FI94756B - Förfarande för framställning av hypoglykemiska och hypokolesterolemiska oxa- och tiazolidindioner - Google Patents

Förfarande för framställning av hypoglykemiska och hypokolesterolemiska oxa- och tiazolidindioner Download PDF

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Publication number
FI94756B
FI94756B FI925522A FI925522A FI94756B FI 94756 B FI94756 B FI 94756B FI 925522 A FI925522 A FI 925522A FI 925522 A FI925522 A FI 925522A FI 94756 B FI94756 B FI 94756B
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FI
Finland
Prior art keywords
formula
preparation
compound
compounds
hydrogen
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Application number
FI925522A
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English (en)
Finnish (fi)
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FI925522A0 (sv
FI94756C (sv
FI925522A (sv
Inventor
Steven Wayne Goldstein
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Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of FI925522A0 publication Critical patent/FI925522A0/sv
Publication of FI925522A publication Critical patent/FI925522A/sv
Application granted granted Critical
Publication of FI94756B publication Critical patent/FI94756B/sv
Publication of FI94756C publication Critical patent/FI94756C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Paints Or Removers (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Claims (6)

1. Förfarande för framställning av en terapeutiskt användbar förening med formeln 5 o 10 eller ett farmaceutlskt godtagbart bassalt därav, 1 vilken formel R är alkyl med 1-6 kolatomer, cykloalkyl med 3 - 6 kolatomer, furyl, tienyl, fenyl eller substltuerad fe- 15 nyl, väri nämnda substituent ar alkyl med 1-3 kolatomer, metoxi, trifluormetyl, klor eller fluor; X är väte, metyl, metoxi, klor eller fluor; ooh Y är 0 eller S, känne- t e c k n a t därav, att man (1) omsätter en förening . med formeln « 20 o Γ? 25 väri R, X ooh Y är säsom definierats, med trifluorättik-syra tills omsättningen är väsentligen total, eller (2) reducerar en förening med formeln N. 0 li 29 94756
2. Förfarande enligt patentkrav 1, känne-t e c k n a t därav, att en förening med formeln s -esc. ..-oir' '"n2 0 10 väri X är väte och Y är 0, framställs.
3. Förfarande enligt patentkrav 2, känne-t e c k n a t därav, att R är fenyl.
4. Förfarande enligt patentkrav 2, känne-t e c k n a t därav, att R är 2-tienyl. 15
5. Förfarande enligt patentkrav 2, känne- t e c k n a t därav, att R är 2-furyl.
6. Förfarande enligt patentkrav 2, känne-t e c k n a t därav, att R är isopropyl. < . · « I 4« 4 r
FI925522A 1990-06-05 1992-12-04 Förfarande för framställning av hypoglykemiska och hypokolesterolemiska oxa- och tiazolidindioner FI94756C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/533,615 US5037842A (en) 1990-06-05 1990-06-05 Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents
US53361590 1990-06-05
US9103541 1991-05-20
PCT/US1991/003541 WO1991019704A2 (en) 1990-06-05 1991-05-20 Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents

Publications (4)

Publication Number Publication Date
FI925522A0 FI925522A0 (sv) 1992-12-04
FI925522A FI925522A (sv) 1992-12-04
FI94756B true FI94756B (sv) 1995-07-14
FI94756C FI94756C (sv) 1995-10-25

Family

ID=24126737

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925522A FI94756C (sv) 1990-06-05 1992-12-04 Förfarande för framställning av hypoglykemiska och hypokolesterolemiska oxa- och tiazolidindioner

Country Status (20)

Country Link
US (1) US5037842A (sv)
EP (1) EP0537300B1 (sv)
JP (1) JPH0714924B2 (sv)
AT (1) ATE121736T1 (sv)
AU (1) AU640284B2 (sv)
CA (1) CA2084195A1 (sv)
DE (1) DE69109291T2 (sv)
DK (1) DK0537300T3 (sv)
ES (1) ES2071339T3 (sv)
FI (1) FI94756C (sv)
HU (1) HUT65676A (sv)
IE (1) IE65628B1 (sv)
IL (1) IL98300A (sv)
MY (1) MY135758A (sv)
NO (1) NO924696L (sv)
NZ (1) NZ238382A (sv)
PT (1) PT97856A (sv)
TW (1) TW200481B (sv)
WO (1) WO1991019704A2 (sv)
ZA (1) ZA914188B (sv)

