FI961537A - Butyrobetaiini/krotonobetaiini-L-karnitiiniaineenvaihduntaan liittyviägeenejä ja niiden käyttö L-karnitiinin mikrobiologiseen valmistukseen - Google Patents

Butyrobetaiini/krotonobetaiini-L-karnitiiniaineenvaihduntaan liittyviägeenejä ja niiden käyttö L-karnitiinin mikrobiologiseen valmistukseen Download PDF

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Publication number
FI961537A
FI961537A FI961537A FI961537A FI961537A FI 961537 A FI961537 A FI 961537A FI 961537 A FI961537 A FI 961537A FI 961537 A FI961537 A FI 961537A FI 961537 A FI961537 A FI 961537A
Authority
FI
Finland
Prior art keywords
carnitine
butyrobetaine
crotonobetaine
gamma
coding
Prior art date
Application number
FI961537A
Other languages
English (en)
Swedish (sv)
Other versions
FI118568B (fi
FI961537A0 (fi
Inventor
Thomas Zimmermann
Josef Werlen
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of FI961537A publication Critical patent/FI961537A/fi
Publication of FI961537A0 publication Critical patent/FI961537A0/fi
Application granted granted Critical
Publication of FI118568B publication Critical patent/FI118568B/fi

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/007—Carnitine; Butyrobetaine; Crotonobetaine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/743—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Agrobacterium; Rhizobium; Bradyrhizobium

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  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI961537A 1993-10-08 1996-04-04 Butyrobetaiini/krotonobetaiini-L-karnitiiniaineenvaihduntaan liittyviä geenejä ja niiden käyttö L-karnitiinin mikrobiologiseen valmistukseen FI118568B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CH303693 1993-10-08
CH303693 1993-10-08
CH3694 1994-01-06
CH3694 1994-01-06
PCT/EP1994/003317 WO1995010613A1 (de) 1993-10-08 1994-10-07 Gene für den butyrobetain/crotonobetain-l-carnitin-stoffwechsel und ihre verwendung zur mikrobiologischen herstellung von l-carnitin
EP9403317 1994-10-07

Publications (3)

Publication Number Publication Date
FI961537A true FI961537A (fi) 1996-04-04
FI961537A0 FI961537A0 (fi) 1996-04-04
FI118568B FI118568B (fi) 2007-12-31

Family

ID=25683317

Family Applications (1)

Application Number Title Priority Date Filing Date
FI961537A FI118568B (fi) 1993-10-08 1996-04-04 Butyrobetaiini/krotonobetaiini-L-karnitiiniaineenvaihduntaan liittyviä geenejä ja niiden käyttö L-karnitiinin mikrobiologiseen valmistukseen

Country Status (17)

