FR2394520A2 - Procede de preparation d'acides 2-arylalcanoiques et de leurs sels et esters - Google Patents

Procede de preparation d'acides 2-arylalcanoiques et de leurs sels et esters

Info

Publication number
FR2394520A2
FR2394520A2 FR7818002A FR7818002A FR2394520A2 FR 2394520 A2 FR2394520 A2 FR 2394520A2 FR 7818002 A FR7818002 A FR 7818002A FR 7818002 A FR7818002 A FR 7818002A FR 2394520 A2 FR2394520 A2 FR 2394520A2
Authority
FR
France
Prior art keywords
preparation
ions
arylalcanoic
esters
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR7818002A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FR2394520A2 publication Critical patent/FR2394520A2/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/28—Preparation of ethers by reactions not forming ether-oxygen bonds from acetals, e.g. by dealcoholysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C07C41/50—Preparation of compounds having groups by reactions producing groups
    • C07C41/56—Preparation of compounds having groups by reactions producing groups by condensation of aldehydes, paraformaldehyde, or ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'addition concerne la préparation de 2-aryl-(alcanoates en C3 à C6 ) suivant le brevet principal. Un énol-éther d'une arylalkylcétone est amené à réagir avec un sel de thallium trivalent dans un solvant organique. Les ions T1**+++ peuvent être régénérés par addition d'un péracide et d'une forme réactive de Mu, Ru, Co, Ir, Hf, Os ou Nb pour oxyder les ions T1**+ en ions T1**+++. L'ester intermédiaire est ensuite transformé en acide 2-aryl-(alcanoïaque en C3 à C6 ) correspondant ou en sel de cet acide. Application à la préparation de médicaments acides tels que ibuprofène, flurbiprofène, fénoprofène, naproxène, etc.
FR7818002A 1977-06-16 1978-06-15 Procede de preparation d'acides 2-arylalcanoiques et de leurs sels et esters Pending FR2394520A2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/807,032 US4135051A (en) 1977-06-16 1977-06-16 Process for preparing arylalkanoic acid derivatives

Publications (1)

Publication Number Publication Date
FR2394520A2 true FR2394520A2 (fr) 1979-01-12

Family

ID=25195406

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7818002A Pending FR2394520A2 (fr) 1977-06-16 1978-06-15 Procede de preparation d'acides 2-arylalcanoiques et de leurs sels et esters

Country Status (3)

Country Link
US (1) US4135051A (fr)
DE (1) DE2824856A1 (fr)
FR (1) FR2394520A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0627398A1 (fr) * 1993-06-01 1994-12-07 Hüls America Inc. Procédé pour la préparation d'ortho esters et 1,1-dialcoxycycloalcanes

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50897B1 (en) * 1980-02-26 1986-08-06 Blaschim Spa Process for preparing esters of alkanoic acids via rearrangement of alpha-haloketals
US4472431A (en) * 1983-08-18 1984-09-18 Methodist Hospital Of Indiana, Inc. Method for treatment of shock
US4692227A (en) * 1986-12-01 1987-09-08 W. R. Grace & Co. Oxidation of organic compounds using thallium ions
JPS6363683A (ja) * 1986-09-04 1988-03-22 Shin Etsu Chem Co Ltd （フェニルジメチルカルビニル）シラン化合物の製造方法
CA2095127C (fr) * 1990-11-19 1998-06-30 Albemarle Corporation Procede pour ameliorer les caracteristiques d'ecoulement de l'ibuprofene crystalline
US5223640A (en) * 1992-12-23 1993-06-29 Hoechst Celanese Corporation Preparation of optically active α-aryl propionic acids
US6080888A (en) * 1997-01-08 2000-06-27 Albemarle Corporation Preparation of olefinic compounds and carboxylic derivatives thereof
US6096920A (en) * 1997-01-08 2000-08-01 Albemarle Corporation Preparation of carboxylic compounds and their derivatives
US5792886A (en) * 1997-01-08 1998-08-11 Albemarle Corporation Production of racemic 2-(6-methoxy-2-naphthyl) propionic acid of precursors thereof
US7021379B2 (en) * 2003-07-07 2006-04-04 Halliburton Energy Services, Inc. Methods and compositions for enhancing consolidation strength of proppant in subterranean fractures
US10865171B1 (en) * 2019-09-04 2020-12-15 Eastman Chemical Company Process to make aromatic enol ethers and olefin isomers of aromatic enol ethers
US10858304B1 (en) * 2019-09-04 2020-12-08 Eastman Chemical Company Aromatic enol ethers

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0627398A1 (fr) * 1993-06-01 1994-12-07 Hüls America Inc. Procédé pour la préparation d'ortho esters et 1,1-dialcoxycycloalcanes
US5401885A (en) * 1993-06-01 1995-03-28 Huls America, Inc. Method of preparing ortho esters and 1.1-dialkoxycycloalkanes
US5550299A (en) * 1993-06-01 1996-08-27 Huls America Inc. Method of preparing 1.1-dialkoxycycloalkanes

Also Published As

Publication number Publication date
DE2824856A1 (de) 1979-01-04
US4135051A (en) 1979-01-16

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