ATE117292T1 - Antiamnesische pyrrolidin-derivate. - Google Patents

Antiamnesische pyrrolidin-derivate.

Info

Publication number
ATE117292T1
ATE117292T1 AT89106061T AT89106061T ATE117292T1 AT E117292 T1 ATE117292 T1 AT E117292T1 AT 89106061 T AT89106061 T AT 89106061T AT 89106061 T AT89106061 T AT 89106061T AT E117292 T1 ATE117292 T1 AT E117292T1
Authority
AT
Austria
Prior art keywords
amnesic
pyrrolidine derivatives
usefull
amnesia
hydrates
Prior art date
Application number
AT89106061T
Other languages
English (en)
Inventor
Masaaki Toda
Shuichi Shinbayashida Ohuchida
Nishigyo-Ku
Hiroyuki Ohno
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Application granted granted Critical
Publication of ATE117292T1 publication Critical patent/ATE117292T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Cosmetics (AREA)
AT89106061T 1988-04-08 1989-04-06 Antiamnesische pyrrolidin-derivate. ATE117292T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8528888 1988-04-08

Publications (1)

Publication Number Publication Date
ATE117292T1 true ATE117292T1 (de) 1995-02-15

Family

ID=13854381

Family Applications (2)

Application Number Title Priority Date Filing Date
AT89106061T ATE117292T1 (de) 1988-04-08 1989-04-06 Antiamnesische pyrrolidin-derivate.
AT92121896T ATE183739T1 (de) 1988-04-08 1989-04-06 N-acylpyrrolidine, verfahren zur herstellung und ihre verwendung zur prevention und/oder behandlung von amnesie

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT92121896T ATE183739T1 (de) 1988-04-08 1989-04-06 N-acylpyrrolidine, verfahren zur herstellung und ihre verwendung zur prevention und/oder behandlung von amnesie

Country Status (7)

Country Link
US (1) US5053414A (de)
EP (3) EP0537802B1 (de)
KR (1) KR0128160B1 (de)
AT (2) ATE117292T1 (de)
DE (2) DE68929059T2 (de)
ES (1) ES2070135T3 (de)
GR (1) GR3015831T3 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340284C (en) * 1987-03-19 1998-12-22 Zeneca Inc. Herbicidal substituted cyclic diones
JP2691442B2 (ja) * 1989-02-20 1997-12-17 株式会社ヤクルト本社 新規なプロリン誘導体
IT1241415B (it) * 1990-03-05 1994-01-14 Yason Srl Derivato dell'acido s-(2-tenoil)-tiolattico ad attivita' farmacologica
WO1991018891A1 (en) * 1990-06-04 1991-12-12 Pfizer Inc. Aromatic pyrrolidine and thiazolidine amides
AU643300B2 (en) * 1990-06-07 1993-11-11 Zeria Pharmaceutical Co., Ltd. Novel arylalkanoylamine derivative and drug containing the same
EP0468469A2 (de) * 1990-07-27 1992-01-29 Japan Tobacco Inc. Prolinderivate
US5506256A (en) * 1990-07-27 1996-04-09 Yoshitomi Pharmaceutical Industries, Ltd. Proline derivatives possessing prolyl endopeptidase-inhibitory activity
FR2669029B1 (fr) * 1990-11-14 1994-09-02 Adir Nouveaux derives de la n-benzoyl proline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2681864B1 (fr) * 1991-09-27 1995-03-31 Adir Nouveaux derives bicycliques azotes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
JP4806628B2 (ja) 2003-05-05 2011-11-02 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤
AU2004290499C1 (en) 2003-11-03 2011-02-24 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
CA2554809C (en) 2004-02-05 2014-04-29 Probiodrug Ag Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase
US8034940B2 (en) 2006-08-09 2011-10-11 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
EP2089383B1 (de) 2006-11-09 2015-09-16 Probiodrug AG 3-hydroxy-1,5-dihydropyrrol-2-one derivate als inhibitoren von glutaminylcyclase zur behandlung von geschwüren, krebs und anderen krankheiten
DK2091948T3 (da) 2006-11-30 2012-07-23 Probiodrug Ag Nye inhibitorer af glutaminylcyclase
CA2679446C (en) 2007-03-01 2016-05-17 Probiodrug Ag New use of glutaminyl cyclase inhibitors
US9656991B2 (en) 2007-04-18 2017-05-23 Probiodrug Ag Inhibitors of glutaminyl cyclase
MX2012002993A (es) 2009-09-11 2012-04-19 Probiodrug Ag Derivados heterociclicos como inhibidores de ciclasa glutaminilo.
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
JP5688745B2 (ja) 2010-03-10 2015-03-25 プロビオドルグ エージー グルタミニルシクラーゼ（ｑｃ、ｅｃ２．３．２．５）の複素環阻害剤
EP2560953B1 (de) 2010-04-21 2016-01-06 Probiodrug AG Hemmer der glutaminylzyklase
ES2570167T3 (es) 2011-03-16 2016-05-17 Probiodrug Ag Derivados de benzimidazol como inhibidores de glutaminil ciclasa
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE5255T1 (de) * 1978-09-05 1983-11-15 American Cyanamid Company Substituierte omega-aroyl(propionyl oder butyryl)-l-proline, diese enthaltende pharmazeutische verbindungen und verfahren zu ihrer herstellung.
US4880827A (en) * 1986-03-18 1989-11-14 Sumitomo Pharmaceuticals Company, Ltd. Pyrrolidine derivatives having inhibitory action for proline specific endopepidase
EP0268190B1 (de) * 1986-11-20 1993-06-16 Ono Pharmaceutical Co., Ltd. Prolinalderivate
ES2052619T3 (es) * 1987-02-23 1994-07-16 Ono Pharmaceutical Co Un procedimiento para la preparacion de los nuevos derivados de tiazolidina.
US4851428A (en) * 1987-03-06 1989-07-25 American Cyanamid Company Mono- and diepoxide derivatives of Δ22-LL-F28249 compounds
DE3712364A1 (de) * 1987-04-11 1988-10-27 Hoechst Ag Neue pyrrolidin-2-(1,3-dicarbonyl)-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung
DE3712365A1 (de) * 1987-04-11 1988-10-27 Hoechst Ag Neue 2-acylpyrrolidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung
DE3742431A1 (de) * 1987-12-15 1989-07-13 Hoechst Ag Neue derivate cyclischer aminosaeuren, verfahren zu ihrer herstellung, sie enthaltende mittel und deren verwendung
JPH0662591B2 (ja) * 1988-12-14 1994-08-17 株式会社ヤクルト本社 新規なチオプロリン誘導体
JP2691442B2 (ja) * 1989-02-20 1997-12-17 株式会社ヤクルト本社 新規なプロリン誘導体

Also Published As

Publication number Publication date
EP0537802A2 (de) 1993-04-21
DE68929059D1 (de) 1999-09-30
KR0128160B1 (ko) 1998-04-04
EP0537802A3 (en) 1993-06-02
EP0345428B1 (de) 1995-01-18
EP0965585A1 (de) 1999-12-22
DE68920632D1 (de) 1995-03-02
GR3015831T3 (en) 1995-07-31
KR900016122A (ko) 1990-11-12
US5053414A (en) 1991-10-01
DE68929059T2 (de) 2000-01-27
EP0345428A1 (de) 1989-12-13
ES2070135T3 (es) 1995-06-01
ATE183739T1 (de) 1999-09-15
EP0537802B1 (de) 1999-08-25
DE68920632T2 (de) 1995-06-14

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee