FI79101B - Foerfarande foer framstaellning av ett nytt terapeutiskt anvaendbart 1-(2,3,4-trimetoxibensyl)-4-/bis(4- fluorfenyl)metyl/piperazin. - Google Patents

Foerfarande foer framstaellning av ett nytt terapeutiskt anvaendbart 1-(2,3,4-trimetoxibensyl)-4-/bis(4- fluorfenyl)metyl/piperazin. Download PDF

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Publication number
FI79101B
FI79101B FI851217A FI851217A FI79101B FI 79101 B FI79101 B FI 79101B FI 851217 A FI851217 A FI 851217A FI 851217 A FI851217 A FI 851217A FI 79101 B FI79101 B FI 79101B
Authority
FI
Finland
Prior art keywords
compound
piperazine
methyl
bis
formula
Prior art date
Application number
FI851217A
Other languages
English (en)
Finnish (fi)
Other versions
FI851217L (fi
FI851217A0 (fi
FI79101C (sv
Inventor
Hiroshi Ohtaka
Toshiro Kanazawa
Keizo Ito
Goro Tsukamoto
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Publication of FI851217A0 publication Critical patent/FI851217A0/fi
Publication of FI851217L publication Critical patent/FI851217L/fi
Publication of FI79101B publication Critical patent/FI79101B/fi
Application granted granted Critical
Publication of FI79101C publication Critical patent/FI79101C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Claims (5)

1. Förfarande för framställning av ett terapeu-tiskt användbart 1-(2,3,4-trimetoxibensyl)-4-^bis(4-fluor-5 fenyl)metyl7piperazin med formeln (I) eller ett farmaceu-tiskt godtagbart syraadditionssalt därav, ^ F H,CO . , JJ 10 Ό.ui 15 kännetecknat därav, att man a) medelst reduktion kondenserar ett bensaldehyd-derivat med den följande allmänna formeln (II) h3C0
20. A (ID H3CO'^VA"Cho h3c6 med 4-^bis(4-fluorfenyl)metyl^piperazin med den följande allmänna formeln (III) fi^TF JJ /J /~\ / ^_f ( (III) ” o eller b) kondenserar ett bensylhalogenidderivat med den följande allmänna formeln (IV)
FI851217A 1984-03-30 1985-03-26 Förfarande för framställning av ett nytt terapeutiskt användbart 1-(2, 3,4-trimetoxibensyl)-4-/bis(4-fluorfenyl)metyl/piperazin. FI79101C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6446484 1984-03-30
JP59064464A JPS60222472A (ja) 1984-03-30 1984-03-30 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物

Publications (4)

Publication Number Publication Date
FI851217A0 FI851217A0 (fi) 1985-03-26
FI851217L FI851217L (fi) 1985-10-01
FI79101B true FI79101B (fi) 1989-07-31
FI79101C FI79101C (sv) 1989-11-10

Family

ID=13258978

Family Applications (1)

Application Number Title Priority Date Filing Date
FI851217A FI79101C (sv) 1984-03-30 1985-03-26 Förfarande för framställning av ett nytt terapeutiskt användbart 1-(2, 3,4-trimetoxibensyl)-4-/bis(4-fluorfenyl)metyl/piperazin.

Country Status (10)

Country Link
US (1) US4663325A (sv)
EP (1) EP0159566B1 (sv)
JP (1) JPS60222472A (sv)
AT (1) ATE31411T1 (sv)
CA (1) CA1248110A (sv)
DE (1) DE3561199D1 (sv)
ES (3) ES8702393A1 (sv)
FI (1) FI79101C (sv)
GR (1) GR850787B (sv)
NO (1) NO163185C (sv)

