) 1979-06-04
SU793390A3 (ru) 1980-12-30
IL55557A0 (en) 1978-12-17
DD138210A5 (de) 1979-10-17
IT7827861A0 (it) 1978-09-19
IL55557A (en) 1982-02-28
PL114494B1 (en) 1981-01-31
IE781878L (en) 1979-03-19
YU216778A (en) 1983-01-21

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