FI81788B - Foerfarande foer framstaellning av terapeutiskt anvaendbara fenotiazinfoereningar. - Google Patents
Foerfarande foer framstaellning av terapeutiskt anvaendbara fenotiazinfoereningar. Download PDFInfo
- Publication number
- FI81788B FI81788B FI834401A FI834401A FI81788B FI 81788 B FI81788 B FI 81788B FI 834401 A FI834401 A FI 834401A FI 834401 A FI834401 A FI 834401A FI 81788 B FI81788 B FI 81788B
- Authority
- FI
- Finland
- Prior art keywords
- compound
- formula
- group
- acid
- dimethylaminopropyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
- C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (6)
1. Förfarande för framställning av terapeutiskt användbara föreningar med formeln (I) eller deras salter 5 eller estrar (i>
10 A N X \ R2 R3 i vilken formel R3 är C3_4-alkylen eller CH-CH; R2 och R3 15 betecknar C^-alkyl eller blldar tillsammans med kväve- atomer en kväveatom innehällande heterocyklisk ring med 4-6 leder; R4 är väte, halogen, R4 är väte, halogen, C1.4-alkyl; och A är C^-alkylen, under förbehäll att ANR2R3 icke är CH2CH2N(C2H5)2, dä R4 är väte och R^OjH är 20 2-CH2C02H, kännetecknat därav, att a) en förening med formeln (III) i; - A L 30 eller en ester därav, omsätts med aminen HNR2R3, väri Rx -R4 har ovan angivna betydelse och L är en avgäende grupp; 44 81 788 b) en förening med formeln (V) R4—^TSTg5— <<" (V,
2. Förfarande enligt patentkravet 1, k ä n n e -5 tecknat därav, att man framställer en förening med formeln (II) 10 9 " R,CO-H A 12 N r/ \r K2 K3 15 eller ett sait eller en ester därav, i vilken formel ^ -R4 och A har samma betydelse som i formeln (I).
3. Förfarande enligt patentkravet 1 eller 2, kännetecknat därav, att Ri är (CH2)n, väri n är ett heltal 0-3, eller CH-CH eller CH(CH3)(CH2)„, väri 20 m är 0 eller 1, eller C(CH3)2.
4. Förfarande enligt nägot av patentkraven 1-3, kännetecknat därav, att NR2R3 är en dimetyl-amino- eller dietylaminogrupp.
5. Förfarande enligt nägot av patentkraven 1-4, 25 kännetecknat därav, att R4 är väte, metyl, klor eller fluor.
5 A l L R ^R K2 R3 10 väri R2, R3, R4 och A har ovan angivna be ty del se, omsätts med en Wittig-reagens, vilken är lämplig för anbrlngande av en sidokedja CH=CHC0R6, väri C0R6 är en syra- eller estergrupp, och därefter avlägsnas vid behov karboxigrup-pens skyddsgrupp, eller en förening med formeln (V) om-15 sätts med malonsyra eller en malonsyraester; c) en förening med formeln (VI) A f N R / ^R 2 3 25 väri R2, R3, R4 och A har ovan angivna betydelse, R2Z är gruppen RjCN, väri Rx är C1.4-alkylen, eller gruppen -CH=C(Y)XH, väri X är syra eller svavel och Y är en ami-nogrupp, hydrolyseras; d) en förening med formeln (VII) 3° %-fpT Tch— Ri°0R6 (vii) H väri Rt och R4 har ovan angivna betydelse och C0Re är en 35 estergrupp, alkyleras, II 45 81 7 88 och att, om sä önskas, en förening med formeln (I) om-vandlas tili en annan förening med formeln (I) pä i och för sig känt sätt genom förtvilning av estergruppen.
