FI945149A - Menetelmä etoposidifosfaatin ja etoposidin valmistamiseksi - Google Patents

Menetelmä etoposidifosfaatin ja etoposidin valmistamiseksi Download PDF

Info

Publication number
FI945149A
FI945149A FI945149A FI945149A FI945149A FI 945149 A FI945149 A FI 945149A FI 945149 A FI945149 A FI 945149A FI 945149 A FI945149 A FI 945149A FI 945149 A FI945149 A FI 945149A
Authority
FI
Finland
Prior art keywords
etoposide
phosphate
etoposide phosphate
benzyl
protecting groups
Prior art date
Application number
FI945149A
Other languages
English (en)
Swedish (sv)
Other versions
FI115913B (fi
FI945149A0 (fi
Inventor
Lee J Silverberg
Purushotham Vemishetti
Jr John L Dillon
John J Usher
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of FI945149A0 publication Critical patent/FI945149A0/fi
Publication of FI945149A publication Critical patent/FI945149A/fi
Application granted granted Critical
Publication of FI115913B publication Critical patent/FI115913B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
FI945149A 1993-11-04 1994-11-01 Menetelmä etoposidifosfaatin ja etoposidin valmistamiseksi FI115913B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14551793 1993-11-04
US08/145,517 US5459248A (en) 1993-11-04 1993-11-04 Process of preparing etoposide phosphate and etoposide

Publications (3)

Publication Number Publication Date
FI945149A0 FI945149A0 (fi) 1994-11-01
FI945149A true FI945149A (fi) 1995-05-05
FI115913B FI115913B (fi) 2005-08-15

Family

ID=22513464

Family Applications (1)

Application Number Title Priority Date Filing Date
FI945149A FI115913B (fi) 1993-11-04 1994-11-01 Menetelmä etoposidifosfaatin ja etoposidin valmistamiseksi

Country Status (20)

Country Link
US (2) US5459248A (fi)
EP (1) EP0652226B1 (fi)
JP (2) JP2801152B2 (fi)
KR (1) KR100351325B1 (fi)
CN (4) CN1046290C (fi)
AT (1) ATE193018T1 (fi)
AU (1) AU692472B2 (fi)
CA (1) CA2133594C (fi)
CY (1) CY2201B1 (fi)
DE (1) DE69424504T2 (fi)
DK (1) DK0652226T3 (fi)
ES (1) ES2146247T3 (fi)
FI (1) FI115913B (fi)
GR (1) GR3034213T3 (fi)
HK (1) HK1003302A1 (fi)
HU (1) HU221969B1 (fi)
IL (1) IL111483A (fi)
PT (1) PT652226E (fi)
SG (1) SG50571A1 (fi)
TW (1) TW420687B (fi)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
IL119749A (en) * 1995-12-04 2001-03-19 Nippon Kayaku Kk Process for producing etoposide
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
AU728986B2 (en) * 1997-06-02 2001-01-25 Bristol-Myers Squibb Company Process for preparing etoposide
EP1117671A2 (en) 1998-09-10 2001-07-25 Phytogen Life Sciences Inc. Synthetic method for the preparation of the antineoplastic agent etoposide
WO2001024763A2 (en) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
KR20050008875A (ko) * 2000-04-19 2005-01-21 시오노기세이야쿠가부시키가이샤 술폰아미드유도체의 제조방법 및 그의 결정
US20030082618A1 (en) * 2001-10-15 2003-05-01 Guangshan Li Methods for detecting genetic aberrations
US20150246137A1 (en) * 2012-09-27 2015-09-03 The University Of North Carolina At Chapel Hill Lipid coated nanoparticles containing agents having low aqueous and lipid solubilities and methods thereof
CN113121618A (zh) * 2021-04-07 2021-07-16 梯尔希（南京）药物研发有限公司 两种依托泊苷杂质的制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2666778A (en) * 1950-05-10 1954-01-19 George M Steinberg Method for the synthesis of organic phosphates
NL6613143A (fi) * 1965-09-21 1967-03-22
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
JPS62209089A (ja) * 1986-03-08 1987-09-14 Kuraray Co Ltd ドリシルグリコピラノシルクロロホスフエイト誘導体およびその製造方法
NZ225599A (en) * 1987-08-04 1991-09-25 Bristol Myers Co Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
US4888419A (en) * 1987-08-31 1989-12-19 Bristol-Myers Company 3'-demethoxyepipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
CA2041280A1 (en) * 1990-05-10 1991-11-11 Yosuke Sawada Arylsulfatase
CN1025918C (zh) * 1990-06-07 1994-09-14 国家医药管理局上海医药工业研究院 抗肿瘤药表鬼臼毒吡喃糖甙的合成新工艺
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (fi) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
JPH07632B2 (ja) * 1991-12-23 1995-01-11 ブリストル−マイヤーズ スクイブ カンパニー エトポシド４’−ホスフェート二ナトリウム塩の安定な六水和物
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5375555A (en) * 1992-10-06 1994-12-27 Dolan; George D. Non-furling flag fasteners
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide

