FI941222A - Ei-peptidyyli-tyyppisiä integriini-inhibiittoreita, jotka ovat spesifisiä GPIIbIIIa-reseptorin suhteen - Google Patents
Ei-peptidyyli-tyyppisiä integriini-inhibiittoreita, jotka ovat spesifisiä GPIIbIIIa-reseptorin suhteen Download PDFInfo
- Publication number
- FI941222A FI941222A FI941222A FI941222A FI941222A FI 941222 A FI941222 A FI 941222A FI 941222 A FI941222 A FI 941222A FI 941222 A FI941222 A FI 941222A FI 941222 A FI941222 A FI 941222A
- Authority
- FI
- Finland
- Prior art keywords
- peptidyl
- integrin inhibitors
- gpiibiiia receptor
- inhibitors specific
- type integrin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78147791A | 1991-10-18 | 1991-10-18 | |
| US07/866,931 US5250679A (en) | 1991-10-18 | 1992-04-10 | Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor |
| PCT/US1992/008788 WO1993008174A1 (en) | 1991-10-18 | 1992-10-15 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPIIbIIIa RECEPTOR |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI941222A0 FI941222A0 (fi) | 1994-03-15 |
| FI941222A true FI941222A (fi) | 1994-06-02 |
Family
ID=27119863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI941222A FI941222A (fi) | 1991-10-18 | 1994-03-15 | Ei-peptidyyli-tyyppisiä integriini-inhibiittoreita, jotka ovat spesifisiä GPIIbIIIa-reseptorin suhteen |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US5250679A (fi) |
| EP (1) | EP0610334B1 (fi) |
| JP (2) | JP3789468B2 (fi) |
| AT (1) | ATE133412T1 (fi) |
| AU (1) | AU673501B2 (fi) |
| CA (1) | CA2119745C (fi) |
| DE (1) | DE69207916T2 (fi) |
| DK (1) | DK0610334T3 (fi) |
| ES (1) | ES2085651T3 (fi) |
| FI (1) | FI941222A (fi) |
| GE (1) | GEP20032957B (fi) |
| GR (1) | GR3019517T3 (fi) |
| MD (1) | MD960330A (fi) |
| NO (1) | NO307417B1 (fi) |
| WO (1) | WO1993008174A1 (fi) |
Families Citing this family (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2703408B2 (ja) * | 1990-12-28 | 1998-01-26 | 麒麟麦酒株式会社 | １，４‐ベンゾチアゼピン誘導体 |
| EP0570493B1 (en) * | 1991-02-08 | 2000-01-05 | Diatide, Inc. | TECHNETIUM-99m LABELED POLYPEPTIDES FOR IMAGING |
| US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
| US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5645815A (en) | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
| US5693636A (en) * | 1991-06-28 | 1997-12-02 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
| US5939412A (en) * | 1992-06-26 | 1999-08-17 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
| US5565449A (en) * | 1991-10-18 | 1996-10-15 | Genentech, Inc. | Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor |
| US5750754A (en) * | 1993-03-29 | 1998-05-12 | Zeneca Limited | Heterocyclic compounds |
| US5652242A (en) * | 1993-03-29 | 1997-07-29 | Zeneca Limited | Heterocyclic derivatives |
| US5753659A (en) * | 1993-03-29 | 1998-05-19 | Zeneca Limited | Heterocyclic compouds |
| EP0690847A1 (en) * | 1993-03-29 | 1996-01-10 | Zeneca Limited | Heterocyclic compounds as platelet aggregation inhibitors |
| CZ250995A3 (en) * | 1993-03-29 | 1996-01-17 | Zeneca Ltd | Pyridine derivatives, process of their preparation and intermediates employed in this process as well as pharmaceutical compositions containing thereof |
| CA2160120A1 (en) * | 1993-04-08 | 1994-10-27 | Richard T. Dean | Radiolabeled compounds for thrombus imaging |
| GB9313285D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Acid derivatives |