6. Förfarande enligtnägot av patentkraven 1-5, kännetecknat därav, att A är en etylen- eller n- eller i-propylengrupp.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8234398 | 1982-12-02 | ||
| GB8234398 | 1982-12-02 | ||
| GB838318832A GB8318832D0 (en) | 1983-07-12 | 1983-07-12 | Chemical compounds |
| GB8318832 | 1983-07-12 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI834401A0 FI834401A0 (fi) | 1983-12-01 |
| FI834401A FI834401A (fi) | 1984-06-03 |
| FI81788B true FI81788B (fi) | 1990-08-31 |
| FI81788C FI81788C (sv) | 1990-12-10 |
Family
ID=26284560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI834401A FI81788C (sv) | 1982-12-02 | 1983-12-01 | Förfarande för framställning av terapeutiskt användbara fenotiazinföre ningar |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0117302B1 (sv) |
| JP (1) | JPH06767B2 (sv) |
| KR (1) | KR890000638B1 (sv) |
| AU (1) | AU572105B2 (sv) |
| BG (2) | BG47647A3 (sv) |
| CA (1) | CA1280749C (sv) |
| DD (1) | DD213922A5 (sv) |
| DE (1) | DE3381689D1 (sv) |
| DK (1) | DK551283A (sv) |
| ES (7) | ES527705A0 (sv) |
| FI (1) | FI81788C (sv) |
| GR (1) | GR81958B (sv) |
| HU (1) | HU193274B (sv) |
| IE (1) | IE56998B1 (sv) |
| IL (2) | IL70359A0 (sv) |
| MC (1) | MC1562A1 (sv) |
| NO (1) | NO160203C (sv) |
| NZ (1) | NZ206458A (sv) |
| PH (1) | PH20433A (sv) |
| PL (2) | PL145778B1 (sv) |
| PT (1) | PT77766B (sv) |
| YU (1) | YU44758B (sv) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8413915D0 (en) * | 1984-05-31 | 1984-07-04 | Wellcome Found | Phenothiazine compounds |
| JPS6256489A (ja) * | 1985-09-04 | 1987-03-12 | Sanwa Kagaku Kenkyusho:Kk | 新規なピロリチジン化合物及びその塩、これらの製法並びにこれらを有効成分とする消化性潰瘍治療剤 |
| US6333322B1 (en) | 1996-03-13 | 2001-12-25 | Eisai Co., Ltd. | Nitrogen-containing tricyclic compounds and drugs containing the same |
| CN101896811B (zh) | 2007-12-10 | 2014-04-16 | 拜尔健康护理有限责任公司 | 制备3-苯基亚氨基-3h-吩噻嗪或3-苯基亚氨基-3h-吩噁嗪介体的方法 |
| EP2758403B1 (en) | 2011-09-21 | 2016-04-27 | Inception Orion, Inc. | Tricyclic compounds useful as neurogenic and neuroprotective agents |
| KR101646962B1 (ko) | 2014-09-29 | 2016-08-10 | 한국과학기술연구원 | CaM 저해활성을 가지는 페노싸이아진 유도체 |
| US10035795B1 (en) | 2017-04-06 | 2018-07-31 | Korea Institute Of Science And Technology | Phenothiazine derivatives having CaM inhibitory activity |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2956996A (en) * | 1960-10-18 | Alkylated phenotfflazenecarboxamede | ||
| NL97951C (sv) * | 1955-11-15 | |||
| NL96990C (sv) * | 1956-01-10 | |||
| NL58901C (sv) * | 1957-02-07 | 1947-02-15 | ||
| NL273878A (sv) * | 1961-01-24 | |||
| US3112310A (en) * | 1962-01-15 | 1963-11-26 | Searle & Co | 10-alkylaminoalkylphenothiazine-2-carboxamides |
-
1983
- 1983-12-01 IE IE2825/83A patent/IE56998B1/en not_active IP Right Cessation
- 1983-12-01 HU HU834128A patent/HU193274B/hu not_active IP Right Cessation
- 1983-12-01 DK DK551283A patent/DK551283A/da not_active Application Discontinuation
- 1983-12-01 PL PL1983252164A patent/PL145778B1/pl unknown
- 1983-12-01 BG BG063286A patent/BG47647A3/xx unknown
- 1983-12-01 NZ NZ206458A patent/NZ206458A/en unknown
- 1983-12-01 DE DE8383112101T patent/DE3381689D1/de not_active Expired - Fee Related
- 1983-12-01 CA CA000442325A patent/CA1280749C/en not_active Expired - Fee Related
- 1983-12-01 NO NO834424A patent/NO160203C/no unknown
- 1983-12-01 KR KR1019830005691A patent/KR890000638B1/ko not_active IP Right Cessation
- 1983-12-01 GR GR73129A patent/GR81958B/el unknown
- 1983-12-01 IL IL8370359A patent/IL70359A0/xx not_active IP Right Cessation
- 1983-12-01 ES ES527705A patent/ES527705A0/es active Granted
- 1983-12-01 JP JP58227775A patent/JPH06767B2/ja not_active Expired - Lifetime
- 1983-12-01 MC MC831675A patent/MC1562A1/xx unknown
- 1983-12-01 BG BG088609A patent/BG50158A3/xx unknown
- 1983-12-01 EP EP83112101A patent/EP0117302B1/en not_active Expired - Lifetime
- 1983-12-01 IL IL8370359Q patent/IL70359A/xx not_active IP Right Cessation
- 1983-12-01 FI FI834401A patent/FI81788C/sv not_active IP Right Cessation
- 1983-12-01 DD DD83257410A patent/DD213922A5/de not_active IP Right Cessation
- 1983-12-01 PH PH29907A patent/PH20433A/en unknown
- 1983-12-01 PL PL25216383A patent/PL252163A1/xx unknown
- 1983-12-01 YU YU2349/83A patent/YU44758B/xx unknown
- 1983-12-01 AU AU21900/83A patent/AU572105B2/en not_active Ceased
- 1983-12-02 PT PT77766A patent/PT77766B/pt not_active IP Right Cessation
-
1984
- 1984-07-16 ES ES534355A patent/ES8506674A1/es not_active Expired
- 1984-07-16 ES ES534358A patent/ES8506676A1/es not_active Expired
- 1984-07-16 ES ES534353A patent/ES534353A0/es active Granted
- 1984-07-16 ES ES534356A patent/ES534356A0/es active Granted
- 1984-07-16 ES ES534357A patent/ES8506675A1/es not_active Expired
- 1984-07-16 ES ES534354A patent/ES534354A0/es active Granted
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: THE WELLCOME FOUNDATION LIMITED |