FR2390960A1 - Composes steroliques 15-oxygenes, ainsi que leur application dans l'inhibition de la biosynthese de l'acide mevalonique - Google Patents

Composes steroliques 15-oxygenes, ainsi que leur application dans l'inhibition de la biosynthese de l'acide mevalonique

Info

Publication number
FR2390960A1
FR2390960A1 FR7814450A FR7814450A FR2390960A1 FR 2390960 A1 FR2390960 A1 FR 2390960A1 FR 7814450 A FR7814450 A FR 7814450A FR 7814450 A FR7814450 A FR 7814450A FR 2390960 A1 FR2390960 A1 FR 2390960A1
Authority
FR
France
Prior art keywords
inhibition
well
application
biosynthesis
oxygen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7814450A
Other languages
English (en)
Other versions
FR2390960B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SCHROEPFER JOHN
Original Assignee
SCHROEPFER JOHN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SCHROEPFER JOHN filed Critical SCHROEPFER JOHN
Publication of FR2390960A1 publication Critical patent/FR2390960A1/fr
Application granted granted Critical
Publication of FR2390960B1 publication Critical patent/FR2390960B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

a. Composés stéroliques 15-oxygénés, ainsi que leur application dans l'inhibition de la biosynthèse de l'acide mévalonique. b. Ces composés répondent à la formule :
FR7814450A 1977-05-16 1978-05-16 Composes steroliques 15-oxygenes, ainsi que leur application dans l'inhibition de la biosynthese de l'acide mevalonique Expired FR2390960B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/797,345 US4202891A (en) 1977-05-16 1977-05-16 15-Oxygenated sterol compounds and the use of such compounds to inhibit the biosynthesis of sterols

Publications (2)

Publication Number Publication Date
FR2390960A1 true FR2390960A1 (fr) 1978-12-15
FR2390960B1 FR2390960B1 (fr) 1985-11-29

Family

ID=25170577

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7814450A Expired FR2390960B1 (fr) 1977-05-16 1978-05-16 Composes steroliques 15-oxygenes, ainsi que leur application dans l'inhibition de la biosynthese de l'acide mevalonique
FR8116129A Pending FR2485021A1 (fr) 1977-05-16 1981-08-21 Nouveaux sterols 15-oxygenes

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR8116129A Pending FR2485021A1 (fr) 1977-05-16 1981-08-21 Nouveaux sterols 15-oxygenes

Country Status (11)

Country Link
US (1) US4202891A (fr)
JP (1) JPS5455734A (fr)
AU (1) AU520703B2 (fr)
BE (1) BE867120A (fr)
CA (1) CA1123739A (fr)
CH (1) CH641352A5 (fr)
DE (3) DE2858726C2 (fr)
FR (2) FR2390960B1 (fr)
GB (1) GB1599863A (fr)
IT (1) IT1156745B (fr)
NL (1) NL7805267A (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0327119A2 (fr) * 1988-02-05 1989-08-09 William Marsh Rice University Procédé de synthèse de 5-alpha-cholest-8(14)-ene-3 bêta-ol-15-one et d'autres stérols oxygénés en 15
EP0335106A2 (fr) * 1988-03-28 1989-10-04 American Cyanamid Company Intermédiaires et procédé de préparation de (3 bêta, 5 alpha) 3-hydroxy-cholest-8(14)en-15-one
WO1993025568A2 (fr) * 1992-06-12 1993-12-23 Sri International Composes antihypercholesterolemiques, compositons pharmaceutiques associees et leurs procedes d'utilisation

