FR19C1053I1 - Inhibiteurs de co-transporteur 2 de sodium glucose et procedes d'utilisation de ceux-ci - Google Patents

Inhibiteurs de co-transporteur 2 de sodium glucose et procedes d'utilisation de ceux-ci

Info

Publication number
FR19C1053I1
FR19C1053I1 FR19C1053C FR19C1053I1 FR 19C1053 I1 FR19C1053 I1 FR 19C1053I1 FR 19C1053 C FR19C1053 C FR 19C1053C FR 19C1053 I1 FR19C1053 I1 FR 19C1053I1
Authority
FR
France
Prior art keywords
transporter
inhibitors
methods
same
sodium glucose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lexicon Pharmaceuticals Inc
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of FR19C1053I1 publication Critical patent/FR19C1053I1/fr
Application granted granted Critical
Publication of FR19C1053I2 publication Critical patent/FR19C1053I2/fr
Active legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
    • C07D291/02—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms not condensed with other rings
    • C07D291/06—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR19C1053C 2006-09-29 2019-09-19 Inhibiteurs de co-transporteur 2 de sodium glucose et procedes d'utilisation de ceux-ci Active FR19C1053I2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84815606P 2006-09-29 2006-09-29
US90571407P 2007-03-08 2007-03-08
US94878007P 2007-07-10 2007-07-10
PCT/US2007/079654 WO2008042688A2 (fr) 2006-09-29 2007-09-27 Inhibiteurs de co-transporteur 2 de sodium glucose et procédés d'utilisation de ceux-ci

Publications (2)

Publication Number Publication Date
FR19C1053I1 true FR19C1053I1 (fr) 2019-11-15
FR19C1053I2 FR19C1053I2 (fr) 2020-04-03

Family

ID=38947681

Family Applications (1)

Application Number Title Priority Date Filing Date
FR19C1053C Active FR19C1053I2 (fr) 2006-09-29 2019-09-19 Inhibiteurs de co-transporteur 2 de sodium glucose et procedes d'utilisation de ceux-ci

Country Status (24)