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JPS61161272A (ja) * 1985-01-11 1986-07-21 Kanebo Ltd 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
US4792553A (en) * 1986-02-04 1988-12-20 Terumo Kabushiki Kaisha Diene derivatives and vasodilators containing the same
FR2614021B1 (fr) * 1987-04-14 1991-03-01 Andre Buzas Derives de la 1-((1,1-diphenyl)-1-alcenyl)-piperazine, procede d'obtention et compositions pharmaceutiques les contenant
DE4108527A1 (de) * 1991-03-15 1992-09-17 Basf Ag Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung
AU646926B2 (en) * 1991-03-20 1994-03-10 Duphar International Research B.V. Alkylenedioxyphenyl ether derivatives having anti-ischaemic, memory enhancing and anti-convulsive activity
KR960701033A (ko) * 1993-12-08 1996-02-24 그레그 씨.브라운 효능있는 칼슘 길항 및 산화방지 활성을 모두 갖는 화합물, 및 세포보호제로서 그것의 사용방법(compounds having both potent calcium antagonist and antioxidant activity and use there of as cytoprotective agents)
WO1999038515A1 (fr) * 1998-01-29 1999-08-05 Akzo Nobel N.V. Agents ameliorant la circulation optique papillaire
MXPA05001958A (es) 2002-08-19 2005-04-28 Pfizer Prod Inc Terapia de combinacion para enfermedades hiperproliferativas.
US7433519B2 (en) 2003-04-04 2008-10-07 Avid Technology, Inc. Bitstream format for compressed image data
US7403561B2 (en) 2003-04-04 2008-07-22 Avid Technology, Inc. Fixed bit rate, intraframe compression and decompression of video
WO2004093813A2 (en) * 2003-04-22 2004-11-04 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders
WO2004093816A2 (en) * 2003-04-22 2004-11-04 Pharmacia Corporation Compositions comprising a selective cox-2 inhibitor and a calcium modulating agent
EA009646B1 (ru) * 2003-05-30 2008-02-28 Рэнбакси Лабораториз Лтд. Замещённые производные пиррола и их применение в качестве ингибиторов hmg-coa
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
EP1865945A4 (en) * 2005-03-11 2008-05-21 Hong Kong Nitric Oxide Ltd TREATMENT COMBINATION FOR ENDOTHELIAL DISORDERS, ANGINA AND DIABETES
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
ATE551059T1 (de) 2005-10-26 2012-04-15 Asahi Kasei Pharma Corp Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie
AU2006313430B2 (en) * 2005-11-08 2012-09-06 Ranbaxy Laboratories Limited Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
TW200744583A (en) * 2006-03-14 2007-12-16 Ranbaxy Lab Ltd Statin stabilizing dosage formulations
MX2009000439A (es) * 2006-07-14 2009-02-04 Ranbaxy Lab Ltd Formas polimorficas de un inhibidor de hmg-coa reductasa y usos de las mismas.
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
CN101622243B (zh) 2007-02-28 2013-12-04 旭化成制药株式会社 磺酰胺衍生物
WO2012037665A1 (en) 2010-09-24 2012-03-29 Oral Delivery Technology Ltd. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
CN102936233B (zh) * 2012-11-16 2016-01-20 葛长乐 一种1-(二(4-氟苯基)甲基)-4-(2,3,4-三甲氧苯基)哌嗪二盐酸盐晶型
CN105143203A (zh) 2013-04-17 2015-12-09 辉瑞大药厂 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
WO2017069343A1 (ko) * 2015-10-20 2017-04-27 한국표준과학연구원 위치조절이 용이한 전자현미경용 전자총 및 이를 포함하는 전자현미경
CN109666008A (zh) * 2018-12-31 2019-04-23 辰欣药业股份有限公司 一种盐酸洛美利嗪的合成方法
CN113574055B (zh) 2019-01-18 2024-07-23 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB705979A (en) * 1951-03-22 1954-03-24 Henri Morren 1.4-aralkyl piperazines and process for the preparation thereof
FR1312427A (fr) * 1961-04-12 1962-12-21 Science Union Et Compagnie Soc Nouveaux dérivés de la pipérazine et leurs préparations
FR1303080A (fr) * 1961-07-25 1962-09-07 Science Union Et Compagnie Soc Pipérazines disubstituées
NL7306771A (sv) * 1972-06-02 1973-12-04
DE2900810A1 (de) * 1979-01-11 1980-07-24 Cassella Ag Substituierte n-benzhydryl-n'-p- hydroxybenzyl-piperazine und verfahren zu ihrer herstellung
GB8320701D0 (en) * 1983-08-01 1983-09-01 Wellcome Found Chemotherapeutic agent

Also Published As

Publication number Publication date
NO851298L (no) 1985-10-01
EP0159566A1 (en) 1985-10-30
ES8702393A1 (es) 1987-01-01
CA1248110A (en) 1989-01-03
ES556981A0 (es) 1988-01-01
JPS60222472A (ja) 1985-11-07
DE3561199D1 (en) 1988-01-28
NO163185C (no) 1990-04-18
FI851217L (fi) 1985-10-01
US4663325A (en) 1987-05-05
GR850787B (sv) 1985-11-25
ES8801236A1 (es) 1988-01-01
EP0159566B1 (en) 1987-12-16
ES8801237A1 (es) 1988-01-01
JPH0313232B2 (sv) 1991-02-22
ES541728A0 (es) 1987-01-01
ES556980A0 (es) 1988-01-01
FI851217A0 (fi) 1985-03-26
ATE31411T1 (de) 1988-01-15
FI79101C (sv) 1989-11-10

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Owner name: AKZO NOBEL N.V.

MA Patent expired