Also Published As

Publication number Publication date
AU7762794A (en) 1995-05-18
JP2801152B2 (ja) 1998-09-21
EP0652226A1 (en) 1995-05-10
TW420687B (en) 2001-02-01
CN1189499A (zh) 1998-08-05
CN1189497A (zh) 1998-08-05
HUT72461A (en) 1996-04-29
PT652226E (pt) 2000-09-29
ATE193018T1 (de) 2000-06-15
FI115913B (fi) 2005-08-15
KR100351325B1 (ko) 2002-10-31
DE69424504T2 (de) 2000-09-21
JP3810906B2 (ja) 2006-08-16
CA2133594C (en) 1999-02-23
IL111483A0 (en) 1995-01-24
ES2146247T3 (es) 2000-08-01
HU221969B1 (hu) 2003-03-28
CN1058017C (zh) 2000-11-01
JPH10152499A (ja) 1998-06-09
HK1003302A1 (en) 1998-10-23
JPH07196680A (ja) 1995-08-01
CN1189500A (zh) 1998-08-05
GR3034213T3 (en) 2000-12-29
FI945149A0 (fi) 1994-11-01
AU692472B2 (en) 1998-06-11
CN1046290C (zh) 1999-11-10
IL111483A (en) 1998-12-06
HU9403157D0 (en) 1994-12-28
EP0652226B1 (en) 2000-05-17
CA2133594A1 (en) 1995-05-05
CN1061047C (zh) 2001-01-24
CY2201B1 (en) 2002-11-08
KR950014128A (ko) 1995-06-15
US5459248A (en) 1995-10-17
DE69424504D1 (de) 2000-06-21
US5688926A (en) 1997-11-18
SG50571A1 (en) 1998-07-20
CN1056378C (zh) 2000-09-13
DK0652226T3 (da) 2000-08-07
CN1106016A (zh) 1995-08-02

Similar Documents

Publication Publication Date Title
FI945149A (fi) Menetelmä etoposidifosfaatin ja etoposidin valmistamiseksi
CO4600741A1 (es) Procedimiento para purificar y aislar 2´-desoxi-2´,2´-di- fluoronucleosidos
AU591351B2 (en) 1,5-diphenylpyrazole-3-carboxylic acid derivatives for the protection of cultivated plants
HUT75261A (en) Process for producing 1-hydroxy-alkylidene-1,1-bisphosphonic acids and intermediates thereof, trimers and tetramers of alkylpyrophosphonate and alkylpyrophosphate as intermediates
ES8601100A1 (es) Un procedimiento para producir 3-(3, 4-dihidroxifenil) serina
ES2187684T3 (es) Procedimiento para preparar productos intermedios para la sintesis de agentes antifungicos.
PT811603E (pt) Derivados da aminotetralona e processo para a producao dos mesmos
IT8521428A0 (it) Processo perfezionato di transaminazione per la produzionedi aminoacidi.
SE8803765D0 (sv) Nya isopolypeptider samt foerfarande foer framstaellning av desamma
DK632187A (da) Ny forbedret fremgangsmaade til fremstilling af penicillansyrederivater
CA2147264A1 (en) Vitamin d derivatives and a process for producing them
GB1211625A (en) Process for the production of n-carboxy anhydrides of amino acids and derivatives thereof
DE59603757D1 (de) Verfahren zur Herstellung von kristallinem O-Isopropylisoharnstoff-hydrochlorid
ES2075028T3 (es) Procedimiento para la preparacion de tripeptidos.
ITRM940566A1 (it) Composti organici
PT87868A (pt) Processo para a preparacao de polopeptideos contendo homociclostatina e ciclostatinauteis como agentes anti-hipertensivos
YU24396A (sh) Postupak za dobijanje 1-hidroksibisfosfonata
JPS557221A (en) Preparation of alethine derivative
BR9004018A (pt) Processo para a preparacao de tris(2,4-di-terc-butilfenil)fosfito
ES8306720A1 (es) "un procedimiento para preparar compuestos precursores de betalactama".
Tono‐oka et al. Enzymatic alcoholyses of NAD: A New type of ADP‐ribosylation reaction catalysed by NAD glycohydrolase
EP0320484A3 (en) Purification of n-acetyl aminophenols
ES8307232A1 (es) Un procedimiento para resolver un acido interfenilen-9-tia-11-oxo-12-azaprostanoico.
ES2071346T3 (es) Tetrapeptidos que derivan de antibioticos dalbaheptidos.

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 115913

Country of ref document: FI