Country Link
US (5) US7781577B2 (fr)
EP (2) EP2308841B1 (fr)
JP (3) JP5283625B2 (fr)
KR (2) KR20150002889A (fr)
AR (1) AR063047A1 (fr)
AT (1) ATE496888T1 (fr)
AU (1) AU2007304971B2 (fr)
BR (1) BRPI0717156B8 (fr)
CA (1) CA2664688C (fr)
DE (1) DE602007012292D1 (fr)
DK (2) DK2308841T3 (fr)
EA (1) EA016511B1 (fr)
ES (1) ES2477216T3 (fr)
FR (1) FR19C1053I2 (fr)
HU (1) HUS1900038I1 (fr)
IL (1) IL197836A (fr)
MX (1) MX2009003305A (fr)
NL (1) NL301003I2 (fr)
NO (1) NO345139B1 (fr)
NZ (1) NZ575811A (fr)
PL (2) PL2308841T3 (fr)
PT (2) PT2308841E (fr)
TW (1) TWI499414B (fr)
WO (1) WO2008042688A2 (fr)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI499414B (zh) * 2006-09-29 2015-09-11 Lexicon Pharmaceuticals Inc 鈉與葡萄糖第２型共同運輸體（ｃｏ-ｔｒａｎｓｐｏｒｔｅｒ ２）的抑制物與其應用方法
WO2008109591A1 (fr) * 2007-03-08 2008-09-12 Lexicon Pharmaceuticals, Inc. Analogues de phlorizine utilisés comme inhibiteurs du co-transporteur 2 du sodium-glucose
CA2694029C (fr) * 2007-07-26 2016-10-04 Lexicon Pharmaceuticals, Inc. Procedes et composes utiles pour la preparation d'inhibiteurs de co-transporteur 2 de sodium-glucose
EP2025674A1 (fr) 2007-08-15 2009-02-18 sanofi-aventis Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament
BRPI0916769A2 (pt) 2008-07-15 2017-09-26 Theracos Inc derivados de benzilbenzeno deuterados e métodos de uso
TWI472521B (zh) * 2008-07-17 2015-02-11 Lexicon Pharmaceuticals Inc （２ｓ，３ｒ，４ｒ，５ｓ，６ｒ）－２－（４－氯－３－（４－乙氧苄基）苯基）－６－（甲硫）四氫－２ｈ－哌喃－３，４，５－三醇的固體形態與其使用方法
NZ599945A (en) 2009-11-02 2014-05-30 Pfizer Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives
WO2011070592A2 (fr) 2009-12-09 2011-06-16 Panacea Biotec Ltd. Nouveaux dérivés de sucres
TWI562775B (en) * 2010-03-02 2016-12-21 Lexicon Pharmaceuticals Inc Methods of using inhibitors of sodium-glucose cotransporters 1 and 2
WO2011107494A1 (fr) 2010-03-03 2011-09-09 Sanofi Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
WO2012025857A1 (fr) * 2010-08-23 2012-03-01 Hetero Research Foundation Dérivés de cycloalkyl méthoxybenzyl phényl pyrane en tant qu'inhibiteurs du cotransporteur de glucose sodium-dépendant (sglt2)
CN102453026A (zh) * 2010-10-27 2012-05-16 上海艾力斯医药科技有限公司 C-芳基葡糖苷衍生物、制备方法及其应用
TWI631963B (zh) * 2011-01-05 2018-08-11 雷西肯製藥股份有限公司 包含鈉－葡萄糖共同輸送體１與２之抑制劑的組合物與應用方法
ES2719656T3 (es) * 2011-06-01 2019-07-11 Green Cross Corp Derivados de difenilmetano novedosos como inhibidores del SGLT2
JP5835598B2 (ja) 2011-06-03 2015-12-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 神経弛緩剤で治療されている患者において代謝性障害を治療するためのｓｇｌｔ−２阻害剤
WO2012172566A2 (fr) * 2011-06-13 2012-12-20 Panacea Biotec Ltd. Nouveaux inhibiteurs sglt
WO2013037390A1 (fr) 2011-09-12 2013-03-21 Sanofi Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
JP2014530186A (ja) 2011-09-13 2014-11-17 パナセア バイオテック リミテッド 新規ｓｇｌｔ阻害剤
EP2760862B1 (fr) 2011-09-27 2015-10-21 Sanofi Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique utilisés comme inhibiteurs de kinase
WO2014081660A1 (fr) * 2012-11-20 2014-05-30 Lexicon Pharmaceuticals, Inc. Inhibiteurs du cotransporteur sodium glucose 1
CN104955481B (zh) 2013-02-04 2017-10-24 大正制药株式会社 便秘症的预防或治疗药
CN103073606B (zh) * 2013-02-05 2016-05-18 中国医药研究开发中心有限公司 5’-s-(4,4’-二甲氧基三苯甲基)-2’-脱氧肌苷的合成与制备方法
EP4245765A3 (fr) 2013-04-04 2024-03-20 Boehringer Ingelheim Vetmedica GmbH Traitement de troubles metaboliques chez des animaux equins
