ES8402270A1 - Procedimiento para la preparacion de aminoacidos biciclicos. - Google Patents

Procedimiento para la preparacion de aminoacidos biciclicos.

Info

Publication number
ES8402270A1
ES8402270A1 ES521656A ES521656A ES8402270A1 ES 8402270 A1 ES8402270 A1 ES 8402270A1 ES 521656 A ES521656 A ES 521656A ES 521656 A ES521656 A ES 521656A ES 8402270 A1 ES8402270 A1 ES 8402270A1
Authority
ES
Spain
Prior art keywords
preparation
alkyl
denotes hydrogen
aryl
bicyclic amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521656A
Other languages
English (en)
Other versions
ES521656A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8402270A1 publication Critical patent/ES8402270A1/es
Publication of ES521656A0 publication Critical patent/ES521656A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE AMINOACIDOS BICICLICOS, DE FORMULA GENERAL (I), EN LA QUE W SIGNIFICA HIDROGENO O UN RADICAL SEPARABLE EN CONDICIONES ACIDAS. CONSISTE EN HACER REACCIONAR COMPUESTOS DE FORMULA (II), EN LA QUE R ELEVADO 2, SIGNIFICA ALCOHILO O ARALCOHILO, CON AGENTES ACILANTES, PARA OBTENER COMPUESTOS DE FORMULA (III), EN LA QUE R ELEVADO 2 TIENE EL SIGNIFICADO YA INDICADO; Y R ELEVADO 3 REPRESENTA ALCOHILO, CICLOALCOHILO, ALQUENILO, ALCOXI O ARILO. LOS COMPUESTOS DE FORMULA (III) SE CICLIZAN PARA FORMAR UNA MEZCLA DE OMPUESTOS ESTEREOISOMEROS, LOS CUALES SE SAPONIFICAN DESPUES DE PREVIO DESDOBLAMIENTO EN ENANTIOMEROS, PARA OBTENER COMPUESTOS DE FORMULA (I). DE APLICACION EN MEDICINA PARA COMBATIR LA HIPERTENSION SANGUINEA DE DIVERSOS ORIGENOS. *FORMULA*.
ES521656A 1982-03-23 1983-04-20 Procedimiento para la preparacion de aminoacidos biciclicos. Granted ES521656A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823210496 DE3210496A1 (de) 1982-03-23 1982-03-23 Neue derivate bicyclischer aminsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
ES8402270A1 true ES8402270A1 (es) 1984-01-16
ES521656A0 ES521656A0 (es) 1984-01-16

Family

ID=6158979

Family Applications (2)

Application Number Title Priority Date Filing Date
ES520802A Expired ES8607281A1 (es) 1982-03-23 1983-03-21 Procedimiento para la preparacion de nuevos derivados de aminoacidos biciclicos.
ES521656A Granted ES521656A0 (es) 1982-03-23 1983-04-20 Procedimiento para la preparacion de aminoacidos biciclicos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES520802A Expired ES8607281A1 (es) 1982-03-23 1983-03-21 Procedimiento para la preparacion de nuevos derivados de aminoacidos biciclicos.

Country Status (23)