| GB9313268D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Chemical compounds |
| US5463011A (en) * | 1993-06-28 | 1995-10-31 | Zeneca Limited | Acid derivatives |
| IL110172A (en) * | 1993-07-22 | 2001-10-31 | Lilly Co Eli | Bicycle compounds and pharmaceuticals containing them |
| US6448269B1 (en) | 1993-07-22 | 2002-09-10 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
| US6137002A (en) | 1993-07-22 | 2000-10-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
| US5731324A (en) * | 1993-07-22 | 1998-03-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
| US5493020A (en) * | 1993-07-29 | 1996-02-20 | Genentech, Inc. | Tricyclic inhibitors of the GPIIb IIIa receptor |
| CA2134192A1 (en) * | 1993-11-12 | 1995-05-13 | Michael L. Denney | 5, 6-bicyclic glycoprotein iib/iiia antagonists |
| DE4341665A1 (de) * | 1993-12-07 | 1995-06-08 | Basf Ag | Bicyclen-Derivate, ihre Herstellung und Verwendung |
| US6403578B1 (en) | 1993-12-21 | 2002-06-11 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
| MA23420A1 (fr) * | 1994-01-07 | 1995-10-01 | Smithkline Beecham Corp | Antagonistes bicycliques de fibrinogene. |
| EP0762882A4 (en) * | 1994-06-29 | 2002-09-11 | Smithkline Beecham Corp | Vibronectin Receptor Antagonists |
| US6458784B1 (en) | 1994-06-29 | 2002-10-01 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
| AU702661B2 (en) * | 1994-06-29 | 1999-02-25 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
| EP0796252A4 (en) * | 1994-12-09 | 1998-02-04 | Smithkline Beecham Corp | BICYCLIC FIBRINOGEN ANTAGONISTS |
| US5639765A (en) * | 1995-01-17 | 1997-06-17 | G. D. Searle & Co. | Guanidinoalkyl glycine β-amino acids useful for inhibiting bone loss |
| US5977101A (en) * | 1995-06-29 | 1999-11-02 | Smithkline Beecham Corporation | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity |
| IL125033A0 (en) * | 1995-12-29 | 1999-01-26 | Smithkline Beecham Corp | Vitronectin receptor antagonists |
| US6107300A (en) * | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
| ATE219764T1 (de) * | 1996-03-29 | 2002-07-15 | Searle & Co | Zimtsäurederivate und deren verwendung als integrin-antagonisten |
| US6686350B1 (en) * | 1996-07-25 | 2004-02-03 | Biogen, Inc. | Cell adhesion inhibitors |
| TR199900781T2 (xx) * | 1996-07-25 | 1999-07-21 | Biogen, Inc. | H�cre yap��ma inhibit�rleri |
| EP0914605B1 (en) | 1996-07-25 | 2007-05-30 | Biogen Idec MA Inc. | Molecular model for vla-4 inhibitors |
| US20030125317A1 (en) | 1996-10-02 | 2003-07-03 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
| PE32799A1 (es) * | 1996-12-25 | 1999-04-09 | Agrogene Ltd | Nuevo derivado del acido aminobutirico para la proteccion de enfermedades fungosas |
| US7109326B2 (en) | 1997-04-15 | 2006-09-19 | Genentech, Inc. | Halo-alkoxycarbonyl prodrugs |
| DE69830577T2 (de) * | 1997-04-15 | 2006-05-04 | Genentech, Inc., South San Francisco | Halo-alkoxycarbonylverbindungen |
| US6197794B1 (en) | 1998-01-08 | 2001-03-06 | Celltech Therapeutics Limited | Phenylalanine derivatives |
| US6329372B1 (en) | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
| CA2319173A1 (en) * | 1998-02-11 | 1999-08-19 | Jingwu Duan | Novel cyclic sulfonamide derivatives as metalloproteinase inhibitors |
| JP2002504534A (ja) | 1998-02-26 | 2002-02-12 | セルテック・セラピューティクス・リミテッド | α４インテグリンの阻害剤としてのフェニルアラニン誘導体 |
