FR2399430A1 - Chlorhydrate dihydrate de 1-(4-amino-6, 7-dimethoxy-2-quinazolinyl)-4- (2-tetrahydrofuroyl)piperazine, et son utilisation comme agents antihypertensif - Google Patents

Chlorhydrate dihydrate de 1-(4-amino-6, 7-dimethoxy-2-quinazolinyl)-4- (2-tetrahydrofuroyl)piperazine, et son utilisation comme agents antihypertensif

Info

Publication number
FR2399430A1
FR2399430A1 FR7822875A FR7822875A FR2399430A1 FR 2399430 A1 FR2399430 A1 FR 2399430A1 FR 7822875 A FR7822875 A FR 7822875A FR 7822875 A FR7822875 A FR 7822875A FR 2399430 A1 FR2399430 A1 FR 2399430A1
Authority
FR
France
Prior art keywords
tetrahydrofuroyl
quinazolinyl
dimethoxy
amino
antihypertensify
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7822875A
Other languages
English (en)
French (fr)
Other versions
FR2399430B1 (enExample
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26760383&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2399430(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of FR2399430A1 publication Critical patent/FR2399430A1/fr
Application granted granted Critical
Publication of FR2399430B1 publication Critical patent/FR2399430B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR7822875A 1977-08-04 1978-08-02 Chlorhydrate dihydrate de 1-(4-amino-6, 7-dimethoxy-2-quinazolinyl)-4- (2-tetrahydrofuroyl)piperazine, et son utilisation comme agents antihypertensif Granted FR2399430A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82167577A 1977-08-04 1977-08-04
US06/078,317 US4251532A (en) 1977-08-04 1979-09-24 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate

Publications (2)

Publication Number Publication Date
FR2399430A1 true FR2399430A1 (fr) 1979-03-02
FR2399430B1 FR2399430B1 (enExample) 1982-08-13

Family

ID=26760383

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7822875A Granted FR2399430A1 (fr) 1977-08-04 1978-08-02 Chlorhydrate dihydrate de 1-(4-amino-6, 7-dimethoxy-2-quinazolinyl)-4- (2-tetrahydrofuroyl)piperazine, et son utilisation comme agents antihypertensif

Country Status (8)

Country Link
US (1) US4251532A (enExample)
JP (1) JPS5427588A (enExample)
AU (1) AU517636B2 (enExample)
CA (1) CA1081229A (enExample)
CH (1) CH635096A5 (enExample)
DE (1) DE2831112A1 (enExample)
FR (1) FR2399430A1 (enExample)
GB (1) GB1591490A (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0172352B1 (en) * 1984-06-22 1990-08-29 Beecham Group Plc Active benzopyran compounds
US4601897A (en) * 1985-11-06 1986-07-22 Pfizer Inc. Prazosin-pirbuterol combination for bronchodilation
EP0237608B1 (de) * 1986-03-21 1992-01-29 HEUMANN PHARMA GMBH & CO Kristalline, wasserfreie Sigma -Form von 2-[4-(2-Furoyl-(2-piperazin)-1-yl]-4-amino-6,7-dimethoxychinazolinhydrochlorid und Verfahren zu ihrer Herstellung
YU70890A (en) * 1989-04-21 1992-05-28 Egyt Gyogyszervegyeszeti Gyar Process for obtaining quinazoline derivatives
US5212176A (en) * 1990-06-29 1993-05-18 Abbott Laboratories R(+)-terazosin
CA2077252C (en) * 1992-08-31 2001-04-10 Khashayar Karimian Methods of making ureas and guanidines, and intermediates therefor
US5294615A (en) * 1993-04-29 1994-03-15 Abbott Laboratories Terazosin polymorph and pharmaceutical composition
US5412095A (en) * 1993-04-29 1995-05-02 Abbott Laboratories Terazosin monohydrochloride and processes and intermediate for its production
JPH07206857A (ja) * 1993-12-28 1995-08-08 Synthelabo Sa アルフゾシン塩酸塩の二水和物
US5504207A (en) * 1994-10-18 1996-04-02 Abbott Laboratories Process and intermediate for the preparation of terazosin hydrochloride dihydrate
US5587377A (en) * 1995-10-24 1996-12-24 Invamed, Inc. Terazosin crystalline polymorph and pharmaceutical compositions thereof
US5952003A (en) * 1996-08-01 1999-09-14 Novartis Corporation Terazosin capsules
IT1286790B1 (it) * 1996-11-29 1998-07-17 Alfa Chem Ital Processo per la produzione della forma i del terazosin monocloridrato anidro
IT1286789B1 (it) * 1996-11-29 1998-07-17 Alfa Chem Ital Processo per la produzione della forma i del terazosin monocloridato anidro
ES2282997T3 (es) * 1996-12-20 2007-10-16 Heumann Pcs Gmbh Nueva forma polimorfa de mesilato e doxazosina (forma iii).
EP0849265A1 (de) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Neue polymorphe Form von Doxazosin-Mesylat (Form II)
EP0849264A1 (de) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Neue polymorphe Form von doxazosinmesylat (Form I)
US6248888B1 (en) 1997-11-14 2001-06-19 Teva Pharmaceutical Industries Ltd. Process for the preparation of terazosin hydrochloride dihydrate
KR100648869B1 (ko) 1998-09-30 2007-02-28 다케다 야쿠힌 고교 가부시키가이샤 방광 배출력 개선제
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
US20070087061A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Method and composition for creating and/or activating a platelet-rich gel by contact with a porous particulate material, for use in wound care, tissue adhesion, or as a matrix for delivery of therapeutic components
US20070086958A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Formation of medically useful gels comprising microporous particles and methods of use
US20070161791A1 (en) * 2006-01-09 2007-07-12 Narsimha Reddy Penthala Process for the preparation of terazosin hydrocloride dihydrate
CN103739596A (zh) * 2013-12-10 2014-04-23 刘磊 用于心脑血管疾病的喹唑啉衍生物
US11224572B1 (en) 2020-08-17 2022-01-18 Novitium Pharma LLC Stable oral liquid composition of terazosin