Country Link
US (1) US5759824A (fi)
EP (1) EP0722500B1 (fi)
JP (1) JP3708543B2 (fi)
KR (1) KR100346293B1 (fi)
CN (2) CN1157480C (fi)
AT (1) ATE257515T1 (fi)
AU (1) AU7854694A (fi)
CA (1) CA2173115C (fi)
CZ (1) CZ288247B6 (fi)
DE (1) DE59410350D1 (fi)
FI (1) FI118568B (fi)
HU (1) HU220798B1 (fi)
NO (1) NO319058B1 (fi)
PL (1) PL180300B1 (fi)
RU (1) RU2133773C1 (fi)
SK (1) SK280580B6 (fi)
WO (1) WO1995010613A1 (fi)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6337197B2 (en) 1998-10-27 2002-01-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Coenzymes useful for the synthesis of L-carnitine
PT1151130E (pt) 1998-10-27 2005-06-30 Sigma Tau Ind Farmaceuti Coenzima utilizada na sintese de l-carnitina
DE19850433A1 (de) * 1998-10-27 2000-05-25 Sigma Tau Ind Farmaceuti Crotonobetainyl-Coenzym A, Verfahren zu seiner Herstellung
DE19850426A1 (de) * 1998-10-27 2000-05-04 Sigma Tau Ind Farmaceuti gamma-Butyrobetainyl-Coenzym A und Verfahren zu seiner Herstellung
US6720168B2 (en) 2000-08-04 2004-04-13 Genencor International, Inc. 2,5-DKG permeases
WO2002012481A2 (en) * 2000-08-04 2002-02-14 Genencor International, Inc. Enhancement of industrial production by increasing substrate transport
DE50209655D1 (de) * 2001-01-31 2007-04-19 Lonza Ag Mikrobiologisches verfahren zur herstellung von l-carnitin
US7229811B2 (en) 2001-08-03 2007-06-12 Genencor International, Inc. 2,5-diketo-D-gluconic acid (2,5-DKG) permeases
ATE531803T1 (de) 2003-06-05 2011-11-15 Ajinomoto Kk Fermentierungsverfahren mittels veränderter bakterien mit einer erhöhten aufnahme von nebenprodukten
KR101166026B1 (ko) 2004-07-12 2012-07-19 씨제이제일제당 (주) 뉴로스포라 크라사 유래 ｌ-카르니틴 생합성 관련유전자를 포함하는 엔테로박테리아세 속 미생물 및 이를이용한 ｌ-카르니틴의 제조방법
BRPI0612611A2 (pt) 2005-07-05 2010-12-07 Lonza Ag processo de secagem por pulverização para produzir um pó ou granulado seco de carnitina
JP4639235B2 (ja) * 2005-07-19 2011-02-23 シージェイ チェイルジェダン コーポレーション Ｌ−カルニチン生合成関連遺伝子を含む腸内細菌属微生物、およびその微生物を用いたｌ−カルニチンの産生方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59192095A (ja) * 1983-04-13 1984-10-31 Ajinomoto Co Inc Ｌ−カルニチンの製造法
IE902689A1 (en) * 1989-07-28 1991-02-27 Lonza Ag A method of discontinuous production of l-carnitine by a¹microbiological process
IT1240833B (it) * 1990-05-14 1993-12-17 Sigma Tau Ind Farmaceuti Procedimento biocatalitico per la produzione di l-(-)- carnitina da crotonilbetaina e ceppi di proteeae per l'uso in tale procedimento
RU2099418C1 (ru) * 1991-11-21 1997-12-20 Лонца Аг Фрагмент днк, обеспечивающий использование бетаина, рекомбинантная плазмидная днк с фрагментом днк, обеспечивающим использование бетаина, штамм бактерий rhizobium/agrobacterium, предназначенный для стабильного хранения плазмиды с фрагментом днк, способ получения штамма бактерий

Also Published As

Publication number Publication date
PL180300B1 (pl) 2001-01-31
EP0722500A1 (de) 1996-07-24
EP0722500B1 (de) 2004-01-07
NO961385D0 (no) 1996-04-03
RU2133773C1 (ru) 1999-07-27
CA2173115A1 (en) 1995-04-20
CZ100596A3 (en) 1996-10-16
SK43196A3 (en) 1996-10-02
HUT74825A (en) 1997-02-28
DE59410350D1 (de) 2004-02-12
ATE257515T1 (de) 2004-01-15
CN1133066A (zh) 1996-10-09
AU7854694A (en) 1995-05-04
CZ288247B6 (en) 2001-05-16
SK280580B6 (sk) 2000-04-10
CN1058523C (zh) 2000-11-15
PL313968A1 (en) 1996-08-05
HU220798B1 (hu) 2002-05-28
NO319058B1 (no) 2005-06-13
FI118568B (fi) 2007-12-31
CN1157480C (zh) 2004-07-14
JP3708543B2 (ja) 2005-10-19
NO961385L (no) 1996-06-03
CN1282791A (zh) 2001-02-07
WO1995010613A1 (de) 1995-04-20
KR100346293B1 (ko) 2002-11-30
US5759824A (en) 1998-06-02
FI961537A0 (fi) 1996-04-04
JPH09503390A (ja) 1997-04-08
CA2173115C (en) 2005-07-26

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