FI943430A - Lääkkeenantojärjestelmä entsyymeillä ja valolle aktivoitavien lääkkeiden samanaikaiseksi vapauttamiseksi - Google Patents

Lääkkeenantojärjestelmä entsyymeillä ja valolle aktivoitavien lääkkeiden samanaikaiseksi vapauttamiseksi Download PDF

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Publication number
FI943430A
FI943430A FI943430A FI943430A FI943430A FI 943430 A FI943430 A FI 943430A FI 943430 A FI943430 A FI 943430A FI 943430 A FI943430 A FI 943430A FI 943430 A FI943430 A FI 943430A
Authority
FI
Finland
Prior art keywords
drug
attached
copolymeric
carrier
anticancer
Prior art date
Application number
FI943430A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI943430A0 (fi
Inventor
Jindrich Kopecek
Nancy Krinick
Original Assignee
Univ Utah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Utah filed Critical Univ Utah
Publication of FI943430A0 publication Critical patent/FI943430A0/fi
Publication of FI943430A publication Critical patent/FI943430A/fi

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/811Peptides or proteins is immobilized on, or in, an inorganic carrier
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812Peptides or proteins is immobilized on, or in, an organic carrier
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815Carrier is a synthetic polymer
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815Carrier is a synthetic polymer
    • Y10S530/816Attached to the carrier via a bridging agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Processing Of Solid Wastes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FI943430A 1992-01-21 1994-07-20 Lääkkeenantojärjestelmä entsyymeillä ja valolle aktivoitavien lääkkeiden samanaikaiseksi vapauttamiseksi FI943430A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/822,924 US5258453A (en) 1992-01-21 1992-01-21 Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light
PCT/US1993/000683 WO1993014142A1 (fr) 1992-01-21 1993-01-21 Systeme d'apport de medicaments pour l'apport simultane de medicaments activables par les enzymes et la lumiere

Publications (2)

Publication Number Publication Date
FI943430A0 FI943430A0 (fi) 1994-07-20
FI943430A true FI943430A (fi) 1994-09-20

Family

ID=25237341

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943430A FI943430A (fi) 1992-01-21 1994-07-20 Lääkkeenantojärjestelmä entsyymeillä ja valolle aktivoitavien lääkkeiden samanaikaiseksi vapauttamiseksi

Country Status (14)

