FI93228B - Förfarande för tillvaratagande av ett glykopeptidantibiotikum av vankomycintyp - Google Patents

Förfarande för tillvaratagande av ett glykopeptidantibiotikum av vankomycintyp Download PDF

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Publication number
FI93228B
FI93228B FI880889A FI880889A FI93228B FI 93228 B FI93228 B FI 93228B FI 880889 A FI880889 A FI 880889A FI 880889 A FI880889 A FI 880889A FI 93228 B FI93228 B FI 93228B
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FI
Finland
Prior art keywords
resin
antibiotic
vancomycin
solution
broth
Prior art date
Application number
FI880889A
Other languages
English (en)
Finnish (fi)
Other versions
FI880889A0 (sv
FI880889A (sv
FI93228C (sv
Inventor
Suzanne Lynn Ebach Glass
Charles William Johnson
John Lawrence Spencer
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI880889A0 publication Critical patent/FI880889A0/sv
Publication of FI880889A publication Critical patent/FI880889A/sv
Application granted granted Critical
Publication of FI93228B publication Critical patent/FI93228B/sv
Publication of FI93228C publication Critical patent/FI93228C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Claims (5)

1. Förfarande för att tillvarata ett glykopeptid-antibiotikum av vankomycintyp, kännetecknat 5 därav, att 1) antibiotikumet adsorberas ur fermentations-växtmediet pä ett sulfonerat polystyrendivinylbensenharts med läg korsbindning, utan regiering av pH och utan fil-trering, 2) hartset avskiljs ur växtmediet och 3) antibiotikumet elueras ur hartset med en vattenlösning med 10 pH-värdet 9-12.
2. Förfarande enligt patentkravet l, kännetecknat därav, att hartset blandas i fermenta-tionsväxtmediet genom att tillsätta hartset i växtmediet satsvis. 15
3. Förfarande enligt patentkravet 1 eller 2, kännetecknat därav, att antibiotikumet är vankomycin.
4. Förfarande enligt patentkravet 1 eller 2, kännetecknat därav, att antibiotikumet är 20 Ά82846.
5. Förfarande enligt patentkravet 1 eller 2, kännetecknat därav, att antibiotikumet är M43A, aktaplanin eller teikomycin. il
FI880889A 1987-02-27 1988-02-25 Förfarande för tillvaratagande av ett glykopeptidantibiotikum av vankomycintyp FI93228C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/019,914 US4845194A (en) 1987-02-27 1987-02-27 Glycopeptide recovery process
US1991487 1987-02-27

Publications (4)

Publication Number Publication Date
FI880889A0 FI880889A0 (sv) 1988-02-25
FI880889A FI880889A (sv) 1988-08-28
FI93228B true FI93228B (sv) 1994-11-30
FI93228C FI93228C (sv) 1995-03-10

Family

ID=21795726

Family Applications (1)

Application Number Title Priority Date Filing Date
FI880889A FI93228C (sv) 1987-02-27 1988-02-25 Förfarande för tillvaratagande av ett glykopeptidantibiotikum av vankomycintyp

Country Status (15)