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS563000A (en) * 1979-06-20 1981-01-13 Green Cross Corp:The Water-soluble cholesterol derivative
US5034548A (en) * 1987-01-30 1991-07-23 E. I. Du Pont De Nemours And Company Steroid derivatives useful as hypocholesterolemics
EP0276823B1 (fr) * 1987-01-30 1992-09-23 The Du Pont Merck Pharmaceutical Company Lanostérols substitués en 14 et 15 et leur utilisation comme hypocholesterolemiants
US5041432A (en) * 1987-01-30 1991-08-20 E. I. Du Pont De Nemours And Company Steroid derivatives useful as hypocholesterolemics
DE3705990A1 (de) * 1987-02-20 1988-09-01 Schering Ag 1-methyl-15(alpha)-(1-oxyalkyl)-androsta-1,4-dien- 3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US5023250A (en) * 1989-08-24 1991-06-11 Smithkline Beecham Corporation Steroidal 14α-carboxy-alkyl derivatives as regulators of HMG-COA reductase
US5219879A (en) * 1990-03-05 1993-06-15 Du Pont Merck Pharmaceutical Company Heterocyclic steroid compounds
JP3029907B2 (ja) * 1991-12-20 2000-04-10 理化学研究所 抗肥満剤
US5371077A (en) * 1992-08-03 1994-12-06 William Marsh Rice University Side chain derivatized 15-oxygenated sterols, methods of using them and a process for preparing them
JP3862295B2 (ja) * 1993-09-30 2006-12-27 独立行政法人理化学研究所 抗肥満剤
CA2373442A1 (fr) * 1999-05-10 2000-11-16 Schering Aktiengesellschaft 14.beta.-h-sterols, compositions pharmaceutiques les contenant et utilisation de ces derives pour la preparation de medicaments destines a reguler la meiose
US8399441B2 (en) * 2004-10-25 2013-03-19 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of lipid homeostasis, for therapy of hypercholesterolemia, hypertriglycerides, fatty liver diseases, and atherosclerosis
WO2006047022A1 (fr) 2004-10-25 2006-05-04 Virginia Commonwealth University Oxysterol sulfate nucleaire, regulateur homeostatique du cholesterol agissant puissamment dans le traitement de l'hypercholesterolemie, de l'hyperlipidemie et de l'atherosclerose
US9034859B2 (en) 2011-04-06 2015-05-19 Virginia Commonwealth University Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation
KR20240051283A (ko) 2013-12-24 2024-04-19 버지니아 커먼웰스 유니버시티 산소첨가된 콜레스테롤 술페이트 (ocs) 의 용도
JP2019524772A (ja) 2016-08-02 2019-09-05 ヴァージニア コモンウェルス ユニバーシティ ５−コレステン−３，２５−ジオール，３−サルフェート（２５ｈｃ３ｓ）又は薬学的に許容される塩及び少なくとも１種の環状オリゴ糖を含む組成物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1493252A1 (de) * 1963-11-01 1969-06-26 Takeda Chemical Industries Ltd Verfahren zur Herstellung von 13beta-Alkyl-14-Hydroxygona-1,3,5(10),9(11)-tetraenen
US3354154A (en) * 1966-01-26 1967-11-21 Syntex Corp 2beta, 3beta-alkylidenedioxy-6-hydroxy-22, 23-bisnorchol-7-enoic acid alkyl esters and process for the production thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CA1976 *
EXBK/76 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0327119A2 (fr) * 1988-02-05 1989-08-09 William Marsh Rice University Procédé de synthèse de 5-alpha-cholest-8(14)-ene-3 bêta-ol-15-one et d'autres stérols oxygénés en 15
EP0327119A3 (en) * 1988-02-05 1990-03-14 Univ William Marsh Rice Y Improved process for synthesis of 5-alpha-cholest-8(14)-en-3 beta-ol-15-one and other 15-oxygenated sterols
EP0335106A2 (fr) * 1988-03-28 1989-10-04 American Cyanamid Company Intermédiaires et procédé de préparation de (3 bêta, 5 alpha) 3-hydroxy-cholest-8(14)en-15-one
EP0335106A3 (fr) * 1988-03-28 1990-08-29 American Cyanamid Company Intermédiaires et procédé de préparation de (3 bêta, 5 alpha) 3-hydroxy-cholest-8(14)en-15-one
WO1993025568A2 (fr) * 1992-06-12 1993-12-23 Sri International Composes antihypercholesterolemiques, compositons pharmaceutiques associees et leurs procedes d'utilisation
WO1993025568A3 (fr) * 1992-06-12 1994-03-17 Stanford Res Inst Int Composes antihypercholesterolemiques, compositons pharmaceutiques associees et leurs procedes d'utilisation

Also Published As

Publication number Publication date
AU3616778A (en) 1979-11-22
CA1123739A (fr) 1982-05-18
DE2821242C2 (fr) 1991-10-24
IT1156745B (it) 1987-02-04
GB1599863A (en) 1981-10-07
BE867120A (fr) 1978-09-18
JPS5455734A (en) 1979-05-04
NL7805267A (nl) 1978-11-20
DE2858726C2 (de) 1992-10-01
IT7849386A0 (it) 1978-05-16
AU520703B2 (en) 1982-02-25
CH641352A5 (de) 1984-02-29
DE2821242A1 (de) 1978-11-23
FR2485021A1 (fr) 1981-12-24
DE2858802C2 (de) 1991-10-02
FR2390960B1 (fr) 1985-11-29
US4202891A (en) 1980-05-13
JPH0214329B2 (fr) 1990-04-06

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ST Notification of lapse