ES2187684T3 - Procedimiento para preparar productos intermedios para la sintesis de agentes antifungicos. - Google Patents
Procedimiento para preparar productos intermedios para la sintesis de agentes antifungicos.Info
- Publication number
- ES2187684T3 ES2187684T3 ES96944241T ES96944241T ES2187684T3 ES 2187684 T3 ES2187684 T3 ES 2187684T3 ES 96944241 T ES96944241 T ES 96944241T ES 96944241 T ES96944241 T ES 96944241T ES 2187684 T3 ES2187684 T3 ES 2187684T3
- Authority
- ES
- Spain
- Prior art keywords
- synthesis
- procedure
- intermediate products
- prepare intermediate
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000001716 anti-fugal effect Effects 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- 102000004882 Lipase Human genes 0.000 abstract 1
- 108090001060 Lipase Proteins 0.000 abstract 1
- 150000002009 diols Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/65—Halogen-containing esters of unsaturated acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Casting Devices For Molds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE DESCRIBE UN PROCESO PARA PRODUCIR UN HIDROXIESTER QUIRAL CRISTALINO DE FORMULA (1.0). EL PROCESO COMPRENDE LA REDUCCION DE UN DIOL DE FORMULA (2.0), CON UNA CANTIDAD EFECTIVA DE ANHIDRIDO ISOBUTIRICO Y UNA CANTIDAD EFECTIVA DE UN ENZIMA LIPASA EN UNA CANTIDAD EFECTIVA DE ACETONITRILO, SIENDO LLEVADA A CABO DICHA REACCION A BAJA TEMPERATURA, Y EN DONDE X 1 Y X 2 SE SELECCIONAN INDEPENDIENTEMENTE ENTRE F O CL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57533495A | 1995-12-20 | 1995-12-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2187684T3 true ES2187684T3 (es) | 2003-06-16 |
Family
ID=24299896
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96944241T Expired - Lifetime ES2187684T3 (es) | 1995-12-20 | 1996-12-18 | Procedimiento para preparar productos intermedios para la sintesis de agentes antifungicos. |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0868525B1 (es) |
JP (4) | JP2000501946A (es) |
KR (1) | KR100456181B1 (es) |
CN (1) | CN1090240C (es) |
AT (1) | ATE232906T1 (es) |
AU (1) | AU716642B2 (es) |
BR (1) | BR9612082A (es) |
CA (1) | CA2240408C (es) |
CZ (1) | CZ292649B6 (es) |
DE (1) | DE69626308T2 (es) |
DK (1) | DK0868525T3 (es) |
ES (1) | ES2187684T3 (es) |
HK (1) | HK1010563A1 (es) |
HU (1) | HU225765B1 (es) |
IL (2) | IL125005A0 (es) |
MX (1) | MX9804958A (es) |
NO (1) | NO320154B1 (es) |
NZ (1) | NZ325566A (es) |
PL (1) | PL185775B1 (es) |
SK (1) | SK284149B6 (es) |
WO (1) | WO1997022710A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6995001B2 (en) | 2002-10-03 | 2006-02-07 | Wyeth Holdings Corporation | Processing for preparing monoprotected diols from symmetric diols |
EP2571847B1 (en) | 2010-05-19 | 2016-09-21 | Sandoz AG | Process for the preparation of chiral hydrazides |
WO2011144657A1 (en) | 2010-05-19 | 2011-11-24 | Sandoz Ag | Purification of posaconazole and posaconazole intermediates |
RU2580318C2 (ru) | 2010-05-19 | 2016-04-10 | Сандоз Аг | Получение промежуточных продуктов для синтеза позаконазола |
CN102906087B (zh) | 2010-05-19 | 2016-03-23 | 桑多斯股份公司 | 制备手性三唑酮的方法 |
CN103635465A (zh) | 2011-06-16 | 2014-03-12 | 桑多斯股份公司 | 制备手性化合物的方法 |
EP2789610A1 (en) | 2013-04-10 | 2014-10-15 | Sandoz Ag | Purification of Posaconazole Intermediates |
CN108727196A (zh) * | 2018-07-23 | 2018-11-02 | 安徽华星化工有限公司 | 一种生产2-甲基-4-氯苯氧乙酸的酯类的方法 |
CN115448912B (zh) * | 2022-10-12 | 2023-09-12 | 四川澄华生物科技有限公司 | 泊沙康唑中间体的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3978193A (en) * | 1992-05-01 | 1993-11-29 | Cognis, Inc. | Process of preparing enriched enantiomers of glycerol carbonate and derivatives thereof for synthesis of beta -blockers |
US5403937A (en) * | 1993-04-30 | 1995-04-04 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
US5442093A (en) * | 1994-05-09 | 1995-08-15 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
-
1996
- 1996-12-18 AU AU14101/97A patent/AU716642B2/en not_active Ceased
- 1996-12-18 HU HU9902113A patent/HU225765B1/hu not_active IP Right Cessation
- 1996-12-18 ES ES96944241T patent/ES2187684T3/es not_active Expired - Lifetime
- 1996-12-18 EP EP96944241A patent/EP0868525B1/en not_active Expired - Lifetime
- 1996-12-18 BR BR9612082A patent/BR9612082A/pt not_active Application Discontinuation
- 1996-12-18 PL PL96327456A patent/PL185775B1/pl unknown
- 1996-12-18 IL IL12500596A patent/IL125005A0/xx unknown
- 1996-12-18 DE DE69626308T patent/DE69626308T2/de not_active Expired - Lifetime
- 1996-12-18 CA CA002240408A patent/CA2240408C/en not_active Expired - Fee Related
- 1996-12-18 NZ NZ325566A patent/NZ325566A/xx not_active IP Right Cessation
- 1996-12-18 WO PCT/US1996/019423 patent/WO1997022710A1/en active IP Right Grant
- 1996-12-18 DK DK96944241T patent/DK0868525T3/da active
- 1996-12-18 AT AT96944241T patent/ATE232906T1/de active
- 1996-12-18 KR KR10-1998-0704645A patent/KR100456181B1/ko not_active IP Right Cessation
- 1996-12-18 SK SK864-98A patent/SK284149B6/sk not_active IP Right Cessation
- 1996-12-18 CZ CZ19981916A patent/CZ292649B6/cs not_active IP Right Cessation
- 1996-12-18 JP JP9522850A patent/JP2000501946A/ja not_active Withdrawn
- 1996-12-18 CN CN96199938A patent/CN1090240C/zh not_active Expired - Fee Related
-
1998
- 1998-06-18 IL IL125005A patent/IL125005A/en not_active IP Right Cessation
- 1998-06-19 MX MX9804958A patent/MX9804958A/es not_active IP Right Cessation
- 1998-06-19 NO NO19982880A patent/NO320154B1/no not_active IP Right Cessation
- 1998-11-06 HK HK98111788A patent/HK1010563A1/xx not_active IP Right Cessation
-
2006
- 2006-08-18 JP JP2006223570A patent/JP2007020573A/ja not_active Withdrawn
-
2008
- 2008-05-29 JP JP2008141693A patent/JP4906785B2/ja not_active Expired - Fee Related
-
2011
- 2011-04-20 JP JP2011094504A patent/JP2011139715A/ja active Pending
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