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2327787A1 (fr) * 1975-10-14 1977-05-13 Abbott Lab Nouveaux agents antihypertenseurs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4092315A (en) * 1976-03-01 1978-05-30 Pfizer Inc. Novel crystalline forms of prazosin hydrochloride

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2327787A1 (fr) * 1975-10-14 1977-05-13 Abbott Lab Nouveaux agents antihypertenseurs

Also Published As

Publication number Publication date
AU3781878A (en) 1980-01-10
CH635096A5 (fr) 1983-03-15
US4251532A (en) 1981-02-17
GB1591490A (en) 1981-06-24
FR2399430B1 (enExample) 1982-08-13
AU517636B2 (en) 1981-08-13
DE2831112A1 (de) 1979-02-15
JPS5427588A (en) 1979-03-01
CA1081229A (en) 1980-07-08
JPH0231078B2 (enExample) 1990-07-11

Similar Documents

Publication Publication Date Title
FR2399430A1 (fr) Chlorhydrate dihydrate de 1-(4-amino-6, 7-dimethoxy-2-quinazolinyl)-4- (2-tetrahydrofuroyl)piperazine, et son utilisation comme agents antihypertensif
FR2698543B1 (fr) Nouvelles compositions à base de taxoides.
MX9700557A (es) Dihidrobenzofuranos.
EE9900217A (et) Sulfiinhappe derivaadid, nende valmistamine ja kasutamine
ES2189235T3 (es) 6-fenilfenantridinas sustituidas.
ES2097174T3 (es) Derivados de la 2-ciclohexan-1-il amina.
FR2372624A1 (fr) Mercaptoacylamino-acides et leur utilisation pour soulager l'hypertension due a l'angiotensine
TR200101961T2 (tr) 1,2-halkalı kinolin türevleri
ES2168737T3 (es) Inhibidores de la oxido nitrico sintasa.
TR200102800T2 (tr) Yeni bileşikler.
YU157191A (sh) Antagonisti receptora fibrinogena
TR199902606T2 (xx) Farnesil transferaz� engelleyici kinazolinonlar.
ES2193137T3 (es) Heteroaril aminas como nuevos inhibidors de acetilcolinesterasa.
FR2399432A1 (fr) Cephalosporines, leurs procedes de preparation et leur utilisation comme agents therapeutiques
CY1111698T1 (el) Συνδυασμος που περιλαμβανει εναν ανταγωνιστη υποδοχεα ατ1 και εναν ενισχυτη εκκρισης ινσουλινης ή εναν ευαισθητοποιητη ινσουλινης
TR199900486T2 (xx) Aziniloksi ve fenoksi-diaril-karbonasit t�revleri.
MX9301783A (es) Derivados de 1-[2-arilsulfonilamino)-etil-1-oxo]-piperidina, su preparacion y su aplicacion en terapeutica.
FR2392007A1 (fr) 3,3,3-triarylalkyl-4-phenylalkyl-4-hydroxy-piperidines, leurs derives, leur preparation et leur utilisation comme antidiarrheiques et analgesiques
FR2382434A1 (fr) N'-(4-phenethyloxy substitue)phenyl) - n - methyl - n - methoxyurees et leur utilisation comme herbicides
TR200000737T2 (tr) İkame edilmiş kroman türevleri.
TR200101711T2 (tr) Antihistaminik spiro bileşikler.
ES8801912A1 (es) Procedimiento para la obtencion de benzopiranos sustituidos.
ATE333457T1 (de) Zyklische gmp-spezifische phosphodiesteraseinhibitoren
TR200001909T2 (tr) Matris metaloprotez inhibitörleri.
DE60112960D1 (de) Kondensierte pyridoindolderivate