Country Link
US (1) US4845194A (sv)
EP (1) EP0280570B1 (sv)
JP (1) JP2659388B2 (sv)
KR (1) KR970003517B1 (sv)
CN (1) CN1032426C (sv)
AT (1) ATE136037T1 (sv)
BG (1) BG47198A3 (sv)
CA (1) CA1338002C (sv)
DE (1) DE3855145T2 (sv)
ES (1) ES2085260T3 (sv)
FI (1) FI93228C (sv)
GR (1) GR3019978T3 (sv)
HU (1) HU199873B (sv)
IE (1) IE71520B1 (sv)
IL (1) IL85557A (sv)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2577133B2 (ja) * 1989-11-27 1997-01-29 スティフティング フォール ド テフニスヘ ウェッテンスハッペン 船舶のプロペラ
US5574135A (en) * 1990-07-10 1996-11-12 Abbott Laboratories Process for making vancomycin
US5258495A (en) * 1990-07-10 1993-11-02 Abbott Laboratories Process for making vancomycin HC1
US5149784A (en) * 1990-07-10 1992-09-22 Abbott Laboratories Process for making vancomycin
CA2133644C (en) * 1992-04-20 2008-09-09 Alexander H. T. Chu Process for making vancomycin
US5919756A (en) * 1996-06-28 1999-07-06 Eli Lilly And Company Amides
TWI233932B (en) * 2001-08-24 2005-06-11 Theravance Inc Process for purifying glycopeptide phosphonate derivatives
KR100476818B1 (ko) * 2002-07-19 2005-03-17 종근당바이오 주식회사 테이코플라닌 에이 투 정제 방법
KR100554481B1 (ko) * 2004-06-30 2006-03-03 씨제이 주식회사 반코마이신 염산염의 정제방법
US20080161536A1 (en) * 2006-12-29 2008-07-03 Abbott Laboratories Vancomycin b hydrochloride crystalline form 1
CN102010462A (zh) * 2009-09-04 2011-04-13 四川金稞生物科技有限公司 应用纳滤浓缩纯化技术从发酵液中制取雷莫拉宁
DE102011107197A1 (de) * 2011-07-13 2013-01-17 Instraction Gmbh Ionenaustauschermaterial mit hoher Salztoleranz
CN103827135B (zh) * 2011-07-13 2016-04-06 因斯特艾克申有限公司 具有高耐盐度的离子交换材料
EP2592090A1 (en) 2011-11-11 2013-05-15 LEK Pharmaceuticals d.d. Process of purification of teicoplanin
EP2592089A1 (en) 2011-11-11 2013-05-15 LEK Pharmaceuticals d.d. Process of purification of teicoplanin
EP3169345A4 (en) 2014-07-17 2018-01-17 The Medicines Company High purity oritavancin and method of producing same
CN106928323B (zh) * 2017-03-02 2021-08-20 重庆乾泰生物医药有限公司 一种高纯度奥利万星关键中间体a82846b的制备方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2786831A (en) * 1954-06-01 1957-03-26 Olin Mathieson Process of recovering basic antibiotics
US3067099A (en) * 1955-09-16 1962-12-04 Lilly Co Eli Vancomycin and method for its preparation
US2990329A (en) * 1957-02-11 1961-06-27 Abbott Lab Preparation of ristocetin a salts
US3660279A (en) * 1969-02-12 1972-05-02 Apothekernes Lab Method for sorption of antibiotics from unfiltered liquids
GB1496386A (en) * 1975-03-05 1977-12-30 Lepetit Spa Antibiotics
US4083964A (en) * 1976-05-24 1978-04-11 Eli Lilly And Company Antibiotic A-35512 for increasing feed utilization efficiency in an animal
US4322406A (en) * 1980-12-18 1982-03-30 Eli Lilly And Company Antibiotic A-4696 factors B1, B2, B3, C1a, C3 and E1
US4461723A (en) * 1980-12-18 1984-07-24 Eli Lilly And Company Antibiotic A-4696 factor G
US4440753A (en) * 1982-03-15 1984-04-03 Eli Lilly And Company Purification of glycopeptide antibiotics using non-functional resins
US4537770A (en) * 1982-03-24 1985-08-27 Eli Lilly And Company A41030 antibiotics
FI73697C (sv) * 1982-06-08 1987-11-09 Lepetit Spa Förfarande för framställning av individuella faktorer 1, 2, 3, 4 och 5 av teikomysin A2.
US4462942A (en) * 1982-07-30 1984-07-31 Eli Lilly And Company A47934 Antibiotic and process for production thereof
GB8307847D0 (en) * 1983-03-22 1983-04-27 Lepetit Spa Antibiotics l 17054 and l 17046
US4558036A (en) * 1984-02-17 1985-12-10 Eli Lilly And Company Actaplanin antibiotics
US4547488A (en) * 1984-04-16 1985-10-15 Eli Lilly And Company Antibiotic M43D, pharmaceutical compositions and method of use
US4548924A (en) * 1984-04-16 1985-10-22 Eli Lilly And Company Antibiotics M43B and M43C, pharmaceutical composition and method of use
US4548925A (en) * 1984-04-16 1985-10-22 Eli Lilly And Company Antibiotic M43A, pharmaceutical composition and method of use
US4552701A (en) * 1984-04-16 1985-11-12 Eli Lilly And Company Glycopeptide antibiotics and process of preparation
US4639433A (en) * 1985-08-14 1987-01-27 Eli Lilly And Company Glycopeptide derivatives
US4643987A (en) * 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
GB8608798D0 (en) * 1986-04-11 1986-05-14 Lepetit Spa Recovery of glycopeptide antibiotics from aqueous solutions

Also Published As

Publication number Publication date
FI880889A0 (sv) 1988-02-25
HU199873B (en) 1990-03-28
DE3855145T2 (de) 1996-09-19
ES2085260T3 (es) 1996-06-01
US4845194A (en) 1989-07-04
FI880889A (sv) 1988-08-28
JPS63237794A (ja) 1988-10-04
JP2659388B2 (ja) 1997-09-30
HUT46338A (en) 1988-10-28
IL85557A0 (en) 1988-08-31
GR3019978T3 (en) 1996-08-31
KR970003517B1 (ko) 1997-03-18
FI93228C (sv) 1995-03-10
EP0280570A3 (en) 1990-01-24
ATE136037T1 (de) 1996-04-15
KR880009990A (ko) 1988-10-06
BG47198A3 (en) 1990-05-15
CN1032426C (zh) 1996-07-31
EP0280570A2 (en) 1988-08-31
EP0280570B1 (en) 1996-03-27
DE3855145D1 (de) 1996-05-02
CN88101111A (zh) 1988-10-26
IE71520B1 (en) 1997-02-12
CA1338002C (en) 1996-01-23
IE880546L (en) 1988-08-27
IL85557A (en) 1993-08-18

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FG Patent granted

Owner name: ELI LILLY AND COMPANY