DK3082829T3 (da) 2013-12-17 2021-05-03 Boehringer Ingelheim Vetmedica Gmbh Sglt2-inhibitorer til behandlingen af metaboliske lidelser i kattedyr
DK3096765T3 (en) 2014-01-23 2019-03-04 Boehringer Ingelheim Vetmedica Gmbh Treatment of metabolic disorders in dogs
ES2811261T3 (es) 2014-04-01 2021-03-11 Boehringer Ingelheim Vetmedica Gmbh Tratamiento de trastornos metabólicos en animales equinos
WO2016046150A1 (fr) 2014-09-25 2016-03-31 Boehringer Ingelheim Vetmedica Gmbh Polythérapie avec des inhibiteurs de sglt2 et des agonistes de la dopamine utilisée pour la prévention des troubles métaboliques chez des équidés
AU2016310535B2 (en) 2015-08-27 2021-08-19 Boehringer Ingelheim Vetmedica Gmbh Liquid pharmaceutical compositions comprising SGLT-2 inhibitors
EP3466958B1 (fr) * 2016-05-25 2020-04-29 Crystal Pharmaceutical (Suzhou) Co., Ltd. Nouvelles formes cristallines d'un médicament inhibiteur des cotransporteurs de sodium-glucose, leur procédé de préparation et leur utilisation
JP2019531320A (ja) 2016-10-19 2019-10-31 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｓｓａｏ／ｖａｐ−１阻害剤とｓｇｌｔ２阻害剤とを含む組合せ、その使用
CN111372930B (zh) * 2018-01-05 2021-08-10 山东丹红制药有限公司 一种SGLTs抑制剂及其应用
WO2019166958A1 (fr) * 2018-02-28 2019-09-06 Mylan Laboratories Ltd Procédé pour la préparation de sotagliflozine
WO2019201752A1 (fr) 2018-04-17 2019-10-24 Boehringer Ingelheim International Gmbh Composition pharmaceutique, méthodes de traitement et utilisations associées
US20210238170A1 (en) * 2018-05-09 2021-08-05 Janssen Pharmaceutica Nv 5,5-Difluoro- and 5-Fluoro-5-Methyl-C-Glycoside Derivatives Useful As Dual SGLT1 / SGLT2 Modulators
WO2020039394A1 (fr) 2018-08-24 2020-02-27 Novartis Ag Nouvelles combinaisons de médicaments
WO2020180647A1 (fr) * 2019-03-01 2020-09-10 Lexicon Pharmaceuticals, Inc. Utilisation de sotagliflozine pour le traitement de patients atteints de diabète sucré de type 1
WO2021004388A1 (fr) 2019-07-05 2021-01-14 山东丹红制药有限公司 Forme cristalline d'inhibiteur de sglt et son application
US20220259247A1 (en) 2019-07-26 2022-08-18 Dongbao Purple Star (Hangzhou) Biopharmaceutical Co., Ltd. Sglts/dpp4 inhibitor and application thereof
EP4006017A4 (fr) * 2019-07-26 2023-09-06 Medshine Discovery Inc. Inhibiteur de sglt2/dpp4 et son application
BR112022010385A2 (pt) 2019-11-28 2022-08-23 Boehringer Ingelheim Vetmedica Gmbh Uso de inibidores de sglt-2 na secagem de mamíferos não humanos
EP4106744A1 (fr) 2020-02-17 2022-12-28 Boehringer Ingelheim Vetmedica GmbH Utilisation d'inhibiteurs de sglt-2 pour la prévention et/ou le traitement de maladies cardiaques chez les félins
CN111763197A (zh) * 2020-07-08 2020-10-13 青岛大学 一种新型手性吲哚类化合物的合成方法
KR20240041966A (ko) 2021-07-28 2024-04-01 베링거잉겔하임베트메디카게엠베하 고양이를 제외한 비인간 포유류, 특히 개에서 심장 질환의 예방 및/또는 치료를 위한 sglt-2 억제제의 용도
CN117715639A (zh) 2021-07-28 2024-03-15 勃林格殷格翰动物保健有限公司 Sglt-2抑制剂用于预防和/或治疗非人哺乳动物中的肾脏病的用途
EP4376819A1 (fr) 2021-07-28 2024-06-05 Boehringer Ingelheim Vetmedica GmbH Utilisation d'inhibiteurs de sglt-2 pour la prévention et/ou le traitement de l'hypertension chez des mammifères non humains
WO2023227492A1 (fr) 2022-05-25 2023-11-30 Boehringer Ingelheim Vetmedica Gmbh Compositions pharmaceutiques aqueuses comprenant des inhibiteurs de sglt-2