Families Citing this family (35)

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US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
GB9017218D0 (en) * 1990-08-06 1990-09-19 Beecham Group Plc Novel compounds
NO179246C (no) * 1991-11-20 1996-09-04 Sankyo Co Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav
US5498621A (en) * 1992-05-01 1996-03-12 Pfizer Inc. Oxazolidinedione hypoglycemic agents
EP0590793B1 (en) * 1992-08-31 1999-10-13 Sankyo Company Limited Oxazolidine derivatives having anti-diabetic and anti-obesity properties, their preparation and their therapeutic uses
US5594016A (en) * 1992-12-28 1997-01-14 Mitsubishi Chemical Corporation Naphthalene derivatives
TW268952B (sv) * 1993-02-26 1996-01-21 Takeda Pharm Industry Co Ltd
AU668818B2 (en) * 1993-04-07 1996-05-16 Taiho Pharmaceutical Co., Ltd. Thiazolidine derivative and pharmaceutical composition containing the same
US5641796A (en) * 1994-11-01 1997-06-24 Eli Lilly And Company Oral hypoglycemic agents
US5925656A (en) * 1995-04-10 1999-07-20 Dr. Reddy's Research Foundation Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5889032A (en) * 1996-05-06 1999-03-30 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5801173A (en) * 1996-05-06 1998-09-01 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5889025A (en) * 1996-05-06 1999-03-30 Reddy's Research Foundation Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
BR9711098B1 (pt) * 1996-07-01 2011-10-04 compostos heterocìclicos, processo para sua preparação e composições farmacêuticas contendo os mesmos e seu uso no tratamento de diabetes e doenças relacionadas.
USRE39266E1 (en) * 1996-07-01 2006-09-05 Dr. Reddy's Laboratories, Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6372750B2 (en) * 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
US6114526A (en) * 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US5885997A (en) * 1996-07-01 1999-03-23 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6313113B1 (en) 1997-04-15 2001-11-06 Reddy-Cheminor, Inc. Heterocyclic compounds having antidiabetic, hypolipidemic and antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
WO1997041119A1 (en) * 1997-05-02 1997-11-06 Dr. Reddy's Research Foundation Novel antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
AU2823797A (en) * 1997-05-02 1997-11-19 Dr. Reddy's Research Foundation Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US6011031A (en) * 1997-05-30 2000-01-04 Dr. Reddy's Research Foundation Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them
JP2002515042A (ja) * 1997-12-02 2002-05-21 ドクター・レディーズ・リサーチ・ファウンデーション 糖尿病、異常脂血症（ｄｙｓｌｉｐｉｄｅｍｉａ）および高血圧の治療に有用なアゾリジンジオン（ａｚｏｌｉｄｉｎｅｄｉｏｎｅ）およびそれらを含有する組成物
JP2003040877A (ja) * 2001-07-24 2003-02-13 Sumika Fine Chemicals Co Ltd ５−［６−（２−フルオロベンジルオキシ）−２−ナフチル］メチル−２，４−チアゾリジンジオンの製造方法及びその精製方法
PT1587821E (pt) * 2002-12-19 2008-09-23 Scripps Research Inst Composições e métodos para estabilização da transtirretina e inibição do enrolamento incorrecto da transtirretina
WO2005113523A1 (en) * 2004-05-20 2005-12-01 Foldrx Pharmaceuticals, Inc. 2-((hetero) aryl)-benzoxazole compounds and derivatives, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
WO2008034016A2 (en) * 2006-09-15 2008-03-20 Foldrx Pharmaceuticals, Inc. Assays for detecting native-state proteins and identifying compounds that modulate the stability of native-state proteins
CA2680212A1 (en) 2007-03-07 2008-09-12 Janssen Pharmaceutica N.V. Substituted phenoxy aminothiazolones as estrogen related receptor-.alpha. modulators
TW200902507A (en) 2007-03-07 2009-01-16 Janssen Pharmaceutica Nv Substituted phenoxy n-alkylated thiazolidinediones as estrogen related receptor-α modulators
AU2008222745A1 (en) 2007-03-07 2008-09-12 Janssen Pharmaceutica N.V. Substituted phenoxy thiazolidinediones as estrogen related receptor-alpha modulators
US8362268B2 (en) * 2008-05-30 2013-01-29 University Of Notre Dame Du Lac Anti-bacterial agents from benzo[d]heterocyclic scaffolds for prevention and treatment of multidrug resistant bacteria
AU2010330894A1 (en) 2009-12-18 2012-07-05 Janssen Pharmaceutica Nv Substituted aminothiazolone indazoles as estrogen related receptor-aalpha modulators
SG2014013270A (en) 2011-09-16 2014-05-29 Pfizer Solid forms of a transthyretin dissociation inhibitor
CN107001267A (zh) * 2014-08-08 2017-08-01 马合伙人株式会社 稠合杂环化合物

