FI92326B - Nonapeptid- och dekapeptidanaloger av LHRH användbara som LHRH-antagonister - Google Patents
Nonapeptid- och dekapeptidanaloger av LHRH användbara som LHRH-antagonister Download PDFInfo
- Publication number
- FI92326B FI92326B FI880509A FI880509A FI92326B FI 92326 B FI92326 B FI 92326B FI 880509 A FI880509 A FI 880509A FI 880509 A FI880509 A FI 880509A FI 92326 B FI92326 B FI 92326B
- Authority
- FI
- Finland
- Prior art keywords
- phe
- pal
- nal
- pro
- leu
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/13—Luteinizing hormone-releasing hormone; related peptides
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Fodder In General (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (10)
1. Nonapeptid- eller dekapeptidanalog av LHRH med formeln (I), 5 A-B-C-Ser-D-E-F-G-Pro-J (I) 123 4 5678 9 10 eller ett fysiologiskt godtagbart salt därav, k ä n n e -10 tecknad därav, att A är nägon av aminoacylgrupper-na N-Ac-3-(1-naftyl)-D,L-alanyl och N-Ac-3-(2-naftyl)-D,L-alanyl, en D- eller L-isomer därav; B är nägon av aminoacylgrupperna D-fenylalanyl, D-p-klor-fenylalanyl, D-p-fluorfenylalanyl och D-a-metyl-p-klorfe-15 nylalanyl; C är nägon av aminoacylgrupperna D-tryptofanyl och 3-(3-pyridyl)-D-alanyl; D är nägon av aminoacylgrupperna L-fenylalanyl, L-tyro-syl, 3-(3-pyridyl)-alanyl och arginyl, eller en amino-20 acylgrupp med strukturformeln -HN-CH-CO- ^«2>n <XI> NH 1 * 2 • 25 R -HN-ONR där n är 1 - 5; R1 är alkyl med 1-6 kolatomer eller fluoralkyl; och R2 är väte eller R1; E är 3-(3-pyridyl)-D-alanyl, D-tyrosyl, D-tryptofanyl el-30 ler en aminoacylgrupp med strukturformeln • -HN-CH-CO- (CVn (ID NH 1 * 2
35 R -HN-C=NR 64 Ο Γ ,· 7 °· C ^ ό 7 O där n Sr 1 - 5; R1 är alkyl med 1-6 kolatomer, och R2 är väte eller R1, eller R1-HN-C*NR2 är /cv
2. Förening enligt patentkravet 1 eller ett fysio-logiskt godtagbart sait därav, kännetecknad därav, att ,· 25 A är N-Ac-D-Nal ( 2); B är D-pCl-Phe; C är D-Trp eller D-Pal(3); D är Tyr, Arg, Deh, Mbh eller Bth; F är Leu; och 30 J är D-AlaNH2.
3. Förening enligt patentkravet 2, kännetecknad därav, att den är N-Ac-D-Nal(2)-D-pCl-Phe-D-Pal(3)-Ser-Tyr-D-Pal(3)-Leu-Pro-D-AlaNH2 eller ett fy-siologiskt godtagbart sait därav. 35
4. Förening enligt patentkravet 2, känne tecknad därav, att den är N-Ac-D-Nal(2)-D-pCl-Phe- li 92326 65 D-Pal(3)-Ser-Tyr-D-Pal(3)-Leu-Deh-Pro-D-AlaNH2 eller ett fysiologiskt godtagbart salt därav.
5. Förening enligt patentkravet 2, känne- t e c k n a d därav, att den är N-Ac-D-Nal(2)-D-pCl-Phe-5 D-Pal(3)-Ser-Mbh-D-Pal(3)-Leu-Mbh-Pro-D-AlaNH2 eller ett fysiologiskt godtagbart salt därav.
5 HN N \ / H där m är 1 - 4;
10 F är nägon av aminoacylgrupperna L-leucyl och L-fenylala-nyl; G är en aminoacylgrupp med strukturformeln -HN-CH-CO- 15 <CH2)n (11) Ϊ" 1 ' 2 R -HN-C=NR där n är 1 - 5; R1 är alkyl med 1-6 kolatomer, eller 20 fluoralkyl; och R2 är väte eller R1; och J är D-alaninamid eller glysinamid.