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3870699A (en) * 1973-03-06 1975-03-11 Upjohn Co Lincomycin analogs
CN1020944C (zh) 1990-01-30 1993-05-26 阿图尔-费希尔股份公司费希尔厂 紧固件
WO1995016049A1 (fr) 1993-12-08 1995-06-15 The Scripps Research Institute Synthese asymetrique chimioenzymatique catalytique d'hydrates de carbone
US6214331B1 (en) * 1995-06-06 2001-04-10 C. R. Bard, Inc. Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained
JP2885191B2 (ja) 1996-07-09 1999-04-19 日本電気株式会社 液晶プロジェクタ
JP3928197B2 (ja) 1997-01-23 2007-06-13 住友化学株式会社 アリール置換芳香族類の製造方法
US6664399B1 (en) 1999-09-02 2003-12-16 E. I. Du Pont De Nemours & Company Triazole linked carbohydrates
US6515117B2 (en) 1999-10-12 2003-02-04 Bristol-Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
PH12000002657B1 (en) 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
TR200202200T2 (tr) 2000-03-17 2002-12-23 Kissei Pharmaceutical Co., Ltd. Glükopiranosiloksibenzilbenzen türevleri, bu türevleri ihtiva eden tıbbi bileşimler ve türevlerin hazırlanması için ara-maddeler.
US6683056B2 (en) 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
US6555519B2 (en) 2000-03-30 2003-04-29 Bristol-Myers Squibb Company O-glucosylated benzamide SGLT2 inhibitors and method
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
AU2002223127A1 (en) 2000-11-30 2002-06-11 Kissei Pharmaceutical Co., Ltd. Intellectual Property Glucopyranosyloxybenzyl benzene derivatives, medicinal compositions containing the same and intermediates in the production thereof
SI1354888T1 (sl) 2000-12-28 2009-10-31 Kissei Pharmaceutical Glukopiranoziloksipirazolni derivati in njihova uporaba v zdravilih
US6936590B2 (en) 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
EP1385856B1 (fr) 2001-04-11 2006-02-22 Bristol-Myers Squibb Company Complexes acides amines de glugocides c-aryle pour le traitement du diabete et procede correspondant
FR2826653B1 (fr) 2001-06-29 2005-10-14 Servier Lab Nouveaux derives de pyrido-pyrido-pyrrolo[3,2-g]pyrrolo [3,4-e]-indole et pyrido-pyrrolo[2,3-a]pyrrolo[3,4-c] carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2003011880A1 (fr) 2001-07-31 2003-02-13 Kissei Pharmaceutical Co., Ltd. Derive de glucopyranosyloxybenzylbenzene, composition medicinale contenant ce derive, usage medicinal de cette composition et produit intermediaire pour produire cette composition
AR034985A1 (es) 2001-08-08 2004-03-24 Takeda Chemical Industries Ltd Compuesto biciclico; produccion y uso del mismo
WO2003020737A1 (fr) 2001-09-05 2003-03-13 Bristol-Myers Squibb Company Inhibiteurs de sglt2 contenant du glucoside de o-pyrazole et methode d'utilisation
WO2003022861A1 (fr) 2001-09-13 2003-03-20 Bristol-Myers Squibb Company Procede de preparation de rebeccamycine et d'analogues correspondants
FR2831169B1 (fr) 2001-10-22 2003-12-12 Servier Lab Nouveaux derives d'hydroxyalkyle indolocarbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7521568B2 (en) 2001-12-14 2009-04-21 Purdue Research Foundation Enantiopure 4-deoxypentenosides, dihydropyrans and tetrahydropyrans and syntheses thereof
US6927294B1 (en) * 2002-03-08 2005-08-09 University Of Southern California Nitrogen-containing heterocycles
DE10213228A1 (de) 2002-03-25 2003-10-16 Bayer Ag Cyclopenten-Derivate
US6562791B1 (en) 2002-03-29 2003-05-13 Council Of Scientific And Industrial Research Glucopyranoside, process for isolation thereof, pharmaceutical composition containing same and use thereof
CA2478889A1 (fr) * 2002-08-09 2004-02-19 Taisho Pharmaceutical Co., Ltd. Derives aryle 5-thio-.beta.-d-glucopyranoside et agents therapeutiques pour le diabete contenant ces derives
AU2002951247A0 (en) 2002-09-06 2002-09-19 Alchemia Limited Compounds that interact with kinases