Country Link
US (1) US5258453A (fr)
EP (1) EP0621880B1 (fr)
JP (1) JPH08500327A (fr)
KR (1) KR100217186B1 (fr)
AT (1) ATE184201T1 (fr)
AU (1) AU663167B2 (fr)
CA (1) CA2128330A1 (fr)
DE (1) DE69326322T2 (fr)
DK (1) DK0621880T3 (fr)
FI (1) FI943430A (fr)
HU (1) HUT68082A (fr)
PL (1) PL172184B1 (fr)
RU (1) RU94038047A (fr)
WO (1) WO1993014142A1 (fr)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5543390A (en) * 1990-11-01 1996-08-06 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Covalent microparticle-drug conjugates for biological targeting
US5827819A (en) 1990-11-01 1998-10-27 Oregon Health Sciences University Covalent polar lipid conjugates with neurologically active compounds for targeting
US5474765A (en) * 1992-03-23 1995-12-12 Ut Sw Medical Ctr At Dallas Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells
US5482719A (en) * 1992-10-30 1996-01-09 Guillet; James E. Drug delivery systems
US20040071637A1 (en) * 1993-04-27 2004-04-15 Elia James P. Method for repairing a damaged portion of a human organ
US5449720A (en) * 1993-05-24 1995-09-12 Biotech Australia Pty Limited Amplification of the VB12 uptake system using polymers
GB9320781D0 (en) * 1993-10-08 1993-12-01 Erba Carlo Spa Polymer-bound camptothecin derivatives
US5444650A (en) * 1994-01-25 1995-08-22 Nippondenso Co., Ltd. Semiconductor programmable read only memory device
US5599831A (en) * 1994-05-27 1997-02-04 Poretz; Ronald D. Method of preparation of pharmaceutical compositions
NO180167C (no) * 1994-09-08 1997-02-26 Photocure As Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol
CN1090022C (zh) * 1995-04-04 2002-09-04 俄克拉荷马创伤治疗所 通过光动力疗法与免疫佐剂联合应用治疗癌症
US6316007B1 (en) 1995-04-04 2001-11-13 Wound Healing Of Oklahoma Combined physical and immunotherapy for cancer
US5776925A (en) * 1996-01-25 1998-07-07 Pharmacyclics, Inc. Methods for cancer chemosensitization
US6375930B2 (en) 1996-06-04 2002-04-23 Board Of Regents, The University Of Texas System Membrane incorporation of texaphyrins
US6493570B1 (en) 1998-11-02 2002-12-10 Photogen, Inc. Method for improved imaging and photodynamic therapy
CA2296056A1 (fr) * 1997-07-10 1999-01-21 Keith Baker Procedes permettant d'alimenter le cerveau en agents therapeutiques de facon universelle
JP2003516305A (ja) * 1997-08-05 2003-05-13 ワトソン ファーマシューティカルズ, インコーポレイテッド インターロイキン−2レセプターに標的化された結合体
US6251866B1 (en) 1997-08-05 2001-06-26 Watson Laboratories, Inc. Conjugates targeted to the interleukin-2 receptor
US8974363B2 (en) 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
CA2317549C (fr) 1998-01-05 2006-04-11 University Of Washington Composition pour l'amelioration du transport par l'utilisation de membranes contenant des lipides et utilisation connexe
US6087952A (en) * 1998-03-06 2000-07-11 Mobile Information Systems, Inc. Remote mobile data suite and method
US6223071B1 (en) 1998-05-01 2001-04-24 Dusa Pharmaceuticals Inc. Illuminator for photodynamic therapy and diagnosis which produces substantially uniform intensity visible light
US20030223978A1 (en) * 1998-05-22 2003-12-04 Nabi Ivan R. Conjugates of an AMF ligand and a cytotoxic molecule for use in cancer therapy
US8557298B2 (en) 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US6986740B2 (en) * 1998-11-02 2006-01-17 Xantech Pharmaceuticals, Inc. Ultrasound contrast using halogenated xanthenes
US6222093B1 (en) * 1998-12-28 2001-04-24 Rosetta Inpharmatics, Inc. Methods for determining therapeutic index from gene expression profiles
US20030114366A1 (en) * 1999-01-11 2003-06-19 Francis J. Martin Microfabricated particles and method for treating solid tumors