| US6136804A (en) | 1998-03-13 | 2000-10-24 | Merck & Co., Inc. | Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions |
| EP1061908A4 (en) * | 1998-03-13 | 2007-01-24 | Merck & Co Inc | COMBINATION THERAPY AND COMPOSITION FOR ACUTE CORONARY MIXING SYNDROME AND ASSOCIATED CONDITIONS |
| GB9805655D0 (en) | 1998-03-16 | 1998-05-13 | Celltech Therapeutics Ltd | Chemical compounds |
| US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
| WO1999050249A2 (en) | 1998-04-01 | 1999-10-07 | Du Pont Pharmaceuticals Company | Pyrimidines and triazines as integrin antagonists |
| GB9811159D0 (en) | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9811969D0 (en) | 1998-06-03 | 1998-07-29 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9812088D0 (en) | 1998-06-05 | 1998-08-05 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9814414D0 (en) | 1998-07-03 | 1998-09-02 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9821061D0 (en) | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9821222D0 (en) | 1998-09-30 | 1998-11-25 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9825652D0 (en) | 1998-11-23 | 1999-01-13 | Celltech Therapeutics Ltd | Chemical compounds |
| US6204282B1 (en) | 1998-11-30 | 2001-03-20 | Schering Corporation | Benzimidazole compounds that are vitronectin receptor antagonists |
| GB9826174D0 (en) | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
| US6339083B1 (en) | 1998-12-14 | 2002-01-15 | Bayer Aktiengesellschaft | Multiheterocyclic pharmAceuticals |
| US6511649B1 (en) | 1998-12-18 | 2003-01-28 | Thomas D. Harris | Vitronectin receptor antagonist pharmaceuticals |
| US6569402B1 (en) | 1998-12-18 | 2003-05-27 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
| WO2000035887A2 (en) | 1998-12-18 | 2000-06-22 | Du Pont Pharm Co | Vitronectin receptor antagonist pharmaceuticals |
| EP1028114A1 (en) | 1999-02-13 | 2000-08-16 | Aventis Pharma Deutschland GmbH | Novel guanidine derivatives as inhibitors of cell adhesion |
| US6171578B1 (en) * | 1999-04-14 | 2001-01-09 | Diatide, Inc. | Benzodiazepine derivatives for imaging thrombi |
| US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
| WO2001004103A1 (en) * | 1999-07-13 | 2001-01-18 | F. Hoffmann-La Roche Ag | Benzazepinones and quinazolines |
| GEP20053477B (en) | 1999-08-13 | 2005-03-25 | Biogen Inc | Cell Adhesion Inhibitors and Pharmaceutical Compositions Containing Them |
| US6514964B1 (en) * | 1999-09-27 | 2003-02-04 | Amgen Inc. | Fused cycloheptane and fused azacycloheptane compounds and their methods of use |
| US6534513B1 (en) | 1999-09-29 | 2003-03-18 | Celltech R&D Limited | Phenylalkanoic acid derivatives |
| DE10028575A1 (de) | 2000-06-14 | 2002-03-14 | Basf Ag | Integrinliganden |
| US6455539B2 (en) | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
| ATE375330T1 (de) | 2000-04-17 | 2007-10-15 | Ucb Pharma Sa | Enamin-derivate als zell-adhäsionsmoleküle |
| US6545013B2 (en) | 2000-05-30 | 2003-04-08 | Celltech R&D Limited | 2,7-naphthyridine derivatives |
| US6403608B1 (en) | 2000-05-30 | 2002-06-11 | Celltech R&D, Ltd. | 3-Substituted isoquinolin-1-yl derivatives |
| AU2001267753A1 (en) | 2000-07-07 | 2002-01-21 | Celltech R And D Limited | Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists |
| WO2002010136A1 (en) | 2000-08-02 | 2002-02-07 | Celltech R & D Limited | 3-substituted isoquinolin-1-yl derivatives |