FR2845995A1 (fr) 2002-10-16 2004-04-23 Servier Lab Nouveaux derives de pyrrolo[3,4-c]carbazole et de pyrido[2,3-b]pyrrolo[3,4-e]indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2845996A1 (fr) 2002-10-16 2004-04-23 Servier Lab Nouveaux derives de[3,4-a:3,4-c]carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2004050122A1 (fr) 2002-12-04 2004-06-17 Kissei Pharmaceutical Co., Ltd. Prevention ou traitement de maladies dues a l'hyperglycemie
DE10258007B4 (de) 2002-12-12 2006-02-09 Sanofi-Aventis Deutschland Gmbh Aromatische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
DE10258008B4 (de) 2002-12-12 2006-02-02 Sanofi-Aventis Deutschland Gmbh Heterocyclische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
WO2004058790A1 (fr) 2002-12-25 2004-07-15 Kissei Pharmaceutical Co., Ltd. Derives heterocycliques contenant de l'azote, compositions medicinales contenant lesdits derives et utilisation medicale desdits derives
EP1581543A4 (fr) 2003-01-03 2008-03-19 Bristol Myers Squibb Co Procedes de production d'inhibiteurs de c-aryle glucoside sglt2
TWI310033B (en) 2003-03-14 2009-05-21 Yamanouchi Pharma Co Ltd C-glycoside derivatives or salts thereof
WO2004089966A1 (fr) 2003-04-01 2004-10-21 Taisho Pharmaceutical Co., Ltd. Procede de preparation selective de 5-thio-$g(b)-d-aldohexopyranoside heteroaryle
US7439232B2 (en) 2003-04-01 2008-10-21 Taisho Pharmaceutical Co., Ltd. Heteroaryl 5-thio-β-D-glucopyranoside derivatives and therapeutic agents for diabetes containing the same
WO2005012318A2 (fr) 2003-08-01 2005-02-10 Janssen Pharmaceutica Nv C-glycosides heterocycliques fusionnes substitues
UA86042C2 (en) 2003-08-01 2009-03-25 Янссен Фармацевтика Н.В. Substituted indazole-o-glucosides
RS20060320A (en) 2003-08-01 2008-08-07 Janssen Pharmaceutica N.V., Substituted indazole-o-glucosides
CA2549022A1 (fr) 2003-08-01 2005-02-10 Janssen Pharmaceutica N.V. Benzimidazole-, benztriazole- et benzimidazolone-o-glucosides substitues
CA2549025A1 (fr) 2003-08-01 2005-02-10 Janssen Pharmaceutica N.V. Indole-o-glucosides substitues
ATE422204T1 (de) 2003-08-26 2009-02-15 Boehringer Ingelheim Int Glucopyranosyloxy-pyrazole, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
US7375090B2 (en) 2003-08-26 2008-05-20 Boehringer Ingelheim International Gmbh Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof
AU2004280256A1 (en) 2003-10-08 2005-04-21 Organix, Inc. Pyrovalerone analogs and therapeutic uses thereof
US7371732B2 (en) 2003-12-22 2008-05-13 Boehringer Ingelheim International Gmbh Glucopyranosyloxy-substituted aromatic compounds, medicaments containing such compounds, their use and process for their manufacture
DE102004017793A1 (de) 2004-02-21 2005-09-08 Biofrontera Discovery Gmbh Trioxacarcine und deren Verwendung
EP1718724B1 (fr) 2004-02-24 2008-08-27 Novozymes A/S Stabilisation d'enzyme dans des detergents liquides
WO2005085265A1 (fr) 2004-03-04 2005-09-15 Kissei Pharmaceutical Co., Ltd. Derive heterocyclique accole, composition medicamenteuse en contenant, et son utilisation medicamenteuse
SG151271A1 (en) 2004-03-16 2009-04-30 Boehringer Ingelheim Int Glucopyranosyl-substituted benzol derivatives, drugs containing said compounds, the use thereof and method for the production thereof
WO2006002233A2 (fr) 2004-06-22 2006-01-05 Wall, Michael, A. Alvaradoines e-n, nouveaux composes anthracenone g-glycosides cytotoxiques et antitumoraux
US7393836B2 (en) * 2004-07-06 2008-07-01 Boehringer Ingelheim International Gmbh D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
JP5080974B2 (ja) 2004-07-08 2012-11-21 チバ ホールディング インコーポレーテッド α−ヒドロキシ及びα−アミノケトンの製造
CN1984898A (zh) 2004-07-08 2007-06-20 安斯泰来制药有限公司 生产薁衍生物的方法和合成该薁衍生物的中间体
