FR2369267A1 - 4a-aryl-octahydro-ih-2-pyrindines, a activite analgesique - Google Patents

4a-aryl-octahydro-ih-2-pyrindines, a activite analgesique

Info

Publication number
FR2369267A1
FR2369267A1 FR7732776A FR7732776A FR2369267A1 FR 2369267 A1 FR2369267 A1 FR 2369267A1 FR 7732776 A FR7732776 A FR 7732776A FR 7732776 A FR7732776 A FR 7732776A FR 2369267 A1 FR2369267 A1 FR 2369267A1
Authority
FR
France
Prior art keywords
aryl
pyrindines
octahydro
analgesic activity
nitrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7732776A
Other languages
English (en)
French (fr)
Other versions
FR2369267B1 (nl
Inventor
Dennis Michael Zimmerman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of FR2369267A1 publication Critical patent/FR2369267A1/fr
Application granted granted Critical
Publication of FR2369267B1 publication Critical patent/FR2369267B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/757—Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR7732776A 1976-11-02 1977-10-28 4a-aryl-octahydro-ih-2-pyrindines, a activite analgesique Granted FR2369267A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73795876A 1976-11-02 1976-11-02

Publications (2)

Publication Number Publication Date
FR2369267A1 true FR2369267A1 (fr) 1978-05-26
FR2369267B1 FR2369267B1 (nl) 1980-05-16

Family

ID=24965981

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7732776A Granted FR2369267A1 (fr) 1976-11-02 1977-10-28 4a-aryl-octahydro-ih-2-pyrindines, a activite analgesique

Country Status (26)

Country Link
JP (1) JPS5356669A (nl)
AR (1) AR223454A1 (nl)
AT (1) ATA782177A (nl)
AU (1) AU513679B2 (nl)
BE (1) BE860314A (nl)
CA (1) CA1100136A (nl)
CS (1) CS211380B2 (nl)
DD (1) DD133795A5 (nl)
DE (1) DE2748466A1 (nl)
DK (1) DK485277A (nl)
ES (3) ES463784A1 (nl)
FR (1) FR2369267A1 (nl)
GB (1) GB1590155A (nl)
GR (1) GR70053B (nl)
HU (1) HU176231B (nl)
IE (1) IE45901B1 (nl)
IL (1) IL53236A0 (nl)
NL (1) NL7712053A (nl)
NZ (1) NZ185539A (nl)
PH (1) PH12590A (nl)
PL (3) PL108610B1 (nl)
PT (1) PT67194B (nl)
RO (3) RO77935A (nl)
SE (3) SE7712218L (nl)
SU (3) SU812174A3 (nl)
ZA (1) ZA776497B (nl)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002937A1 (en) * 1977-12-27 1979-07-11 Eli Lilly And Company Novel pyrindines and their preparation, formulations and use

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4277608A (en) * 1979-06-21 1981-07-07 Eli Lilly And Company Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines
US4236009A (en) * 1979-06-21 1980-11-25 Eli Lilly And Company Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines
ZA9510829B (en) * 1994-12-23 1996-07-03 Smithkline Beecham Corp 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds
EP2595989B1 (en) 2010-05-06 2016-07-13 Vertex Pharmaceuticals Incorporated Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
WO2012106499A1 (en) 2011-02-02 2012-08-09 Vertex Pharmaceuticals Incorporated Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels
US10385070B2 (en) 2011-02-18 2019-08-20 Vertex Pharmaceuticals Incorporated Chroman-spirocyclic piperidine amides as modulators of ion channels
US8828996B2 (en) 2011-03-14 2014-09-09 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002937A1 (en) * 1977-12-27 1979-07-11 Eli Lilly And Company Novel pyrindines and their preparation, formulations and use

Also Published As

Publication number Publication date
SE7712218L (sv) 1978-05-03
ZA776497B (en) 1979-06-27
PT67194A (en) 1977-11-01
GB1590155A (en) 1981-05-28
DK485277A (da) 1978-05-03
DE2748466A1 (de) 1978-05-03
FR2369267B1 (nl) 1980-05-16
ES463783A1 (es) 1979-07-16
SU913941A3 (en) 1982-03-15
SE8103107L (sv) 1981-05-18
PL109690B1 (en) 1980-06-30
PL201885A1 (pl) 1978-12-04
PH12590A (en) 1979-06-27
JPS5356669A (en) 1978-05-23
CA1100136A (en) 1981-04-28
SU845777A3 (ru) 1981-07-07
IL53236A0 (en) 1977-12-30
IE45901B1 (en) 1982-12-29
NL7712053A (nl) 1978-05-05
PL108466B1 (en) 1980-04-30
PT67194B (en) 1979-03-23
AU513679B2 (en) 1980-12-18
BE860314A (fr) 1978-04-28
DD133795A5 (de) 1979-01-24
ATA782177A (de) 1981-10-15
PL108610B1 (en) 1980-04-30
HU176231B (en) 1981-01-28
ES463784A1 (es) 1978-06-16
GR70053B (nl) 1982-07-26
ES472276A1 (es) 1979-10-01
SU812174A3 (ru) 1981-03-07
AU3023577A (en) 1979-05-10
SE8103106L (sv) 1981-05-18
RO78300A (ro) 1982-04-12
CS211380B2 (en) 1982-02-26
RO77935A (ro) 1981-12-25
IE45901L (en) 1978-05-02
RO72900A (ro) 1981-11-04
NZ185539A (en) 1979-12-11
AR223454A1 (es) 1981-08-31

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Legal Events

Date Code Title Description
ST Notification of lapse