6. Förening enligt patentkravet 2, känne- t e c k n a d därav, att den är N-Ac-D-Nal(2)-D-pCl-Phe-D-Pal(3)-Ser-Pal(3)-D-Pal(3)-Leu-Bth-Pro-D-AlaNH2 eller 10 ett fysiologiskt godtagbart salt därav.
7. Förening enligt patentkravet 2, känne- t e c k n a d därav, att den är N-Ac-D-Nal(2)-D-pCl-Phe-D-Pal(3)-Ser-Arg-D-Pal(3)-Leu-Deh-Pro-D-AlaNH2 eller ett fysiologiskt godtagbart salt därav. 15
8. Förening enligt patentkravet 2, känne- t e c k n a d därav, att den är N-Ac-D-Nal(2)-D-pCl-Phe-D-Pal(3)-Ser-Bth-D-Tyr-Leu-Bth-Pro-D-AlaNH2 eller ett fysiologiskt godtagbart salt därav.
9. Förening enligt patentkravet 2, känne- 20 tecknad därav, att den är N-Ac-D-Nal(2)-D-pCl-Phe-D-Pal(3)-Ser-Tyr-D-Deh-Leu-Deh-Pro-D-AlaNH2 eller ett fysiologiskt godtagbart salt därav.
10. Komposition, kännetecknad därav, att den innehäller en förening enligt nägot av patentkra- . 25 ven 1-9 blandat med ätminstone ett fysiologiskt godtagbart fyllmedel. • -
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI930694A FI92211C (sv) | 1987-02-05 | 1993-02-17 | Förfarande för framställning av terapeutiskt användbara nonapeptid- och dekapeptidanaloger, vilka är antagonister för LHRH |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/010,923 US4801577A (en) | 1987-02-05 | 1987-02-05 | Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists |
| US1092387 | 1987-02-05 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI880509A0 FI880509A0 (sv) | 1988-02-04 |
| FI880509A FI880509A (sv) | 1988-08-06 |
| FI92326B true FI92326B (sv) | 1994-07-15 |
| FI92326C FI92326C (sv) | 1994-10-25 |
Family
ID=21748050
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI880509A FI92326C (sv) | 1987-02-05 | 1988-02-04 | Nonapeptid- och dekapeptidanaloger av LHRH användbara som LHRH-antagonister |
| FI930694A FI92211C (sv) | 1987-02-05 | 1993-02-17 | Förfarande för framställning av terapeutiskt användbara nonapeptid- och dekapeptidanaloger, vilka är antagonister för LHRH |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI930694A FI92211C (sv) | 1987-02-05 | 1993-02-17 | Förfarande för framställning av terapeutiskt användbara nonapeptid- och dekapeptidanaloger, vilka är antagonister för LHRH |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US4801577A (sv) |
| EP (1) | EP0277829B1 (sv) |
| JP (1) | JPH0791314B2 (sv) |
| KR (1) | KR930008095B1 (sv) |
| AT (1) | ATE109159T1 (sv) |
| AU (1) | AU614275B2 (sv) |
| BR (1) | BR1100688A (sv) |
| CA (1) | CA1339043C (sv) |
| DE (2) | DE10075027I2 (sv) |
| DK (1) | DK173544B1 (sv) |
| ES (1) | ES2056908T3 (sv) |
| FI (2) | FI92326C (sv) |
| HK (1) | HK35997A (sv) |
| HU (3) | HU215855B (sv) |
| IE (1) | IE63707B1 (sv) |
| IL (1) | IL85316A (sv) |
| LU (1) | LU90657I2 (sv) |
| MX (1) | MX9202737A (sv) |
| NL (1) | NL300016I2 (sv) |
| NO (3) | NO176440C (sv) |
| NZ (1) | NZ223403A (sv) |
| ZA (1) | ZA88795B (sv) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5688519A (en) * | 1987-04-06 | 1997-11-18 | Leonard; Robert J. | Flash-flow fused medicinal implants |
| US4935491A (en) * | 1987-08-24 | 1990-06-19 | Board Of Regents, The University Of Texas System | Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine |
| HU203204B (en) * | 1987-09-15 | 1991-06-28 | Sandoz Ag | Process for producing suppository containing calcitonin and taurocholic acid |
