FI813283L - Karboxialkyldipeptider foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska kompositioner - Google Patents

Karboxialkyldipeptider foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska kompositioner

Info

Publication number
FI813283L
FI813283L FI813283A FI813283A FI813283L FI 813283 L FI813283 L FI 813283L FI 813283 A FI813283 A FI 813283A FI 813283 A FI813283 A FI 813283A FI 813283 L FI813283 L FI 813283L
Authority
FI
Finland
Prior art keywords
lower alkyl
chem
bridge
hydrogen
karboxialkyldipeptider
Prior art date
Application number
FI813283A
Other languages
English (en)
Other versions
FI83222B (fi
FI83222C (fi
Inventor
Bernard R Neustadt
Elijah H Gold
Elizabeth M Smith
Original Assignee
Essex Laeaekkeet Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26895254&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI813283(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Essex Laeaekkeet Oy filed Critical Essex Laeaekkeet Oy
Publication of FI813283L publication Critical patent/FI813283L/fi
Publication of FI83222B publication Critical patent/FI83222B/fi
Application granted granted Critical
Publication of FI83222C publication Critical patent/FI83222C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI813283A 1980-10-23 1981-10-20 Foerfarande foer framstaellning av farmakologiskt verksamma karboxialkyldipeptider. FI83222C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19988680A 1980-10-23 1980-10-23
US19988680 1980-10-23
US25848481A 1981-04-28 1981-04-28
US25848481 1981-04-28

Publications (3)

Publication Number Publication Date
FI813283L true FI813283L (fi) 1982-04-24
FI83222B FI83222B (fi) 1991-02-28
FI83222C FI83222C (fi) 1991-06-10

Family

ID=26895254

Family Applications (1)

Application Number Title Priority Date Filing Date
FI813283A FI83222C (fi) 1980-10-23 1981-10-20 Foerfarande foer framstaellning av farmakologiskt verksamma karboxialkyldipeptider.

Country Status (28)

Country Link
US (2) US4818749A (fi)
EP (1) EP0050800B2 (fi)
JP (1) JPH01163197A (fi)
KR (1) KR880001843B1 (fi)
AT (1) ATE20469T1 (fi)
AU (1) AU554362B2 (fi)
CA (1) CA1341206C (fi)
CY (1) CY1469A (fi)
DE (2) DE3174844D1 (fi)
DK (1) DK161523C (fi)
ES (1) ES8308838A1 (fi)
FI (1) FI83222C (fi)
GR (1) GR75059B (fi)
HK (1) HK36189A (fi)
HU (1) HU193146B (fi)
IE (1) IE53802B1 (fi)
IL (1) IL64085A (fi)
KE (1) KE3845A (fi)
LU (1) LU88621I2 (fi)
MA (1) MA19309A1 (fi)
MY (1) MY8700683A (fi)
NL (1) NL940001I2 (fi)
NO (2) NO164983C (fi)
NZ (1) NZ198702A (fi)
OA (1) OA06929A (fi)
PH (1) PH21916A (fi)
PT (1) PT73861B (fi)
SG (1) SG78188G (fi)

Cited By (13)

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US4933361A (en) * 1981-12-29 1990-06-12 Hoechst Aktiengesellschaft Derivatives of bicyclic aminoacids agents containing these compounds and their use
US4977260A (en) * 1986-11-21 1990-12-11 Hoechst Aktiengesellschaft Intermediates for preparing mono-, bi- and tricyclic amino acids
US5011940A (en) * 1987-07-03 1991-04-30 Hoechst Aktiengesellschaft Process for the preparation of bicyclic amino carboxylic acids, intermediates in this process, and their use
US5053519A (en) * 1981-11-05 1991-10-01 Hoechst Ag Cis, endo-2-azabicyclo-[3.3.0]-octane-5-carboxylic acids
US5055591A (en) * 1983-09-16 1991-10-08 Hoechst Aktiengesellschaft Process for the preparation of octahydropenta(b)pyrrole carboxylates
US5068351A (en) * 1983-09-16 1991-11-26 Hoechst Aktiengesellschaft Process for the preparation of n octahydropenta (6) pyrrole carboxylates
US5098910A (en) * 1986-10-02 1992-03-24 Hoechst Aktiengesellschaft Combination of angiotensin-converting enzyme inhibitors with calcium antagonists as well as their use in drugs
US5175306A (en) * 1983-01-31 1992-12-29 Hoechst Aktiengesellschaft Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
US5403856A (en) * 1984-04-12 1995-04-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency using angiotensin-converting enzyme inhibitors
US5550255A (en) * 1984-08-28 1996-08-27 Hoechst Aktiengesellschaft Cis, endo-2-azabicycloalkane-3-carboxylic acid derivatives
US5747504A (en) * 1984-04-12 1998-05-05 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency using angiotensin-converting enzyme inhibitors

