AU3616778A - 15-oxygenated sterol compounds - Google Patents

15-oxygenated sterol compounds

Info

Publication number
AU3616778A
AU3616778A AU36167/78A AU3616778A AU3616778A AU 3616778 A AU3616778 A AU 3616778A AU 36167/78 A AU36167/78 A AU 36167/78A AU 3616778 A AU3616778 A AU 3616778A AU 3616778 A AU3616778 A AU 3616778A
Authority
AU
Australia
Prior art keywords
sterol compounds
oxygenated sterol
oxygenated
compounds
sterol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU36167/78A
Other versions
AU520703B2 (en
Inventor
Jr. Edward James Parish And Andrew August Kandutsch George John Schroepfer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Schroeper George John Jr & Parish Edward James & Kandutsch Andrew August
Original Assignee
Schroeper George John Jr & Parish
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schroeper George John Jr & Parish filed Critical Schroeper George John Jr & Parish
Publication of AU3616778A publication Critical patent/AU3616778A/en
Application granted granted Critical
Publication of AU520703B2 publication Critical patent/AU520703B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU36167/78A 1977-05-16 1978-05-16 15-oxygenated sterol compounds Expired AU520703B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
USUS797345 1977-05-16
US05/797,345 US4202891A (en) 1977-05-16 1977-05-16 15-Oxygenated sterol compounds and the use of such compounds to inhibit the biosynthesis of sterols

Publications (2)

Publication Number Publication Date
AU3616778A true AU3616778A (en) 1979-11-22
AU520703B2 AU520703B2 (en) 1982-02-25

Family

ID=25170577

Family Applications (1)

Application Number Title Priority Date Filing Date
AU36167/78A Expired AU520703B2 (en) 1977-05-16 1978-05-16 15-oxygenated sterol compounds

Country Status (11)

Country Link
US (1) US4202891A (en)
JP (1) JPS5455734A (en)
AU (1) AU520703B2 (en)
BE (1) BE867120A (en)
CA (1) CA1123739A (en)
CH (1) CH641352A5 (en)
DE (3) DE2821242A1 (en)
FR (2) FR2390960B1 (en)
GB (1) GB1599863A (en)
IT (1) IT1156745B (en)
NL (1) NL7805267A (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS563000A (en) * 1979-06-20 1981-01-13 Green Cross Corp:The Water-soluble cholesterol derivative
ES2046217T3 (en) * 1987-01-30 1994-02-01 The Du Pont Merck Pharmaceutical Company LANOSTEROLS 14,15-SUBSTITUTED AND ITS USE AS HYPOCHOLESTEROLEMIC AGENTS.
US5041432A (en) * 1987-01-30 1991-08-20 E. I. Du Pont De Nemours And Company Steroid derivatives useful as hypocholesterolemics
US5034548A (en) * 1987-01-30 1991-07-23 E. I. Du Pont De Nemours And Company Steroid derivatives useful as hypocholesterolemics
DE3705990A1 (en) * 1987-02-20 1988-09-01 Schering Ag 1-METHYL-15 (ALPHA) - (1-OXYALKYL) -ANDROSTA-1,4-DIEN-3,17-DIONE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
US4897475A (en) * 1988-02-05 1990-01-30 William Marsh Rice University Process for synthesis of 5α-cholest-8(14)-en-3β-ol-15-one and other 15-oxygenated sterols
US4900477A (en) * 1988-03-28 1990-02-13 American Cyanamid Company Novel intermediates and an improved process for producing the compound (3β,5α)-3-hydroxycholest-8(14)-en-15-one
US5023250A (en) * 1989-08-24 1991-06-11 Smithkline Beecham Corporation Steroidal 14α-carboxy-alkyl derivatives as regulators of HMG-COA reductase
US5219879A (en) * 1990-03-05 1993-06-15 Du Pont Merck Pharmaceutical Company Heterocyclic steroid compounds
JP3029907B2 (en) * 1991-12-20 2000-04-10 理化学研究所 Anti-obesity agent
US5510340A (en) * 1992-06-12 1996-04-23 Sri International Antihypercholesterolemic compounds and related pharmaceutical compositions and methods of use
US5371077A (en) * 1992-08-03 1994-12-06 William Marsh Rice University Side chain derivatized 15-oxygenated sterols, methods of using them and a process for preparing them
JP3862295B2 (en) * 1993-09-30 2006-12-27 独立行政法人理化学研究所 Anti-obesity agent
WO2000068245A1 (en) * 1999-05-10 2000-11-16 Schering Aktiengesellschaft 14β-H-STEROLS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND USE OF THESE DERIVATIVES FOR THE PREPARATION OF MEIOSIS REGULATING MEDICAMENTS
US8399441B2 (en) 2004-10-25 2013-03-19 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of lipid homeostasis, for therapy of hypercholesterolemia, hypertriglycerides, fatty liver diseases, and atherosclerosis
WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
US9034859B2 (en) 2011-04-06 2015-05-19 Virginia Commonwealth University Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation
BR112016014611A8 (en) 2013-12-24 2023-05-09 Univ Virginia Commonwealth USES OF OXYGENATED CHOLESTEROL SULFATES (OCS)
MX2019001323A (en) 2016-08-02 2019-07-04 Univ Virginia Commonwealth Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1080333A (en) * 1963-11-01 1967-08-23 Takeda Chemical Industries Ltd New 14-hydroxy steroids
US3354154A (en) * 1966-01-26 1967-11-21 Syntex Corp 2beta, 3beta-alkylidenedioxy-6-hydroxy-22, 23-bisnorchol-7-enoic acid alkyl esters and process for the production thereof

Also Published As

Publication number Publication date
US4202891A (en) 1980-05-13
IT7849386A0 (en) 1978-05-16
GB1599863A (en) 1981-10-07
AU520703B2 (en) 1982-02-25
BE867120A (en) 1978-09-18
IT1156745B (en) 1987-02-04
DE2821242A1 (en) 1978-11-23
FR2390960A1 (en) 1978-12-15
FR2485021A1 (en) 1981-12-24
CA1123739A (en) 1982-05-18
DE2821242C2 (en) 1991-10-24
DE2858726C2 (en) 1992-10-01
CH641352A5 (en) 1984-02-29
JPH0214329B2 (en) 1990-04-06
DE2858802C2 (en) 1991-10-02
FR2390960B1 (en) 1985-11-29
NL7805267A (en) 1978-11-20
JPS5455734A (en) 1979-05-04

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