CA1090334A - Alkylthio-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro- 1h-3-benzazepines a action dopaminergique - Google Patents

Alkylthio-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro- 1h-3-benzazepines a action dopaminergique

Info

Publication number
CA1090334A
CA1090334A CA294,973A CA294973A CA1090334A CA 1090334 A CA1090334 A CA 1090334A CA 294973 A CA294973 A CA 294973A CA 1090334 A CA1090334 A CA 1090334A
Authority
CA
Canada
Prior art keywords
hydrogen
tetrahydro
methylthio
phenyl
carbons
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA294,973A
Other languages
English (en)
Inventor
Kenneth G. Holden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Inc
Original Assignee
Smith Kline and French Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Canada Ltd filed Critical Smith Kline and French Canada Ltd
Application granted granted Critical
Publication of CA1090334A publication Critical patent/CA1090334A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CA294,973A 1977-01-19 1978-01-16 Alkylthio-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro- 1h-3-benzazepines a action dopaminergique Expired CA1090334A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76050077A 1977-01-19 1977-01-19
US760,500 1985-07-31

Publications (1)

Publication Number Publication Date
CA1090334A true CA1090334A (fr) 1980-11-25

Family

ID=25059291

Family Applications (1)

Application Number Title Priority Date Filing Date
CA294,973A Expired CA1090334A (fr) 1977-01-19 1978-01-16 Alkylthio-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro- 1h-3-benzazepines a action dopaminergique

Country Status (15)

Country Link
JP (1) JPS6040423B2 (fr)
AU (1) AU510459B2 (fr)
BE (1) BE862878A (fr)
CA (1) CA1090334A (fr)
CH (2) CH642634A5 (fr)
DE (1) DE2802086A1 (fr)
DK (1) DK19978A (fr)
FR (2) FR2378017A1 (fr)
GB (2) GB1597912A (fr)
HU (1) HU175836B (fr)
IE (1) IE46761B1 (fr)
LU (1) LU78873A1 (fr)
NL (1) NL7800637A (fr)
SE (1) SE437265B (fr)
ZA (1) ZA777444B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5481290A (en) * 1977-11-17 1979-06-28 Smithkline Corp Benzazepin compound
US4171359A (en) * 1978-04-12 1979-10-16 Smithkline Corporation Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US4251525A (en) * 1979-05-25 1981-02-17 Smithkline Corporation 3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
DE3065940D1 (en) * 1979-07-10 1984-01-26 Smithkline Beckman Corp Synergistic antihypertensive compositions
US7504391B2 (en) * 2003-05-22 2009-03-17 Schering Corporation Selective D1/D5 receptor antagonists for the treatment of obesity and CNS disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH555831A (de) * 1967-02-17 1974-11-15 Scherico Ltd Verfahren zur herstellung von neuen benzazepinen.
US3609139A (en) * 1969-04-01 1971-09-28 Sandoz Ag Substituted dibenzdiazonines
US4011319A (en) * 1975-07-02 1977-03-08 Smithkline Corporation Pharmaceutical compositions and methods involving benzazepine derivatives
GB1561305A (en) * 1975-07-02 1980-02-20 Smithkline Corp Benzazepine derivatives and pharmeceutical compositions containing them

Also Published As

Publication number Publication date
SE7800455L (sv) 1978-07-20
CH642634A5 (en) 1984-04-30
JPS5390281A (en) 1978-08-08
CH640228A5 (en) 1983-12-30
JPS6040423B2 (ja) 1985-09-11
ZA777444B (en) 1978-10-25
SE437265B (sv) 1985-02-18
DE2802086A1 (de) 1978-07-20
IE46761B1 (en) 1983-09-21
NL7800637A (nl) 1978-07-21
AU3246578A (en) 1979-07-26
BE862878A (fr) 1978-07-13
AU510459B2 (en) 1980-06-26
LU78873A1 (fr) 1978-06-09
FR2378017A1 (fr) 1978-08-18
GB1597912A (en) 1981-09-16
DK19978A (da) 1978-07-20
IE780111L (en) 1978-07-19
HU175836B (hu) 1980-10-28
FR2378017B1 (fr) 1981-07-10
GB1597911A (en) 1981-09-16
FR2384759A1 (fr) 1978-10-20
FR2384759B1 (fr) 1980-07-18

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