FI890028A - Menetelmä 2-substituoitujen adenosiinijohdannaisten valmistamiseksi - Google Patents

Menetelmä 2-substituoitujen adenosiinijohdannaisten valmistamiseksi Download PDF

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Publication number
FI890028A
FI890028A FI890028A FI890028A FI890028A FI 890028 A FI890028 A FI 890028A FI 890028 A FI890028 A FI 890028A FI 890028 A FI890028 A FI 890028A FI 890028 A FI890028 A FI 890028A
Authority
FI
Finland
Prior art keywords
preparation
adenosine derivatives
substituted adenosine
substituted
derivatives
Prior art date
Application number
FI890028A
Other languages
English (en)
Swedish (sv)
Other versions
FI90430B (fi
FI890028A0 (fi
FI90430C (fi
Inventor
Alan J Hutchison
John E Francis
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of FI890028A0 publication Critical patent/FI890028A0/fi
Publication of FI890028A publication Critical patent/FI890028A/fi
Publication of FI90430B publication Critical patent/FI90430B/fi
Application granted granted Critical
Publication of FI90430C publication Critical patent/FI90430C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
FI890028A 1988-01-07 1989-01-04 Menetelmä 2-substituoitujen adenosiinijohdannaisten valmistamiseksi FI90430C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14205588A 1988-01-07 1988-01-07
US14205588 1988-01-07
US19396888 1988-05-13
US07/193,968 US5034381A (en) 1988-01-07 1988-05-13 2-(substituted amino) adenosines as antihypertensives

Publications (4)

Publication Number Publication Date
FI890028A0 FI890028A0 (fi) 1989-01-04
FI890028A true FI890028A (fi) 1989-07-08
FI90430B FI90430B (fi) 1993-10-29
FI90430C FI90430C (fi) 1994-02-10

Family

ID=26839719

Family Applications (1)

Application Number Title Priority Date Filing Date
FI890028A FI90430C (fi) 1988-01-07 1989-01-04 Menetelmä 2-substituoitujen adenosiinijohdannaisten valmistamiseksi

Country Status (17)

Country Link
US (1) US5034381A (fi)
EP (1) EP0323807A3 (fi)
JP (1) JPH01265100A (fi)
KR (1) KR890011903A (fi)
AU (1) AU618055B2 (fi)
CA (1) CA1325209C (fi)
DD (1) DD283402A5 (fi)
DK (1) DK5089A (fi)
FI (1) FI90430C (fi)
HU (1) HU202550B (fi)
IL (1) IL88877A0 (fi)
MX (1) MX14446A (fi)
NO (1) NO169843C (fi)
NZ (1) NZ227542A (fi)
PH (1) PH26672A (fi)
PT (1) PT89392B (fi)
ZA (1) ZA8984B (fi)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4977144A (en) * 1988-08-02 1990-12-11 Ciba-Geigy Corporation Imidazo[4,5-b]pyridine derivatives as cardiovascular agents
AU3820989A (en) * 1988-08-02 1990-02-08 Ciba-Geigy Ag 7-amino-3-beta-d-ribofuranosyl-3h-imidazo(4,5-b) pyridin-5-amine derivatives
US5189027A (en) 1990-11-30 1993-02-23 Yamasa Shoyu Kabushiki Kaisha 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases
US5206222A (en) * 1991-05-22 1993-04-27 Vanderbilt University Methods for the reduction of myocardial reperfusion injury
IT1254915B (it) * 1992-04-24 1995-10-11 Gloria Cristalli Derivati di adenosina ad attivita' a2 agonista
IL107101A0 (en) * 1992-09-30 1993-12-28 Merrell Dow Pharma 2-substituted adenosines with a-2 receptor affinity
US5426101A (en) * 1992-09-30 1995-06-20 Merrell Dow Pharmaceuticals Inc. 2-substituted adenosines with A-2 receptor affinity
WO1994023723A1 (en) * 1993-04-15 1994-10-27 New York University Adenosine receptor agonists for the promotion of wound healing
US5817641A (en) * 1994-07-21 1998-10-06 Thomas Jefferson University Treatment of enterotoxigenic diarrhea with 2-substituted adenosine derivatives
AU740770B2 (en) 1997-06-18 2001-11-15 Aderis Pharmaceuticals, Inc. Compositions and methods for preventing restenosis following revascularization procedures
US5972903A (en) * 1997-10-07 1999-10-26 Regents Of The University Of California Corporation Method for promoting angiogenesis using heparin and adenosine
WO1999017784A1 (en) 1997-10-07 1999-04-15 Regents Of The University Of California Corporation Treating occlusive peripheral vascular disease and coronary disease with combinations of heparin and an adenoside a2 agonist, or with adenosine
AU751470B2 (en) * 1998-07-09 2002-08-15 Sequella, Inc. Novel antibacterial compounds
AU4343500A (en) 1999-04-16 2000-11-02 Schering Corporation Use of azetidinone compounds
TWI245047B (en) * 1999-08-20 2005-12-11 Sankyo Co Novel A-500359 derivatives
US20050033044A1 (en) 2003-05-19 2005-02-10 Bristol-Myers Squibb Pharma Company Methods for preparing 2-alkynyladenosine derivatives
MX2007009783A (es) 2005-02-17 2007-08-22 Wyeth Corp Derivados de indol, benzotiofeno, benzofurano e indeno cicloalquilfusionados.
US20090136460A1 (en) * 2007-07-10 2009-05-28 Vanderbilt University Use of adenosine receptor ligands to promote cell adhesion in cell-based therapies
AU2014340114B2 (en) * 2013-10-23 2018-10-18 Academia Sinica Compounds for use in prevention and treatment of neurodegenerative diseases and pain

