FI75365C - Foerfarande foer framstaellning av monoklonal antikropp till maensklig protymocytantigen medelst deras hybridcellinje. - Google Patents

Foerfarande foer framstaellning av monoklonal antikropp till maensklig protymocytantigen medelst deras hybridcellinje. Download PDF

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Publication number
FI75365C
FI75365C FI803757A FI803757A FI75365C FI 75365 C FI75365 C FI 75365C FI 803757 A FI803757 A FI 803757A FI 803757 A FI803757 A FI 803757A FI 75365 C FI75365 C FI 75365C
Authority
FI
Finland
Prior art keywords
cells
thymocytes
antibody
atcc crl
cell
Prior art date
Application number
FI803757A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI75365B (fi
FI803757L (fi
Inventor
Patrick Chung-Shu Kung
Gideon Goldstein
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22277974&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI75365(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Publication of FI803757L publication Critical patent/FI803757L/fi
Priority to FI850061A priority Critical patent/FI75433C/fi
Application granted granted Critical
Publication of FI75365B publication Critical patent/FI75365B/fi
Publication of FI75365C publication Critical patent/FI75365C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hybrid Cells (AREA)
FI803757A 1979-12-04 1980-12-03 Foerfarande foer framstaellning av monoklonal antikropp till maensklig protymocytantigen medelst deras hybridcellinje. FI75365C (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI850061A FI75433C (fi) 1979-12-04 1985-01-07 Diagnostiskt foerfarande, i vilket anvaends en specifik monoklonal antikropp till maensklig protymocyt antigen och i foerfarandet anvaendbar komposition.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/100,072 US4364935A (en) 1979-12-04 1979-12-04 Monoclonal antibody to a human prothymocyte antigen and methods of preparing same
US10007279 1979-12-04

Publications (3)

Publication Number Publication Date
FI803757L FI803757L (fi) 1981-06-05
FI75365B FI75365B (fi) 1988-02-29
FI75365C true FI75365C (fi) 1988-06-09

Family

ID=22277974

Family Applications (1)

Application Number Title Priority Date Filing Date
FI803757A FI75365C (fi) 1979-12-04 1980-12-03 Foerfarande foer framstaellning av monoklonal antikropp till maensklig protymocytantigen medelst deras hybridcellinje.

Country Status (22)

Country Link
US (1) US4364935A (index.php)
EP (1) EP0030815B1 (index.php)
JP (2) JPS5695123A (index.php)
AT (1) ATE13317T1 (index.php)
AU (1) AU545223B2 (index.php)
CA (1) CA1183470A (index.php)
DE (2) DE30815T1 (index.php)
DK (1) DK153954C (index.php)
ES (1) ES8303097A1 (index.php)
FI (1) FI75365C (index.php)
GR (1) GR72923B (index.php)
HK (1) HK24386A (index.php)
IE (1) IE50725B1 (index.php)
IL (1) IL61624A (index.php)
MY (1) MY8600519A (index.php)
NO (1) NO159888C (index.php)
NZ (1) NZ195647A (index.php)
PH (1) PH17510A (index.php)
PT (1) PT72146B (index.php)
SG (1) SG7386G (index.php)
YU (1) YU45078B (index.php)
ZA (1) ZA807567B (index.php)