| NZ226557A (en) * | 1987-10-15 | 1990-07-26 | Syntex Inc | Pharmaceutical compositions for the intranasal administration of a biologically active polypeptide in powder form and process for their preparation |
| US5110904A (en) * | 1989-08-07 | 1992-05-05 | Abbott Laboratories | Lhrh analogs |
| US5137669A (en) * | 1988-03-02 | 1992-08-11 | Endocon, Inc. | Manufacture of partially fused peptide pellet |
| US5039660A (en) * | 1988-03-02 | 1991-08-13 | Endocon, Inc. | Partially fused peptide pellet |
| DE68915784T2 (de) * | 1989-03-09 | 1994-09-29 | Endocom, Inc., Boston, Mass. | Teilweise geschmolzenes peptidpellet. |
| US6156731A (en) * | 1989-05-10 | 2000-12-05 | G. D. Searle & Co. | Polypeptide composition for oral administration |
| US5232707A (en) * | 1989-07-10 | 1993-08-03 | Syntex (U.S.A.) Inc. | Solvent extraction process |
| US5169932A (en) * | 1989-10-30 | 1992-12-08 | The Salk Institute For Biological Studies | Gnrh analogs |
| US5084443A (en) * | 1989-12-04 | 1992-01-28 | Biomeasure, Inc. | Promoting expression of acetylcholine receptors with lhrh antagonist |
| US5064939A (en) * | 1990-02-06 | 1991-11-12 | The Salk Institute For Biological Studies | Cyclic gnrh antagonists |
| US5212288A (en) * | 1990-02-20 | 1993-05-18 | Syntex (U.S.A.) Inc. | Temporary minimal protection synthesis of serine-containing polypeptides |
| DK0477499T3 (da) * | 1990-08-04 | 1994-05-30 | Hoechst Ag | Gonadoliberin-antagonister |
| US5783562A (en) * | 1990-11-10 | 1998-07-21 | Asta Medica Aktiengesellschaft | Luteinizing hormone releasing hormone analogs |
| CN1036343C (zh) * | 1990-11-10 | 1997-11-05 | 天津市计划生育研究所 | 新促黄体生成素释放激素拮抗类似物的制备方法 |
| IL101074A (en) * | 1991-03-14 | 1997-09-30 | Salk Inst For Biological Studi | GnRH ANALOGS AND THEIR PREPARATION |
| US5516887A (en) * | 1991-04-25 | 1996-05-14 | Romano Deghenghi | Luteinizing hormone releasing hormone antagonist peptides |
| DE4117507A1 (de) * | 1991-05-24 | 1992-11-26 | Schering Ag | Verfahren zur herstellung von n(pfeil hoch)6(pfeil hoch)-substituierten lysin-derivaten |
| WO1993003752A1 (en) * | 1991-08-19 | 1993-03-04 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Decapeptide having dopamine stimulating activity |
| JPH06510046A (ja) * | 1991-08-26 | 1994-11-10 | アボツト・ラボラトリーズ | 治療薬の舌下または頬投与のための組成物及び方法 |
| US5487898A (en) * | 1991-08-26 | 1996-01-30 | Abbott Laboratories | Compositions and method for the sublingual or buccal administration therapeutic agents |
| US5656727A (en) * | 1992-09-15 | 1997-08-12 | The Administrators Of The Tulane Educational Fund | Antagonists of LHRH |
| US5480969A (en) * | 1992-09-15 | 1996-01-02 | The Administrators Of The Tulane Educational Fund | Antagonists of LHRH |
| DE4305225A1 (de) * | 1993-02-19 | 1994-08-25 | Asta Medica Ag | Neues Herstellverfahren für Cetrorelix Lyophilisat |
| US6828415B2 (en) | 1993-02-19 | 2004-12-07 | Zentaris Gmbh | Oligopeptide lyophilisate, their preparation and use |
| US5843901A (en) | 1995-06-07 | 1998-12-01 | Advanced Research & Technology Institute | LHRH antagonist peptides |
| US6043218A (en) | 1996-10-22 | 2000-03-28 | Medical University Of South Carolina | Positively charged non-natural amino acids, methods of making thereof, and use thereof in peptides |
