FI94925C - Menetelmä dispergoituvan kiinteän lääkeainekoostumuksen valmistamiseksi - Google Patents
Menetelmä dispergoituvan kiinteän lääkeainekoostumuksen valmistamiseksi Download PDFInfo
- Publication number
- FI94925C FI94925C FI894899A FI894899A FI94925C FI 94925 C FI94925 C FI 94925C FI 894899 A FI894899 A FI 894899A FI 894899 A FI894899 A FI 894899A FI 94925 C FI94925 C FI 94925C
- Authority
- FI
- Finland
- Prior art keywords
- weight
- disintegrant
- diclofenac
- preparing
- process according
- Prior art date
Links
- 239000007787 solid Substances 0.000 title claims abstract description 7
- 239000000203 mixture Substances 0.000 title claims description 21
- 238000000034 method Methods 0.000 title claims description 8
- 229940079593 drug Drugs 0.000 title description 3
- 239000003814 drug Substances 0.000 title description 3
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229960001259 diclofenac Drugs 0.000 claims abstract description 16
- 239000007884 disintegrant Substances 0.000 claims abstract description 14
- 239000003085 diluting agent Substances 0.000 claims abstract description 10
- 239000002253 acid Substances 0.000 claims abstract description 6
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 11
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 11
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 11
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 11
- 229920002785 Croscarmellose sodium Polymers 0.000 claims description 9
- 239000000314 lubricant Substances 0.000 claims description 8
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 6
- 239000008101 lactose Substances 0.000 claims description 6
- 239000000080 wetting agent Substances 0.000 claims description 6
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 5
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 claims description 2
- 229960005168 croscarmellose Drugs 0.000 claims description 2
- 229960000913 crospovidone Drugs 0.000 claims description 2
- 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims description 2
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims description 2
- 229940080313 sodium starch Drugs 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 229940032147 starch Drugs 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 239000013583 drug formulation Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 description 23
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 7
- 229960001681 croscarmellose sodium Drugs 0.000 description 7
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 7
- UBVSIAHUTXHQTD-UHFFFAOYSA-N 2-n-(4-bromophenyl)-1,3,5-triazine-2,4-diamine Chemical compound NC1=NC=NC(NC=2C=CC(Br)=CC=2)=N1 UBVSIAHUTXHQTD-UHFFFAOYSA-N 0.000 description 6
- 235000012732 erythrosine Nutrition 0.000 description 6
- 239000004359 castor oil Substances 0.000 description 5
- 235000019438 castor oil Nutrition 0.000 description 5
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 5
- 239000000454 talc Substances 0.000 description 5
- 229910052623 talc Inorganic materials 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 4
- 235000016954 Ribes hudsonianum Nutrition 0.000 description 3
- 241001312569 Ribes nigrum Species 0.000 description 3
- 235000001466 Ribes nigrum Nutrition 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000004141 Sodium laurylsulphate Substances 0.000 description 2