Families Citing this family (131)

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US4595675A (en) * 1979-09-19 1986-06-17 Hoechst Aktiengesellschaft Bicyclic α-iminocarboxylic acid compounds having hypotensive activity
US4616029A (en) * 1979-12-07 1986-10-07 Adir Perhydromdole-2-carboxylic acids as antihypertensives
US4616030A (en) * 1979-12-07 1986-10-07 Adir Perhydroindole-2-carboxylic acids as antihypertensives
US4644008A (en) * 1979-12-07 1987-02-17 Adir Perhydroindole-2-carboxylic acids as antihypertensives
US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
US4616031A (en) * 1979-12-07 1986-10-07 Adir Perhydroindole-2-carboxylic acids as antihypertensives
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
EP0278530A3 (de) * 1980-08-30 1989-08-02 Hoechst Aktiengesellschaft Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung
EP0050800B2 (en) * 1980-10-23 1995-06-07 Schering Corporation Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
US4906615A (en) * 1980-12-18 1990-03-06 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
US4610816A (en) * 1980-12-18 1986-09-09 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
DE3276311D1 (en) * 1981-02-17 1987-06-19 Warner Lambert Co Octahydro-2-(omega-mercaptoalkanoyl)3-oxo-1h-isoindole-1-carboxylic acids and esters
US4496542A (en) * 1981-03-30 1985-01-29 Usv Pharmaceutical Corporation N-substituted-amido-amino acids
US4766110A (en) * 1981-08-21 1988-08-23 Ryan James W Novel complex amido and imido derivatives of carboxyalkyl peptides
EP0081094A1 (en) * 1981-11-12 1983-06-15 Merck & Co. Inc. Substituted omega-amino-carboxymethyldipeptide antihypertensive agents
US4503043A (en) * 1981-12-07 1985-03-05 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-isoindole-1-carboxylic acids
ATE25244T1 (de) * 1981-12-29 1987-02-15 Hoechst Ag Neue derivate bicyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung.
DE3360065D1 (en) * 1982-03-08 1985-03-28 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
DE3211397A1 (de) * 1982-03-27 1983-11-10 Hoechst Ag, 6230 Frankfurt Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE3211676A1 (de) * 1982-03-30 1983-10-06 Hoechst Ag Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung
US4555503A (en) * 1982-05-05 1985-11-26 Merck & Co., Inc. N2 -(Substituted)carboxymethyl-N6 -(substituted)-lysyl-and αε-aminoalkyl)glycyl amino acid antihypertensive agents
US4483850A (en) * 1982-05-10 1984-11-20 Merck & Co., Inc. N-Terminal substituted oligopeptide converting enzyme inhibitors
DE3218540A1 (de) * 1982-05-17 1983-11-24 Hoechst Ag, 6230 Frankfurt Spiro-2-aza-alkan-3-carbonitrile, verfahren zu ihrer herstellung und ihre verwendung
EP0103077B1 (en) * 1982-06-17 1988-05-18 Schering Corporation Substituted dipeptides, methods for their production, pharmaceutical compositions containing them, method for making such pharmaceutical compositions
AU1643283A (en) * 1982-07-19 1984-01-26 E.R. Squibb & Sons, Inc. Substituted peptides
US4470973A (en) * 1982-07-19 1984-09-11 E. R. Squibb & Sons, Inc. Substituted peptide compounds
US4500713A (en) * 1982-09-23 1985-02-19 Usv Pharmaceutical Corporation Therapeutic dipeptides
US4634716A (en) * 1982-09-30 1987-01-06 Merck & Co., Inc. Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful as antihypertensive agents
DE3242151A1 (de) * 1982-11-13 1984-05-17 Hoechst Ag, 6230 Frankfurt Neue derivate tricyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung, sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
US4642315A (en) * 1982-11-18 1987-02-10 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4587234A (en) * 1982-11-18 1986-05-06 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
DE3246503A1 (de) * 1982-12-16 1984-06-20 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
EP0114333B1 (en) * 1982-12-27 1990-08-29 Schering Corporation Pharmaceutical composition
US4826812A (en) * 1982-12-27 1989-05-02 Schering Corporation Antiglaucoma agent
DE3300774A1 (de) * 1983-01-12 1984-07-12 Hoechst Ag, 6230 Frankfurt Neue spirocyclische aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue spirocyclische aminosaeuren als zwischenprodukte und verfahren zu deren herstellung
DE3302125A1 (de) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
DE3303344A1 (de) 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern
US4596791A (en) * 1983-03-16 1986-06-24 Usv Pharmaceutical Corp. Compounds for treating hypertension
US4666906A (en) * 1983-03-16 1987-05-19 Usv Pharmaceutical Corporation Compounds for treating hypertension
DK156484A (da) * 1983-03-16 1984-09-17 Usv Pharma Corp Aminosyrederivater
GB8311286D0 (en) * 1983-04-26 1983-06-02 Searle & Co Carboxyalkyl peptide derivatives
US4585758A (en) * 1983-05-20 1986-04-29 Usv Pharmaceutical Corp. Angiotensin-converting enzyme inhibitors
US4584285A (en) * 1983-06-02 1986-04-22 Schering Corporation Antihypertensive agents
US4783444A (en) * 1984-09-17 1988-11-08 Schering Corporation Antiglaucoma compositions and methods
FR2546886B2 (fr) * 1983-06-06 1986-05-16 Adir Derives d'acides isoindoledicarboxyliques, leur preparation et compositions pharmaceutiques les contenant
DE3322530A1 (de) * 1983-06-23 1985-01-10 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren
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Also Published As