GB9905911D0 (en) 1999-03-15 1999-05-05 Photocure As Method
AU1820400A (en) * 1999-11-17 2001-05-30 School Of Pharmacy, University Of London, The Conjugates of hpma copolymer and ellipticin
AU2764801A (en) * 2000-01-07 2001-07-24 University Of Washington Enhanced transport of agents using membrane disruptive agents
US6455073B1 (en) 2000-07-10 2002-09-24 Enzrel, Inc. Covalent microparticle-drug conjugates for biological targeting
US6454790B1 (en) * 2000-07-21 2002-09-24 Ceramoptec Industries, Inc. Treatment for Barrett's syndrome
KR20080080685A (ko) 2000-11-29 2008-09-04 피씨아이 바이오테크 에이에스 사이토졸 내로의 분자 전달을 위한 광화학적 내부이행
WO2002049672A2 (fr) * 2000-12-21 2002-06-27 Mcgill University Compose utilise pour cibler des cellules specifiques a toxicite systemique reduite
ES2300439T3 (es) * 2001-04-30 2008-06-16 Zystor Therapeutics , Inc. Reconocimiento subcelular de proteinas terapeuticas.
US7629309B2 (en) 2002-05-29 2009-12-08 Zystor Therapeutics, Inc. Targeted therapeutic proteins
US20040005309A1 (en) * 2002-05-29 2004-01-08 Symbiontics, Inc. Targeted therapeutic proteins
US7560424B2 (en) * 2001-04-30 2009-07-14 Zystor Therapeutics, Inc. Targeted therapeutic proteins
WO2002090390A1 (fr) * 2001-05-04 2002-11-14 University Of Utah Research Foundation Acide hyaluronique contenant des bioconjugues: administration ciblee de medicaments anticancereux dans des cellules cancereuses
US20030124742A1 (en) * 2001-08-22 2003-07-03 Prakash Ramesh K. Conjugates targeted to target receptors
US20030072761A1 (en) * 2001-10-16 2003-04-17 Lebowitz Jonathan Methods and compositions for targeting proteins across the blood brain barrier
WO2003051113A1 (fr) 2001-12-14 2003-06-26 The University Of Wyoming Methodes et compositions de liberation controlee de medicaments
US6846311B2 (en) * 2002-04-02 2005-01-25 Acueity, Inc. Method and apparatus for in VIVO treatment of mammary ducts by light induced fluorescence
US20050169883A1 (en) * 2002-05-06 2005-08-04 Prestwich Glenn D. Preblocking with non-ha gags increases effectiveness of ha conjugated anticancer agents
ATE359802T1 (de) * 2002-10-04 2007-05-15 Photokinetix Inc Photokinetische abgabe von biologisch aktiven subtanzen unter verwendung von pulsierendem inkohaerentem licht.
US20050244400A1 (en) * 2004-02-10 2005-11-03 Zystor Therapeutics, Inc. Acid alpha-glucosidase and fragments thereof
ES2641570T3 (es) * 2004-03-31 2017-11-10 University Of Utah Research Foundation Sistemas de suministro macromoleculares para imagenología no invasiva, evaluación y tratamiento de artritis y otras enfermedades inflamatorias
US20070287680A1 (en) * 2004-05-10 2007-12-13 University Of Utah Research Foundation Combined Active and Passive Targeting of Biologically Active Agents
EP1888115A2 (fr) * 2005-05-16 2008-02-20 Universite De Geneve Composes destines a la photochimiotherapie
US7465312B2 (en) 2006-05-02 2008-12-16 Green Medical, Inc. Systems and methods for treating superficial venous malformations like spider veins
US20070299431A1 (en) * 2006-05-02 2007-12-27 Green Medical, Inc. Systems and methods for treating superficial venous malformations like spider veins
US20090326435A1 (en) * 2006-05-02 2009-12-31 Green Medical, Inc. Systems and methods for treating superficial venous malformations like varicose or spider veins
WO2007143209A2 (fr) * 2006-06-02 2007-12-13 University Of Virginia Patent Foundation Polymères de dicétonate luminescents
EP2492684B1 (fr) 2006-06-02 2016-12-28 President and Fellows of Harvard College Remodelage de surface de protéine
GB0618524D0 (en) 2006-09-20 2006-11-01 Isis Innovation Multimeric particles