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670265A1 (de) * 1967-08-25 1971-01-28 Boehringer Mannheim Gmbh 2-Amino-Adenosinderivate und Verfahren zu deren Herstellung
NL7203984A (fi) * 1971-04-10 1972-10-12
US3917583A (en) * 1972-08-04 1975-11-04 Icn Pharmaceuticals 2-Substituted cyclic AMP derivatives
AR205247A1 (es) * 1973-02-07 1976-04-21 Icn Pharmaceuticals Procedimiento para preparar derivados de amp 2-substituidos
JPS5630355B2 (fi) * 1974-01-21 1981-07-14
AU5118979A (en) * 1978-10-16 1980-04-24 Takeda Chemical Industries Ltd. 2,6-diaminoebularines
JPS55139399A (en) * 1979-04-12 1980-10-31 Asahi Chem Ind Co Ltd Novel adenosine derivative substituted in the 2-position
JPS56152437U (fi) * 1980-04-14 1981-11-14
US4501735A (en) * 1983-12-05 1985-02-26 Warner-Lambert Company N6-(1- and 2-benzocycloalkyl) adenosines
DE3406533A1 (de) * 1984-02-23 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten
DE3587717T2 (de) * 1984-04-18 1994-04-28 Whitby Research Inc N-6-thienyl-substituierte Adenosinderivate als herzgefässerweiternde Mittel.
US4594350A (en) * 1984-07-30 1986-06-10 Reagents Of University Of Minnesota (3-ethoxypropionate) esters of cyclaradine
US4683223A (en) * 1985-09-09 1987-07-28 Warner-Lambert Company N6 -Benzopyrano-and benzothiopyrano adenosines and methods of use
US4593019A (en) * 1984-10-26 1986-06-03 Warner-Lambert Company N6 -tricyclic adenosines
US4791103A (en) * 1985-02-08 1988-12-13 Warner-Lambert Company 2,N6 -disubstituted adenosines, derivatives and methods of use
US4600707A (en) * 1985-01-25 1986-07-15 Warner-Lambert Company Benzothien-3-yl adenosine; benzothien-3-yl adenosine, S-oxide; and benzothien-3-yl, S,S-dioxide adenosine compounds
US4755594A (en) * 1986-01-31 1988-07-05 Warner-Lambert Company N6 -substituted adenosines
US4843066A (en) * 1986-11-27 1989-06-27 Nippon Zoki Pharmaceutical Co., Ltd. Novel adenosine derivatives and pharmaceutical composition containing them as an active ingredient
EP0277917A3 (en) * 1987-02-04 1990-03-28 Ciba-Geigy Ag Certain adenosine 5'-carboxamide derivatives

Also Published As

Publication number Publication date
CA1325209C (en) 1993-12-14
FI90430B (fi) 1993-10-29
NO169843C (no) 1992-08-12
DD283402A5 (de) 1990-10-10
US5034381A (en) 1991-07-23
NO885821D0 (no) 1988-12-30
JPH01265100A (ja) 1989-10-23
MX14446A (es) 1994-01-31
HU202550B (en) 1991-03-28
AU2776789A (en) 1989-07-13
FI890028A0 (fi) 1989-01-04
EP0323807A3 (en) 1990-06-20
PT89392B (pt) 1993-09-30
NZ227542A (en) 1992-03-26
IL88877A0 (en) 1989-08-15
ZA8984B (en) 1989-08-30
PT89392A (pt) 1990-02-08
DK5089D0 (da) 1989-01-06
NO885821L (no) 1989-07-10
AU618055B2 (en) 1991-12-12
HUT48904A (en) 1989-07-28
FI90430C (fi) 1994-02-10
EP0323807A2 (en) 1989-07-12
PH26672A (en) 1992-09-15
NO169843B (no) 1992-05-04
DK5089A (da) 1989-07-08
KR890011903A (ko) 1989-08-23

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MM Patent lapsed
MM Patent lapsed

Owner name: CIBA-GEIGY AG