| KR20050044413A (ko) | 2001-11-13 | 2005-05-12 | 3-디멘져널 파마슈티칼즈 인코오포레이티드 | 치환된 1,4-벤조디아제핀 및 암 치료를 위한 그의 용도 |
| US7078409B2 (en) * | 2002-03-28 | 2006-07-18 | Beta Pharma, Inc. | Fused quinazoline derivatives useful as tyrosine kinase inhibitors |
| US20060127385A1 (en) | 2002-12-06 | 2006-06-15 | The Trustees Of Boston University | Method for sustaining enos activity |
| US7196112B2 (en) | 2004-07-16 | 2007-03-27 | Biogen Idec Ma Inc. | Cell adhesion inhibitors |
| EP1904069B1 (en) | 2005-07-15 | 2018-06-13 | Albany Molecular Research, Inc. | Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| NZ566180A (en) | 2005-07-29 | 2011-04-29 | Resverlogix Corp | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
| MX2009008099A (es) | 2007-02-01 | 2009-12-14 | Resverlogix Corp | Compuestos para la prevencion y tratamiento de enfermedades cardiovasculares. |
| US20090012103A1 (en) | 2007-07-05 | 2009-01-08 | Matthew Abelman | Substituted heterocyclic compounds |
| NZ586440A (en) | 2008-06-26 | 2011-07-29 | Resverlogix Corp | Methods of preparing quinazolinone derivatives |
| WO2010053757A1 (en) | 2008-10-29 | 2010-05-14 | Gilead Palo Alto, Inc. | 2 -oxoquinoxalin blockers of the late sodium channel |
| WO2010074807A1 (en) | 2008-10-30 | 2010-07-01 | Gilead Palo Alto, Inc. | 3, 4-dihydroquinolin-2 ( 1h ) -one derivatives as sodium channel modulators |
| US20100125091A1 (en) | 2008-11-14 | 2010-05-20 | Gilead Palo Alto, Inc. | Substituted heterocyclic compounds as ion channel modulators |
| EP2382194B1 (en) | 2009-01-08 | 2014-03-12 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular disease |
| WO2010106436A2 (en) | 2009-03-18 | 2010-09-23 | Resverlogix Corp. | Novel anti-inflammatory agents |
| EP3431086B1 (en) | 2009-04-22 | 2020-06-17 | Resverlogix Corp. | Novel anti-inflammatory agents |
| EA025824B1 (ru) | 2009-07-27 | 2017-02-28 | Джилид Сайэнс, Инк. | Конденсированные гетероциклические соединения в качестве модуляторов ионных каналов |
| CA2802288C (en) | 2010-07-02 | 2018-08-21 | Gilead Sciences, Inc. | Triazolopyridinone compounds as ion channel modulators |
| CA2834164A1 (en) | 2011-05-10 | 2012-11-15 | Gilead Sciences, Inc. | Fused benzoxazinones as ion channel modulators |
| NO3175985T3 (fi) | 2011-07-01 | 2018-04-28 | ||
| AU2015224425B2 (en) * | 2011-07-01 | 2017-02-09 | Gilead Sciences, Inc. | Fused benzoxazepinones as ion channel modulators |
| AU2013201608B9 (en) * | 2011-07-01 | 2015-07-23 | Gilead Sciences, Inc. | Fused benzoxazepinones as ion channel modulators |
| TWI549944B (zh) * | 2011-07-01 | 2016-09-21 | 吉李德科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
| US9610251B2 (en) | 2011-11-01 | 2017-04-04 | Resverlogix Corp. | Pharmaceutical compositions for substituted quinazolinones |
| US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| US9765039B2 (en) | 2012-11-21 | 2017-09-19 | Zenith Epigenetics Ltd. | Biaryl derivatives as bromodomain inhibitors |
| WO2014096965A2 (en) | 2012-12-21 | 2014-06-26 | Rvx Therapeutics Inc. | Novel heterocyclic compounds as bromodomain inhibitors |
| CN114984016A (zh) | 2015-03-13 | 2022-09-02 | 雷斯韦洛吉克斯公司 | 用于治疗补体相关疾病之组合物及治疗方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3371085A (en) * | 1959-12-10 | 1968-02-27 | Hoffmann La Roche | 5-aryl-3h-1,4-benzodiazepin-2(1h)-ones |
| US3374264A (en) * | 1962-10-04 | 1968-03-19 | Hoffmann La Roche | N-haloacetyl-anthranilic acids and esters |