| US6566330B1 (en) | 1996-10-22 | 2003-05-20 | Medical University Of South Carolina Foundation Research Development | Positively charged non-natural amino acids, methods of making and using thereof in peptides |
| US5968895A (en) * | 1996-12-11 | 1999-10-19 | Praecis Pharmaceuticals, Inc. | Pharmaceutical formulations for sustained drug delivery |
| DE19712718C2 (de) * | 1997-03-26 | 1999-09-23 | Asta Medica Ag | Immobilisierte und aktivitätsstabilisierte Komplexe von LHRH-Antagonisten und Verfahren zu deren Herstellung |
| WO1998058657A1 (en) * | 1997-06-20 | 1998-12-30 | Akzo Nobel N.V. | Gonadotropin releasing hormone antagonist |
| US6217844B1 (en) | 1998-04-27 | 2001-04-17 | Praecis Pharmaceuticals, Inc. | Methods for detecting lesions in dense breast tissue using LHRH antagonists |
| US6455499B1 (en) | 1999-02-23 | 2002-09-24 | Indiana University Foundation | Methods for treating disorders associated with LHRH activity |
| US6598784B2 (en) * | 2000-12-20 | 2003-07-29 | Meadwestvaco Packaging Syatens, Llc | Beverage carton with strap type carrying handle |
| WO2002056903A2 (en) * | 2001-01-17 | 2002-07-25 | Praecis Pharmaceuticals Inc. | Methods for treating hormone associated conditions using a combination of lhrh antagonists and specific estrogen receptor modulators |
| GB0320806D0 (en) | 2003-09-05 | 2003-10-08 | Astrazeneca Ab | Therapeutic treatment |
| CA2552241C (en) | 2003-12-30 | 2013-10-01 | Durect Corporation | Co-polymeric devices for controlled release of active agents |
| JP5361210B2 (ja) * | 2008-02-22 | 2013-12-04 | キヤノン株式会社 | 樹脂組成物および成形体 |
| CN102584945A (zh) * | 2012-02-09 | 2012-07-18 | 深圳翰宇药业股份有限公司 | 一种醋酸加尼瑞克的制备方法 |
| CN104231055A (zh) * | 2013-06-18 | 2014-12-24 | 深圳翰宇药业股份有限公司 | 加尼瑞克前体以及由其制备醋酸加尼瑞克的方法 |
| CN109443592A (zh) * | 2018-09-19 | 2019-03-08 | 东华大学 | 一种温敏嵌段共聚物低临界溶解温度的测定方法 |
| CN111943960B (zh) | 2019-07-29 | 2022-02-15 | 广东东阳光药业有限公司 | 取代的嘧啶二酮类化合物及其用途 |
| EP4428137A1 (en) | 2021-11-01 | 2024-09-11 | Shandong Luye Pharmaceutical Co., Ltd. | Gonadotropin-releasing hormone antagonist, and preparation method therefor and use thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4215038A (en) * | 1978-10-16 | 1980-07-29 | The Salk Institute For Biological Studies | Peptides which inhibit gonadal function |
| US4419347A (en) * | 1980-10-06 | 1983-12-06 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists |
| US4341767A (en) * | 1980-10-06 | 1982-07-27 | Syntex Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists |
| US4581169A (en) * | 1982-12-21 | 1986-04-08 | Syntex (U.S.A.) Inc. | Nona-peptide and deca-peptide analogs of LHRH, useful as LHRH antagonists |
| US4667014A (en) * | 1983-03-07 | 1987-05-19 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists |
| US4481190A (en) * | 1982-12-21 | 1984-11-06 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists |
| FI832053L (fi) * | 1982-06-10 | 1983-12-11 | Syntex Inc | Nonapeptid- och dekapeptidanaloger av lhrh anvaendbara som lhrh-antagonister samt deras framstaellningsfoerfarande |
| ZA846154B (en) * | 1983-08-16 | 1985-03-27 | Akzo Nv | Lh-rh antagonists |
| EP0145032B1 (en) * | 1983-08-16 | 1987-11-04 | Akzo N.V. | Lh- rh antagonists |
| US4569927A (en) * | 1984-02-23 | 1986-02-11 | The Salk Institute For Biological Studies | GnRH Antagonists IV |