DE102004034690A1 (de) 2004-07-17 2006-02-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Methyliden-D-xylopyranosyl-und Oxo-D-xylopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
JP5010918B2 (ja) 2004-07-21 2012-08-29 キッセイ薬品工業株式会社 肝臓脂肪の異常蓄積に起因する疾患の進展抑制剤
TW200606129A (en) 2004-07-26 2006-02-16 Chugai Pharmaceutical Co Ltd Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same
CA2574451A1 (fr) 2004-07-27 2006-02-02 Boehringer Ingelheim International Gmbh Cyclenes substitues par d-glucopyranosyle-phenyle, medicaments contenant lesdits composes, leur utilisation et procede de production correspondant
DE102004039096A1 (de) 2004-08-11 2006-02-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg D-Xylopyranosyl-phenyl-substituierte Cyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
WO2006018150A1 (fr) * 2004-08-11 2006-02-23 Boehringer Ingelheim International Gmbh Cycles a substitution d-xylopyranosyl-phenyle, medicaments contenant ces composes, leur utilisation, et leur procede de production
DE102004046583A1 (de) 2004-09-23 2006-03-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg D-Xylopyranosyl-phenyl-substituierte Cyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE102004048388A1 (de) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg D-Pyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
JP2008515821A (ja) 2004-10-06 2008-05-15 レセプトイコン・アンパルトセルスカブ 薬物誘発性細胞毒性の予防のための化合物の使用
US7622451B2 (en) 2004-11-03 2009-11-24 University Of Kansas Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
WO2006050501A2 (fr) 2004-11-03 2006-05-11 University Of Kansas Analogues de novobiocine en tant qu'agents anticancereux
TW200637839A (en) 2005-01-07 2006-11-01 Taisho Pharmaceutical Co Ltd 1-thio-d-glucitol derivatives
JP5264183B2 (ja) 2005-02-23 2013-08-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング グルコピラノシル置換（（ヘテロ）アリールエチニル−ベンジル）−ベンゼン誘導体及びナトリウム依存性グルコース共輸送体２（ｓｇｌｔ２）インヒビターとしてのそれらの使用
RU2407745C2 (ru) 2005-03-25 2010-12-27 Инспайр Фармасьютикалз, Инк. Цитоскелетоактивные соединения, композиция и применение
US20060240496A1 (en) 2005-04-21 2006-10-26 Lakshmi Anne Immunogens, derivatives and immunoassay for ethyl glucuronide
US7723309B2 (en) 2005-05-03 2010-05-25 Boehringer Ingelheim International Gmbh Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments
DE602006017566D1 (de) 2005-08-30 2010-11-25 Boehringer Ingelheim Pharma Glucopyranosyl-substituierte benzyl-derivate, medikamente mit solchen verbindungen, ihre verwendung und herstellungsverfahren dafür
US8253752B2 (en) 2006-07-20 2012-08-28 Qualcomm Incorporated Method and apparatus for encoder assisted pre-processing
EP2049524A2 (fr) 2006-07-24 2009-04-22 Tetralogic Pharmaceuticals Corporation Inhibiteurs des iap
TWI499414B (zh) * 2006-09-29 2015-09-11 Lexicon Pharmaceuticals Inc 鈉與葡萄糖第２型共同運輸體（ｃｏ-ｔｒａｎｓｐｏｒｔｅｒ ２）的抑制物與其應用方法
US20080107744A1 (en) * 2006-11-06 2008-05-08 Jack Fa-De Chu Injectable hollow tissue filler
WO2008109591A1 (fr) 2007-03-08 2008-09-12 Lexicon Pharmaceuticals, Inc. Analogues de phlorizine utilisés comme inhibiteurs du co-transporteur 2 du sodium-glucose
CA2694029C (fr) 2007-07-26 2016-10-04 Lexicon Pharmaceuticals, Inc. Procedes et composes utiles pour la preparation d'inhibiteurs de co-transporteur 2 de sodium-glucose
US8015005B2 (en) 2008-02-15 2011-09-06 Motorola Mobility, Inc. Method and apparatus for voice searching for stored content using uniterm discovery
TWI472521B (zh) 2008-07-17 2015-02-11 Lexicon Pharmaceuticals Inc （２ｓ，３ｒ，４ｒ，５ｓ，６ｒ）－２－（４－氯－３－（４－乙氧苄基）苯基）－６－（甲硫）四氫－２ｈ－哌喃－３，４，５－三醇的固體形態與其使用方法
WO2014081660A1 (fr) * 2012-11-20 2014-05-30 Lexicon Pharmaceuticals, Inc. Inhibiteurs du cotransporteur sodium glucose 1