| GB1124133A (en) * | 1964-10-02 | 1968-08-21 | Abbott Lab | Substituted 1,4-benzodiazepine-2,5-diones |
| US3415814A (en) * | 1966-09-28 | 1968-12-10 | Sterling Drug Inc | 4-(cyclopropylmethyl)-3h-1,4-benzodiazepine-2,5(1h,4h)-dione |
| DE1918072A1 (de) * | 1969-04-09 | 1970-10-15 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von 1-substituierten 4-Alkyl-3H-1,4-benzodiazepin-2,5-[1H,4H]-dionen |
| US3551414A (en) * | 1969-05-16 | 1970-12-29 | United States Steel Corp | 6,7-dihydro-5h-dibenz(c,e)azepin-7-ones |
| CA1143728A (en) * | 1979-10-04 | 1983-03-29 | Max Gerecke | Imidazodiazepine derivatives |
| CA1184175A (en) * | 1981-02-27 | 1985-03-19 | Walter Hunkeler | Imidazodiazepines |
| CA1174673A (en) * | 1981-02-27 | 1984-09-18 | Walter Hunkeler | Imidazodiazepines |
| US4585768A (en) * | 1984-04-10 | 1986-04-29 | Tanabe Seiyaku Co., Ltd. | 1,5-benzothiazepine derivatives and processes for preparing the same |
| US4689326A (en) * | 1985-10-17 | 1987-08-25 | Research Corporation | Process for controlling hyperlipidemia |
| CA1319144C (en) * | 1986-11-14 | 1993-06-15 | Quirico Branca | Tetrahydronaphthalene derivatives |
| EP0322779A3 (en) * | 1987-12-29 | 1991-05-08 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzolactam compounds and pharmaceutical uses thereof |
| ZW6189A1 (en) * | 1988-05-09 | 1990-05-09 | Smithkline Beckman Corp | Anti-aggregatory peptides |
| US5039805A (en) * | 1988-12-08 | 1991-08-13 | Hoffmann-La Roche Inc. | Novel benzoic and phenylacetic acid derivatives |
| US5084466A (en) * | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
| CA2008116C (en) * | 1989-02-23 | 2001-11-20 | Thomas Weller | Glycine derivatives |
| FR2645744B1 (fr) * | 1989-04-13 | 1994-01-21 | Roussel Uclaf | Derives de la benzothiazepine, leur procede de preparation et les intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant |
| US5318899A (en) * | 1989-06-16 | 1994-06-07 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
| US5384309A (en) * | 1989-07-17 | 1995-01-24 | Genentech, Inc. | Cyclized peptides and their use as platelet aggregation inhibitors |
| US5061693A (en) * | 1989-07-28 | 1991-10-29 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| FR2652352A1 (fr) * | 1989-09-28 | 1991-03-29 | Jouveinal Sa | Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique. |
| NZ235564A (en) * | 1989-10-13 | 1993-10-26 | Merck & Co Inc | Fibrinogen receptor antagonist and pharmaceutical compositions |
| CA2027936C (en) * | 1989-10-23 | 2001-07-24 | Smithkline Beecham Corporation | Cyclic anti-aggregatory peptides |
| US5053392A (en) * | 1989-12-01 | 1991-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors |
| JPH0747582B2 (ja) * | 1989-12-11 | 1995-05-24 | 杏林製薬株式会社 | キナゾリン―３―アルカン酸誘導体とその塩およびその製造法 |
| JPH05509294A (ja) * | 1990-04-06 | 1993-12-22 | ラ ホヤ キャンサー リサーチ ファウンデーション | 血栓症治療のための方法および組成物 |
| DE4102024A1 (de) * | 1991-01-24 | 1992-07-30 | Thomae Gmbh Dr K | Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| US5693636A (en) * | 1991-06-28 | 1997-12-02 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
| RU2124503C1 (ru) * | 1992-05-18 | 1999-01-10 | И.Р.Сквибб энд Санз, Инк. | Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция |
-
1992
- 1992-04-10 US US07/866,931 patent/US5250679A/en not_active Expired - Lifetime