Country Link
US (2) US4562202A (es)
EP (1) EP0089637B1 (es)
JP (2) JPS58172367A (es)
KR (1) KR900007241B1 (es)
AR (1) AR247199A1 (es)
AT (1) ATE22883T1 (es)
AU (2) AU560805B2 (es)
CA (1) CA1223868A (es)
DE (2) DE3210496A1 (es)
DK (1) DK171256B1 (es)
ES (2) ES8607281A1 (es)
FI (1) FI76559C (es)
GR (1) GR78519B (es)
HU (2) HU188439B (es)
IE (1) IE55091B1 (es)
IL (1) IL68199A (es)
MA (1) MA19753A1 (es)
MX (1) MX6452A (es)
NO (1) NO162856C (es)
NZ (1) NZ203638A (es)
PH (2) PH19645A (es)
PT (1) PT76424B (es)
ZA (1) ZA831989B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
NZ202903A (en) * 1981-12-29 1988-01-08 Hoechst Ag 1-- pe pyrrol-2-yl-carboxylic acid derivatives and pharmaceutical compositions
US5175306A (en) * 1983-01-31 1992-12-29 Hoechst Aktiengesellschaft Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
DE3303344A1 (de) 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern
FI841052A (fi) * 1983-03-16 1984-09-17 Usv Pharma Corp Foereningar foer behandling av blodtryckssjukdomar.
DE3333454A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3333455A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
DE3410732A1 (de) * 1984-03-23 1985-09-26 Hoechst Ag, 6230 Frankfurt Methode zur behandlung des glaukoms
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
DE3431541A1 (de) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
DE3518514A1 (de) * 1985-05-23 1986-11-27 Hoechst Ag, 6230 Frankfurt Neue derivate bicyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
US4678802A (en) * 1985-07-09 1987-07-07 Pfizer Inc. 1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
DE3639879A1 (de) * 1986-11-21 1988-06-01 Hoechst Ag Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
DE3722007A1 (de) * 1987-07-03 1989-01-12 Hoechst Ag Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
US5128346A (en) * 1987-09-21 1992-07-07 Abbott Laboratories Derivatives of D-glutamic acid and D-aspartic acid
HU904967D0 (en) * 1988-04-22 1991-01-28 Hoechst Ag Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives
DD284030A5 (de) 1988-11-24 1990-10-31 Hoechst Ag,De Verfahren zur herstellung von peptiden mit bradykinin-antagonistischer wirkung
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
EP0796855B1 (de) 1996-03-20 2002-02-06 Hoechst Aktiengesellschaft Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
MXPA05011168A (es) * 2003-04-15 2005-12-14 Warner Lambert Co Derivados de prolina biciclicos [b]-condensados y sus usos para tratar afecciones artriticas.
EP1615886A1 (en) * 2003-04-15 2006-01-18 Warner-Lambert Company LLC [c]-fused bicyclic proline derivatives and their use for treating arthritic conditions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
GB2086390B (en) * 1980-11-03 1984-06-06 Ciba Geigy Ag 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application

Also Published As

Publication number Publication date
NO162856C (no) 1990-02-28
HUT35643A (en) 1985-07-29
US4668797A (en) 1987-05-26
GR78519B (es) 1984-09-27
MX6452A (es) 1993-09-01
ES520802A0 (es) 1986-05-16
DE3366919D1 (en) 1986-11-20
IE55091B1 (en) 1990-05-23
KR900007241B1 (ko) 1990-10-06
DK130683A (da) 1983-09-24
IL68199A (en) 1988-04-29
JPH0559104B2 (es) 1993-08-30
MA19753A1 (fr) 1983-10-01
ES521656A0 (es) 1984-01-16
ATE22883T1 (de) 1986-11-15
PT76424A (de) 1983-04-01
AU610060B2 (en) 1991-05-16
FI76559C (fi) 1988-11-10
JPH0471920B2 (es) 1992-11-16
US4562202A (en) 1985-12-31
JPH02275852A (ja) 1990-11-09
EP0089637A2 (de) 1983-09-28
AU560805B2 (en) 1987-04-16
IE830621L (en) 1983-09-23
FI76559B (fi) 1988-07-29
PH19645A (en) 1986-06-04
CA1223868A (en) 1987-07-07
AU6859687A (en) 1987-05-07
HU188439B (en) 1986-04-28
NO162856B (no) 1989-11-20
NO830999L (no) 1983-09-26
DK171256B1 (da) 1996-08-12
AU1270483A (en) 1983-09-29
EP0089637B1 (de) 1986-10-15
JPS58172367A (ja) 1983-10-11
PT76424B (de) 1986-01-27
DE3210496A1 (de) 1983-10-06
PH22323A (en) 1988-07-29
KR840004071A (ko) 1984-10-15
EP0089637A3 (en) 1984-07-18
FI830938L (fi) 1983-09-24
DK130683D0 (da) 1983-03-22
NZ203638A (en) 1987-05-29
AR247199A1 (es) 1994-11-30
ES8607281A1 (es) 1986-05-16
ZA831989B (en) 1983-11-30
FI830938A0 (fi) 1983-03-21

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