FI93460B - Menetelmä uusien insuliinijohdannaisten valmistamiseksi - Google Patents

Menetelmä uusien insuliinijohdannaisten valmistamiseksi

Info

Publication number
FI93460B
FI93460B FI864560A FI864560A FI93460B FI 93460 B FI93460 B FI 93460B FI 864560 A FI864560 A FI 864560A FI 864560 A FI864560 A FI 864560A FI 93460 B FI93460 B FI 93460B
Authority
FI
Finland
Prior art keywords
insulin derivatives
pct
preparation
new insulin
sec
Prior art date
Application number
FI864560A
Other languages
English (en)
Swedish (sv)
Other versions
FI93460C (fi
FI864560A (fi
FI864560A0 (fi
Inventor
Per Balschmidt
Finn Benned Hansen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of FI864560A publication Critical patent/FI864560A/fi
Publication of FI864560A0 publication Critical patent/FI864560A0/fi
Application granted granted Critical
Publication of FI93460B publication Critical patent/FI93460B/fi
Publication of FI93460C publication Critical patent/FI93460C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
FI864560A 1985-03-15 1986-11-10 Menetelmä uusien insuliinijohdannaisten valmistamiseksi FI93460C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK119785A DK119785D0 (da) 1985-03-15 1985-03-15 Insulinpraeparat
PCT/DK1986/000023 WO1986005497A1 (en) 1985-03-15 1986-03-14 Novel insulin derivatives and pharmaceutical preparations containing these derivatives

Publications (4)

Publication Number Publication Date
FI864560A FI864560A (fi) 1986-11-10
FI864560A0 FI864560A0 (fi) 1986-11-10
FI93460B true FI93460B (fi) 1994-12-30
FI93460C FI93460C (fi) 1995-04-10

Family

ID=8102063

Family Applications (2)

Application Number Title Priority Date Filing Date
FI864559A FI864559A (fi) 1985-03-15 1986-11-10 Nya insulinderivat och farmaceutiska preparat innehaollande dessa derivat.
FI864560A FI93460C (fi) 1985-03-15 1986-11-10 Menetelmä uusien insuliinijohdannaisten valmistamiseksi

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI864559A FI864559A (fi) 1985-03-15 1986-11-10 Nya insulinderivat och farmaceutiska preparat innehaollande dessa derivat.

Country Status (11)

Country Link
US (1) US5028586A (fi)
EP (2) EP0216832B1 (fi)
JP (2) JPS62502538A (fi)
AT (2) ATE84546T1 (fi)
AU (2) AU5622686A (fi)
DE (2) DE3687500T2 (fi)
DK (3) DK119785D0 (fi)
FI (2) FI864559A (fi)
IL (2) IL78161A0 (fi)
NO (2) NO864555L (fi)
WO (2) WO1986005496A1 (fi)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK347086D0 (da) * 1986-07-21 1986-07-21 Novo Industri As Novel peptides
DK113585D0 (da) * 1985-03-12 1985-03-12 Novo Industri As Nye peptider
US5157021A (en) * 1985-03-15 1992-10-20 Novo Nordisk A/S Insulin derivatives and pharmaceutical preparations containing these derivatives
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
AU612141B2 (en) * 1987-02-25 1991-07-04 Novo Nordisk A/S Novel insulin derivatives
BR8803345A (pt) * 1988-06-30 1990-02-13 Biobras Bioquimica Do Brasil S Processo aperfeicoado para producao em larga escala de cristais de insulina humana purificada
BR8803346A (pt) * 1988-06-30 1990-02-13 Biobras Bioquimica Do Brasil S Processo aperfeicoado para producao em larga escala de cristais de insulina purificada
KR900701842A (ko) * 1988-07-20 1990-12-04 헨리 브뢰늄 인간 인슐린 동족체와 그를 포함하는 제제
US5716927A (en) * 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
WO1992010284A2 (en) 1990-12-07 1992-06-25 Cnc Development, Inc. Catalytic chemical reactor
DK33591D0 (fi) * 1991-02-27 1991-02-27 Novo Nordisk As
JPH06510754A (ja) * 1991-05-24 1994-12-01 アミリン・ファーマシューティカルズ，インコーポレイテッド 食欲不振および関連症状の治療用のアミリンおよび可能性としてインスリンを含有する組成物
US5461031A (en) * 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
AUPO269996A0 (en) * 1996-10-01 1996-10-24 Walter And Eliza Hall Institute Of Medical Research, The A method of prophylaxis and treatment
US5898067A (en) * 1997-02-07 1999-04-27 Novo Nordisk A/S Crystallization of proteins
WO2004041331A1 (en) * 2002-11-01 2004-05-21 Antares Pharma, Inc. Administration of insulin by jet injection
CN1909930B (zh) 2004-01-21 2015-12-16 诺和诺德医疗保健公司 转谷氨酰胺酶介导的肽的接合
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
EP1991575A1 (en) * 2006-02-21 2008-11-19 Novo Nordisk A/S Single-chain insulin analogues and pharmaceutical formulations thereof
AU2009210570B2 (en) * 2008-01-30 2014-11-20 Indiana University Research And Technology Corporation Ester-based insulin prodrugs
CN102325539A (zh) 2008-12-19 2012-01-18 印第安纳大学研究及科技有限公司 基于酰胺的胰高血糖素超家族肽前药
MX2011006527A (es) * 2008-12-19 2011-08-17 Univ Indiana Res & Tech Corp Agentes medicinales unidos a dipeptido.
CA2803164C (en) 2010-06-24 2018-08-21 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
US9573987B2 (en) 2011-12-20 2017-02-21 Indiana University Research And Technology Corporation CTP-based insulin analogs for treatment of diabetes
EP3395358B1 (en) 2012-09-26 2019-11-06 Indiana University Research and Technology Corporation Insulin analog dimers
US20160024169A1 (en) 2013-03-14 2016-01-28 Indiana University Research And Technology Corporation Insulin-incretin conjugates
US10385107B2 (en) 2014-09-24 2019-08-20 Indiana Univeresity Researc and Technology Corporation Lipidated amide-based insulin prodrugs
US10232020B2 (en) 2014-09-24 2019-03-19 Indiana University Research And Technology Corporation Incretin-insulin conjugates