- 1992-10-15 AU AU27976/92A patent/AU673501B2/en not_active Expired
- 1992-10-15 JP JP50779093A patent/JP3789468B2/ja not_active Expired - Lifetime
- 1992-10-15 ES ES92922468T patent/ES2085651T3/es not_active Expired - Lifetime
- 1992-10-15 WO PCT/US1992/008788 patent/WO1993008174A1/en active Application Filing
- 1992-10-15 MD MD96-0330A patent/MD960330A/ro unknown
- 1992-10-15 GE GEAP19922402A patent/GEP20032957B/en unknown
- 1992-10-15 DE DE69207916T patent/DE69207916T2/de not_active Expired - Lifetime
- 1992-10-15 DK DK92922468.1T patent/DK0610334T3/da active
- 1992-10-15 CA CA002119745A patent/CA2119745C/en not_active Expired - Lifetime
- 1992-10-15 EP EP92922468A patent/EP0610334B1/en not_active Expired - Lifetime
- 1992-10-15 AT AT92922468T patent/ATE133412T1/de active
-
1993
- 1993-05-06 US US08/058,722 patent/US5403836A/en not_active Expired - Lifetime
-
1994
- 1994-03-15 FI FI941222A patent/FI941222A/fi unknown
- 1994-04-15 NO NO941378A patent/NO307417B1/no not_active IP Right Cessation
-
1996
- 1996-04-02 GR GR960400905T patent/GR3019517T3/el unknown
-
2003
- 2003-04-08 JP JP2003104672A patent/JP2003300962A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0610334B1 (en) | 1996-01-24 |
| NO307417B1 (no) | 2000-04-03 |
| US5403836A (en) | 1995-04-04 |
| AU673501B2 (en) | 1996-11-14 |
| DK0610334T3 (da) | 1996-06-03 |
| NO941378L (no) | 1994-06-20 |
| DE69207916T2 (de) | 1996-10-17 |
| AU2797692A (en) | 1993-05-21 |
| JP3789468B2 (ja) | 2006-06-21 |
| EP0610334A1 (en) | 1994-08-17 |
| MD960330A (ro) | 1998-05-31 |
| FI941222A0 (fi) | 1994-03-15 |
| ATE133412T1 (de) | 1996-02-15 |
| JP2003300962A (ja) | 2003-10-21 |
| JPH07500341A (ja) | 1995-01-12 |
| NO941378D0 (no) | 1994-04-15 |
| WO1993008174A1 (en) | 1993-04-29 |
| CA2119745A1 (en) | 1993-04-29 |
| CA2119745C (en) | 2007-02-20 |
| ES2085651T3 (es) | 1996-06-01 |
| GEP20032957B (en) | 2003-04-25 |
| US5250679A (en) | 1993-10-05 |
| DE69207916D1 (de) | 1996-03-07 |
| GR3019517T3 (en) | 1996-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI941222A (fi) | Ei-peptidyyli-tyyppisiä integriini-inhibiittoreita, jotka ovat spesifisiä GPIIbIIIa-reseptorin suhteen | |
| ES2137175T3 (es) | Antagonistas del receptor fibrinogeno. | |
| ATE153665T1 (de) | Tricyclische inhibitoren von gp ii b iii a rezeptoren | |
| DK0512829T3 (da) | Fibrinogenreceptorantagonister | |
| DE69131311D1 (de) | Fibrinogen-Rezeptor-Antagonisten | |
| DE60112055D1 (de) | Inhibitoren von gamma-secretase | |
| DE69327536D1 (de) | Fibrinogenrezeptor-antagonisten | |
| DK0682664T3 (da) | Forbindelser med både potent calciumantagonist og antioxiderende aktivitet og anvendelse deraf som cytobeskyttende midler | |
| FI934298A (fi) | Kristallin tiagabine-hydrokloridmonohydrat, dess framstaellning och dess anvaendning | |
| ES2088128T3 (es) | Aminosulfonilureas inhibidoras de acat. | |
| DK1147105T3 (da) | Optisk aktivt pyridyl-4H-1,2,4-oxadiazinderivat og anvendelse af dette til behandling af karsygdomme | |
| DK1100824T3 (da) | Forbindelser med væksthormonfrigivende egenskaber | |
| AP9200443A0 (en) | Heterocyclic compounds. | |
| DK0720597T3 (da) | Triarylethylenderivater til terapeutisk anvendelse | |
| FI952018A (fi) | BHAP-yhdisteiden käyttö yhdessä muiden ei-nukleosidi-käänteistransskriptaasi-inhibiittoreiden kanssa HIV-infektion hoitoon | |
| ES2093515T3 (es) | Aplicacion del riluzol como radio-restaurador. |