- 235000019658 bitter taste Nutrition 0.000 description 2
- 239000008119 colloidal silica Substances 0.000 description 2
- 229960004515 diclofenac potassium Drugs 0.000 description 2
- KXZOIWWTXOCYKR-UHFFFAOYSA-M diclofenac potassium Chemical compound [K+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl KXZOIWWTXOCYKR-UHFFFAOYSA-M 0.000 description 2
- 229960001193 diclofenac sodium Drugs 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 2
- CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 229940124346 antiarthritic agent Drugs 0.000 description 1
- 239000003435 antirheumatic agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
- 238000007907 direct compression Methods 0.000 description 1
- 239000007919 dispersible tablet Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000002662 enteric coated tablet Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- -1 magnesium stearate Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000007939 sustained release tablet Substances 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical class [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8824392 | 1988-10-18 | ||
| GB888824392A GB8824392D0 (en) | 1988-10-18 | 1988-10-18 | Dispersible formulation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI894899A0 FI894899A0 (fi) | 1989-10-16 |
| FI94925B FI94925B (fi) | 1995-08-15 |
| FI94925C true FI94925C (fi) | 1995-11-27 |
Family
ID=10645384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI894899A FI94925C (fi) | 1988-10-18 | 1989-10-16 | Menetelmä dispergoituvan kiinteän lääkeainekoostumuksen valmistamiseksi |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0365480B1 (de) |
| JP (1) | JP2795924B2 (de) |
| KR (1) | KR0151131B1 (de) |
| AT (1) | ATE79538T1 (de) |
| AU (1) | AU626924B2 (de) |
| CA (1) | CA2000763C (de) |
| DE (1) | DE68902531T2 (de) |
| DK (1) | DK170793B1 (de) |
| ES (1) | ES2052065T3 (de) |
| FI (1) | FI94925C (de) |
| GB (1) | GB8824392D0 (de) |
| GR (1) | GR3006304T3 (de) |
| IE (1) | IE62557B1 (de) |
| IL (1) | IL91949A (de) |
| NZ (1) | NZ231023A (de) |
| PH (1) | PH30526A (de) |
| PT (1) | PT92002B (de) |
| SA (1) | SA90100079B1 (de) |
| ZA (1) | ZA897853B (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2059260B1 (es) | 1992-10-06 | 1995-04-16 | Espanola Prod Quimicos | Procedimiento de preparacion de comprimidos conteniendo diclofenaco; dispersables en agua. |
| DE4403943A1 (de) | 1994-02-08 | 1995-08-10 | Hexal Pharma Gmbh | Orale Azrneimittelzubereitung mit Diclofenac-Natrium |
| ES2082723B1 (es) * | 1994-07-20 | 1996-10-01 | Lilly Sa | Formulacion farmaceutica de fluoxetina en forma dispersable. |
| US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
| ATE477793T1 (de) * | 1996-06-14 | 2010-09-15 | Kyowa Hakko Kirin Co Ltd | Eine im mund schnell zerfallende tablette |
| US5958453A (en) * | 1996-10-31 | 1999-09-28 | Takeda Chemical Industries, Ltd. | Solid pharmaceutical preparation with improved buccal disintegrability and/or dissolubility |
| US6312724B1 (en) | 1997-04-04 | 2001-11-06 | Isa Odidi | Sustained release pharmaceutical matrix tablet of pharmaceutically acceptable salts of diclofenac and process for preparation thereof |
| ES2559766T3 (es) | 1998-05-18 | 2016-02-15 | Takeda Pharmaceutical Company Limited | Comprimidos disgregables en la boca |
