ES2105783T3 - Inhibidores de metaloproteasas matriciales. - Google Patents

Inhibidores de metaloproteasas matriciales.

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Publication number
ES2105783T3
ES2105783T3 ES94932023T ES94932023T ES2105783T3 ES 2105783 T3 ES2105783 T3 ES 2105783T3 ES 94932023 T ES94932023 T ES 94932023T ES 94932023 T ES94932023 T ES 94932023T ES 2105783 T3 ES2105783 T3 ES 2105783T3
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ES
Spain
Prior art keywords
sup
ilo
compounds
hidroxido
carboxido
Prior art date
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Expired - Lifetime
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ES94932023T
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English (en)
Inventor
Arlindo L Castelhano
Zhengyu Yuan
Stephen Horne
Teng J Liak
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Syntex USA LLC
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Syntex USA LLC
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
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    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07D263/18—Oxygen atoms
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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  • Biochemistry (AREA)
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  • Rheumatology (AREA)
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  • Ophthalmology & Optometry (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
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  • Peptides Or Proteins (AREA)
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Abstract

LA INVENCION SE DIRIGE A COMPUESTOS DE LA FORMULA (I): EN LA QUE R{SUP,1} ES MERCAPTO, ACETILTIO, CARBOXIDO, HIDROXICARBAMOILO, ALCOXICARBONILO, ARILOXICARBONILO, ARALCOXICARBONILO, BENCILOXICARBAMOILO O (I) (EN DONDE R{SUP,6} ES ARILO OPCIONALMENTE SUSTITUIDO, EN DONDE EL GRUPO DE ARILO ES QUINOL-2-ILO, NAFT-1-ILO, NAFT-2-ILO, PIRIDILO O FENILO); R{SUP,2} ES ALQUILO, ARALQUILO O CICLOALQUILALQUILO; R{SUP,3} ES CICLOALQUILO, ALQUILO (OPCIONALMENTE SUSTITUIDO POR CICLOALQUILO, HIDROXIDO, MERCAPTO, ALQUILTIO, ARALCOXIDO, CARBOXIDO, AMINO, ALQUILAMINO, GUANIDINO, CARBAMOILO, PIRIDILO O INDOILO), O ARALQUILO (OPCIONALMENTE SUSTITUIDO POR HIDROXIDO, CARBOXIDO, ALQUILO O ALCOXIDO); R{SUP,4} ES NITRO, AMINO, CIANO, HIDROXIDO, ALCOXIDO, CARBOXIDO, ALCOXICARBONILO, ALQUILSULFONILO, HALOALQUILO, ALCOXICARBONILALQUILO, TETRAZOILO, CARBAMOILO (OPCIONALMENTE SUSTITUIDO POR ALQUILO O DIALQUILAMINOALQUILO) O AMINOSULFONILO (OPCIONALMENTE SUSTITUIDO POR ALQUILO); Y R{SUP,5} ES HIDROGENO, HALOGENO O HIDROXI; LOS COMPUESTOS SON ESTEREOISOMEROS SIMPLES O MEZCLAS DE LOS MISMOS; TAMBIEN SE PRESENTAN LAS SALES FARMACOLOGICAMENTE ACEPTABLES DE LOS MISMOS. LOS COMPUESTOS SON UTILES EN LA INHIBICION DE LA PROTEASA DE MATRIZ EN LOS MAMIFEROS.
ES94932023T 1993-11-04 1994-11-03 Inhibidores de metaloproteasas matriciales. Expired - Lifetime ES2105783T3 (es)

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JP (1) JPH09505038A (es)
KR (1) KR100352199B1 (es)
CN (1) CN1044249C (es)
AT (1) ATE155471T1 (es)
AU (1) AU683317B2 (es)
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DE (1) DE69404324T2 (es)
DK (1) DK0726903T3 (es)
ES (1) ES2105783T3 (es)
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GB9601042D0 (en) * 1996-01-17 1996-03-20 Smithkline Beecham Plc Medical use
US5831004A (en) * 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5840698A (en) * 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
CZ292617B6 (cs) 1995-11-23 2003-11-12 British Biotech Pharmaceuticals Limited Inhibitory metaloproteinázy a farmaceutický prostředek
ES2233275T3 (es) * 1995-12-08 2005-06-16 Agouron Pharmaceuticals, Inc. Intermediarios que sirven para la preparacion de inhibidores de metaloproteinasas.
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
DE69737605T2 (de) * 1996-01-23 2008-04-03 Shionogi & Co., Ltd. Sulfonierte aminosäurederivate und metalloproteinase-inhibitoren, die diese enthalten
HUP9903014A3 (en) * 1996-07-18 2000-08-28 Pfizer Phosphinate derivatives having matrix metalloprotease inhibitor effect and medicaments containing the same
CZ62799A3 (cs) * 1996-08-28 1999-07-14 The Procter & Gamble Company Heterocyklické metaloproteázové inhibitory
US6462023B1 (en) 1996-09-10 2002-10-08 British Biotech Pharmaceuticals, Ltd. Cytostatic agents
PL191366B1 (pl) 1996-09-10 2006-05-31 Vernalis Oxford Ltd Zastosowanie pochodnych kwasu hydroksamowego, pochodne kwasu hydroksamowego oraz kompozycje farmaceutyczne je zawierające
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US6034136A (en) * 1997-03-20 2000-03-07 Novartis Ag Certain cyclic thio substituted acylaminoacid amide derivatives
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US6420427B1 (en) 1997-10-09 2002-07-16 Ono Pharmaceutical Co., Ltd. Aminobutyric acid derivatives
IL136889A0 (en) 1998-01-09 2001-06-14 Pfizer Matrix metalloprotease inhibitors
US6329418B1 (en) 1998-04-14 2001-12-11 The Procter & Gamble Company Substituted pyrrolidine hydroxamate metalloprotease inhibitors
US6329400B1 (en) 1998-08-26 2001-12-11 Glaxo Wellcome Inc. Formamide compounds as therapeutic agents
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JP2003528082A (ja) 2000-03-21 2003-09-24 ザ プロクター アンド ギャンブル カンパニー ニフッ化酪酸メタロプロテアーゼ阻害物質
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UA48121C2 (uk) 2002-08-15
HU9601154D0 (en) 1996-07-29
GR3024248T3 (en) 1997-10-31
NZ275315A (en) 1997-07-27
BR9407960A (pt) 1996-11-26
DE69404324D1 (de) 1997-08-21
PL314134A1 (en) 1996-08-19
WO1995012603A1 (en) 1995-05-11
JPH09505038A (ja) 1997-05-20
AU8089794A (en) 1995-05-23
DK0726903T3 (da) 1997-10-13
KR100352199B1 (ko) 2002-11-11
CN1134153A (zh) 1996-10-23
ATE155471T1 (de) 1997-08-15
PL178326B1 (pl) 2000-04-28
RU2132327C1 (ru) 1999-06-27
AU683317B2 (en) 1997-11-06
CN1044249C (zh) 1999-07-21
CZ287642B6 (en) 2001-01-17
NO961780D0 (no) 1996-05-02
ZA948691B (en) 1996-05-03
CA2175667A1 (en) 1995-05-11
FI961857A0 (fi) 1996-05-02
NO306726B1 (no) 1999-12-13
CZ126096A3 (en) 1996-11-13
EP0726903B1 (en) 1997-07-16
NO961780L (no) 1996-07-03
KR960705830A (ko) 1996-11-08
HUT74730A (en) 1997-02-28
DE69404324T2 (de) 1998-01-08
EP0726903A1 (en) 1996-08-21
FI961857A7 (fi) 1996-07-01

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