FR2394519A2 - Procede de preparation d'acides 2-arylalcanoiques et de leurs sels et esters - Google Patents
Procede de preparation d'acides 2-arylalcanoiques et de leurs sels et estersInfo
- Publication number
- FR2394519A2 FR2394519A2 FR7818001A FR7818001A FR2394519A2 FR 2394519 A2 FR2394519 A2 FR 2394519A2 FR 7818001 A FR7818001 A FR 7818001A FR 7818001 A FR7818001 A FR 7818001A FR 2394519 A2 FR2394519 A2 FR 2394519A2
- Authority
- FR
- France
- Prior art keywords
- preparation
- salts
- acids
- esters
- arylalcanoic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/28—Preparation of ethers by reactions not forming ether-oxygen bonds from acetals, e.g. by dealcoholysis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/48—Preparation of compounds having groups
- C07C41/50—Preparation of compounds having groups by reactions producing groups
- C07C41/56—Preparation of compounds having groups by reactions producing groups by condensation of aldehydes, paraformaldehyde, or ketones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
L'addition concerne la préparation d'acides 2-arylalcanoïques, de leurs sels et esters suivant le brevet principal. Le procédé de préparation consiste à faire réagir un énol-éther d'une arylalkylcétone avec un sel de thallium trivalent dans un solvant organique. Les ions de T1 trivalent peuvent être régénérés par addition d'un péracide et d'une forme réactive de Mn, Ru, Co, Ir, Hf, Os ou Nb pour oxyder T1**+ en T1**+++. L'ester intermédiaire est ensuite transformé en acide 2-aryl-(alcanoïque en C3 -C6 correspondant ou en son sel. Le groupe aryle est choisi de manière que le produit acide obtenu soit un composé tel qu'un médicament anti-inflammatoire, analgésique ou anti-pyrétique (ibuprofène, flurbiprofène, fénoprofène naproxène) ou un produit pour l'agriculture.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/807,031 US4142054A (en) | 1977-06-16 | 1977-06-16 | Process for preparing arylalkanoic acid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2394519A2 true FR2394519A2 (fr) | 1979-01-12 |
Family
ID=25195403
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7818001A Pending FR2394519A2 (fr) | 1977-06-16 | 1978-06-15 | Procede de preparation d'acides 2-arylalcanoiques et de leurs sels et esters |
Country Status (4)
Country | Link |
---|---|
US (1) | US4142054A (fr) |
JP (1) | JPS545938A (fr) |
DE (1) | DE2824833A1 (fr) |
FR (1) | FR2394519A2 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2391183A1 (fr) * | 1977-05-17 | 1978-12-15 | Merck Patent Gmbh | Hydroxyalkylphenones et leur application comme photosensibilisateurs |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE50897B1 (en) * | 1980-02-26 | 1986-08-06 | Blaschim Spa | Process for preparing esters of alkanoic acids via rearrangement of alpha-haloketals |
US4723033A (en) * | 1982-11-24 | 1988-02-02 | Syntex Pharmaceuticals International Ltd. | Manufacture of optically active α-arylalkanoic acids and precursors thereof |
US4472431A (en) * | 1983-08-18 | 1984-09-18 | Methodist Hospital Of Indiana, Inc. | Method for treatment of shock |
US4670586A (en) * | 1984-09-12 | 1987-06-02 | Nippon Chemicals Co., Ltd. | Method for the production of α-aryl-alkanoic acid |
US5663416A (en) * | 1990-05-22 | 1997-09-02 | Cortech Inc. | Oxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastase |
US6080888A (en) * | 1997-01-08 | 2000-06-27 | Albemarle Corporation | Preparation of olefinic compounds and carboxylic derivatives thereof |
US5792886A (en) * | 1997-01-08 | 1998-08-11 | Albemarle Corporation | Production of racemic 2-(6-methoxy-2-naphthyl) propionic acid of precursors thereof |
US6096920A (en) * | 1997-01-08 | 2000-08-01 | Albemarle Corporation | Preparation of carboxylic compounds and their derivatives |
WO2008097471A1 (fr) * | 2007-02-02 | 2008-08-14 | Shivvers Steve D | Dispositif de séchage à haut rendement équipé de zones de chauffage et de séchage à plusieurs étages |
CN114149310A (zh) * | 2021-11-23 | 2022-03-08 | 万华化学(四川)有限公司 | 一种不饱和酮的制备方法 |
-
1977
- 1977-06-16 US US05/807,031 patent/US4142054A/en not_active Expired - Lifetime
-
1978
- 1978-06-06 DE DE19782824833 patent/DE2824833A1/de not_active Withdrawn
- 1978-06-15 FR FR7818001A patent/FR2394519A2/fr active Pending
- 1978-06-16 JP JP7315578A patent/JPS545938A/ja active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2391183A1 (fr) * | 1977-05-17 | 1978-12-15 | Merck Patent Gmbh | Hydroxyalkylphenones et leur application comme photosensibilisateurs |
Also Published As
Publication number | Publication date |
---|---|
JPS545938A (en) | 1979-01-17 |
US4142054A (en) | 1979-02-27 |
DE2824833A1 (de) | 1978-12-21 |
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