ZA777444B - Alkylthio-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines having dopaminergic activity - Google Patents

Alkylthio-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines having dopaminergic activity

Info

Publication number
ZA777444B
ZA777444B ZA00777444A ZA777444A ZA777444B ZA 777444 B ZA777444 B ZA 777444B ZA 00777444 A ZA00777444 A ZA 00777444A ZA 777444 A ZA777444 A ZA 777444A ZA 777444 B ZA777444 B ZA 777444B
Authority
ZA
South Africa
Prior art keywords
benzazepines
alkylthio
tetrahydro
dihydroxy
phenyl
Prior art date
Application number
ZA00777444A
Other languages
English (en)
Inventor
K Holden
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of ZA777444B publication Critical patent/ZA777444B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA00777444A 1977-01-19 1977-12-14 Alkylthio-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines having dopaminergic activity ZA777444B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76050077A 1977-01-19 1977-01-19

Publications (1)

Publication Number Publication Date
ZA777444B true ZA777444B (en) 1978-10-25

Family

ID=25059291

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00777444A ZA777444B (en) 1977-01-19 1977-12-14 Alkylthio-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines having dopaminergic activity

Country Status (15)

Country Link
JP (1) JPS6040423B2 (fr)
AU (1) AU510459B2 (fr)
BE (1) BE862878A (fr)
CA (1) CA1090334A (fr)
CH (2) CH642634A5 (fr)
DE (1) DE2802086A1 (fr)
DK (1) DK19978A (fr)
FR (2) FR2378017A1 (fr)
GB (2) GB1597912A (fr)
HU (1) HU175836B (fr)
IE (1) IE46761B1 (fr)
LU (1) LU78873A1 (fr)
NL (1) NL7800637A (fr)
SE (1) SE437265B (fr)
ZA (1) ZA777444B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5481290A (en) * 1977-11-17 1979-06-28 Smithkline Corp Benzazepin compound
US4171359A (en) * 1978-04-12 1979-10-16 Smithkline Corporation Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US4251525A (en) * 1979-05-25 1981-02-17 Smithkline Corporation 3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
ATE5634T1 (de) * 1979-07-10 1984-01-15 Smithkline Beckman Corporation Synergistische blutdrucksenkende zusammensetzungen.
JP2006526021A (ja) * 2003-05-22 2006-11-16 シェーリング　コーポレイション 肥満およびｃｎｓ障害を治療する選択的ｄ１／ｄ５レセプタアンタゴニストとしての５ｈ−ベンゾ［ｄ］ナフト［２，１−ｂ］アゼピン誘導体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH555831A (de) * 1967-02-17 1974-11-15 Scherico Ltd Verfahren zur herstellung von neuen benzazepinen.
US3609139A (en) * 1969-04-01 1971-09-28 Sandoz Ag Substituted dibenzdiazonines
US4011319A (en) * 1975-07-02 1977-03-08 Smithkline Corporation Pharmaceutical compositions and methods involving benzazepine derivatives
GB1561305A (en) * 1975-07-02 1980-02-20 Smithkline Corp Benzazepine derivatives and pharmeceutical compositions containing them

Also Published As

Publication number Publication date
FR2378017A1 (fr) 1978-08-18
IE780111L (en) 1978-07-19
BE862878A (fr) 1978-07-13
CA1090334A (fr) 1980-11-25
SE437265B (sv) 1985-02-18
NL7800637A (nl) 1978-07-21
HU175836B (hu) 1980-10-28
LU78873A1 (fr) 1978-06-09
FR2384759B1 (fr) 1980-07-18
CH640228A5 (en) 1983-12-30
IE46761B1 (en) 1983-09-21
GB1597911A (en) 1981-09-16
JPS6040423B2 (ja) 1985-09-11
AU3246578A (en) 1979-07-26
CH642634A5 (en) 1984-04-30
JPS5390281A (en) 1978-08-08
FR2378017B1 (fr) 1981-07-10
SE7800455L (sv) 1978-07-20
GB1597912A (en) 1981-09-16
AU510459B2 (en) 1980-06-26
FR2384759A1 (fr) 1978-10-20
DK19978A (da) 1978-07-20
DE2802086A1 (de) 1978-07-20

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