FI942252A0 - Piperazinderivat - Google Patents
PiperazinderivatInfo
- Publication number
- FI942252A0 FI942252A0 FI942252A FI942252A FI942252A0 FI 942252 A0 FI942252 A0 FI 942252A0 FI 942252 A FI942252 A FI 942252A FI 942252 A FI942252 A FI 942252A FI 942252 A0 FI942252 A0 FI 942252A0
- Authority
- FI
- Finland
- Prior art keywords
- group
- substituted
- aryl
- alkylene
- nitrogen
- Prior art date
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
- Indole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Chemical And Physical Treatments For Wood And The Like (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11277193 | 1993-05-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
FI942252A0 true FI942252A0 (sv) | 1994-05-13 |
FI942252A FI942252A (sv) | 1994-11-15 |
Family
ID=14595104
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI942252A FI942252A (sv) | 1993-05-14 | 1994-05-13 | Piperazinderivat |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0624584B1 (sv) |
JP (2) | JP3220591B2 (sv) |
KR (1) | KR100303737B1 (sv) |
CN (1) | CN1049654C (sv) |
AT (1) | ATE169914T1 (sv) |
AU (2) | AU677644B2 (sv) |
CA (1) | CA2123548C (sv) |
DE (1) | DE69412534T2 (sv) |
DK (1) | DK0624584T3 (sv) |
EE (1) | EE03139B1 (sv) |
ES (1) | ES2125372T3 (sv) |
FI (1) | FI942252A (sv) |
GR (1) | GR3027679T3 (sv) |
HK (1) | HK1002221A1 (sv) |
NO (1) | NO306901B1 (sv) |
RU (1) | RU2124511C1 (sv) |
SG (1) | SG48920A1 (sv) |
SI (1) | SI0624584T1 (sv) |
TW (1) | TW418198B (sv) |
Families Citing this family (56)
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SE9103752D0 (sv) * | 1991-12-18 | 1991-12-18 | Astra Ab | New compounds |
JP3948744B2 (ja) * | 1994-11-04 | 2007-07-25 | 大日本住友製薬株式会社 | 新規なラクタム誘導体 |
ES2156605T3 (es) * | 1994-11-14 | 2001-07-01 | Daiichi Seiyaku Co | Procedimiento de preparacion de un 3,5-hidrato de dihidrocloruro de 3-(2-(4-(3-cloro-2-metilfenil)-1-piperazinil)etil)-5,6-dimetoxi-1-(4-imidazolilmetil)-1h-indazol. |
CA2180190A1 (en) * | 1995-07-10 | 1997-01-11 | Kazumi Ogata | Benzylpiperazine derivatives |
WO1997041108A1 (en) * | 1996-04-30 | 1997-11-06 | Warner-Lambert Company | Substituted piperazines and piperidines as central nervous system agents |
WO1998008816A1 (fr) * | 1996-08-26 | 1998-03-05 | Meiji Seika Kaisha, Ltd. | Derives d'indoxyle et psychotropes |
US5859246A (en) * | 1997-01-30 | 1999-01-12 | Neurogen Corporation | 1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands |
US6479495B1 (en) * | 1997-09-29 | 2002-11-12 | Aventis Pharmaceuticals Inc. | Aminoalkylphenol derivatives and related compounds |
ATE346840T1 (de) * | 1997-09-29 | 2006-12-15 | Aventis Pharma Inc | Aminoalkylphenol-derivate zur behandlung von depression und gedächtnis-funktionsstörung |
US6596706B1 (en) | 1997-11-07 | 2003-07-22 | Daiichi Pharmaceutical Co., Ltd. | Piperazine-cyclodextrin complexes |
AR022303A1 (es) | 1999-01-22 | 2002-09-04 | Lundbeck & Co As H | Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion |
GB9914371D0 (en) * | 1999-06-18 | 1999-08-18 | Smithkline Beecham Plc | Novel compounds |
DE19934432A1 (de) | 1999-07-22 | 2001-02-01 | Merck Patent Gmbh | Indolderivate |
WO2002004433A2 (en) | 2000-07-06 | 2002-01-17 | Neurogen Corporation | Melanin concentrating hormone receptor ligands |
BR0209678A (pt) | 2001-05-18 | 2004-09-14 | Astrazeneca Ab | Composto, processo para preparar e uso do mesmo, composição farmacêutica, e, métodos para o tratamento da dor e de distúrbios gastrintestinais funcionais |
IL158941A0 (en) | 2001-05-22 | 2004-05-12 | Neurogen Corp | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues |
