FI960482A7 - Matriksin metalloproteaasien inhibiittorit - Google Patents

Matriksin metalloproteaasien inhibiittorit

Info

Publication number
FI960482A7
FI960482A7 FI960482A FI960482A FI960482A7 FI 960482 A7 FI960482 A7 FI 960482A7 FI 960482 A FI960482 A FI 960482A FI 960482 A FI960482 A FI 960482A FI 960482 A7 FI960482 A7 FI 960482A7
Authority
FI
Finland
Prior art keywords
matrix metalloprotease
metalloprotease inhibitors
inhibitors
matrix
metalloprotease
Prior art date
Application number
FI960482A
Other languages
English (en)
Swedish (sv)
Other versions
FI960482A0 (fi
FI112660B (fi
Inventor
L Arlindo Castelhano
J Teng Liak
Stephen Horne
Zhengyo Yuan
Alexander Krantz
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of FI960482A0 publication Critical patent/FI960482A0/fi
Publication of FI960482A7 publication Critical patent/FI960482A7/fi
Application granted granted Critical
Publication of FI112660B publication Critical patent/FI112660B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI960482A 1993-08-05 1996-02-02 Menetelmä matriksin metalloproteaasien inhibiittoreina käyttökelpoisten trisyklisten indolijohdannaisten valmistamiseksi FI112660B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10265593A 1993-08-05 1993-08-05
US10265593 1993-08-05
US9408510 1994-07-27
PCT/US1994/008510 WO1995004735A1 (en) 1993-08-05 1994-07-27 Matrix metalloprotease inhibitors

Publications (3)

Publication Number Publication Date
FI960482A0 FI960482A0 (fi) 1996-02-02
FI960482A7 true FI960482A7 (fi) 1996-02-02
FI112660B FI112660B (fi) 2003-12-31

Family

ID=22290977

Family Applications (1)

Application Number Title Priority Date Filing Date
FI960482A FI112660B (fi) 1993-08-05 1996-02-02 Menetelmä matriksin metalloproteaasien inhibiittoreina käyttökelpoisten trisyklisten indolijohdannaisten valmistamiseksi

Country Status (22)

Country Link
EP (1) EP0712403B1 (fi)
JP (1) JPH09501430A (fi)
KR (1) KR100347646B1 (fi)
CN (1) CN1040211C (fi)
AT (1) ATE157979T1 (fi)
AU (1) AU679109B2 (fi)
BR (1) BR9407217A (fi)
CA (1) CA2168791A1 (fi)
CZ (1) CZ290030B6 (fi)
DE (1) DE69405572T2 (fi)
DK (1) DK0712403T3 (fi)
ES (1) ES2105744T3 (fi)
FI (1) FI112660B (fi)
GR (1) GR3024698T3 (fi)
HU (1) HU222818B1 (fi)
NO (1) NO307755B1 (fi)
NZ (1) NZ271765A (fi)
PL (1) PL177661B1 (fi)
RU (1) RU2132851C1 (fi)
UA (1) UA50707C2 (fi)
WO (1) WO1995004735A1 (fi)
ZA (1) ZA945847B (fi)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773428A (en) * 1993-08-05 1998-06-30 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
US6013792A (en) * 1993-08-05 2000-01-11 Syntex (U.S.A.), Inc. Matrix metalloprotease inhibitors
CZ292617B6 (cs) 1995-11-23 2003-11-12 British Biotech Pharmaceuticals Limited Inhibitory metaloproteinázy a farmaceutický prostředek
ES2233275T3 (es) * 1995-12-08 2005-06-16 Agouron Pharmaceuticals, Inc. Intermediarios que sirven para la preparacion de inhibidores de metaloproteinasas.
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
US6462023B1 (en) 1996-09-10 2002-10-08 British Biotech Pharmaceuticals, Ltd. Cytostatic agents
PL191366B1 (pl) 1996-09-10 2006-05-31 Vernalis Oxford Ltd Zastosowanie pochodnych kwasu hydroksamowego, pochodne kwasu hydroksamowego oraz kompozycje farmaceutyczne je zawierające
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US5985911A (en) * 1997-01-07 1999-11-16 Abbott Laboratories C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion
US5952320A (en) * 1997-01-07 1999-09-14 Abbott Laboratories Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US6329400B1 (en) 1998-08-26 2001-12-11 Glaxo Wellcome Inc. Formamide compounds as therapeutic agents
US6172064B1 (en) 1998-08-26 2001-01-09 Glaxo Wellcome Inc. Formamides as therapeutic agents
GB9818605D0 (en) 1998-08-26 1998-10-21 Glaxo Group Ltd Formamide compounds as therepeutic agents
US6288261B1 (en) 1998-12-18 2001-09-11 Abbott Laboratories Inhibitors of matrix metalloproteinases
GB9907055D0 (en) * 1999-03-29 1999-05-19 British Biotech Pharm Antibacterial agents
JP2004527545A (ja) * 2001-04-20 2004-09-09 ファイザー・プロダクツ・インク １，３−置換インデンおよびアリール縮合アザ多環式化合物の調製方法
US20070066827A1 (en) * 2003-01-15 2007-03-22 Pfizer Inc. Process for the preparation of aryl fused polycyclic lactams
RU2378279C1 (ru) * 2008-05-28 2010-01-10 Государственное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) CПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 1,2,3,6-ТЕТРАГИДРОПИРРОЛО[1,2-d][1,4]ДИАЗОЦИНОВ

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9000846D0 (en) * 1990-01-15 1990-03-14 Beecham Group Plc Novel compounds
GB9022117D0 (en) * 1990-10-11 1990-11-21 Beecham Group Plc Novel compounds
CA2102890A1 (en) * 1991-05-28 1992-11-29 Soumya P. Sahoo Substituted n-carboxyalkylpeptidyl derivatives as antidegenerative active agents
GB9122859D0 (en) * 1991-10-28 1991-12-11 Smithkline Beecham Plc Novel compounds

Also Published As

Publication number Publication date
WO1995004735A1 (en) 1995-02-16
HUT74586A (en) 1997-01-28
GR3024698T3 (en) 1997-12-31
CN1132511A (zh) 1996-10-02
FI960482A0 (fi) 1996-02-02
EP0712403B1 (en) 1997-09-10
NZ271765A (en) 1996-11-26
JPH09501430A (ja) 1997-02-10
DE69405572D1 (de) 1997-10-16
CZ30896A3 (en) 1996-07-17
ES2105744T3 (es) 1997-10-16
DE69405572T2 (de) 1998-02-12
CN1040211C (zh) 1998-10-14
DK0712403T3 (da) 1998-01-26
ZA945847B (en) 1996-02-05
BR9407217A (pt) 1996-09-17
NO307755B1 (no) 2000-05-22
UA50707C2 (uk) 2002-11-15
PL312797A1 (en) 1996-05-13
CZ290030B6 (cs) 2002-05-15
PL177661B1 (pl) 1999-12-31
EP0712403A1 (en) 1996-05-22
AU7551994A (en) 1995-02-28
ATE157979T1 (de) 1997-09-15
RU2132851C1 (ru) 1999-07-10
HU222818B1 (hu) 2003-11-28
NO960447D0 (no) 1996-02-02
CA2168791A1 (en) 1995-02-16
KR100347646B1 (ko) 2002-12-05
FI112660B (fi) 2003-12-31
NO960447L (no) 1996-04-01
AU679109B2 (en) 1997-06-19

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Legal Events

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