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NL940001I2 (nl) 1998-03-02
DK161523B (da) 1991-07-15
KR880001843B1 (ko) 1988-09-21
HU193146B (en) 1987-08-28
GR75059B (fi) 1984-07-13
IE812475L (en) 1982-04-23
NO813546L (no) 1982-04-26
ATE20469T1 (de) 1986-07-15
MA19309A1 (fr) 1982-07-01
KR830007519A (ko) 1983-10-21
NL940001I1 (nl) 1994-03-01
EP0050800B2 (en) 1995-06-07
SG78188G (en) 1989-03-23
HK36189A (en) 1989-05-12
NO164983C (no) 1990-12-05
OA06929A (fr) 1983-05-31
US4818749A (en) 1989-04-04
KE3845A (en) 1989-04-07
ES506414A0 (es) 1983-10-01
IL64085A (en) 1986-12-31
NO164983B (no) 1990-08-27
AU7661481A (en) 1982-04-29
PH21916A (en) 1988-04-08
EP0050800A1 (en) 1982-05-05
DK161523C (da) 1991-12-23
MY8700683A (en) 1987-12-31
DK462581A (da) 1982-04-24
CA1341206C (en) 2001-03-20
IE53802B1 (en) 1989-03-01
JPH01163197A (ja) 1989-06-27
PT73861A (en) 1981-11-01
EP0050800B1 (en) 1986-06-18
DE19575012I2 (de) 2002-01-24
US4831157A (en) 1989-05-16
PT73861B (en) 1985-11-12
LU88621I2 (fr) 1995-09-01
ES8308838A1 (es) 1983-10-01
DE3174844D1 (en) 1986-07-24
FI83222B (fi) 1991-02-28
AU554362B2 (en) 1986-08-21
NO1995008I1 (no) 1995-09-22
NZ198702A (en) 1985-08-30
FI83222C (fi) 1991-06-10
CY1469A (en) 1989-07-21

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