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US4806349A (en) * 1979-12-04 1989-02-21 Ortho Pharmaceutical Corporation Hybrid cell line for producing monoclonal antibody to a human prothymocyte antigen, antibody, and methods
US4582797A (en) * 1980-09-25 1986-04-15 The Salk Institute For Biological Studies Monoclonal antibodies specific for human hematopoietic cell surface glycoproteins
JPS5823847B2 (ja) * 1981-02-06 1983-05-18 株式会社 林原生物化学研究所 抗ヒト蛋白質抗体の製造方法
DE3105150A1 (de) * 1981-02-12 1982-08-19 Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG, 6380 Bad Homburg Herstellung von anti-t-lymphozyten-globulin.
US4434156A (en) 1981-10-26 1984-02-28 The Salk Institute For Biological Studies Monoclonal antibodies specific for the human transferrin receptor glycoprotein
USRE32011E (en) * 1981-12-14 1985-10-22 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
WO1983003259A1 (en) * 1982-03-15 1983-09-29 Univ Columbia Method for introducing cloned, amplifiable genes into eucaryotic cells and for producing proteinaceous products
US4443427A (en) * 1982-06-21 1984-04-17 Sidney Farber Cancer Institute, Inc. Monoclonal antibody
US4579827A (en) * 1983-03-11 1986-04-01 Sloan-Kettering Institute For Cancer Research Monoclonal antibodies to human gastrointestinal cancers and hybridoma method of production of the monoclonal antibodies
JPS60231699A (ja) * 1983-11-09 1985-11-18 Aichiken 正常及び悪性ヒト造血器細胞に対するモノクローナル抗体
FR2560212B1 (fr) * 1984-02-24 1989-12-29 Unicet Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps
US5431897A (en) * 1985-04-19 1995-07-11 Sloan-Kettering Institute For Cancer Research Method of imaging colorectal carcinoma lesion and composition for use therein
US4705687A (en) * 1985-06-17 1987-11-10 Ortho Pharmaceutical (Canada) Ltd. Treatment of autoimmune diseases such as rheumatoid arthritis with suppressor factor
US4970299A (en) * 1986-07-03 1990-11-13 Sloan-Kettering Institute For Cancer Research Monoclonal antibodies selective for prostate cancer
US5601819A (en) * 1988-08-11 1997-02-11 The General Hospital Corporation Bispecific antibodies for selective immune regulation and for selective immune cell binding
CA2310805A1 (en) * 1997-11-24 1999-06-03 Johnson T. Wong Methods for treatment of hiv or other infections using a t cell or viral activator and anti-retroviral combination therapy
FR2878852B1 (fr) * 2000-09-28 2007-02-23 Imtix Sangstat Procede de production d'immunoglobulines anti-thymocytes humains
US7653260B2 (en) 2004-06-17 2010-01-26 Carl Zeis MicroImaging GmbH System and method of registering field of view
US8582924B2 (en) 2004-06-30 2013-11-12 Carl Zeiss Microimaging Gmbh Data structure of an image storage and retrieval system
EP2061505B9 (en) * 2006-09-01 2013-04-03 Genticel Composition for eliciting a specific ctl response, comprising a lympho-ablative compound and a molecule that contains antigenic sequences and targets professional antigen presenting cells
US9493578B2 (en) 2009-09-02 2016-11-15 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
JP5953303B2 (ja) 2010-07-29 2016-07-20 ゼンコア インコーポレイテッド 改変された等電点を有する抗体
US12466897B2 (en) 2011-10-10 2025-11-11 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
US10851178B2 (en) 2011-10-10 2020-12-01 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
CN110981964B (zh) 2013-01-14 2023-09-15 Xencor股份有限公司 新型异二聚体蛋白
US10968276B2 (en) 2013-03-12 2021-04-06 Xencor, Inc. Optimized anti-CD3 variable regions
US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
US9701759B2 (en) 2013-01-14 2017-07-11 Xencor, Inc. Heterodimeric proteins
US10487155B2 (en) 2013-01-14 2019-11-26 Xencor, Inc. Heterodimeric proteins
US10131710B2 (en) 2013-01-14 2018-11-20 Xencor, Inc. Optimized antibody variable regions
US11053316B2 (en) 2013-01-14 2021-07-06 Xencor, Inc. Optimized antibody variable regions
AU2014207549B2 (en) 2013-01-15 2018-12-06 Xencor, Inc. Rapid clearance of antigen complexes using novel antibodies
US10106624B2 (en) 2013-03-15 2018-10-23 Xencor, Inc. Heterodimeric proteins
US10858417B2 (en) 2013-03-15 2020-12-08 Xencor, Inc. Heterodimeric proteins
US10519242B2 (en) 2013-03-15 2019-12-31 Xencor, Inc. Targeting regulatory T cells with heterodimeric proteins
EP3421495A3 (en) 2013-03-15 2019-05-15 Xencor, Inc. Modulation of t cells with bispecific antibodies and fc fusions
EP3104882B1 (en) 2014-02-14 2019-06-05 Centrose, Llc Extracellular targeted drug conjugates
RS59907B1 (sr) 2014-03-28 2020-03-31 Xencor Inc Bispecifična antitela koja se vezuju za cd38 i cd3
US10526417B2 (en) 2014-11-26 2020-01-07 Xencor, Inc. Heterodimeric antibodies that bind CD3 and CD38
SG11201704283PA (en) 2014-11-26 2017-06-29 Xencor Inc Heterodimeric antibodies that bind cd3 and tumor antigens
US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
US10428155B2 (en) 2014-12-22 2019-10-01 Xencor, Inc. Trispecific antibodies
WO2016141387A1 (en) 2015-03-05 2016-09-09 Xencor, Inc. Modulation of t cells with bispecific antibodies and fc fusions
US11623957B2 (en) 2015-12-07 2023-04-11 Xencor, Inc. Heterodimeric antibodies that bind CD3 and PSMA
LT3468586T (lt) 2016-06-14 2024-12-10 Xencor, Inc. Bispecifiniai antikūnai prieš imuninės sistemos kontrolės taškų inhibitorius
MX2018016265A (es) 2016-06-28 2019-07-04 Xencor Inc Anticuerpos heterodimericos que se unen al receptor 2 de somatostatina.
US10793632B2 (en) 2016-08-30 2020-10-06 Xencor, Inc. Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
NZ793452A (en) 2016-10-14 2025-09-26 Xencor Inc IL15/IL15Rα HETERODIMERIC FC-FUSION PROTEINS
MA49517A (fr) 2017-06-30 2020-05-06 Xencor Inc Protéines de fusion fc hétérodimères ciblées contenant il-15/il-15ra et domaines de liaison à l'antigène
AU2018366199A1 (en) 2017-11-08 2020-05-28 Xencor, Inc. Bispecific and monospecific antibodies using novel anti-PD-1 sequences
US10981992B2 (en) 2017-11-08 2021-04-20 Xencor, Inc. Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
CN111655718B (zh) 2017-12-19 2025-07-22 Xencor股份有限公司 经过工程化的il-2 fc融合蛋白
EP3773911A2 (en) 2018-04-04 2021-02-17 Xencor, Inc. Heterodimeric antibodies that bind fibroblast activation protein
EP3781598A1 (en) 2018-04-18 2021-02-24 Xencor, Inc. Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains
JP2021521784A (ja) 2018-04-18 2021-08-30 ゼンコア インコーポレイテッド ＩＬ−１５／ＩＬ−１５ＲａＦｃ融合タンパク質とＰＤ−１抗原結合ドメインを含むＰＤ−１標的化ヘテロダイマー融合タンパク質およびそれらの使用
WO2020072821A2 (en) 2018-10-03 2020-04-09 Xencor, Inc. Il-12 heterodimeric fc-fusion proteins
CN114173875B (zh) 2019-03-01 2025-04-15 Xencor股份有限公司 结合enpp3和cd3的异二聚抗体
WO2021231976A1 (en) 2020-05-14 2021-11-18 Xencor, Inc. Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3
CN117157319A (zh) 2021-03-09 2023-12-01 Xencor股份有限公司 结合cd3和cldn6的异二聚抗体
JP2024509274A (ja) 2021-03-10 2024-02-29 ゼンコア インコーポレイテッド Ｃｄ３及びｇｐｃ３に結合するヘテロ二量体抗体
CN114085818A (zh) * 2021-11-19 2022-02-25 蔡开来 一种抗大熊猫Thy1单克隆抗体及其杂交瘤细胞株和应用