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JPS5430171A (en) * 1977-08-10 1979-03-06 Taiho Pharmaceutical Co Ltd Isooxazole derivative and production
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
US4753956A (en) * 1981-01-02 1988-06-28 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4689336A (en) * 1981-01-02 1987-08-25 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine 2,4-diones
US4550172A (en) * 1984-09-21 1985-10-29 American Home Products Corporation Novel heterocyclic compounds as antiallergic agents
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
WO1986007056A1 (en) * 1985-05-21 1986-12-04 Pfizer Inc. Hypoglycemic thiazolidinediones
JPH06779B2 (ja) * 1985-06-10 1994-01-05 武田薬品工業株式会社 チアゾリジオン誘導体およびそれを含んでなる医薬組成物
JPS62234085A (ja) * 1985-12-18 1987-10-14 Sankyo Co Ltd チアゾリジン誘導体を有効成分とする糖尿病性合併症治療剤
FI91869C (sv) * 1987-03-18 1994-08-25 Tanabe Seiyaku Co Förfarande för framställning av som antidiabetiskt användbara benzoxazolderivat
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US4791125A (en) * 1987-12-02 1988-12-13 Pfizer Inc. Thiazolidinediones as hypoglycemic and anti-atherosclerosis agents
US5061717A (en) * 1988-03-08 1991-10-29 Pfizer Inc. Thiazolidinedione hypoglycemic agents

Also Published As

Publication number Publication date
IE65628B1 (en) 1995-11-01
WO1991019704A2 (en) 1991-12-26
NO924696D0 (no) 1992-12-04
FI925522A0 (sv) 1992-12-04
FI94756C (sv) 1995-10-25
HU9203837D0 (en) 1993-03-29
EP0537300A1 (en) 1993-04-21
MY135758A (en) 2008-06-30
AU640284B2 (en) 1993-08-19
ZA914188B (en) 1993-01-27
NZ238382A (en) 1995-12-21
IL98300A (en) 1996-01-31
DE69109291T2 (de) 1995-08-31
DK0537300T3 (da) 1995-07-03
IE911885A1 (en) 1991-12-18
CA2084195A1 (en) 1991-12-06
JPH05506456A (ja) 1993-09-22
TW200481B (sv) 1993-02-21
FI925522A (sv) 1992-12-04
NO924696L (no) 1992-12-04
US5037842A (en) 1991-08-06
WO1991019704A3 (en) 1992-03-19
PT97856A (pt) 1992-03-31
IL98300A0 (en) 1992-06-21
ES2071339T3 (es) 1995-06-16
JPH0714924B2 (ja) 1995-02-22
DE69109291D1 (de) 1995-06-01
AU8753191A (en) 1992-01-07
EP0537300B1 (en) 1995-04-26
ATE121736T1 (de) 1995-05-15
HUT65676A (en) 1994-07-28

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