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903068A (en) * 1972-12-26 1975-09-02 Us Health Education & Welfare Facile synthesis of human insulin by modification of porcine insulin
DE3064479D1 (en) * 1979-04-13 1983-09-08 Shionogi & Co Process for preparing a b30-threonine insulin
JPS55138391A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd New synthetic method of peptide derivative
JPS55138393A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
US4421685A (en) * 1980-03-27 1983-12-20 Eli Lilly And Company Process for producing an insulin
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
IE52768B1 (en) * 1981-04-06 1988-02-17 Boots Co Ltd 1-arylcyclobutylalkylamine compounds useful as therapeutic agents
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DK113585D0 (da) * 1985-03-12 1985-03-12 Novo Industri As Nye peptider

Also Published As

Publication number Publication date
JPS62502538A (ja) 1987-10-01
NO174278C (no) 1994-04-13
DK545686A (da) 1986-11-14
DE3673737D1 (de) 1990-10-04
NO864556D0 (no) 1986-11-14
FI93460C (fi) 1995-04-10
EP0216832A1 (en) 1987-04-08
WO1986005496A1 (en) 1986-09-25
IL78160A (en) 1991-06-10
FI864560A (fi) 1986-11-10
WO1986005497A1 (en) 1986-09-25
ATE84546T1 (de) 1993-01-15
EP0216833A1 (en) 1987-04-08
DK159856B (da) 1990-12-17
FI864560A0 (fi) 1986-11-10
IL78161A0 (en) 1986-07-31
US5028586A (en) 1991-07-02
DE3687500D1 (de) 1993-02-25
ATE56022T1 (de) 1990-09-15
DE3687500T2 (de) 1993-07-01
NO864555D0 (no) 1986-11-14
DK545786A (da) 1986-11-14
JPS62502196A (ja) 1987-08-27
AU5622686A (en) 1986-10-13
AU5622786A (en) 1986-10-13
DK119785D0 (da) 1985-03-15
NO174278B (no) 1994-01-03
IL78160A0 (en) 1986-07-31
NO864555L (no) 1986-11-14
EP0216832B1 (en) 1990-08-29
DK545686D0 (da) 1986-11-14
DK545786D0 (da) 1986-11-14
EP0216833B1 (en) 1993-01-13
FI864559A0 (fi) 1986-11-10
FI864559A (fi) 1986-11-10
DK159856C (da) 1991-05-06
NO864556L (no) 1986-11-14
AU596968B2 (en) 1990-05-24

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Owner name: NOVO NORDISK A/S