| US4690916A (en) * | 1984-11-13 | 1987-09-01 | Syntex (U.S.A.) Inc. | Nona and decapeptide analogs of LHRH useful as LHRH antagonists |
| AU2012488A (en) * | 1987-07-31 | 1989-02-02 | Syntex (U.S.A.) Inc. | Combination therapy with lhrh antagonist analogs and 19nor progestational steroids |
| US5300492A (en) * | 1988-02-10 | 1994-04-05 | Tap Pharmaceuticals | LHRH analogs |
| DE4117507A1 (de) * | 1991-05-24 | 1992-11-26 | Schering Ag | Verfahren zur herstellung von n(pfeil hoch)6(pfeil hoch)-substituierten lysin-derivaten |
| US5480969A (en) * | 1992-09-15 | 1996-01-02 | The Administrators Of The Tulane Educational Fund | Antagonists of LHRH |
| ES2164096T3 (es) * | 1992-12-18 | 2002-02-16 | Abbott Lab | Antagonistas de lhrh que comprenden restos de aminoacilo modificados en posicion 5 y 6. |
| US5502035A (en) * | 1993-08-06 | 1996-03-26 | Tap Holdings Inc. | N-terminus modified analogs of LHRH |
| US5516759A (en) * | 1994-12-08 | 1996-05-14 | Tap Holdings Inc. | LHRH antagonists having lactam groups at the N-terminus |
| US5574011A (en) * | 1995-04-04 | 1996-11-12 | Tien; Henry C. | Compositions and methods for the treatment of male-pattern baldness |
-
1987
- 1987-02-05 US US07/010,923 patent/US4801577A/en not_active Expired - Lifetime
-
1988
- 1988-02-04 DE DE2000175027 patent/DE10075027I2/de active Active
- 1988-02-04 HU HU19/88A patent/HU215855B/hu unknown
- 1988-02-04 AU AU11265/88A patent/AU614275B2/en not_active Expired
- 1988-02-04 ES ES88300927T patent/ES2056908T3/es not_active Expired - Lifetime
- 1988-02-04 JP JP63026418A patent/JPH0791314B2/ja not_active Expired - Lifetime
- 1988-02-04 HU HU921483A patent/HUT63855A/hu unknown
- 1988-02-04 NO NO880494A patent/NO176440C/no not_active IP Right Cessation
- 1988-02-04 AT AT88300927T patent/ATE109159T1/de active
- 1988-02-04 EP EP88300927A patent/EP0277829B1/en not_active Expired - Lifetime
- 1988-02-04 NZ NZ223403A patent/NZ223403A/xx unknown
- 1988-02-04 DE DE3850789T patent/DE3850789T2/de not_active Expired - Lifetime
- 1988-02-04 DK DK198800572A patent/DK173544B1/da not_active IP Right Cessation
- 1988-02-04 IL IL85316A patent/IL85316A/xx not_active IP Right Cessation
- 1988-02-04 CA CA000558099A patent/CA1339043C/en not_active Expired - Lifetime
- 1988-02-04 IE IE29888A patent/IE63707B1/en not_active IP Right Cessation
- 1988-02-04 ZA ZA88795A patent/ZA88795B/xx unknown
- 1988-02-04 FI FI880509A patent/FI92326C/sv active IP Right Grant
- 1988-02-05 KR KR1019880001047A patent/KR930008095B1/ko not_active IP Right Cessation
-
1992
- 1992-06-08 MX MX9202737A patent/MX9202737A/es unknown
- 1992-07-03 NO NO922632A patent/NO301014B1/no not_active IP Right Cessation
-
1993
- 1993-02-17 FI FI930694A patent/FI92211C/sv active Protection Beyond IP Right Term
- 1993-06-02 US US08/526,940 patent/US5767082A/en not_active Expired - Lifetime
-
1995
- 1995-02-17 HU HU95P/P00080P patent/HU210819A9/hu unknown
-
1997
- 1997-03-20 HK HK35997A patent/HK35997A/xx not_active IP Right Cessation
- 1997-05-08 BR BR1100688-9A patent/BR1100688A/pt active IP Right Grant
-
2000
- 2000-09-04 NL NL300016C patent/NL300016I2/nl unknown
- 2000-10-18 LU LU90657C patent/LU90657I2/fr unknown
-
2001
- 2001-01-16 NO NO2001001C patent/NO2001001I1/no unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| FG | Patent granted |
Owner name: SYNTEX (U.S.A.) INC. |