DK0712403T3 - Matrix-metalloproteaseinhibitorer - Google Patents

Matrix-metalloproteaseinhibitorer

Info

Publication number
DK0712403T3
DK0712403T3 DK94925699.4T DK94925699T DK0712403T3 DK 0712403 T3 DK0712403 T3 DK 0712403T3 DK 94925699 T DK94925699 T DK 94925699T DK 0712403 T3 DK0712403 T3 DK 0712403T3
Authority
DK
Denmark
Prior art keywords
alkoxycarbonyl
carboxy
alkyl
hydrogen
hydroxyaminocarbonyl
Prior art date
Application number
DK94925699.4T
Other languages
English (en)
Inventor
Arlindo L Castelhano
Teng J Liak
Zhengyo Yuan
Alexander Krantz
Stephen Horne
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Application granted granted Critical
Publication of DK0712403T3 publication Critical patent/DK0712403T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
DK94925699.4T 1993-08-05 1994-07-27 Matrix-metalloproteaseinhibitorer DK0712403T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10265593A 1993-08-05 1993-08-05

Publications (1)

Publication Number Publication Date
DK0712403T3 true DK0712403T3 (da) 1998-01-26

Family

ID=22290977

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94925699.4T DK0712403T3 (da) 1993-08-05 1994-07-27 Matrix-metalloproteaseinhibitorer

Country Status (22)

Country Link
EP (1) EP0712403B1 (da)
JP (1) JPH09501430A (da)
KR (1) KR100347646B1 (da)
CN (1) CN1040211C (da)
AT (1) ATE157979T1 (da)
AU (1) AU679109B2 (da)
BR (1) BR9407217A (da)
CA (1) CA2168791A1 (da)
CZ (1) CZ290030B6 (da)
DE (1) DE69405572T2 (da)
DK (1) DK0712403T3 (da)
ES (1) ES2105744T3 (da)
FI (1) FI112660B (da)
GR (1) GR3024698T3 (da)
HU (1) HU222818B1 (da)
NO (1) NO307755B1 (da)
NZ (1) NZ271765A (da)
PL (1) PL177661B1 (da)
RU (1) RU2132851C1 (da)
UA (1) UA50707C2 (da)
WO (1) WO1995004735A1 (da)
ZA (1) ZA945847B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773428A (en) * 1993-08-05 1998-06-30 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
US6013792A (en) * 1993-08-05 2000-01-11 Syntex (U.S.A.), Inc. Matrix metalloprotease inhibitors
ATE205184T1 (de) 1995-11-23 2001-09-15 British Biotech Pharm Metalloproteinase inhibitoren
DK0874830T3 (da) * 1995-12-08 2003-04-22 Agouron Pharma Metalloproteinaseinhibitor, farmaceutisk præparat indeholdende denne og den farmaceutiske anvendelse samt en fremgangsmåde til fremstilling deraf
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
EP0925278B1 (en) 1996-09-10 2002-07-17 British Biotech Pharmaceuticals Limited Cytostatic hydroxamic acid derivatives
US6462023B1 (en) 1996-09-10 2002-10-08 British Biotech Pharmaceuticals, Ltd. Cytostatic agents
US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US5985911A (en) * 1997-01-07 1999-11-16 Abbott Laboratories C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion
US5952320A (en) * 1997-01-07 1999-09-14 Abbott Laboratories Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
GB9818605D0 (en) 1998-08-26 1998-10-21 Glaxo Group Ltd Formamide compounds as therepeutic agents
US6172064B1 (en) 1998-08-26 2001-01-09 Glaxo Wellcome Inc. Formamides as therapeutic agents
US6329400B1 (en) 1998-08-26 2001-12-11 Glaxo Wellcome Inc. Formamide compounds as therapeutic agents
US6288261B1 (en) 1998-12-18 2001-09-11 Abbott Laboratories Inhibitors of matrix metalloproteinases
GB9907055D0 (en) 1999-03-29 1999-05-19 British Biotech Pharm Antibacterial agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9000846D0 (en) * 1990-01-15 1990-03-14 Beecham Group Plc Novel compounds
GB9022117D0 (en) * 1990-10-11 1990-11-21 Beecham Group Plc Novel compounds
EP0586537A4 (en) * 1991-05-28 1997-06-25 Merck & Co Inc Substituted n-carboxyalkylpeptidyl derivatives as antidegenerative active agents
GB9122859D0 (en) * 1991-10-28 1991-12-11 Smithkline Beecham Plc Novel compounds

Also Published As

Publication number Publication date
GR3024698T3 (en) 1997-12-31
CN1132511A (zh) 1996-10-02
ES2105744T3 (es) 1997-10-16
PL177661B1 (pl) 1999-12-31
NO307755B1 (no) 2000-05-22
CN1040211C (zh) 1998-10-14
CZ290030B6 (cs) 2002-05-15
AU7551994A (en) 1995-02-28
FI112660B (fi) 2003-12-31
KR100347646B1 (ko) 2002-12-05
CZ30896A3 (en) 1996-07-17
NO960447L (no) 1996-04-01
FI960482A0 (fi) 1996-02-02
EP0712403B1 (en) 1997-09-10
NO960447D0 (no) 1996-02-02
FI960482A (fi) 1996-02-02
PL312797A1 (en) 1996-05-13
HU222818B1 (hu) 2003-11-28
JPH09501430A (ja) 1997-02-10
CA2168791A1 (en) 1995-02-16
EP0712403A1 (en) 1996-05-22
BR9407217A (pt) 1996-09-17
RU2132851C1 (ru) 1999-07-10
HUT74586A (en) 1997-01-28
WO1995004735A1 (en) 1995-02-16
UA50707C2 (uk) 2002-11-15
ATE157979T1 (de) 1997-09-15
DE69405572D1 (de) 1997-10-16
ZA945847B (en) 1996-02-05
AU679109B2 (en) 1997-06-19
DE69405572T2 (de) 1998-02-12
NZ271765A (en) 1996-11-26

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