CN1150176C (zh) * | 2002-05-22 | 2004-05-19 | 上海医药工业研究院 | 芳烷酮哌嗪衍生物及其应用 |
PL215454B1 (pl) | 2002-10-23 | 2013-12-31 | Janssen Pharmaceutica Nv | Pochodne piperazynylobenzamidu, ich zastosowanie oraz kompozycja farmaceutyczna je zawierajaca |
SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203302D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
US20050075364A1 (en) * | 2003-07-01 | 2005-04-07 | Kap-Sun Yeung | Indole, azaindole and related heterocyclic N-substituted piperazine derivatives |
JP4563387B2 (ja) * | 2003-09-09 | 2010-10-13 | エフ.ホフマン−ラ ロシュ アーゲー | 精神病の処置のためのグリシン取り込み阻害剤としての1−ベンゾイル−ピペラジン誘導体 |
WO2005110982A2 (en) | 2004-04-07 | 2005-11-24 | Neurogen Corporation | Substituted 1-benzyl-4-substituted piperazine analogues |
AU2005275181A1 (en) | 2004-07-14 | 2006-02-23 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7645881B2 (en) | 2004-07-22 | 2010-01-12 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
DK1781631T3 (da) | 2004-08-02 | 2012-05-14 | Astrazeneca Ab | Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf |
US7622486B2 (en) | 2004-09-23 | 2009-11-24 | Reddy Us Therapeutics, Inc. | Pyridine compounds, process for their preparation and compositions containing them |
ATE430142T1 (de) | 2004-12-09 | 2009-05-15 | Hoffmann La Roche | Phenylpiperazin-methanon-derivate |
DE602005019465D1 (de) | 2004-12-15 | 2010-04-01 | Hoffmann La Roche | Bi- und trizyklische substituierte phenyl-methanone als inhibitoren von glycin-i (glyt-1)-transportern zur behandlung der alzheimer-krankheit |
US7485637B2 (en) | 2005-01-04 | 2009-02-03 | Hoffmann-La Roche Inc. | Benzoyl-tetrahydropiperidine derivatives |
RU2396270C2 (ru) | 2005-01-07 | 2010-08-10 | Ф.Хоффманн-Ля Рош Аг | Производные [4-(гетероарил)пиперазин-1-ил]-(2,5-замещенный фенил)метанона в качестве ингибиторов переносчика глицина-1 (glyt-1) для лечения неврологических и психоневрологических заболеваний |
ES2332529T3 (es) | 2005-01-26 | 2010-02-08 | F. Hoffmann-La Roche Ag | Derivados de fenil-metanona y su empleo como inhibidores del transportador 1 de glicina. |
EP1848694B1 (en) | 2005-02-07 | 2009-11-25 | F. Hoffmann-Roche AG | Heterocyclic substituted phenyl methanones as inhibitors of the glycine transporter 1 |
CN101277934A (zh) * | 2005-08-12 | 2008-10-01 | 阿斯利康(瑞典)有限公司 | 使代谢型谷氨酸-受体-增效的异吲哚酮 |
US7544685B2 (en) | 2005-08-17 | 2009-06-09 | H. Lundbeck A/S | 2,3-dihydroindole compounds |
US8003624B2 (en) * | 2005-08-25 | 2011-08-23 | Schering Corporation | Functionally selective ALPHA2C adrenoreceptor agonists |
CA2622760C (en) | 2005-09-16 | 2012-12-04 | Janssen Pharmaceutica N.V. | Cyclopropyl amines as modulators of the histamine h3 receptor |
JP4783154B2 (ja) | 2006-01-11 | 2011-09-28 | 東芝モバイルディスプレイ株式会社 | 平面表示装置及びその駆動方法 |
TWI417100B (zh) * | 2007-06-07 | 2013-12-01 | Astrazeneca Ab | 二唑衍生物及其作為代謝型麩胺酸受體增效劑-842之用途 |
JP5255994B2 (ja) * | 2008-11-04 | 2013-08-07 | 国立大学法人 岡山大学 | 核内受容体リガンド |
CN102260214B (zh) * | 2009-12-29 | 2013-12-04 | 浙江大学 | 一种吲唑化合物的制备方法 |
BR102012000187A2 (pt) * | 2012-01-05 | 2018-04-10 | Univ Rio De Janeiro | Derivados n-fenilpiperazínicos antagonistas de adrenoceptores a1a, a1d e de receptores 5-ht1a no tratamento da hiperplasia prostática benigna, composições farmacêuticas contendo os mesmos |
CN102653521B (zh) * | 2012-04-27 | 2014-08-06 | 首都师范大学 | 吲哚-2-酮的哌嗪硫代甲酰肼衍生物及其制备方法和用途 |
EP2864322B1 (en) | 2012-06-20 | 2016-04-27 | Novartis AG | Complement pathway modulators and uses thereof |
EP3027607B1 (en) | 2013-07-29 | 2020-08-26 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use thereof |
WO2015090235A1 (en) | 2013-12-20 | 2015-06-25 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use thereof |