| DE69934582T2 (de) * | 1998-06-11 | 2007-10-04 | Pharmacia & Upjohn Co. Llc, Kalamazoo | Delavirdin tablettenformulierung |
| WO2000006126A1 (en) | 1998-07-28 | 2000-02-10 | Takeda Chemical Industries, Ltd. | Rapidly disintegrable solid preparation |
| US9358214B2 (en) | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
| DE10351448A1 (de) * | 2003-11-04 | 2005-06-09 | Bayer Healthcare Ag | Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften |
| US9884014B2 (en) | 2004-10-12 | 2018-02-06 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
| US20060105039A1 (en) | 2004-10-21 | 2006-05-18 | Jin-Wang Lai | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
| US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
| JO3352B1 (ar) | 2005-06-17 | 2019-03-13 | Apr Applied Pharma Res Sa | صيغ دايكلوفيناك وطرق استخدامه |
| UA97813C2 (uk) * | 2006-12-05 | 2012-03-26 | Янссен Фармацевтика Н.В. | Фумаратна сіль (альфа s, бета r)-6-бром-альфа-[2-(диметиламіно)етил]-2-метоксі-альфа-1-нафталеніл-бета-феніл-3-хінолінетанолу |
| TW201113266A (en) * | 2009-09-02 | 2011-04-16 | Ziopharm Oncology Inc | Pharmaceutical formulations for indibulin |
| JP5309262B2 (ja) | 2009-12-02 | 2013-10-09 | アプタリス ファーマ リミテッド | フェキソフェナジン・マイクロカプセル及びそれを含む組成物 |
| US11957792B2 (en) | 2012-04-19 | 2024-04-16 | Glatt Ag | Taste-masked pharmaceutical compositions containing diclofenac |
| DE202022100544U1 (de) | 2022-01-31 | 2022-02-16 | Ranjitsing Babasing Bayas | Neue orale Streifen- oder Dünnfilmform von Diclofenac-Natrium |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1200178B (it) | 1986-07-23 | 1989-01-05 | Alfa Farmaceutici Spa | Formulazioni galeniche a cessione programmata contenenti farmaci ad attivita' antiflogistica |
| IT1215726B (it) * | 1988-01-18 | 1990-02-22 | Alfa Wassermann Spa | Formulazioni galeniche a cessione programmata. |
| CH675537A5 (de) * | 1988-03-25 | 1990-10-15 | Ciba Geigy Ag |
-
1988
- 1988-10-18 GB GB888824392A patent/GB8824392D0/en active Pending
-
1989
- 1989-10-10 DE DE8989810772T patent/DE68902531T2/de not_active Expired - Lifetime
- 1989-10-10 ES ES89810772T patent/ES2052065T3/es not_active Expired - Lifetime
- 1989-10-10 EP EP89810772A patent/EP0365480B1/de not_active Expired - Lifetime
- 1989-10-10 PH PH39357A patent/PH30526A/en unknown
- 1989-10-10 AT AT89810772T patent/ATE79538T1/de not_active IP Right Cessation
- 1989-10-11 IL IL91949A patent/IL91949A/xx not_active IP Right Cessation
- 1989-10-16 NZ NZ231023A patent/NZ231023A/xx unknown
- 1989-10-16 PT PT92002A patent/PT92002B/pt not_active IP Right Cessation
- 1989-10-16 FI FI894899A patent/FI94925C/fi active IP Right Grant
- 1989-10-16 KR KR1019890014819A patent/KR0151131B1/ko not_active Expired - Lifetime
- 1989-10-16 CA CA002000763A patent/CA2000763C/en not_active Expired - Lifetime
- 1989-10-17 IE IE333689A patent/IE62557B1/en not_active IP Right Cessation
- 1989-10-17 JP JP1268293A patent/JP2795924B2/ja not_active Expired - Lifetime
- 1989-10-17 DK DK515489A patent/DK170793B1/da not_active IP Right Cessation
- 1989-10-17 AU AU42970/89A patent/AU626924B2/en not_active Expired
- 1989-10-17 ZA ZA897853A patent/ZA897853B/xx unknown
-
1990
- 1990-01-06 SA SA90100079A patent/SA90100079B1/ar unknown
-
1992
- 1992-11-20 GR GR920401772T patent/GR3006304T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3006304T3 (de) | 1993-06-21 |
