CA1079639A - Derives de la 3-benzazepine - Google Patents

Derives de la 3-benzazepine

Info

Publication number
CA1079639A
CA1079639A CA255,817A CA255817A CA1079639A CA 1079639 A CA1079639 A CA 1079639A CA 255817 A CA255817 A CA 255817A CA 1079639 A CA1079639 A CA 1079639A
Authority
CA
Canada
Prior art keywords
hydrogen
hydroxy
composition
methoxy
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA255,817A
Other languages
English (en)
Inventor
Paulette E. Setler
Carl Kaiser
Robert G. Pendleton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Inc
Original Assignee
Smith Kline and French Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/592,708 external-priority patent/US4011319A/en
Priority claimed from US05/602,042 external-priority patent/US4052506A/en
Application filed by Smith Kline and French Canada Ltd filed Critical Smith Kline and French Canada Ltd
Application granted granted Critical
Publication of CA1079639A publication Critical patent/CA1079639A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CA255,817A 1975-07-02 1976-06-28 Derives de la 3-benzazepine Expired CA1079639A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/592,708 US4011319A (en) 1975-07-02 1975-07-02 Pharmaceutical compositions and methods involving benzazepine derivatives
US05/602,042 US4052506A (en) 1975-08-05 1975-08-05 Pharmaceutical compositions and method of producing anti-parkinsonism activity

Publications (1)

Publication Number Publication Date
CA1079639A true CA1079639A (fr) 1980-06-17

Family

ID=27081519

Family Applications (1)

Application Number Title Priority Date Filing Date
CA255,817A Expired CA1079639A (fr) 1975-07-02 1976-06-28 Derives de la 3-benzazepine

Country Status (10)

Country Link
JP (1) JPS527981A (fr)
AU (1) AU507272B2 (fr)
CA (1) CA1079639A (fr)
DE (1) DE2629887A1 (fr)
FR (1) FR2315934A1 (fr)
GB (1) GB1561305A (fr)
IE (1) IE43920B1 (fr)
IL (1) IL49931A (fr)
LU (1) LU75269A1 (fr)
NL (1) NL7607184A (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA777444B (en) * 1977-01-19 1978-10-25 Smithkline Corp Alkylthio-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines having dopaminergic activity
US4104379A (en) * 1977-01-19 1978-08-01 Smithkline Corporation Substituted 1-alkylthiophenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4490392A (en) * 1977-08-11 1984-12-25 Tanabe Seiyaku Co., Ltd. Benzylalcohol derivative and process for preparing
JPS5481290A (en) * 1977-11-17 1979-06-28 Smithkline Corp Benzazepin compound
US4171359A (en) * 1978-04-12 1979-10-16 Smithkline Corporation Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
EP0022330B1 (fr) * 1979-07-10 1983-12-21 Smithkline Beckman Corporation Compositions synergiques anti-hypertensives
EP0103830A3 (fr) * 1982-09-22 1985-07-31 Bayer Ag Dérivés de phényléthylamine comme stimulateurs de croissance
US5068326A (en) * 1989-04-03 1991-11-26 Kung Hank F Dopamine receptor ligands and imaging agents
GB9903671D0 (en) * 1999-02-17 1999-04-14 Cenes Ltd Dopamine D-1 receptor agonist compounds
GB0130576D0 (en) * 2001-12-20 2002-02-06 Cenes Ltd Dopamine D1 receptor agonist pro-drug compounds & derivatives
JP2006526021A (ja) * 2003-05-22 2006-11-16 シェーリング　コーポレイション 肥満およびｃｎｓ障害を治療する選択的ｄ１／ｄ５レセプタアンタゴニストとしての５ｈ−ベンゾ［ｄ］ナフト［２，１−ｂ］アゼピン誘導体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3393192A (en) * 1965-04-26 1968-07-16 Schering Corp Novel benzazepines
GB1118688A (en) * 1967-02-17 1968-07-03 Scherico Ltd Novel benzazepines and process for making same
US3609138A (en) * 1967-12-22 1971-09-28 Ciba Geigy Corp 1-aryl-3-benzazepines

Also Published As

Publication number Publication date
FR2315934B1 (fr) 1978-11-17
NL7607184A (nl) 1977-01-04
AU507272B2 (en) 1980-02-07
LU75269A1 (fr) 1977-02-18
GB1561305A (en) 1980-02-20
FR2315934A1 (fr) 1977-01-28
IE43920B1 (en) 1981-07-01
AU1554076A (en) 1978-01-05
IL49931A0 (en) 1976-08-31
IE43920L (en) 1977-01-02
IL49931A (en) 1981-12-31
DE2629887A1 (de) 1977-01-20
JPS527981A (en) 1977-01-21

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Legal Events

Date Code Title Description
MKEX Expiry