Also Published As

Publication number Publication date
IL197836A (en) 2014-01-30
IL197836A0 (en) 2009-12-24
TW200826929A (en) 2008-07-01
ATE496888T1 (de) 2011-02-15
BRPI0717156B8 (pt) 2021-05-25
CA2664688C (fr) 2015-03-17
US7781577B2 (en) 2010-08-24
NZ575811A (en) 2011-10-28
JP2010504998A (ja) 2010-02-18
JP2015120736A (ja) 2015-07-02
EP2308841A3 (fr) 2011-10-26
JP5701845B2 (ja) 2015-04-15
PL2308841T3 (pl) 2014-09-30
DK2308841T3 (da) 2014-06-30
PL2089361T3 (pl) 2011-06-30
BRPI0717156A2 (pt) 2013-10-15
KR101492277B1 (ko) 2015-02-11
US9365602B2 (en) 2016-06-14
DK2089361T3 (da) 2011-04-18
ES2477216T3 (es) 2014-07-16
AR063047A1 (es) 2008-12-23
JP5889453B2 (ja) 2016-03-22
AU2007304971A1 (en) 2008-04-10
KR20090061072A (ko) 2009-06-15
TWI499414B (zh) 2015-09-11
US20190099436A1 (en) 2019-04-04
AU2007304971B2 (en) 2013-06-20
NO345139B1 (no) 2020-10-12
US20080113922A1 (en) 2008-05-15
DK2089361T5 (da) 2012-01-16
PT2089361E (pt) 2011-05-02
US20170087172A1 (en) 2017-03-30
US8476413B2 (en) 2013-07-02
DE602007012292D1 (de) 2011-03-10
NL301003I1 (fr) 2019-09-02
FR19C1053I2 (fr) 2020-04-03
NO20091700L (no) 2009-06-16
MX2009003305A (es) 2009-05-28
JP5283625B2 (ja) 2013-09-04
EP2089361B1 (fr) 2011-01-26
EP2308841A2 (fr) 2011-04-13
WO2008042688A3 (fr) 2008-06-12
PT2308841E (pt) 2014-06-11
EP2089361A2 (fr) 2009-08-19
CA2664688A1 (fr) 2008-04-10
HUS1900038I1 (hu) 2019-09-30
BRPI0717156B1 (pt) 2020-06-30
EA200970337A1 (ru) 2009-08-28
US20100311673A1 (en) 2010-12-09
EP2308841B1 (fr) 2014-04-16
KR20150002889A (ko) 2015-01-07
US20140135277A1 (en) 2014-05-15
NL301003I2 (nl) 2019-10-29
PL2089361T4 (pl) 2012-09-28
WO2008042688A2 (fr) 2008-04-10
EA016511B1 (ru) 2012-05-30
JP2013079243A (ja) 2013-05-02

Similar Documents

Publication Publication Date Title
FR19C1053I2 (fr) Inhibiteurs de co-transporteur 2 de sodium glucose et procedes d'utilisation de ceux-ci
FR20C1033I1 (fr) Anticorps anti-cd79b, immuno-conjugues et procedes d'utilisation
ZA201000219B (en) Methods and compounds useful for the preparation of sodium glucose co-transporter 2 inhibitors
CY2014012I1 (el) Χορηγηση αναστολεων διπεπτιδυλοπεπτιδασης
HK1183020A1 (zh) 鈉-葡萄糖協同轉運蛋白 的抑制劑及其用法
MA28802B1 (fr) Utilisations therapeutiques d'inhibiteurs de rtp801
DK1989206T3 (da) E1-aktiveringsenzymhæmmere
DE602005022454D1 (de) Enzymatische nachweistechniken
DK1848718T3 (da) E1 aktiveringsenzymhæmmere
MA30684B1 (fr) Anticorps anti-mn et leurs procedes d'utilisation.
DE60301868D1 (de) Blutzuckerspiegelmessgerät
FR2897664B1 (fr) Garnitures d'etancheite et procede d'utilisation.
DK2035001T3 (da) Stabile laquinimod-tilberedninger
BRPI0716354A2 (pt) "composiÇço e mÉtodo"
DK2049557T3 (da) 1-(-D-glycopyranosyl)-3-(4-cyclopropylphenylmethyl)-4-halogenindolderivater og anvendelse heraf som sglt-inhibitorer
MA28582B1 (fr) Composes de thieno-pyridinone et procedes de traitement associes
DK2377931T3 (da) Varianter af glycosidhydrolase
DE502005000109D1 (de) Chirurgisches instrumentensystem
FR2900549B1 (fr) Ensemble de conditionnement et d'application
NO20054188D0 (no) Et arrangement av fagverksstag
JP2006502186A5 (ja) β-グルカンの使用
FI20020210A (fi) Moniprosessoriympäristöön tarkoitettu laitteistopohjainen opastin
FR2905620B1 (fr) Machine-outil notamment de percage-rivetage et ses procedes de travail
BRPI0716374A2 (pt) "dispositivos médicos"
DE112006003699A5 (de) Auslenkbares mikromechanisches System sowie dessen Verwendung