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US4172124A (en) * 1978-04-28 1979-10-23 The Wistar Institute Method of producing tumor antibodies
US4284412A (en) * 1979-07-13 1981-08-18 Ortho Diagnostics, Inc. Method and apparatus for automated identification and enumeration of specified blood cell subclasses

Also Published As

Publication number Publication date
NO159888B (no) 1988-11-07
EP0030815A3 (en) 1981-12-30
IE802511L (en) 1981-06-04
PH17510A (en) 1984-09-07
DK153954C (da) 1989-02-20
IL61624A (en) 1984-07-31
IL61624A0 (en) 1981-01-30
DE3070655D1 (en) 1985-06-20
PT72146A (en) 1981-01-01
ES497425A0 (es) 1982-12-16
NZ195647A (en) 1984-07-06
ATE13317T1 (de) 1985-06-15
YU45078B (en) 1992-03-10
DE30815T1 (de) 1984-07-19
CA1183470A (en) 1985-03-05
US4364935A (en) 1982-12-21
NO159888C (no) 1989-02-15
EP0030815A2 (en) 1981-06-24
DK153954B (da) 1988-09-26
NO803661L (no) 1981-06-05
DK517380A (da) 1981-06-05
FI75365B (fi) 1988-02-29
FI803757L (fi) 1981-06-05
PT72146B (en) 1982-07-05
ZA807567B (en) 1982-07-28
IE50725B1 (en) 1986-06-25
AU6501280A (en) 1981-06-11
JPH0159870B2 (index.php) 1989-12-20
EP0030815B1 (en) 1985-05-15
HK24386A (en) 1986-04-11
JPS649999B2 (index.php) 1989-02-21
YU306780A (en) 1984-04-30
MY8600519A (en) 1986-12-31
JPS6413988A (en) 1989-01-18
SG7386G (en) 1986-11-21
JPS5695123A (en) 1981-08-01
AU545223B2 (en) 1985-07-04
ES8303097A1 (es) 1983-02-16
GR72923B (index.php) 1984-01-11

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Owner name: ORTHO PHARMACEUTICAL CORPORATION