FI830938L - Nya derivat av bicykliska aminosyror, foerfaranden foer deras framstaellning, dess innehaollande meoch deras anvaendning och nya bicykliska aminosyror som mellanprodukter och foerfaranden foer derasframstaellning - Google Patents

Nya derivat av bicykliska aminosyror, foerfaranden foer deras framstaellning, dess innehaollande meoch deras anvaendning och nya bicykliska aminosyror som mellanprodukter och foerfaranden foer derasframstaellning

Info

Publication number
FI830938L
FI830938L FI830938A FI830938A FI830938L FI 830938 L FI830938 L FI 830938L FI 830938 A FI830938 A FI 830938A FI 830938 A FI830938 A FI 830938A FI 830938 L FI830938 L FI 830938L
Authority
FI
Finland
Prior art keywords
aminosyror
nya
och
deras
foerfaranden foer
Prior art date
Application number
FI830938A
Other languages
English (en)
Other versions
FI76559C (fi
FI830938A0 (fi
FI76559B (fi
Inventor
Hansjoerg Urbach
Rainer Henning
Volker Teetz
Hans Wissmann
Reinhard Becker
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI830938A0 publication Critical patent/FI830938A0/fi
Publication of FI830938L publication Critical patent/FI830938L/fi
Application granted granted Critical
Publication of FI76559B publication Critical patent/FI76559B/fi
Publication of FI76559C publication Critical patent/FI76559C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI830938A 1982-03-23 1983-03-21 Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara hexahydroindol-2-karboxylsyraderivat och nya mellanprodukter. FI76559C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3210496 1982-03-23
DE19823210496 DE3210496A1 (de) 1982-03-23 1982-03-23 Neue derivate bicyclischer aminsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung

Publications (4)

Publication Number Publication Date
FI830938A0 FI830938A0 (fi) 1983-03-21
FI830938L true FI830938L (fi) 1983-09-24
FI76559B FI76559B (fi) 1988-07-29
FI76559C FI76559C (fi) 1988-11-10

Family

ID=6158979

Family Applications (1)

Application Number Title Priority Date Filing Date
FI830938A FI76559C (fi) 1982-03-23 1983-03-21 Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara hexahydroindol-2-karboxylsyraderivat och nya mellanprodukter.

Country Status (23)

Country Link
US (2) US4562202A (fi)
EP (1) EP0089637B1 (fi)
JP (2) JPS58172367A (fi)
KR (1) KR900007241B1 (fi)
AR (1) AR247199A1 (fi)
AT (1) ATE22883T1 (fi)
AU (2) AU560805B2 (fi)
CA (1) CA1223868A (fi)
DE (2) DE3210496A1 (fi)
DK (1) DK171256B1 (fi)
ES (2) ES8607281A1 (fi)
FI (1) FI76559C (fi)
GR (1) GR78519B (fi)
HU (2) HUT35643A (fi)
IE (1) IE55091B1 (fi)
IL (1) IL68199A (fi)
MA (1) MA19753A1 (fi)
MX (1) MX6452A (fi)
NO (1) NO162856C (fi)
NZ (1) NZ203638A (fi)
PH (2) PH19645A (fi)
PT (1) PT76424B (fi)
ZA (1) ZA831989B (fi)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
CA1341296C (en) * 1981-12-29 2001-09-25 Hansjorg Urbach 2-azabicycloalkane-3-carboxylic acid derivatives, processes for their preparation, agents containing these compounds and their use
US5175306A (en) * 1983-01-31 1992-12-29 Hoechst Aktiengesellschaft Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
DE3303344A1 (de) 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern
DK156484A (da) * 1983-03-16 1984-09-17 Usv Pharma Corp Aminosyrederivater
DE3333454A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3333455A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
DE3410732A1 (de) * 1984-03-23 1985-09-26 Hoechst Ag, 6230 Frankfurt Methode zur behandlung des glaukoms
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
DE3431541A1 (de) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
DE3518514A1 (de) * 1985-05-23 1986-11-27 Hoechst Ag, 6230 Frankfurt Neue derivate bicyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
US4678802A (en) * 1985-07-09 1987-07-07 Pfizer Inc. 1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
DE3639879A1 (de) * 1986-11-21 1988-06-01 Hoechst Ag Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
DE3722007A1 (de) * 1987-07-03 1989-01-12 Hoechst Ag Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
US5128346A (en) * 1987-09-21 1992-07-07 Abbott Laboratories Derivatives of D-glutamic acid and D-aspartic acid
HU904967D0 (en) * 1988-04-22 1991-01-28 Hoechst Ag Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives
DD284030A5 (de) 1988-11-24 1990-10-31 Hoechst Ag,De Verfahren zur herstellung von peptiden mit bradykinin-antagonistischer wirkung
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
PT796855E (pt) 1996-03-20 2002-07-31 Hoechst Ag Inibicao da reabsorcao nos ossos e antagonistas de vitronectina
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
CA2522195A1 (en) * 2003-04-15 2004-10-28 Warner-Lambert Company Llc [b]-fused bicyclic proline derivatives and their use for treating arthritic conditions
MXPA05010165A (es) * 2003-04-15 2005-11-16 Warner Lambert Co Derivados de prolina biciclicos [c]-condensados y su uso para el tratamiento de estados artriticos.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
GB2086390B (en) * 1980-11-03 1984-06-06 Ciba Geigy Ag 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application

Also Published As

Publication number Publication date
PH22323A (en) 1988-07-29
CA1223868A (en) 1987-07-07
DE3366919D1 (en) 1986-11-20
US4562202A (en) 1985-12-31
MA19753A1 (fr) 1983-10-01
DE3210496A1 (de) 1983-10-06
AU1270483A (en) 1983-09-29
JPH0559104B2 (fi) 1993-08-30
GR78519B (fi) 1984-09-27
NO162856B (no) 1989-11-20
FI76559C (fi) 1988-11-10
ATE22883T1 (de) 1986-11-15
FI830938A0 (fi) 1983-03-21
IL68199A (en) 1988-04-29
AR247199A1 (es) 1994-11-30
NO162856C (no) 1990-02-28
DK171256B1 (da) 1996-08-12
ES8402270A1 (es) 1984-01-16
ES520802A0 (es) 1986-05-16
US4668797A (en) 1987-05-26
KR900007241B1 (ko) 1990-10-06
PH19645A (en) 1986-06-04
EP0089637B1 (de) 1986-10-15
ES521656A0 (es) 1984-01-16
AU610060B2 (en) 1991-05-16
AU560805B2 (en) 1987-04-16
NO830999L (no) 1983-09-26
ES8607281A1 (es) 1986-05-16
DK130683D0 (da) 1983-03-22
JPS58172367A (ja) 1983-10-11
EP0089637A3 (en) 1984-07-18
JPH0471920B2 (fi) 1992-11-16
DK130683A (da) 1983-09-24
NZ203638A (en) 1987-05-29
JPH02275852A (ja) 1990-11-09
HU188439B (en) 1986-04-28
IE55091B1 (en) 1990-05-23
HUT35643A (en) 1985-07-29
ZA831989B (en) 1983-11-30
IE830621L (en) 1983-09-23
AU6859687A (en) 1987-05-07
FI76559B (fi) 1988-07-29
PT76424A (de) 1983-04-01
EP0089637A2 (de) 1983-09-28
PT76424B (de) 1986-01-27
KR840004071A (ko) 1984-10-15
MX6452A (es) 1993-09-01

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Legal Events

Date Code Title Description
MA Patent expired

Owner name: HOECHST AKTIENGESELLSCHAFT