| DE68902531T2 (de) | 1993-04-08 |
| CA2000763A1 (en) | 1990-04-18 |
| DE68902531D1 (de) | 1992-09-24 |
| IE893336L (en) | 1990-04-18 |
| PT92002B (pt) | 1995-06-30 |
| PT92002A (pt) | 1990-04-30 |
| KR0151131B1 (ko) | 1998-10-15 |
| JPH02164824A (ja) | 1990-06-25 |
| AU4297089A (en) | 1990-04-26 |
| CA2000763C (en) | 2000-11-14 |
| KR900005964A (ko) | 1990-05-07 |
| ZA897853B (en) | 1992-07-29 |
| DK515489A (da) | 1990-04-19 |
| NZ231023A (en) | 1991-09-25 |
| EP0365480A1 (de) | 1990-04-25 |
| EP0365480B1 (de) | 1992-08-19 |
| DK515489D0 (da) | 1989-10-17 |
| ATE79538T1 (de) | 1992-09-15 |
| ES2052065T3 (es) | 1994-07-01 |
| GB8824392D0 (en) | 1988-11-23 |
| DK170793B1 (da) | 1996-01-22 |
| IL91949A0 (en) | 1990-06-10 |
| AU626924B2 (en) | 1992-08-13 |
| FI894899A0 (fi) | 1989-10-16 |
| PH30526A (en) | 1997-06-13 |
| JP2795924B2 (ja) | 1998-09-10 |
| SA90100079B1 (ar) | 1999-03-21 |
| IL91949A (en) | 1993-08-18 |
| IE62557B1 (en) | 1995-02-08 |
| FI94925B (fi) | 1995-08-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI94925C (fi) | Menetelmä dispergoituvan kiinteän lääkeainekoostumuksen valmistamiseksi | |
| US5256699A (en) | Dispersible tablet formulation of diclofenac acid free base | |
| EP1443917B1 (de) | Tamsulosin tabletten | |
| EP0384514B1 (de) | Tablette mit Doppelwirkung | |
| KR100202154B1 (ko) | 파라세타몰 및 돔페리돈을 함유한 필름 피복 정제 | |
| NZ201008A (en) | Oral preparations containing dipyridamole and at least 5 molar equivalents of orally acceptable acidic excipient | |
| EP0221732A2 (de) | Tabletten mit verzögerter Abgabe | |
| NZ205894A (en) | Pharmaceutical compositions containing mopidamol(2,6-bis(diethanolamino)-4-piperidino-pyrimido(5,4-d)pyrimidine) | |
| US20030118647A1 (en) | Extended release tablet of metformin | |
| EP0605514A1 (de) | Pharmazeutische zusammemsetzungen mit verzoegerter freigabe. | |
| EP0500851A1 (de) | Verfahren zur herstellung einer einen wärme-, licht- und feuchtigkeit empfindlichen wirkstoff mit einer monoklinisch kristallinen struktur enthaltenden tabletten oder dragee zusammensetzung. | |
| JPH0757726B2 (ja) | 高分子量ヒドロキシプロピルメチルセルロースを基剤にした徐放性錠剤 | |
| EP2364694A1 (de) | Pramipexol-Formulierungen mit gesteuerter Freisetzung | |
| JP5524435B2 (ja) | 新規医薬組成物及びその調製のための方法 | |
| JP2008536922A (ja) | オランザピンの医薬用経口崩壊錠 | |
| EP0121901B1 (de) | Tabletten mit pH-unabhängiger kontrollierter Freisetzung | |
| KR100700472B1 (ko) | 프로펜 함유 제약 혼합물 | |
| US20060030581A1 (en) | Mannitol formulation for integrin receptor antagonist | |
| JP6328138B2 (ja) | Ｎ−［５−［２−（３，５−ジメトキシフェニル）エチル］−２ｈ−ピラゾール−３−イル］−４−［（３ｒ，５ｓ）−３，５−ジメチルピペラジン−１−イル］ベンズアミドの医薬製剤 | |
| WO2011036677A2 (en) | Sustained release composition of ranolazine | |
| WO2007081341A1 (en) | Controlled release formulation of divalproic acid and its derivatives | |
| WO2023128898A1 (en) | Pharmaceutical compositions comprising macitentan as active ingredient and other relevant excipients | |
| JP2016188188A (ja) | エンタカポン含有医薬組成物 | |
| JP2018199729A (ja) | エンタカポン含有医薬組成物 | |
| HK1022831B (en) | Pharmaceutical composition for oral administration of a n-piperidino-3-pyrazolecarboxamide derivative, its salts and their solvates |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| PC | Transfer of assignment of patent |
Owner name: NOVARTIS AG |
|
| FG | Patent granted |
Owner name: NOVARTIS AG |