FR2378017A1 - Alkylthio-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines, leur procede de preparation et application en therapeutique - Google Patents

Alkylthio-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines, leur procede de preparation et application en therapeutique

Info

Publication number
FR2378017A1
FR2378017A1 FR7800998A FR7800998A FR2378017A1 FR 2378017 A1 FR2378017 A1 FR 2378017A1 FR 7800998 A FR7800998 A FR 7800998A FR 7800998 A FR7800998 A FR 7800998A FR 2378017 A1 FR2378017 A1 FR 2378017A1
Authority
FR
France
Prior art keywords
benzazepines
alkylthio
tetrahydro
dihydroxy
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7800998A
Other languages
English (en)
Other versions
FR2378017B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
SmithKline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Corp filed Critical SmithKline Corp
Publication of FR2378017A1 publication Critical patent/FR2378017A1/fr
Application granted granted Critical
Publication of FR2378017B1 publication Critical patent/FR2378017B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

L'invention a pour objet des composés de formule :
FR7800998A 1977-01-19 1978-01-13 Alkylthio-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines, leur procede de preparation et application en therapeutique Granted FR2378017A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76050077A 1977-01-19 1977-01-19

Publications (2)

Publication Number Publication Date
FR2378017A1 true FR2378017A1 (fr) 1978-08-18
FR2378017B1 FR2378017B1 (fr) 1981-07-10

Family

ID=25059291

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7800998A Granted FR2378017A1 (fr) 1977-01-19 1978-01-13 Alkylthio-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines, leur procede de preparation et application en therapeutique
FR7816583A Granted FR2384759A1 (fr) 1977-01-19 1978-06-02 1-phenyl-2,3,4,5 tetrahydro-1h benzazepine-7,8-diones

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7816583A Granted FR2384759A1 (fr) 1977-01-19 1978-06-02 1-phenyl-2,3,4,5 tetrahydro-1h benzazepine-7,8-diones

Country Status (15)

Country Link
JP (1) JPS6040423B2 (fr)
AU (1) AU510459B2 (fr)
BE (1) BE862878A (fr)
CA (1) CA1090334A (fr)
CH (2) CH642634A5 (fr)
DE (1) DE2802086A1 (fr)
DK (1) DK19978A (fr)
FR (2) FR2378017A1 (fr)
GB (2) GB1597911A (fr)
HU (1) HU175836B (fr)
IE (1) IE46761B1 (fr)
LU (1) LU78873A1 (fr)
NL (1) NL7800637A (fr)
SE (1) SE437265B (fr)
ZA (1) ZA777444B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5481290A (en) * 1977-11-17 1979-06-28 Smithkline Corp Benzazepin compound
US4171359A (en) * 1978-04-12 1979-10-16 Smithkline Corporation Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US4251525A (en) * 1979-05-25 1981-02-17 Smithkline Corporation 3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
DE3065940D1 (en) * 1979-07-10 1984-01-26 Smithkline Beckman Corp Synergistic antihypertensive compositions
JP2006526021A (ja) * 2003-05-22 2006-11-16 シェーリング　コーポレイション 肥満およびｃｎｓ障害を治療する選択的ｄ１／ｄ５レセプタアンタゴニストとしての５ｈ−ベンゾ［ｄ］ナフト［２，１−ｂ］アゼピン誘導体

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3609139A (en) * 1969-04-01 1971-09-28 Sandoz Ag Substituted dibenzdiazonines
CH555831A (de) * 1967-02-17 1974-11-15 Scherico Ltd Verfahren zur herstellung von neuen benzazepinen.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4011319A (en) * 1975-07-02 1977-03-08 Smithkline Corporation Pharmaceutical compositions and methods involving benzazepine derivatives
GB1561305A (en) * 1975-07-02 1980-02-20 Smithkline Corp Benzazepine derivatives and pharmeceutical compositions containing them

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH555831A (de) * 1967-02-17 1974-11-15 Scherico Ltd Verfahren zur herstellung von neuen benzazepinen.
US3609139A (en) * 1969-04-01 1971-09-28 Sandoz Ag Substituted dibenzdiazonines

Also Published As

Publication number Publication date
SE7800455L (sv) 1978-07-20
JPS6040423B2 (ja) 1985-09-11
IE780111L (en) 1978-07-19
AU510459B2 (en) 1980-06-26
IE46761B1 (en) 1983-09-21
HU175836B (hu) 1980-10-28
DE2802086A1 (de) 1978-07-20
GB1597912A (en) 1981-09-16
SE437265B (sv) 1985-02-18
ZA777444B (en) 1978-10-25
GB1597911A (en) 1981-09-16
FR2378017B1 (fr) 1981-07-10
BE862878A (fr) 1978-07-13
CH640228A5 (en) 1983-12-30
LU78873A1 (fr) 1978-06-09
FR2384759B1 (fr) 1980-07-18
CA1090334A (fr) 1980-11-25
FR2384759A1 (fr) 1978-10-20
DK19978A (da) 1978-07-20
JPS5390281A (en) 1978-08-08
NL7800637A (nl) 1978-07-21
CH642634A5 (en) 1984-04-30
AU3246578A (en) 1979-07-26

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