FI946133A0 - Takykiniinireseptorien antagonisteina toimivia morfoliini- ja tiomorfoliiniyhdisteitä - Google Patents

Takykiniinireseptorien antagonisteina toimivia morfoliini- ja tiomorfoliiniyhdisteitä

Info

Publication number
FI946133A0
FI946133A0 FI946133A FI946133A FI946133A0 FI 946133 A0 FI946133 A0 FI 946133A0 FI 946133 A FI946133 A FI 946133A FI 946133 A FI946133 A FI 946133A FI 946133 A0 FI946133 A0 FI 946133A0
Authority
FI
Finland
Prior art keywords
receptor antagonists
morpholine
tachykinin receptor
compounds acting
thiomorpholine compounds
Prior art date
Application number
FI946133A
Other languages
English (en)
Swedish (sv)
Other versions
FI111363B (fi
FI946133A (fi
Inventor
Conrad P Dorn
Jeffrey J Hale
Malcolm Maccoss
Sander G Mills
Tamara Ladduwahetty
Shrenik K Shah
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI946133A0 publication Critical patent/FI946133A0/fi
Publication of FI946133A publication Critical patent/FI946133A/fi
Application granted granted Critical
Publication of FI111363B publication Critical patent/FI111363B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
FI946133A 1992-06-29 1994-12-28 Menetelmä terapeuttisesti käyttökelpoisten morfoliiniyhdisteiden valmistamiseksi FI111363B (fi)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US90597692A 1992-06-29 1992-06-29
US90597692 1992-06-29
US97144892A 1992-11-04 1992-11-04
US97144892 1992-11-04
US6191493A 1993-05-19 1993-05-19
US6191493 1993-05-19
PCT/US1993/006181 WO1994000440A1 (en) 1992-06-29 1993-06-29 Morpholine and thiomorpholine tachykinin receptor antagonists
US9306181 1993-06-29

Publications (3)

Publication Number Publication Date
FI946133A0 true FI946133A0 (fi) 1994-12-28
FI946133A FI946133A (fi) 1994-12-28
FI111363B FI111363B (fi) 2003-07-15

Family

ID=27370159

Family Applications (1)

Application Number Title Priority Date Filing Date
FI946133A FI111363B (fi) 1992-06-29 1994-12-28 Menetelmä terapeuttisesti käyttökelpoisten morfoliiniyhdisteiden valmistamiseksi

Country Status (34)

Country Link
EP (1) EP0577394B1 (fi)
JP (1) JP2634372B2 (fi)
KR (1) KR100301212B1 (fi)
CN (1) CN1049431C (fi)
AT (1) ATE186532T1 (fi)
AU (1) AU4656193A (fi)
BG (1) BG62963B1 (fi)
BR (1) BR1100375A (fi)
CA (1) CA2099233A1 (fi)
CY (1) CY2200B1 (fi)
CZ (1) CZ288530B6 (fi)
DE (1) DE69326977T2 (fi)
DK (1) DK0577394T3 (fi)
DZ (1) DZ1700A1 (fi)
ES (1) ES2141133T3 (fi)
FI (1) FI111363B (fi)
GR (1) GR3031824T3 (fi)
HK (1) HK1009268A1 (fi)
HR (1) HRP931003B1 (fi)
HU (1) HU219713B (fi)
IL (1) IL106142A (fi)
LV (1) LV12568B (fi)
MX (1) MX9303888A (fi)
MY (1) MY108836A (fi)
NO (1) NO305698B1 (fi)
NZ (1) NZ254476A (fi)
RO (1) RO114448B1 (fi)
RU (1) RU2140914C1 (fi)
SI (1) SI9300346B (fi)
SK (1) SK281093B6 (fi)
TW (1) TW358808B (fi)
WO (1) WO1994000440A1 (fi)
YU (1) YU49036B (fi)
ZA (1) ZA934624B (fi)

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ATE186532T1 (de) 1999-11-15
YU45293A (sh) 1996-10-18
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BG99274A (bg) 1996-04-30
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LV12568A (en) 2000-11-20
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AU4156893A (en) 1994-01-06
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HK1009268A1 (en) 1999-05-28
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