JP2010509344A (ja) * 2006-11-13 2010-03-25 ザイストール セラピューティクス, インコーポレイテッド ポンペ病を治療するための方法
JP5627571B2 (ja) 2008-05-07 2014-11-19 バイオマリン ファーマシューティカル インコーポレイテッド リソソーム標的化ペプチドおよびその使用
JP2012505228A (ja) * 2008-10-07 2012-03-01 レクサン ファーマシューティカルズ インコーポレイテッド Hpma−ドセタキセルまたはゲムシタビンコンジュゲートおよびその使用
KR20100083632A (ko) * 2009-01-14 2010-07-22 울산대학교 산학협력단 표적 단백질 분해효소 감응형 항암제 전구체
JP2012525146A (ja) * 2009-04-28 2012-10-22 プレジデント アンド フェロウズ オブ ハーバード カレッジ 細胞透過のための過剰に荷電されたタンパク質
ES2569514T3 (es) 2009-06-17 2016-05-11 Biomarin Pharmaceutical Inc. Formulaciones para enzimas lisosómicas
BR112012008772A2 (pt) 2009-10-13 2017-06-20 Rexahn Pharmaceuticals Inc sistemas poliméricos para a liberação de agentes anti-câncer
US8492339B2 (en) * 2009-10-26 2013-07-23 Empire Technology Development Llc Angiogenesis promoted by caged growth factors
WO2011112482A2 (fr) 2010-03-08 2011-09-15 University Of Utah Research Foundation Conjugués d'administration de médicaments polymères, leurs procédés de fabrication et leurs méthodes d'utilisation
EP3858385A3 (fr) 2010-05-25 2021-10-27 Syndevrx, Inc. Inhibiteurs des metap2 conjugués à des polymères et leurs méthodes d'utilisation dans le domaine thérapeutique
US9895449B2 (en) 2010-05-25 2018-02-20 Syndevrx, Inc. Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof
US8883503B2 (en) 2011-06-23 2014-11-11 Indian Institute Of Technology Kanpur Hydrogel scaffolds for tissue engineering
DK2774625T3 (en) * 2011-09-05 2017-06-12 Hiroshi Maeda POLYMER TYPE FLUORESCING MOLECULE PROBE
US11773188B2 (en) 2012-01-20 2023-10-03 Immunophotonics, Inc Chitosan-derived compositions
DK2804611T3 (da) 2012-01-20 2020-11-09 Immunophotonics Inc Chitosanafledte forbindelser
US11111316B2 (en) 2012-01-20 2021-09-07 Immunophotonics, Inc. Chitosan-derived compositions
DK2984085T3 (da) 2013-04-10 2019-10-21 Syndevrx Inc Modificerede eller polymerkonjugerede fumagillol metap2-hæmmere til anvendelse i behandling af fedme
JP2019501898A (ja) 2015-12-10 2019-01-24 シンデブルックス,インコーポレイティド フマギロール誘導体およびその多形体
KR20180100663A (ko) 2016-01-11 2018-09-11 신데브알엑스, 인크. 대사 기능장애에 의하여 유도된 종양에 대한 치료
MX2018015916A (es) 2016-06-16 2019-03-28 Oncoselect Therapeutics Llc Compuestos de porfirina y composiciones útiles para el tratamiento de cáncer.
JP7136807B2 (ja) 2017-04-17 2022-09-13 ザ・ユニバーシティ・オブ・シカゴ ヒトの健康及び疾患の治療用途向けの短鎖脂肪酸の腸への送達用ポリマー材料
JP6894747B2 (ja) * 2017-04-19 2021-06-30 キヤノン株式会社 重合体
AU2019366819A1 (en) 2018-10-26 2021-06-03 Syndevrx Inc. Biomarkers of MetAP2 inhibitors and applications thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0103184B1 (fr) * 1982-08-12 1990-01-17 Kanegafuchi Chemical Industry Co., Ltd. Activation de terpolymères biocompatibles par des agents biologiques dont les compléments à fixer sont des effecteurs pathologiques
GB8500209D0 (en) * 1985-01-04 1985-02-13 Ceskoslovenska Akademie Ved Synthetic polymeric drugs
EP0213811A3 (fr) * 1985-08-16 1987-09-09 Johnson Matthey, Inc., Composés dirigés par une bactériocine pour le traitement du cancer

Also Published As

Publication number Publication date
AU3593093A (en) 1993-08-03
FI943430A0 (fi) 1994-07-20
DE69326322T2 (de) 2000-02-17
ATE184201T1 (de) 1999-09-15
US5258453A (en) 1993-11-02
AU663167B2 (en) 1995-09-28
WO1993014142A1 (fr) 1993-07-22
DK0621880T3 (da) 1999-12-20
EP0621880A1 (fr) 1994-11-02
JPH08500327A (ja) 1996-01-16
HU9402142D0 (en) 1994-09-28
KR100217186B1 (ko) 1999-09-01
EP0621880B1 (fr) 1999-09-08
HUT68082A (en) 1995-05-29
CA2128330A1 (fr) 1993-07-22
DE69326322D1 (de) 1999-10-14
RU94038047A (ru) 1996-06-10
PL172184B1 (pl) 1997-08-29
EP0621880A4 (fr) 1995-04-19

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