CN105078993B (zh) * | 2015-08-26 | 2019-02-22 | 浙江大果生物医药科技有限公司 | 一种吲唑类化合物组合物及其制备方法和应用 |
CN105061317B (zh) * | 2015-08-26 | 2017-08-25 | 浙江大果生物医药科技有限公司 | 一类吲唑盐类化合物及其制备方法和应用 |
CN106632268A (zh) * | 2016-11-18 | 2017-05-10 | 河南师范大学 | 用于治疗脑源性疾病的钙调蛋白抑制剂的合成方法 |
CN110407752A (zh) * | 2019-08-22 | 2019-11-05 | 浙江大果生物医药科技有限公司 | 一种药物的草酸盐晶型及其制备方法 |
TWI749881B (zh) * | 2019-11-21 | 2021-12-11 | 大陸商深圳信立泰藥業股份有限公司 | 二氧代哌類衍生物、其製備方法及其在醫藥上的應用 |
CN112608303B (zh) * | 2020-12-25 | 2021-10-26 | 华南理工大学 | 一种哌嗪类中间体及其制备方法与应用 |
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US3362956A (en) * | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
US4510307A (en) * | 1980-08-20 | 1985-04-09 | Asahi Kasei Kogyo Kabushiki Kaisha | 6-Quinazolinesulfonyl derivatives and process for preparation thereof |
US4544657A (en) * | 1983-05-19 | 1985-10-01 | Hoffmann-La Roche Inc. | Substituted isoquinolines |
GB9220735D0 (en) * | 1992-10-02 | 1992-11-18 | British Tech Group | Heterocyclic amines |
-
1994
- 1994-05-12 RU RU94016183/04A patent/RU2124511C1/ru not_active IP Right Cessation
- 1994-05-13 AT AT94107496T patent/ATE169914T1/de not_active IP Right Cessation
- 1994-05-13 CN CN94105810A patent/CN1049654C/zh not_active Expired - Fee Related
- 1994-05-13 EP EP94107496A patent/EP0624584B1/en not_active Expired - Lifetime
- 1994-05-13 SG SG1996003753A patent/SG48920A1/en unknown
- 1994-05-13 NO NO941802A patent/NO306901B1/no not_active IP Right Cessation
- 1994-05-13 DK DK94107496T patent/DK0624584T3/da active
- 1994-05-13 FI FI942252A patent/FI942252A/sv unknown
- 1994-05-13 DE DE69412534T patent/DE69412534T2/de not_active Expired - Fee Related
- 1994-05-13 ES ES94107496T patent/ES2125372T3/es not_active Expired - Lifetime
- 1994-05-13 AU AU63096/94A patent/AU677644B2/en not_active Ceased
- 1994-05-13 JP JP09939194A patent/JP3220591B2/ja not_active Expired - Fee Related
- 1994-05-13 SI SI9430169T patent/SI0624584T1/xx not_active IP Right Cessation
- 1994-05-13 CA CA002123548A patent/CA2123548C/en not_active Expired - Fee Related
- 1994-05-14 KR KR1019940010542A patent/KR100303737B1/ko not_active IP Right Cessation
- 1994-05-25 TW TW083104731A patent/TW418198B/zh not_active IP Right Cessation
- 1994-11-22 EE EE9400389A patent/EE03139B1/xx not_active IP Right Cessation
-
1997
- 1997-06-17 AU AU24952/97A patent/AU698486B2/en not_active Ceased
-
1998
- 1998-01-21 HK HK98100555A patent/HK1002221A1/xx not_active IP Right Cessation
- 1998-08-20 GR GR980401824T patent/GR3027679T3/el unknown
-
2001
- 2001-06-13 JP JP2001178197A patent/JP2002053553A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN1049654C (zh) | 2000-02-23 |
CN1101039A (zh) | 1995-04-05 |
DE69412534D1 (de) | 1998-09-24 |
CA2123548C (en) | 2003-04-08 |
AU698486B2 (en) | 1998-10-29 |
AU2495297A (en) | 1997-09-04 |
JP2002053553A (ja) | 2002-02-19 |
RU94016183A (ru) | 1996-04-10 |
GR3027679T3 (en) | 1998-11-30 |
AU6309694A (en) | 1994-11-17 |
KR100303737B1 (ko) | 2001-11-22 |
EP0624584A1 (en) | 1994-11-17 |
JPH0797364A (ja) | 1995-04-11 |
AU677644B2 (en) | 1997-05-01 |
NO941802L (no) | 1994-11-15 |
RU2124511C1 (ru) | 1999-01-10 |
ATE169914T1 (de) | 1998-09-15 |
FI942252A (sv) | 1994-11-15 |
NO306901B1 (no) | 2000-01-10 |
NO941802D0 (no) | 1994-05-13 |
TW418198B (en) | 2001-01-11 |
ES2125372T3 (es) | 1999-03-01 |
SI0624584T1 (en) | 1998-10-31 |
CA2123548A1 (en) | 1994-11-15 |
DE69412534T2 (de) | 1999-04-29 |
SG48920A1 (en) | 1998-05-18 |
JP3220591B2 (ja) | 2001-10-22 |
HK1002221A1 (en) | 1998-08-07 |
DK0624584T3 (da) | 1999-05-25 |
EE03139B1 (et) | 1998-12-15 |
EP0624584B1 (en) | 1998-08-19 |
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